معرفی
Marc C Llaguno is a Research Scientist and Site Director of Cryo-Electron Microscopy at the Yale School of Medicine (YSM), Department of Neuroscience. He specializes in structural biology and cryoelectron microscopy, focusing on mitochondrial ATP synthase and its role in cell death mechanisms. His research explores the molecular basis of mitochondrial megachannels and their implications in neurodegenerative diseases and cellular energetics.
Education:
- PhD in Physics, University of Pennsylvania (2004)
- BS in Physics, University of the Philippines (1997)
Research Focus:
Dr. Llaguno's work centers on resolving the structure and function of mitochondrial ATP synthase, a critical enzyme in cellular energy production. His team uses advanced cryo-EM techniques to study how structural changes in this enzyme lead to megachannel formation, triggering cell death pathways. Recent studies highlight the enzyme's role in excitotoxic neuronal death and mitochondrial permeability transition pores.
Labs:
He directs the CCMI Electron Microscopy Lab, a core facility supporting structural biology research at YSM. The lab provides cutting-edge cryo-EM infrastructure for studying biological complexes at near-atomic resolution.
