Daniel Keedy

Dr. Daniel Keedy is an Assistant Professor in the Department of Chemistry and Biochemistry at the City University of New York (CUNY) Advanced Science Research Center (ASRC). His research focuses on understanding protein dynamics, enzymology, and structural biology, particularly in phosphatases such as PTP1B and STEP. He employs advanced techniques like X-ray crystallography, cryo-EM, and hydrogen-deuterium exchange (HDX) mass spectrometry to elucidate allosteric mechanisms and conformational heterogeneity.

Keedy's work emphasizes discovering novel drug targets through fragment screening and computational modeling. His lab develops innovative methods for multiconformer modeling (e.g., qFit software) and explores extreme environmental effects (temperature/pressure) on enzyme structures. Key collaborators include structural biologists and computational chemists to bridge experimental and theoretical insights.

His research has implications for metabolic disorders, cancer, and neurodegenerative diseases. He maintains an active laboratory (keedylab.org) and contributes to open-source tools for structural biology analysis. No awards or fellowships are listed in the provided text.