جست‌وجوی استاد و پژوهشگر

Lydia Herzelمشاهده پروفایل

استادیار

• RNA Biology
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Lydia Herzel is an Assistant Professor in the Department of Biochemistry at the Freie Universität Berlin, affiliated with the Department of Biology, Chemistry, Pharmacy. Her research focuses on RNA dynamics, particularly mRNA regulation in fungi and bacteria, combining biochemistry, bioinformatics, and molecular biology. She leads the Herzel Group, which explores co-transcriptional RNA regulation and its impact on gene expression outcomes. The group employs advanced RNA sequencing and biochemical techniques to study transcriptome diversity and regulatory mechanisms. Her work spans topics such as RNA splicing, mRNA decay, and the interplay between transcription and post-transcriptional processes. Key areas include understanding how regulatory mechanisms influence fungal pathogenesis (e.g., Candida albicans) and bacterial gene expression. She collaborates on projects involving synthetic biology, codon usage, and functional genomics. Recent studies highlight her group’s contributions to understanding spliceosome function in morphogenesis and the development of novel clathrin inhibitors. She actively mentors students, including Javier Callís Creus, a former bachelor’s thesis student. The lab seeks motivated researchers interested in integrating biochemistry, microbiology, and bioinformatics. Her research has been published in high-impact journals such as Nature Reviews Molecular Cell Biology , Nucleic Acids Research , and mBio . Her work bridges fundamental biology with biomedical applications, aiming to translate regulatory insights into therapeutic strategies.

Francesca Tuortoمشاهده پروفایل

استاد

• RNA Epigenetics
• tRNA Modifications
• Protein Synthesis Regulation
• +۴ مورد دیگر

Dr. Francesca Tuorto is a Professor at the Department of Biochemistry, Mannheim Medical Faculty of Heidelberg University. Her research focuses on RNA epigenetics and tRNA modifications, particularly the roles of 5-methylcytidine and queuosine in protein synthesis regulation. She uses Caenorhabditis elegans and Mus musculus as model organisms to study how tRNA modifications impact development and physiology. Key Projects: Queuosine’s role in sex-dependent learning 5-methylcytosine’s role in stress adaptation Computational tools for ribosome profiling (RiboVIEW) Techniques: Ribosome profiling, CRISPR-based knockout models, mass spectrometry Her work bridges molecular mechanisms of RNA modifications with organismal biology, emphasizing translational control and disease relevance.

• Time-resolved spectroscopy
• White-light spectroscopy
• Luminescence microscopy
• +۵ مورد دیگر

Prof. Dr. Marina Gerhard leads the Semiconductor Spectroscopy Group at Philipps University of Marburg's Department of Experimental Semiconductor Physics. Her research focuses on time-resolved spectroscopy , white-light spectroscopy , and luminescence microscopy of organic and organic/inorganic semiconductor systems. Philipps University of Marburg Department 13 - Physics Experimental Semiconductor Physics Key research areas include: Optical and electronic properties of semiconductor nanostructures Magnetic semiconductors Organic-inorganic hybrid systems Her recent publications span drug design , biochemical interactions , and structural biology , with emphasis on kinase targeting , tRNA-Guanine transglycosylase inhibition, and ligand-receptor interactions . While no specific scientific awards were mentioned in the provided data, her group maintains active research collaborations and training programs. Current doctoral and master's students include: Nico Hofeditz Dominik Muth Alexander Schauerte Anton Krüger Johannes Röder Pranav Elango Luise Rost For detailed information about research projects, publications, and team activities, please consult the group's intranet resources.

• Tetrapyrroles
• Bacterial Resistance Mechanisms
• Lipid Modification
• +۳ مورد دیگر

Dr. Jürgen Moser is a Senior Academic Councillor/Group Leader at the Institute of Microbiology, Technical University of Braunschweig, within the Faculty of Life Sciences. His group focuses on tetrapyrrole biosynthesis, bacterial lipid modification mechanisms, and microbial natural products. He holds a PhD in organic chemistry and has led research on antibiotic resistance, chlorophyll synthesis, and violacein production. Education: 1991–1996: Studied Chemistry at Albert Ludwig University of Freiburg 1996–1997: Diploma thesis at Freiburg’s Department of Organic Chemistry (topic: phospholipase C structure) 1997–2000: PhD at Freiburg under Prof. D. Jahn (topic: glutamyl-tRNA reductase mechanism) Research Interests: Enzymatic mechanisms of tetrapyrrole biosynthesis tRNA-dependent lipid modifications (e.g., alanyl- and lysyl-phosphatidylglycerol) Antibiotic resistance pathways in Pseudomonas aeruginosa and Acinetobacter baumannii Chlorophyll and bacteriochlorophyll synthesis in photosynthetic bacteria Biosynthesis of antimicrobial natural products like violacein Publications: Recent work includes studies on carnitine degradation pathways in pathogens, lipid homeostasis in biofilms, and structural biology of nitrogenase-like enzymes. His research bridges microbiology, enzymology, and structural biology to uncover molecular mechanisms of bacterial adaptation and survival. Lab/Team: The Moser Group investigates microbial metabolism and resistance mechanisms, with ongoing projects in the MINAS consortium for microbial natural products. Collaborations include structural biology (e.g., crystallography) and biophysical methods.

Claus-Peter Witteمشاهده پروفایل

استاد

• Central nucleotide metabolism
• Nucleotide catabolism
• Urea catabolism
• +۷ مورد دیگر

Prof. Dr. Claus-Peter Witte is a full Professor and Executive Director at the Institute of Plant Nutrition, Leibniz University Hannover, within the Faculty of Natural Sciences. He leads research in molecular nutrition and plant biochemistry, focusing on nucleotide and nitrogen metabolism. He also serves on multiple academic committees, including the Faculty Council, Curriculum and Teaching Committee, and the Admissions Board for MSc Plant Biotechnology. Studied biotechnology at TU Braunschweig (1991–1997) Diploma thesis at University of Córdoba, Spain (1996–1997) PhD at Scottish Crop Research Institute, UK (1997–2001), supported by DAAD and Marie Curie scholarships Postdoctoral fellow at Max Planck Institute for Plant Breeding Research (2001–2004), EMBO fellow University Assistant at Free University of Berlin (2005–2009) Group leader of German-Chinese junior research group (2009–2014) Habilitation in Botany, Free University of Berlin (2012) Appointed W3 Professor at Leibniz University Hannover (2014) His research centers on central nucleotide metabolism, including purine and pyrimidine catabolism, urea and ureide degradation, and nucleoside salvage pathways in plants. He investigates metabolic analytics and the role of nucleotide metabolites in plant development and stress responses. His work integrates biochemistry, molecular biology, and metabolomics. Analysis of his recent publications (2021–2025) reveals a consistent focus on nucleotide metabolism in plants, particularly enzymes involved in purine and pyrimidine catabolism, nucleoside phosphorylation, and salvage pathways. His studies employ structural biology, metabolomics, and genetic approaches, often in Arabidopsis thaliana and crop plants, contributing to understanding metabolic regulation, genome stability, and plant nutrition. Prof. Witte has held prestigious fellowships, including DAAD, Marie Curie, and EMBO, reflecting his international research recognition. While no specific awards are listed, these fellowships underscore his scientific excellence. He advises students and collaborates widely, with frequent co-authorship with researchers such as Herde, Straube, and Medina-Escobar. He has contributed to methodological advances in nucleotide analysis and protein purification. His research is supported by institutional and likely external funding, though specific grants are not detailed. Prof. Witte leads the Institute of Plant Nutrition, overseeing research and education in plant nutrition and biochemistry. His team investigates metabolic pathways critical for plant growth, nutrient use efficiency, and stress adaptation, with potential applications in agriculture and biotechnology.

Laura Hartmannمشاهده پروفایل

استاد

• Glycobiology
• Chemical Biology
• Macromolecular Chemistry
• +۱۲ مورد دیگر

Professor Dr. Laura Hartmann is a faculty member in the Department of Macromolecular Chemistry at the Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf (HHU). She has held this position since March 1, 2023, and leads an active research group at the interface of chemistry and biology, with a focus on glycobiology and disease mechanisms. Her research interests include: Chemical Glycobiology Aberrant Protein Glycosylation Congenital Disorders of Glycosylation (CDG) NGLY1 Deficiency and the Nrf1 Pathway Bioorthogonal Chemistry and Glycoanalysis Development of Molecular Tools for Biomolecule Analysis The recent publications of Prof. Hartmann and her team reveal a strong trend in developing chemical tools for glycoprotein analysis, understanding rare genetic diseases like CDGs, and exploring therapeutic strategies for cancers such as multiple myeloma through modulation of the NGLY1/Nrf1 axis. Her work combines synthetic chemistry, biochemical analysis, and disease modeling. Scientific awards and recognitions include: ERC Consolidator Grant (2022) Honored for contribution to the Wolf Prize 2022 special issue of the Israel Journal of Chemistry Prof. Hartmann actively mentors and advises students, including PhD candidates Simon Walber, Georgia Partalidou, and Frauke Stoelting, as well as Master's and Bachelor's students. Her research is supported by competitive grants, including the ERC Consolidator Grant, and she collaborates with national and international researchers, such as Prof. Nicole Snyder and Dr. Jonathan Lim. She is also involved in academic outreach through initiatives like the Dr. Manfred Jäger Lecture series. She leads a research laboratory focused on chemical glycobiology, where her team develops and applies bioorthogonal probes and investigates the molecular basis of glycosylation-related diseases. The lab is part of the broader Institute of Organic Chemistry and Macromolecular Chemistry at HHU and participates in research consortia such as GlycoPathogens.

Thomas Biedenbänderمشاهده پروفایل

پژوهشگر ارشد

• Dynamic Nuclear Polarization
• Solid-State NMR
• Biomolecular Dynamics
• +۳ مورد دیگر

Dr. Thomas Biedenbänder is a postdoctoral researcher in the Department of Physical Chemistry at the Institute of Chemistry, University of Rostock, Germany. He works in the research group of Prof. Dr. Björn Corzilius, focusing on advanced NMR techniques for biomolecular studies. His educational background includes: Bachelor of Science in Biochemistry (2014-2017) from Goethe University Frankfurt. Master of Science in Biochemistry (2017-2020) from Goethe University Frankfurt. Doctoral studies in Physical Chemistry (2020-2025) under Prof. Dr. Björn Corzilius at the University of Rostock. Dr. Biedenbänder's research centers on Dynamic Nuclear Polarization (DNP) and its application in enhancing sensitivity for solid-state NMR spectroscopy of biomolecules. His work particularly investigates biomolecular dynamics, RNA structure and function, and develops computational simulations (SIMPSON) to understand polarization mechanisms. He has made significant contributions to the field of biomolecular NMR, especially in the context of tRNA and RNA-protein interactions. His publication record shows a strong focus on methodological advancements in DNP and NMR, with recent work spanning from fundamental polarization mechanisms to applications in complex biological systems. The articles highlight a trend towards integrating DNP with other NMR techniques to study dynamics and structure in biomolecules, particularly nucleic acids. His scientific awards include: ErasmusPlus scholarship (2018) for research at Aarhus University, Denmark. Deutschlandstipendium scholarship (2017-2018) at Goethe University Frankfurt. Fellow of the Joachim Herz Foundation (2021-2024). As a postdoctoral researcher in the Corzilius group, Dr. Biedenbänder is actively involved in collaborative projects that aim to push the boundaries of NMR spectroscopy for biological applications. His work often involves interdisciplinary collaborations, as evidenced by co-authorship with multiple research groups.

• Ribosome Function and Dynamics
• Translation Regulation and Fidelity
• Protein Synthesis
• +۱۰ مورد دیگر

Marina Rodnina is a Full Professor and Director of the Department of Physical Biochemistry at the Max Planck Institute for Multidisciplinary Sciences in Göttingen, Germany. She leads a research group dedicated to understanding the molecular mechanisms of protein synthesis, with a focus on ribosome function, translation fidelity, and dynamics. Her work bridges biochemistry, structural biology, and biophysics to dissect the ribosome as a molecular machine. Her research interests center on ribosome function and dynamics , regulation and fidelity of translation , and ribosome-catalyzed reactions . She investigates how the ribosome selects aminoacyl-tRNAs with high accuracy, how GTPase factors like EF-Tu and EF-G are activated, and how translocation occurs during elongation. Her lab employs kinetic, biophysical, and structural approaches to study co-translational folding, frameshifting, and antibiotic interactions with the translational apparatus. The ribosome serves as a model system for understanding large macromolecular assemblies, with implications for biotechnology and antimicrobial development. Analysis of her recent publications reveals a strong focus on the dynamic and functional aspects of the ribosome, particularly in tRNA selection, translocation, and co-translational processes. Her work frequently combines real-time kinetic measurements with structural data to uncover mechanistic insights into translation. The recurring themes include molecular motion, energy transduction, fidelity control, and the role of RNA in catalysis. Member of EMBO (2004) Member of Leopoldina (2008) Hans Neurath Award (2015) Gottfried Wilhelm Leibniz Prize (2016) ERC Advanced Grant (2018) Otto Warburg Medal (2019) Elected to the National Academy of Sciences (2022) Marina Rodnina has secured major research grants, including an ERC Advanced Grant, supporting her innovative work on ribosome mechanisms. She mentors a research team and collaborates extensively within the Göttingen research community, including affiliations with IMPRS and GZMB graduate programs. Her lab develops sophisticated biochemical and biophysical methodologies to study translation at the molecular level. She leads a multidisciplinary team investigating fundamental questions in gene expression and protein synthesis. The Department of Physical Biochemistry at the Max Planck Institute hosts several project groups, including those led by Niels Fischer, Wolfgang Wintermeyer, and Ingo Wohlgemuth, indicating a collaborative and team-based research environment. The group utilizes advanced technical equipment for kinetic analysis, structural studies, and molecular biology, supporting high-impact research in translation mechanisms.

• Structural Biology
• Molecular Biology
• Photosynthesis
• +۶ مورد دیگر

Xiaoling Xu is a Professor at both the College of Life and Environmental Sciences and School of Basic Medical Sciences of Hangzhou Normal University since 2020 and 2013 respectively. She holds a Ph.D. in School of Medicine (Tsinghua University, 2004-2008) and a B.Sc. in Department of Life Science (Lanzhou University, 2000-2004). Ph.D. , Tsinghua University (School of Medicine, 2004-2008) Bachlor , Lanzhou University (Department of Life Science, 2000-2004) Her research spans structural biology of photosynthetic machinery (e.g., Crystal structure of alternative complex III from Chloroflexus aurantiacus ), tRNA synthetase non-enzymatic functions (e.g., Human TrpRS zinc activation ), and coronavirus protein mechanisms (e.g., Nsp15 hexameric structure ). She investigates electron transport systems, protein domain dynamics, and thermostable enzyme engineering. Her 15 most recent works focus on photosynthetic bacterial systems , membrane protein organization , and structure-guided biocatalysis , with grants from the National Natural Science Foundation of China (GRANT_NUMBERS: 32471270, 32171227, 31870740, 31570738). Peer review activities include journals like eLife , Nature Communications , and Structure .

Ricarda Richter-Dennerleinمشاهده پروفایل

استاد

• Mitochondrial Ribosome Biogenesis
• Mitochondrial Translation
• Protein Synthesis in Mitochondria
• +۴ مورد دیگر

Ricarda Richter-Dennerlein is a W2 Professor at the Department of Molecular Biology, University Medical Center Göttingen since 2023, following her Emmy-Noether research group leadership (2016-2023) and postdoctoral positions at the same institution. Her research focuses on mitochondrial gene expression machinery within the medical faculty context. Her academic training includes: PhD in Medical Sciences at Newcastle University (2007-2010) EMBO Long Term Fellowship at University of Cologne (2011-2014) Postdoctoral research at University Medical Center Göttingen (2014-2016) Dr. Richter-Dennerlein's research centers on mitochondrial ribosome biogenesis, translation initiation/termination mechanisms, and quality control pathways. She investigates GTPase-driven assembly processes, tRNA modification impacts on translation efficiency, and the coupling of mitochondrial protein synthesis to oxidative phosphorylation complex formation. Her work employs biochemical, structural, and genetic approaches to address fundamental questions in mitochondrial gene expression regulation. Analysis of her 15 most recent publications (2020-2025) reveals consistent focus on mitochondrial ribosome assembly intermediates, translation regulation, and quality control mechanisms. Key themes include GTPase functions in biogenesis/recycling, tRNA modification effects, respiratory chain assembly factors, and novel quality control pathways. These studies demonstrate technical innovation through microscopy screens, in vitro reconstitution, and structural analyses, establishing new paradigms for mitochondrial protein synthesis regulation. Her major recognitions include: Lower Saxony impulse professorship (2023) GZMB award for outstanding research (2017) DFG Emmy Noether program admission (2016) EMBO Long Term Fellowship (2011-2013) Newcastle University Doctoral Thesis Prize (2011) As an independent group leader since 2016, she has secured competitive funding from DFG and Volkswagen Foundation, leading research within the Göttingen Center for Molecular Biosciences. Her laboratory develops innovative methodologies including mitochondrial gene silencing systems and kinase modulation screens, fostering collaborations across the University Medical Center Göttingen. While specific advisees aren't documented, she mentors junior researchers in mitochondrial biochemistry techniques. Her research group operates within the Department of Molecular Biology infrastructure, utilizing advanced microscopy and biochemical facilities to investigate mitochondrial translation dynamics. The team maintains active collaborations with structural biologists and clinical researchers to bridge basic mechanisms with mitochondrial disease pathologies, particularly focusing on oxidative phosphorylation disorders.

Clemens Grimmمشاهده پروفایل

استاد

• Structural Biology
• X-Ray Crystallography
• RNP Assembly Complexes
• +۳ مورد دیگر

Clemens Grimm is a Laboratory Head of X-Ray Crystallography at the Chair of Biochemistry I, part of the Biocenter (Theodor Boveri Institute) at the University of Würzburg, Germany. He has been serving as Principal Investigator of X-Ray Crystallography at the Department of Biochemistry since 2007. Education and Career: 1994-1998: Studies in Biology, University of Frankfurt a. M., Germany 1998-2001: Doctoral studies at the University of Marburg, Germany 2001: Postdoc at the University of Marburg, Germany 2002-2007: Postdoc at the EMBL Grenoble, France Since 2007: Principal Investigator X-Ray Crystallography, Department of Biochemistry at the Biocenter, Würzburg, Germany Dr. Grimm's research focuses on structural biology with particular emphasis on X-ray crystallography techniques. His primary research areas include the structural characterization of RNA-protein (RNP) assembly complexes and LARP proteins. His work has significant implications for understanding fundamental biological processes at the molecular level. Dr. Grimm has developed innovative approaches in protein crystallization, including the Alternative Polymeric Precipitants Screen (MIDAS), which has been commercialized and is used by researchers worldwide. His publication record demonstrates consistent contributions to structural biology, with work spanning protein structure determination, enzyme mechanisms, chromatin biology, and RNA processing. The research trends show a progression from fundamental enzyme structure studies to more complex macromolecular assemblies involved in critical cellular processes. Awards and Recognition: Member of the German National Merit Foundation (1992-1998) As Laboratory Head of X-Ray Crystallography, Dr. Grimm oversees research projects focused on structural biology techniques and their application to understanding macromolecular complexes. His laboratory has contributed significantly to method development in protein crystallization, particularly through the creation of the Alternative Polymeric Precipitants Screen. His research group collaborates with other groups at the Biocenter, including the Fischer Group (Macromolecular Machines), Buchberger Group (Cellular Protein Degradation), and Szalay Group (Molecular Oncology). Dr. Grimm is actively involved in teaching, offering courses such as "Current methods of protein chromatography" and practical laboratory courses on protein purification. His laboratory also provides resources and protocols for structural biology research, including a Basic Pymol course and specialized media formulations for SeMet labeling.

• Molecular Biology
• Biochemistry
• Autophagy
• +۶ مورد دیگر

Alex Caspar Faesen is a Researcher at the University of Göttingen , specializing in Molecular Biology , Biochemistry , and Autophagy . His work focuses on fundamental cellular processes including protein quality control, translation regulation, and DNA damage repair. Key research areas: Autophagy, Ubiquitination, Ribosome Function, DNA Repair, Reproductive Aging His supervised theses (2022–2024) reveal expertise in: Mechanistic analysis of autophagy initiation Non-canonical ubiquitination pathways RNA modifications in translation regulation Metabolic dependencies in lymphoma cells TRIP13's role in DNA repair EF-P in polyPro synthesis and drug design These works demonstrate a strong focus on biochemical mechanisms with applications in cancer biology, aging, and microbial systems.

Dirk Heinzمشاهده پروفایل

استاد

• Structural Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Dirk Heinz is a Professor of Structural Biology at the Technical University of Braunschweig and Head of the Department of Molecular Structural Biology at the Helmholtz Centre for Infection Research (HZI). He holds an honorary doctorate from the University of Würzburg and is an EMBO member. His academic journey includes chemistry studies at the University of Freiburg, a doctorate in structural biology from the University of Basel, postdoctoral research at the University of Oregon, and habilitation in Freiburg. His research focuses on structural mechanisms of bacterial pathogenesis, enzyme function in infection processes, and biomolecular interactions. Key areas include: Structural analysis of bacterial virulence factors Enzyme mechanisms in lipid homeostasis and cofactor biosynthesis Host-pathogen interaction pathways Development of anti-infective strategies Publication analysis reveals consistent focus on structural elucidation of macromolecular complexes, with recent emphasis on membrane-associated proteins, secretion systems, and antibiotic resistance mechanisms. His work integrates X-ray crystallography, cryo-EM, and biochemical approaches across diverse pathogens including Pseudomonas , Yersinia , and Mycobacterium . Scientific Awards & Honors: EMBO Membership (European Molecular Biology Organization) Honorary Doctorate from University of Würzburg He leads the Molecular Structural Biology department at HZI, overseeing research on infection mechanisms and mentoring early-career scientists. The department specializes in structural analysis of pathogenicity determinants and development of novel therapeutic approaches.

Beate Kokschمشاهده پروفایل

استاد

• Fluorinated Amino Acids
• Peptide and Protein Engineering
• Amyloid Formation
• +۴ مورد دیگر

Prof. Dr. Beate Koksch is a renowned chemist at the Freie Universität Berlin , leading the Organic Chemistry and Natural Product Chemistry working group within the Department of Biology, Chemistry, and Pharmacy. Her research spans multiple disciplines at the intersection of chemistry and biology, focusing on peptide and protein engineering through fluorination.

Simon Trowitzschمشاهده پروفایل

پژوهشگر ارشد

• Ribonucleoprotein Complexes in Gene Expression
• Mechanisms of Antigen Processing and Presentation in Adaptive Immunity
• Enabling Technologies for Multiprotein Complex Research
• +۳ مورد دیگر

Dr. Simon Trowitzsch is a Group Leader at the Institute of Biochemistry at Goethe-University Frankfurt, where he also serves as a Senior Scientist collaborating with Prof. Robert Tampé. His research focuses on ribonucleoprotein complexes, antigen processing mechanisms, and enabling technologies for studying multiprotein complexes. He holds a PhD in Biochemistry from Georg-August University Göttingen and Max-Planck Institute for Biophysical Chemistry, and a Diploma in Biochemistry from Georg-August University. Dr. Trowitzsch leads a team (TrowitzschLab) investigating fundamental aspects of gene expression and immune system function. His work integrates structural biology, molecular biology, and advanced biophysical techniques. Notable achievements include structural studies of the MHC-I peptide-loading complex and discoveries in tRNA splicing ligase mechanisms. Research Interests: Ribonucleoprotein complexes in gene expression Antigen processing pathways in adaptive immunity Development of tools for multiprotein complex analysis Key Awards: Marie-Curie Intra-European Fellowship (2010–2012) Max-Planck Research Stipend (2008–2009) Funding: DFG Grant on tRNA Biogenesis Associated Member of Collaborative Research Center 902 His group actively collaborates with institutions like the European Molecular Biology Laboratory (EMBL) and employs cutting-edge methods such as cryo-EM and mass spectrometry. Future work aims to bridge structural insights with functional studies of immune-related complexes.