معرفی
Mikael Adner is a Senior Lecturer at the Karolinska Institutet, affiliated with the Institute of Environmental Medicine and leading the Unit of Experimental Asthma and Allergy Research. His work bridges physiology, pharmacology, and molecular immunology to uncover mechanisms behind asthma-related airway constrictions.
- Senior Lecturer, Karolinska Institutet (2021–present)
- Docent, Karolinska Institutet (2006)
- Research Focus: Respiratory Medicine & Allergy
Research interests center on asthma pathophysiology, emphasizing:
- Mast cell activation and its role in airway inflammation
- Cytokine signaling (e.g., IL-13, IL-33, TLR pathways)
- Lipid mediator metabolism and its impact on bronchoconstriction
- Development of guinea pig and human bronchi models for translational studies
- Novel bronchodilators (quinolines, polyvinylalcohol-carbazate)
- Mechanisms of DNA damage in respiratory epithelium
His recent publications highlight trends in allergic inflammation, with studies on:
- TLR activation and airway hyperresponsiveness
- Mast cell heterogeneity via single-cell RNA sequencing
- COVID-19-induced metabolic changes
- Targeting oxylipins for asthma treatments
- Anti-inflammatory properties of chemical compounds
- Role of serotonin and cytokines in airway responses
Collaborations include researchers from multiple institutions, with a focus on translational asthma research using in vivo, ex vivo, and in vitro approaches. Current projects aim to identify new therapeutic targets for asthma and allergic diseases.
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