Clinton Mathias

Clinton Mathias is an Associate Professor of Nutritional Immunogenetics at the Department of Nutritional Sciences, University of Connecticut. He previously served as a Professor and Associate Professor of Pharmacology at Western New England University’s College of Pharmacy and Health Sciences (2010–2022) and currently holds an Adjunct Associate Professor role at the University of Massachusetts Amherst.

• Ph.D. in Biomedical Sciences (Immunology), University of Connecticut Health Center (2005)
• M.Sc. in Microbiology, University of Mumbai (1997)
• B.Sc. in Microbiology and Biochemistry, St. Xavier’s College, Mumbai (1995)

Dr. Mathias’ research focuses on mast cell biology, exploring their role in allergic responses, host defense, and disease. His work investigates how diet, epigenetic modifications, and cytokines like IL-10 and IL-33 modulate mast cell function at single-cell, genomic, and epigenetic levels. Current projects aim to identify therapeutic strategies for food allergies and respiratory disorders by targeting IL-10 as a mast cell growth factor and analyzing diet-induced epigenetic changes.

His publications highlight mast cell-plasticity, dietary antigen effects, IL-10’s dual role in IgE-mediated activation, and epigenetic regulators of food allergic responses. Awards include the AAI Distinguished Service Award, multiple Excellence in Scholarship Awards, and Professor of the Year honors.

• AAI Laboratory Travel Grant (2022)
• AAI Distinguished Service Award (2019)
• Professor of the Year nominations (2019, 2022)
• Excellence in Scholarship Award (2019, Western New England University)
• AACP Excellence in Innovative Research Award (2016)
• Undergraduate Faculty Travel Grant (2016, 2014, 2013)
• Excellence in Service Award (2016)
• Professor of the Year Award (2014)
• Excellence in Scholarship Award (2013)

Dr. Mathias has secured NIH RO1 and R15 grants to study IL-10’s role in allergic responses and curcumin’s inhibitory effects, alongside NSF and institutional funding. His lab at UConn (https://mathiaslab.nusc.uconn.edu/) investigates mast cell interactions with immune cells in the gut and airways, emphasizing nutritional and cytokine-based therapies.