معرفی
Shujun Liu is a Researcher at the Center for Neuroscience and Regeneration Research, Yale School of Medicine, Yale University. His work focuses on ion channel biology, particularly sodium (NaV) and potassium (Kv) channels, in sensory neurons and their role in pain mechanisms, inflammation, and neuropathic disorders. He investigates protein trafficking, axonal dynamics, and channelopathies using advanced live-cell imaging and stem cell-derived neuron models.
Research Interests: Dr. Liu’s research explores how sodium and potassium channels regulate neuronal excitability under physiological and pathological conditions. Key topics include: (1) inflammatory modulation of NaV1.7 and Kv channels in nociceptors, (2) mechanisms of axonal protein trafficking and recycling, (3) drug effects (e.g., paclitaxel) on ion channel localization, and (4) modeling inherited pain syndromes using induced pluripotent stem cells (iPSCs). His work bridges basic neurobiology with translational pain research.
Publications Trends: Recent studies highlight co-trafficking of depolarizing NaV and hyperpolarizing Kv channels, compartment-specific channel regulation by TNF-α, and Ih current’s role in stabilizing DRG neuron excitability. These findings advance understanding of pain pathophysiology and potential therapeutic targets.
Labs & Collaborations: Collaborates closely with Professors Stephen Waxman, Sulayman Dib-Hajj, and Sidharth Tyagi on projects related to ion channel dysfunction in chronic pain and neurological disorders.