معرفی
Elizabeth Jonas is the Harvey and Kate Cushing Professor of Medicine (Endocrinology) and Professor of Neuroscience at Yale University’s School of Medicine. She holds affiliations with the Diabetes Research Center, Endocrinology Fellowship Training Program, and the Interdepartmental Neuroscience Program. Her research focuses on mitochondrial function in neurodegenerative diseases, synaptic plasticity, and cellular metabolism. Jonas earned her MD from New York University (1986) and BA from Yale University (1982), with postdoctoral training at Yale under Leonard Kaczmarek.
Her work explores mitochondrial ion channels (e.g., the ATP synthase c-subunit pore) and their roles in cell death, neurodevelopment, and energy efficiency. Key areas include mitochondrial permeability transition pore mechanisms, Bcl-xL’s role in synaptic health, and DJ-1’s impact on Parkinson’s disease. Recent findings highlight mitochondrial dysfunction in Fragile X Syndrome and potential therapeutic targets like alpha-tocotrienol.
Jonas has been recognized with the 2025 Biophysical Society Award in Biophysics of Health and Disease and election to the Association of American Physicians (2022). Her lab investigates translational applications of mitochondrial biology, including stroke, neurodegeneration, and developmental brain disorders.
Her research spans structural biology (ATP synthase cryo-EM studies), neurophysiology (synaptic plasticity mechanisms), and clinical implications (novel treatments for metabolic and neurological disorders). Collaborations include Leonard Kaczmarek, Pawel Licznerski, and Marc C. Llaguno.
