Carole Oskeritzian

Carole Oskeritzian, Ph.D., is a Professor in the Department of Pathology, Microbiology & Immunology at the University of South Carolina School of Medicine Columbia. Her research focuses on the cellular and molecular mechanisms underlying allergic inflammatory diseases such as asthma, atopic dermatitis, and anaphylaxis, with a central emphasis on mast cell biology and sphingosine-1-phosphate (S1P) signaling.

She earned her Ph.D. and M.S. in Immunology from Denis Diderot University (Paris 7), and her B.S. and M.S. in Biology and Biochemistry from Paris-Val-de-Marne University (Paris 12). Her training also includes research at The Pasteur Institute and Virginia Commonwealth University.

Her research program investigates:

• Mast cell development, survival, and phenotype plasticity
• The role of S1P in autocrine inflammatory amplification loops
• S1P and its receptor S1PR2 in systemic anaphylaxis
• Regulation of chymase and CD88 expression by IL-6 and S1P
• The mast cell/S1P/eosinophil triad in chronic lung and skin inflammation

Analysis of her recent publications reveals a consistent focus on mast cell signaling pathways—particularly those involving MRGPRX2, Siglec-9, and S1P—as key regulators of allergic and inflammatory responses. Her work spans fundamental molecular mechanisms to translational implications, including drug adverse reactions and immune modulation in cancer.

She has authored numerous peer-reviewed articles and reviews in high-impact journals such as Journal of Allergy and Clinical Immunology, Frontiers in Immunology, and Pharmacology & Therapeutics. Notable review articles include comprehensive analyses of S1P in allergic diseases and mast cell plasticity in cancer.

Dr. Oskeritzian actively mentors students and researchers, though specific advisee names are not listed. Her work is supported by robust collaborations and a sustained publication record, indicating ongoing research activity and leadership in immunology. She has no listed scientific awards in the provided text, but her extensive publication history and senior academic rank reflect significant scholarly impact.

She is involved in advanced laboratory research utilizing in vitro and in vivo models to dissect mast cell functions and signaling pathways, contributing to the development of mechanistically tailored therapies for chronic inflammatory conditions.