A. Thomas Look

A. Thomas Look is a Professor at the Department of Pediatric Oncology, Dana-Farber Cancer Institute, affiliated with Harvard Medical School. His research focuses on cancer genetics using zebrafish models to study human leukemias and solid tumors.

• Research Interests: Cancer genetics, zebrafish as a model organism, developmental pathways in malignancies, transgenic approaches for tumor modeling, and pharmacological targeting of oncogenes/tumor suppressors.

Recent publications highlight work on synthetic lethal strategies in TET2-mutant cancers, Pin1 inhibition for Myc-driven tumors, and metabolic enzymes like DLST as therapeutic targets in neuroblastoma. Studies also explore p53 pathway interactions and combination therapies for melanoma and ganglioneuromas.