معرفی
Huiqing (Jane) Zhou is an Assistant Professor of Chemistry at Boston College, affiliated with the Morrissey College of Arts and Sciences and the Chemistry Department. Her research focuses on developing technologies to map and modulate RNA chemical modifications (epitranscriptome) in mammalian systems. She employs interdisciplinary approaches including directed evolution, biochemistry, mass spectrometry, and structural biology to study the regulatory mechanisms of these modifications in gene expression and disease.
Education:
- B.S., Nankai University
- Ph.D., Duke University
Research Interests: Her lab explores how RNA modifications influence transcript stability, interactions, and expression, with applications in disease modeling and gene therapy. Key areas include base-resolution mapping of modifications, engineering tools for modification manipulation, and understanding dysregulated epitranscriptomes in diseases like Alzheimer’s.
Publications: Her work spans publications in Nature Methods, Biochemistry, and Nucleic Acids Research, focusing on reverse transcriptase evolution, Hoogsteen base pairing dynamics, and RNA modification detection technologies.
Awards: 2017 Chicago Fellows Fellowship.
Lab & Funding: Supported by Boston College and grants from the National Institutes of Health (NIGMS, NCI). Her lab develops cutting-edge tools to visualize and modulate RNA modifications, aiming to identify novel drug targets and advance gene therapy strategies.
