Thomas J. D. Jørgensen

Thomas J. D. Jørgensen is an Associate Professor and Head of the Research Section of Biomedical Mass Spectrometry at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. He leads an active research group focusing on protein structural dynamics using mass spectrometry and hydrogen/deuterium exchange methodologies.

His research interests lie at the intersection of biochemistry, structural biology, and systems biology, particularly in understanding how protein dynamics govern function and dysfunction in diseases such as Parkinson’s and metabolic disorders. He employs advanced mass spectrometry techniques to study conformational changes, protein-protein interactions, and enzyme regulation, with a strong emphasis on lipoprotein metabolism and neurodegenerative disease mechanisms.

The most recent articles highlight a consistent focus on protein dynamics in lipid metabolism, conformational diseases, and glycoprotein analysis, utilizing hydrogen/deuterium exchange mass spectrometry (HDX-MS) and related techniques. Themes include allosteric regulation of enzymes, protein unfolding, and structural phenotyping of disease-related aggregates.

• Member of the evaluation committee at the Swedish Research Council (2015)
• Chairman of multiple PhD evaluation committees (2014)
• Editorial and peer-review contributions to the scientific community

He currently supervises PhD students and is involved in several major research projects funded by organizations such as the Michael J. Fox Foundation and Novo Nordisk Fonden. His lab, the Thomas J. D. Jørgensen Lab, includes postdoctoral researchers, academic staff, and industrial PhD students, fostering a collaborative and interdisciplinary research environment focused on biomedical mass spectrometry and systems biology.