Daniel J. Deredge

Daniel J. Deredge, PhD, is an Assistant Professor in the Department of Pharmaceutical Sciences at the University of Maryland School of Pharmacy. His research integrates structural protein mass spectrometry and computational chemistry to study the structure, dynamics, and function of biologically significant proteins.

• University: University of Maryland
• School: School of Pharmacy
• Department: Department of Pharmaceutical Sciences
• Position: Assistant Professor

Education:

• PhD in Biochemistry, Louisiana State University
• BS in Biochemistry, Louisiana State University
• Postdoctoral Training, Biophysics and Physiology, Case Western Reserve University
• Postdoctoral Training, Pharmaceutical Sciences, University of Maryland School of Pharmacy

Dr. Deredge's research centers on the application of hydrogen-deuterium exchange mass spectrometry (HDX-MS) to understand protein conformational changes and dynamics in systems such as viral RNA polymerases (e.g., Dengue virus NS5), bacterial heme uptake proteins, and neurotransmitter:sodium symporters. He combines experimental HDX-MS data with computational modeling to refine molecular dynamics ensembles and gain deeper mechanistic insights. A current focus includes optimizing the formulation of protein therapeutics, bridging fundamental biophysics with pharmaceutical applications.

Although no publications are listed in the provided text, his research program suggests a strong emphasis on integrative structural biology and biophysical characterization of membrane and viral proteins. He is actively recruiting graduate and postdoctoral researchers, indicating a growing and dynamic research group.

Scientific Awards:

Dr. Deredge has not received any scientific awards listed in the provided information.

Advising and Grants:

Dr. Deredge is currently recruiting PhD and MS students as well as postdoctoral fellows for his laboratory, indicating active research and likely external funding to support these positions. While specific grants are not mentioned, his research scope suggests support from agencies such as the NIH or NSF. He is building a research program that trains students in advanced biophysical and computational techniques.

Labs and Teams:

Dr. Deredge leads the Deredge Lab at the University of Maryland School of Pharmacy, focused on structural mass spectrometry and computational integration. The lab is actively developing methodologies to combine HDX-MS data with computational models to study protein dynamics. More information about current research projects can be found at https://deredgelab.com/current-research/. The lab website is currently under construction.