معرفی
Charles Giardina is a Professor at the University of Connecticut in the Department of Cell and Developmental Biology. He holds a Ph.D. from SUNY Stony Brook and completed postdoctoral research at Cornell University. His work focuses on molecular and cellular mechanisms in colon cancer, particularly NF-kB signaling, HDAC inhibition, and transcriptional regulation.
- Ph.D., Molecular Biology, SUNY Stony Brook
- Postdoctoral Research, Cornell University
His research explores how chemical and physical injuries affect gene regulation and cell survival in colon cancer. Key areas include epigenetic modifications, inflammation, and chemopreventive agents like butyrate and green tea extract.
His 15 most recent articles (2010-2018) highlight studies on NF-kB dynamics, HDAC3 overexpression in colon cancer, spindle assembly disruption, and dietary methyl donor depletion as therapeutic strategies. Collaborations with researchers such as David W. Rosenberg and Laura E. Harrison underscore his interdisciplinary approach.
Scientific recognition includes the Toxicol Sci paper of the year (1999) for work on acetaminophen’s effects on NF-kB signaling.
Giardina’s lab utilizes intestinal organoids and hyperbaric oxygen therapy models to study tumor microenvironments and renal injury in diabetes. His work bridges molecular biology, pharmacology, and toxicology to identify novel cancer targets.
