جست‌وجوی استاد و پژوهشگر

• Biochemistry
• Molecular Biology
• RNA Synthesis
• +۲ مورد دیگر

Purnima Mala is a Postdoctoral Research Associate in the Department of Chemistry at the University of Massachusetts Amherst, conducting advanced research at the intersection of biochemistry and molecular engineering. Her institutional affiliation places her within the university's core chemistry research infrastructure at Lederle Graduate Research Tower. Her research program centers on: RNA Biochemistry : Novel synthesis, modification, and quality assessment of RNA molecules Protein Engineering : Non-natural amino acid incorporation and tRNA modification strategies Biophysical Applications : Development of analytical approaches for RNA studies Analysis of her 2018-2025 publications reveals a clear progression from fundamental nucleic acid chemistry toward sophisticated biophysical applications. Her work demonstrates increasing specialization in T7 RNA polymerase mechanisms and genetic code expansion techniques, with growing emphasis on translational applications in synthetic biology and therapeutic development. Scientific Awards: No awards or honors were documented in the available materials. Advising and Grants: Current information does not specify graduate student mentorship activities or externally funded research grants associated with her position.

• Molecular Biology
• Cancer Research
• RNA Biology
• +۵ مورد دیگر

Helena Fritz is a Research Engineer at Lund University, affiliated with the Division of Molecular Hematology (DMH), RNA and Stem Cell Biology, StemTherapy, and LUCC (Lund University Cancer Centre). Her work spans cancer biology, RNA metabolism, and neuroanatomy, contributing to UN Sustainable Development Goals like SDG 3 (Good Health and Well-being). Specializes in Axl RTK signaling in renal cancer Investigates RNA splicing and tRNA fragmentation mechanisms Develops neuroanatomical imaging techniques for insect brains Her research explores cross-disciplinary themes including retrotransposon-driven inflammation, epigenetic regulation in hematological malignancies, and tissue clearing technologies. Recent publications in Cell Reports and Molecular Cell highlight her contributions to RNA biology and cancer progression. Key collaborations include work with international teams on tumor suppression networks and stem cell therapies. She contributes to translational medicine through studies on drug resistance mechanisms in renal cancer.

• Epigenetics
• Chromatin Structure and Function
• RNA Biology
• +۴ مورد دیگر

Oliver J Rando is a Professor in the Department of Biochemistry and Molecular Biotechnology at UMass Chan Medical School. His research focuses on epigenetic inheritance , chromatin structure , and genomic regulation . He holds an Endowed Chair in Biochemistry and Molecular Biotechnology and leads studies using genomic tools like DNA microarrays and high-throughput sequencing to analyze chromatin dynamics. His work explores histone modification patterns , nucleosome replacement mechanisms , and non-coding RNA roles in epigenetic transmission. Current projects investigate chromatin's role in yeast stress responses , stem cell pluripotency , and sperm RNA contributions to embryonic development. Key research questions include: How chromatin motifs are established by genomic sequences Mechanisms of replication-independent histone exchange Function of histone modification crosstalk Chromatin's role in filtering cellular signals Epigenetic packaging during gametogenesis

• General Microbiology Instruction
• Molecular Microbiology Instruction
• Microbiology Education
• +۳ مورد دیگر

Tammy Bullwinkle is an Associate Professor of Teaching in the Department of Microbiology at The Ohio State University, affiliated with the College of Arts and Sciences. She holds a B.S. from Nazareth College (2004) and a Ph.D. from the University at Buffalo (2010). Her expertise focuses on microbiology education, particularly in molecular microbiology instruction and curriculum development. She actively contributes to undergraduate and graduate teaching programs, including designing inquiry-based experiments for the Molecular Microbiology Lab course, and serves on the Department’s Curriculum Committee. Her research background spans molecular mechanisms of protein synthesis, bacterial stress responses, and bacteriophage biology. She collaborates with institutions like the University at Buffalo and international teams to investigate translation fidelity, amino acid stress adaptation, and genetic code mistranslation. Her work bridges fundamental biological research with innovative educational methodologies. Bullwinkle oversees lab instruction, mentors Graduate Teaching Assistants, and integrates cutting-edge research findings into classroom materials. Her teaching philosophy emphasizes inquiry-based learning and hands-on experimentation to enhance student engagement in microbiology. Despite no listed awards, her academic contributions are evident through impactful peer-reviewed publications in high-impact journals like Journal of Biological Chemistry and Nucleic Acids Research .

Mridusmita Saikiaمشاهده پروفایل

مدرس

• Biomedical Engineering
• Molecular Biology
• Genomics
• +۳ مورد دیگر

Dr. Mridusmita Saikia is a Lecturer at the Meinig School of Biomedical Engineering, Cornell University, since 2020. Her research focuses on biomedical engineering, biomolecular engineering, and molecular and cellular engineering, with expertise in RNA modifications, diabetes pathogenesis, and single-cell RNA sequencing. She teaches courses in Cellular and Molecular Engineering, emphasizing foundational concepts applicable to biomedical innovations. Education includes a B.Sc. (Chemistry, St. Stephen’s College, University of Delhi, 2002), M.Sc. (Chemistry, IIT Delhi, 2004), M.S. (Chemistry, University of Chicago, 2005), and Ph.D. (Chemistry, University of Chicago, 2009). Postdoctoral research was conducted at Case Western Reserve University and Cornell University. Her research explores non-coding RNAs and their roles in gene expression, with recent work on immune cell function and pancreatic beta-cell pathology linked to diabetes. She employs single-cell sequencing and molecular engineering techniques to advance understanding of cellular mechanisms in health and disease. Awards: Robert & Vanne Cowie Teaching Award (2022), CRISTEL Award (2022–2023), Prodo Labs Best Talk Award (2020), and multiple fellowships including the Burroughs Wellcome Fellowship (2005–2006). Teaching includes courses like BME 2010 (Physiology of Health/Disease), BME 3010 (Cellular Principles), and BME 5830 (Cell-Biomaterial Interactions). Her pedagogy aims to bridge foundational concepts with clinical and engineering applications. Research outputs span diabetes mechanisms, RNA stress responses, and single-cell profiling. Collaborations include studies on GLP-1 receptor signaling, beta-cell differentiation, and tiRNA functions in apoptosis.

Alper Akayمشاهده پروفایل

پژوهشگر ارشد

• RNA modifications
• Gene regulation
• Developmental biology
• +۳ مورد دیگر

Dr. Alper Akay is a UKRI Future Leaders Fellow and Principal Investigator at the University of East Anglia (UEA), leading the RNA (epi)Genetics Lab within the School of Biological Sciences. His work focuses on understanding how RNA modifications regulate gene expression during animal development, primarily using C. elegans as a model. He holds a BSc in Biology from Middle East Technical University, an MSc in Molecular Biology and Bioinformatics from the University of Amsterdam, and a PhD in Life Sciences from the University of Dundee. His lab develops methodologies to identify modified RNAs and studies their roles in germ cell development and metabolism. Current projects include investigating the functional role of RNA methylomes and splicing regulation in human cancers. His research is supported by a UKRI Future Leaders Fellowship. He mentors PhD and MSc students and collaborates internationally. Key achievements include pioneering studies on RNA modification dynamics under stress conditions and developing tools for genetic modification of plant-parasitic nematodes. Education: PhD in Life Sciences, University of Dundee (2007–2012) MSc in Molecular Biology and Bioinformatics, University of Amsterdam (2005–2007) BSc in Biology, Middle East Technical University (2000–2005) Awards: UKRI Future Leaders Fellowship (2020–present) Labs/Teams: RNA (epi)Genetics Lab, Cells and Tissues Group

James Van Deventerمشاهده پروفایل

دانشیار

• Synthetic Biology
• Chemical Biology
• Protein Engineering
• +۷ مورد دیگر

James Van Deventer is an Associate Professor in the Department of Chemical and Biological Engineering and Biomedical Engineering at Tufts University's School of Engineering. He holds appointments in both departments and maintains an active research laboratory focused on biomolecular engineering approaches to cancer treatment and complex diseases. Dr. Van Deventer received his B.S. in chemical engineering from Stanford University, followed by M.S. and Ph.D. degrees at the California Institute of Technology. His doctoral research in Professor David Tirrell's laboratory employed noncanonical amino acids in protein engineering and biophysics applications. He completed postdoctoral training in Professor K. Dane Wittrup's laboratory at MIT's Koch Institute for Integrative Cancer Research, where he worked on engineering antibodies targeting cancer-associated fibroblasts and enhancing yeast display with noncanonical amino acids. His research focuses on disrupting enzymatic and signaling processes within the tumor microenvironment through biomolecular engineering, synthetic biology, and chemical biology approaches. His laboratory is enhancing the chemical versatility of yeast display to discover inhibitors that combine the best properties of chemical compounds and proteins (biologics). The group also uses quantitative approaches to understand and improve genetic code manipulation in yeast, particularly the addition of amino acids to the genetic code. This work has significant implications for developing new strategies to treat cancer and other complex diseases. Dr. Van Deventer's recent publications show a strong trend toward genetic code expansion, noncanonical amino acid incorporation, and advanced yeast display technologies. His work bridges fundamental protein engineering with therapeutic applications, particularly in cancer treatment and inhibitor discovery. The research demonstrates increasing sophistication in manipulating biological systems for therapeutic purposes, with recent work focusing on dual amino acid incorporation and covalent antibody engineering. National Institutes of Health Outstanding Investigator Award for Early Career Researchers (R35, National Institute of General Medical Sciences, 2019) Bright Futures Assistant Professor (2020-2024) Emerging BIOT Leader (2020) Emerging Investigator (2020) Tufts Graduate Student Council Outstanding Faculty Contribution to Graduate Education (2021, 2022, 2023) Dr. Van Deventer has secured significant research funding from the National Institutes of Health, National Science Foundation, and U.S. Army Research Office. His laboratory actively mentors graduate students, as evidenced by multiple teaching awards. He serves on the Tufts Faculty Research Support Advisory Committee and has consulted for biotechnology companies including Foresite Labs and Neochromosome. His teaching activities include courses in Chemical Process Principles, Biomolecular Engineering and Design, and Bioengineering Seminar Series, where he has developed specialized content in biomolecular engineering since 2017. His laboratory work centers on yeast display technology enhancement, genetic code manipulation, and tumor microenvironment disruption. The team develops innovative approaches that combine chemical compounds and protein biologics to create next-generation therapeutic inhibitors.

Rémi Zallotمشاهده پروفایل

مدرس ارشد

• Microbial Genetics
• Antibiotic Resistance
• Bioinformatics
• +۳ مورد دیگر

Dr Rémi Zallot is a Senior Lecturer in Biochemistry within the Department of Life Sciences at Manchester Metropolitan University. His research focuses on elucidating the biological functions of uncharacterised genes in infectious pathogens, particularly non-tuberculous mycobacteria (NTM), to identify novel drug targets and biotechnological applications. He employs a multidisciplinary approach integrating bioinformatics, biochemistry, genetics, and microbiology. Key areas include antibiotic resistance mechanisms, metabolic pathway analysis, and the development of genomic enzymology tools. Education: PhD in Biochemistry and Plant Biology from Université de Bordeaux (specializing in Arabidopsis lipase characterization), followed by postdoctoral roles at the University of Florida (B vitamin metabolism) and University of Illinois (Enzyme Function Initiative tools). He held a Marie Skłodowska-Curie Fellowship at Swansea University for the deCrYPtion project. Research interests include NTM pathogenesis, enzyme function discovery, and bioinformatics tool development. Current projects include the STEROSPRING award studying NTM sterol catabolism and contributions to the EFI web tools. Awards include the Academy of Medical Sciences Springboard Award and Marie Skłodowska-Curie Fellowship. Teaching responsibilities include leading the Biomedical Cell Biology module and contributing to Medical Microbiology courses. He supervises undergraduate and Master’s students, as well as a Postdoctoral Research Associate under the SteroSpring grant. Awards: Academy of Medical Sciences Springboard Award (SBF009\1016), Marie Skłodowska-Curie Individual Fellowship (Grant 839116). Grants: Academy of Medical Sciences, Manchester Metropolitan University Research Accelerator, Higher Education Investment and Recovery Fund, and MMT Research Funds. Collaborations include key partners at the University of Illinois, University of Florida, and National University of Singapore through the EFI initiative.

Huiqing Zhouمشاهده پروفایل

استادیار

• Epitranscriptomics
• RNA Modifications
• Nucleic Acid Chemistry
• +۴ مورد دیگر

Huiqing (Jane) Zhou is an Assistant Professor of Chemistry at Boston College, affiliated with the Morrissey College of Arts and Sciences and the Chemistry Department. Her research focuses on developing technologies to map and modulate RNA chemical modifications (epitranscriptome) in mammalian systems. She employs interdisciplinary approaches including directed evolution, biochemistry, mass spectrometry, and structural biology to study the regulatory mechanisms of these modifications in gene expression and disease. Education: B.S., Nankai University Ph.D., Duke University Research Interests: Her lab explores how RNA modifications influence transcript stability, interactions, and expression, with applications in disease modeling and gene therapy. Key areas include base-resolution mapping of modifications, engineering tools for modification manipulation, and understanding dysregulated epitranscriptomes in diseases like Alzheimer’s. Publications: Her work spans publications in Nature Methods , Biochemistry , and Nucleic Acids Research , focusing on reverse transcriptase evolution, Hoogsteen base pairing dynamics, and RNA modification detection technologies. Awards: 2017 Chicago Fellows Fellowship. Lab & Funding: Supported by Boston College and grants from the National Institutes of Health (NIGMS, NCI). Her lab develops cutting-edge tools to visualize and modulate RNA modifications, aiming to identify novel drug targets and advance gene therapy strategies.

Kabirul Islamمشاهده پروفایل

دانشیار

• Epigenetics
• Organic Synthesis
• Bioorganic Chemistry
• +۶ مورد دیگر

Kabirul Islam is an Associate Professor in the Department of Chemistry at the University of Pittsburgh, affiliated with the Dietrich School of Arts and Sciences. His research focuses on chemical approaches to understand epigenetic mechanisms in human biology and disease, integrating organic synthesis, bioorganic chemistry, and structural biology. Key projects include developing chemoproteomic tools like interaction-based protein profiling (IBPP) and allele-specific chemical genetics to study epigenetic regulators. Research interests span epigenetic protein interactions, metabolic-epigenetic links (e.g., 2-ketoglutarate-dependent demethylases), and precision medicine targeting epigenetic drivers of cancer and obesity. The Islam Lab employs synthetic chemistry, protein engineering, and advanced spectroscopic methods to modulate and interrogate chromatin modifications. Publications highlight contributions to TET enzyme analysis, histone demethylase inhibition, and photochemical tools for interactome profiling. Ongoing work explores allele-specific modulation of epigenetic machinery and boron-based oligonucleotide delivery systems. Lab activities include mentoring graduate and undergraduate students, postdoctoral researchers, and collaborations across chemistry, biology, and materials science. The group actively seeks to bridge chemical innovation with biomedical applications, emphasizing translational research in epigenetic therapies.

Peter Bealمشاهده پروفایل

استاد

• Chemical Biology
• RNA Editing
• RNA Interference
• +۳ مورد دیگر

Peter Beal is a Professor in the Chemical Biology Program at the University of California, Davis. His research focuses on using synthetic chemistry to study RNA structure, function, and therapeutic applications. Key areas include RNA editing by ADAR enzymes and RNA interference via siRNA modifications. He leads the Beal Lab and collaborates extensively with structural biologists like Andrew Fisher. Appointed UC Davis faculty in 2006 NIH T32 Training Grant Program Director (2015) Fellow of the American Association for the Advancement of Science (2012) Research interests: - Designing nucleoside analogs to interrogate RNA biology - Developing siRNA-based therapeutics with reduced immunogenicity - Elucidating ADAR2's mechanism and site selectivity through structural studies - Creating tools to modulate RNA editing in living cells His NIH-funded projects investigate RNA editing's role in disease and siRNA optimization for clinical use. Recent work includes fluorescent adenosine analogs for real-time editing monitoring and computational screening of siRNA modifiers. Scientific awards: Camille Dreyfus Teacher Scholar (2000), Robert Parry Teaching Award (2005) Grants: Active NIH grants for RNA editing studies and siRNA development. Collaborates with industry on therapeutic siRNA candidates. Labs/Teams: Beal Lab focuses on chemical biology approaches to RNA biology. Active in the UC Davis Chemical Biology Program.

Ola Larssonمشاهده پروفایل

پژوهشگر

• Cancer Biology
• Molecular Biology
• Translational Regulation of Gene Expression
• +۳ مورد دیگر

Ola Larsson is a Principal Researcher and Head of the Department of Oncology-Pathology at Karolinska Institutet , Sweden. Since July 2025, he has led this department, focusing on translational control in cancer biology. His research explores how dysregulated mRNA translation drives oncogenesis and tumor microenvironment dynamics. Key Research Themes: mTOR signaling, stress responses, epigenetic regulation, and metabolic adaptation in cancer. Methodological Contributions: Co-developed anota , anota2seq , and NOMAD for translational profiling. Recent Work spans breast cancer mechanotransduction, pancreatic tumor translation programs, and stress-induced reprogramming in neurodevelopmental and metabolic diseases. His Nature (2025) study on the integrated stress response highlights translational plasticity in cancer, while Brain (2025) links TSC2 loss to neurodevelopmental transcript suppression. Collaborative efforts include tumor-stromal interactions in Nature Reviews Cancer (2023) and metabolic control via Cell Metabolism (2022) studies. Leadership includes heading the Department of Oncology-Pathology since 2025 and serving as a Docent at Karolinska Institutet since 2016. His Proceedings of the National Academy of Sciences (2020) work on MNK2 in macrophages and Nature (2013) on TP53 mutations underscore his translational expertise.

Jason Chinمشاهده پروفایل

پژوهشگر

• Synthetic Biology
• Genetic Code Expansion
• Protein Engineering
• +۴ مورد دیگر

Jason Chin is a Researcher at the University of Cambridge, affiliated with the Centre for Chemical and Synthetic Biology. His work focuses on systematic genetic code reprogramming and synthetic biology, enabling site-specific incorporation of unnatural amino acids into proteins across diverse organisms. He has pioneered orthogonal translation pathways and quadruplet codon reading systems. Institution: University of Cambridge Research Focus: Genetic code expansion, protein engineering, post-translational modifications Key Techniques: Orthogonal ribosomes, photocrosslinkers, fluorogenic labeling His research spans applications in E. coli , yeast, mammalian cells, and whole organisms like C. elegans and D. melanogaster , addressing processes such as embryonic development, tumor biology, and neuronal plasticity. Publications highlight advancements in orthogonal tRNA synthetase systems, codon compression, and in vivo protein labeling. No scientific awards or students are explicitly mentioned in the provided text.

Kathy Fange Liuمشاهده پروفایل

دانشیار

• RNA Biochemistry
• Cancer Biology
• Epitranscriptomics
• +۳ مورد دیگر

Kathy Fange Liu, Ph.D., is an Associate Professor with tenure at the University of Pennsylvania Perelman School of Medicine. She serves as Co-Director of the Penn Center for Genome Integrity and Group Lead at the Penn Institute for RNA Innovation. The lab combines deep mechanistic studies with innovative therapeutic development across four major research directions: X-Y paired homologous proteins, cancer fusion proteins, ribosome biology, and cross-RNA modification coregulation. Research highlights include pioneering the concept of RNA modification coregulation (DOI:10.1073/pnas.1913448117), where enzyme-mediated modifications across RNA species demonstrate interconnected networks. Current projects investigate rRNA-modifying enzymes' dual roles in ribosome assembly and genome organization, while developing targeted therapies for fusion oncoproteins like TRIM24-ERG (US patent 63/797,545). 2025 Damon Runyon-Rachleff Innovator Award Stage 2 2024 St. Baldrick's Research Grant 2023 Linda Pechenik Montague Investigator 2022 Damon Runyon & ACS Scholar awards 2019 NIH MIRA R35 award Lab members include 6 postdocs (Praneeth Bommisetti, Yanze Jian, Sarai Mendoza, Yulia Gonskikh, Hyojeong Hwang, Sheetal Tushir) and 3 graduate trainees. Former lab members Hui Shen (now professor at China Pharmaceutical University), Julian Stoute (Ph.D. 2023), and Jordan Ontiveros (Ph.D. 2022) received multiple fellowships during their tenure. Key grants include NIH/NHLBI R01 (2022), CZI Multi-Institutional Collaboration (2024), and continuous support from private foundations like CURE Childhood Cancer and Alex's Lemonade Stand. The lab actively develops technologies for RNA modification analysis while maintaining strong collaborative ties across Penn's epigenetics and structural biology programs.

Sebastian Leidelمشاهده پروفایل

استاد

• RNA Biochemistry
• RNA Modifications
• tRNA Modification
• +۶ مورد دیگر

Prof. Dr. Sebastian Leidel is a Full Professor of RNA Biochemistry at the Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) at the University of Bern, where he leads a research group focused on RNA modifications and their biological functions. He is also affiliated with the Multidisciplinary Center for Infectious Diseases (MCID) at the University of Bern and is part of the Swiss National Focus in Research on RNA & Disease jointly hosted by the University of Bern and the ETH Zürich. His educational background includes: Undergraduate studies in Protestant Theology (1991-2001) at University of Siegen, University of Marburg, Hebrew University Jerusalem and Heidelberg University Diploma studies in Biology (1996-2001) at Heidelberg University Diploma Thesis with Hans Schöler at the University of Pennsylvania (2000-2001) on "Induced Expression of Oct4 in Embryoid Bodies" PhD Thesis with Pierre Gönczy at the Swiss Institute for Experimental Cancer Research, Lausanne (2001-2005) on "Centrosome duplication in Caenorhabditis elegans: The role of sas genes" Prof. Leidel's research centers on RNA biochemistry, particularly focusing on chemical modifications of RNA nucleotides. His work investigates how these modifications affect cellular processes, development, and disease. His laboratory employs diverse model organisms ranging from yeast to zebrafish and human cell cultures, utilizing advanced techniques such as ribosome profiling and RNA mass spectrometry. His research has significant implications for understanding fundamental biological processes and developing potential therapeutic approaches for diseases including cancer and infectious diseases. Analysis of Prof. Leidel's recent publications reveals a strong focus on tRNA modifications and their roles in various biological processes. His work spans from fundamental enzymology of modification pathways to the physiological consequences of these modifications in development, disease, and pathogen virulence. A notable trend is the exploration of how RNA modifications influence translation dynamics, mRNA stability, and cellular stress responses, with implications for cancer biology and infectious disease mechanisms. His notable scientific achievements include: ERC Starting Grant (2012) James Heineman Research Award for Outstanding Research Achievements (2016) Prof. Leidel has established a productive research program with numerous collaborative projects. His work on RNA modifications has led to significant insights into how these molecular changes affect cellular function, with particular emphasis on the URM1 pathway and tRNA modifications. His research group has developed innovative methodologies for studying RNA modifications and their functional consequences, contributing to both basic science and potential clinical applications. He has secured competitive funding including an ERC Starting Grant, demonstrating the significance and innovation of his research program. Prof. Leidel leads a research group at the University of Bern that is part of the Multidisciplinary Center for Infectious Diseases and the Swiss National Focus in Research on RNA & Disease. His laboratory brings together expertise in biochemistry, molecular biology, and advanced analytical techniques to tackle questions about RNA modifications. The group collaborates extensively with other researchers both within the University of Bern and internationally, forming a dynamic team focused on advancing our understanding of RNA biology.