Chih Hung Lo

Chih Hung Lo is an Assistant Professor in the Department of Biology and Interdisciplinary Neuroscience Program at Syracuse University's College of Arts and Sciences. His research focuses on molecular mechanisms of neurodegeneration and neuroinflammation, with emphasis on autophagy, lysosomal dysfunction, and receptor signaling in Alzheimer's disease and multiple sclerosis.

Dr. Lo's educational background includes:

• Ph.D. from University of Minnesota (2019)
• B.B.A. from National University of Singapore (2014)
• B.E. from National University of Singapore (2014)

His research spans Neurodegeneration, Alzheimer's Disease, Multiple Sclerosis, Neuroinflammation, Autophagy, and Drug Discovery. The Lo Lab investigates how autophagy and lysosomal dysfunction—driven by inflammatory cytokine receptor signaling (e.g., TNF), lipid dysregulation, and intrinsically disordered proteins (e.g., tau)—contribute to neuroinflammation. They combine interdisciplinary approaches to study receptor structure-function and protein dynamics for biosensor engineering and high-throughput drug screening, with strong focus on nanomedicine for brain targeting.

Analysis of his recent publications (2020-2023) reveals dominant themes in lysosomal acidification dysfunction in neurodegeneration, TNFR1 signaling modulation, tau oligomerization, and bioengineering applications for translational neuroscience. His work bridges molecular mechanisms with clinical applications, particularly in Alzheimer's and multiple sclerosis therapeutics.

Dr. Lo's scientific honors include:

• Trainee Professional Development Award, Society for Neuroscience (2023)
• Selected as Young Scientist for Lindau Nobel Laureate Meeting (2023)
• BBA Rising Star in Biochemistry & Biophysics (2023)
• UMN Best Dissertation Award (2020)
• BME Department Best Dissertation Award (2020)

He actively mentors students through Syracuse's graduate programs and serves as Review Editor for Frontiers in Molecular Neuroscience, Guest Editor for International Journal of Molecular Sciences, and peer reviewer for multiple journals. His academic service includes editorial roles for Pharmaceuticals and Immunology, and membership in the Society for Neuroscience.

The Lo Lab operates at the neuroscience-bioengineering interface, maintaining collaborations with Yale, Harvard, and Nanyang Technological University. Current projects focus on developing TNFR1 biosensors, tau oligomer-targeted therapies, and nanomedicine platforms for brain delivery, with strong emphasis on clinical translation of basic discoveries.