جست‌وجوی استاد و پژوهشگر

Beat Fierzمشاهده پروفایل

دانشیار

• Epigenetics
• Chemical Biology
• Molecular Biology
• +۳ مورد دیگر

Beat Fierz is an Associate Professor at École Polytechnique Fédérale de Lausanne (EPFL) in the School of Basic Sciences (SB), affiliated with the Institute of Chemical Sciences and Engineering (ISIC) and the Laboratory of Biophysical Chemistry of Macromolecules (LCBM). He holds additional roles as Director of the Doctoral Program in Chemistry and Chemical Engineering (EDCH) and oversees doctoral education within the SCGC teaching unit. His research focuses on chromatin dynamics, epigenetic regulation, and chemical biology approaches to study histone modifications and protein interactions. He has supervised over 14 PhD students and teaches courses in advanced chemistry and chemical biology. His work bridges molecular mechanisms of chromatin structure with cellular processes like DNA repair and transcriptional regulation. Research Interests: Dr. Fierz investigates how post-translational modifications of histones (e.g., ubiquitylation, acetylation) regulate chromatin compaction, silencing, and accessibility. He employs single-molecule techniques and chemical synthesis to reconstitute and analyze chromatin states, with applications in understanding epigenetic diseases, aging, and CRISPR-Cas9 genome editing dynamics. Recent studies highlight mechanisms of HP1α-mediated heterochromatin assembly and pioneer transcription factor invasion into compact chromatin. Doctoral Program Leadership: As Director of the EDCH program, he oversees training in chemistry and chemical engineering, ensuring academic rigor and interdisciplinary collaboration. His lab collaborates extensively with EPFL's Chemical Biology NCCR and contributes to initiatives like the Chemical Biology Seminar Series. Lab & Teams: The LCBM lab uses innovative tools like 'MagIC beads' and semisynthetic nucleosomes to study chromatin modifications. Current projects include exploring how ubiquitin signals modulate DNA repair proteins and how histone aging impacts chromatin stability. Collaborations span biophysics, biochemistry, and synthetic chemistry.

Junfang Wuمشاهده پروفایل

استاد

• Neurotrauma
• Neuropharmacology
• Neuroinflammation
• +۷ مورد دیگر

Dr. Junfang Wu is a Professor in the Department of Anesthesiology and holds a secondary appointment in Neurobiology at the University of Maryland School of Medicine. She serves as Associate Director of UM-MIND (University of Maryland - Medicine Institute for Neuroscience Discovery), Director of the Anesthesiology Center for Neuroscience Research, and Vice-Chair for Translational Research in the Department of Anesthesiology. Her academic journey includes a BM in Medicine, MS in Pharmacology from Jiangxi Medical College, and PhD in Neuropharmacology from Nanjing Medical University, followed by postdoctoral training at China's Institute of Materia Medica and NIH. Research Focus: Neurotrauma, neuroinflammation, autophagy-lysosomal pathway, extracellular vesicles, Hv1/NOX2/ROS, TrkB.T1 Key Techniques: Rodent models of SCI/TBI, behavioral evaluations, EV characterization, quantitative imaging, molecular/cellular biology Dr. Wu's research explores the cellular and molecular mechanisms of neurological dysfunction following CNS trauma, with emphasis on autophagy-lysosomal disruption, microglial Hv1 channels, and EV-mediated neuroinflammatory signaling. Her 2025 Aging and disease study reveals age-dependent transcriptional changes post-anesthesia, while 2024 Brain, Behavior, and Immunity work demonstrates how SCI alters EV cargoes to drive brain neuroinflammation. Her team recently discovered that Hv1 proton channel ablation in microglia provides neuroprotection in SCI models. Her scientific contributions are recognized through the 2025 Matjasko Professorship in Anesthesiology Research. She has secured multiple NIH grants including: R01 NS145443 (2025-2030): cGAS signaling in brain trauma-induced neuroinflammation R01 AG077541 (2022-2027): TBI olfactory dysfunction and dementia progression 2RF1 NS094527 (2016-2027): Autophagy mechanisms in SCI R01 NS110825 (2020-2026): Hv1 channel in SCI/TBI Dr. Wu's laboratory personnel include Research Associates Yun Li and Zhuofan Lei, Post-doctoral Fellows Balaji Krishnamachary and Zihui Wang, Research Assistant Hui Li, and medical student Ruth Park. Her work spans from bench research on lysosomal damage to clinical implications for Alzheimer's disease-related dementia (AD/ADRD) and potential therapeutic strategies.

Gaurav Aryaمشاهده پروفایل

استاد

• Viral DNA Packaging
• Polymer-Nanoparticle Composites
• Virus Assembly
• +۷ مورد دیگر

Gaurav Arya is a Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science at Duke University, with additional appointments in the Department of Chemistry and Biomedical Engineering. His research laboratory employs physics-based computational tools to investigate biological and soft-material systems at the molecular scale. Ph.D. from University of Notre Dame (2003) B.Tech. from Indian Institute of Technology Delhi (1998) Research focuses on: Molecular modeling and simulations Statistical mechanics DNA nanotechnology Viral DNA packaging Chromatin biophysics Polymer-nanoparticle composites Recent research trends emphasize AI-driven materials discovery and programmable DNA nanostructures. Key grants include: NSF DMREF: Architecting DNA nanodevices (2023-2027) DOE Mesoscale Self-Assembly (2020-2027) UC San Diego Ligand-Nanocrystal Interlayer Studies (2024-2027) Scientific contributions: Featured in 2025 Nature Communications on DNA superstructures 2022 Science Advances on DNA nanodevice reconfiguration 2021 PNAS on viral DNA packaging motors

• Medical Genetics
• Neurology
• Bioinformatics
• +۴ مورد دیگر

Professor Ahmet Okay Çağlayan at Dokuz Eylül University's School of Medicine specializes in Medical Genetics with a focus on neurodevelopmental disorders. His work integrates next-generation sequencing and genomic approaches to unravel rare genetic variants in structural brain abnormalities. Established Medical Genetics Department Teaching at undergraduate, graduate, and medical school levels Active in editorial and peer-review roles for top-tier journals Research spans neurogenetics, molecular diagnostics, and genomic medicine with emphasis on: Whole-exome sequencing applications Homozygosity mapping Linkage analysis Neurodevelopmental disease mechanisms Cortical malformations Genotype-phenotype correlations Recent publications highlight advancements in: Identifying novel pathogenic variants (NAGLU, KLHL40, PIBF1) Elucidating mTOR pathway dysregulation in lissencephaly Characterizing rare metabolic and neurodegenerative syndromes Developing genomic diagnostic frameworks for Turkish populations Metrics indicate: 197 WoS publications H-index: 4250 (Scopus) 24 research projects

Jeffrey K. Mooreمشاهده پروفایل

دانشیار

• Microtubule networks
• Cell biology
• Molecular motors
• +۷ مورد دیگر

Jeffrey K. Moore is an Associate Professor in the Department of Cell and Developmental Biology at the University of Colorado Anschutz Medical Campus. He also serves as the Director of the Graduate Program in Cell Biology, Stem Cells and Development. His research focuses on understanding how microtubule networks organize cells and regulate crucial cellular processes, with implications for human diseases including cancer and neuropathies. Dr. Moore received his Ph.D. from the University of Rochester in 2006. His academic journey has led him to specialize in cellular organization mechanisms, particularly how the microtubule cytoskeleton controls organelle positioning during cell division and migration. His work bridges fundamental cell biology with potential clinical applications. Dr. Moore's research interests center on the molecular mechanisms that regulate microtubule dynamics and function. His laboratory investigates how molecular motors interact with microtubule tracks, how mitosis is coordinated with cell polarity during asymmetric cell divisions, and how cells develop resistance to microtubule-targeting cancer drugs. His work combines powerful yeast genetics with quantitative microscopy and protein biochemistry to uncover fundamental principles of cellular organization. The laboratory's research has significant implications for understanding human diseases where microtubule dysfunction plays a critical role. Dr. Moore's publications reveal how specialized microtubules serve different cellular functions through tubulin isotypes and post-translational modifications. His work on the 'tubulin code' has advanced understanding of how microtubule networks can be differentially regulated in various cellular contexts. Recent publications examine α-tubulin regulation, tubulin isotype specialization, and the role of microtubule-based forces in genome stability. As Director of the Graduate Program in Cell Biology, Stem Cells and Development, Dr. Moore mentors numerous graduate students in the Department of Cell and Developmental Biology. His research program is supported by grants from the National Institutes of Health and other funding agencies focused on understanding fundamental cellular processes with implications for human health. The Moore Lab at the University of Colorado Anschutz Medical Campus utilizes the budding yeast Saccharomyces cerevisiae as a primary model system. The lab brings together researchers with expertise in genetics, cell biology, biochemistry, and quantitative imaging to tackle questions about cellular organization. Their collaborative approach has led to important insights into how cells manipulate their internal architecture for proper function, with findings relevant to understanding disease mechanisms and potential therapeutic approaches.

Gerardo G. Piroliمشاهده پروفایل

عضو هیئت علمی

• Mitochondrial Diseases
• Protein Succination
• Metabolic Regulation
• +۷ مورد دیگر

Gerardo G. Piroli is a Research Assistant Professor in the Department of Pharmacology, Physiology & Neuroscience at the University of South Carolina School of Medicine. His research focuses on protein succination in the context of mitochondrial diseases such as Leigh syndrome, with a particular interest in how metabolic stress impacts cellular function. Ph.D. in Biochemistry and Physiology, University of Buenos Aires School of Pharmacy and Biochemistry Postdoctoral Training, The Rockefeller University and University of Buenos Aires B.Sc. in Biochemist and Pharmacist, University of Buenos Aires School of Pharmacy and Biochemistry Dr. Piroli's research centers on the irreversible post-translational modification of proteins known as succination, which occurs when fumarate reacts with cysteine residues. His work has shown that the voltage-dependent anion channel (VDAC) is a key target of succination in the brain of the Ndufs4 KO mouse model of Leigh syndrome, potentially exacerbating mitochondrial dysfunction. He is currently exploring therapeutic interventions such as antioxidants and alternative electron carriers to reduce succination and improve outcomes in mitochondrial disorders. His recent publications highlight trends in mitochondrial and metabolic stress, protein modifications, neurodegeneration, and endocrine regulation. Research spans from fundamental biochemistry to disease models, including diabetes, cancer, and stress-related neuropsychiatric conditions. Scientific contributions include: Identification of tubulin as a novel succinated protein Linking mitochondrial stress to ER stress in adipocytes Exploring fumarase deficiency in Mycobacterium tuberculosis Investigating insulin resistance in hippocampal function Dr. Piroli is actively involved in teaching medical and graduate students, covering pharmacology, physiology, and biochemical basis of disease. He leads small group discussions and lectures on topics including antimicrobials, metabolic integration, signal transduction, and the HPA axis. While no formal advisees are listed, his lab work under Dr. Norma Frizzell suggests mentorship of junior researchers. He has not received publicly listed awards, but his sustained publication record and interdisciplinary research indicate significant scientific impact. His work is conducted within the Basic Science Building at the University of South Carolina School of Medicine, where he contributes to a collaborative environment focused on understanding the molecular basis of metabolic and neurological diseases.

• Cardiovascular Research
• Cardiomyopathy
• Gene Therapy
• +۳ مورد دیگر

Lucie Carrier is a Professor at the Institute of Experimental Pharmacology and Toxicology , University Medical Center Hamburg-Eppendorf. She leads a research group focusing on cardiomyopathy mechanisms , particularly involving sarcomere proteins like cardiac myosin-binding protein C (MyBP-C) and their role in hypertrophic cardiomyopathy (HCM) . Her work explores ubiquitin-proteasome system dysfunction, autophagy , and gene therapy approaches for HCM. Key collaborators include Thomas Eschenhagen and Sandra Schlossarek . Research Interests : Sarcomere mutations, proteasome inhibition, RNA editing, cardiac remodeling, iPSC models, and microRNA regulation in HCM. Grants & Projects : Multiple studies on Mybpc3 -targeted mouse models, iPSC-derived cardiomyocytes, and pharmacological interventions (e.g., nebivolol, sacubitril/valsartan). Key Contributions : Discoveries about MyBP-C phosphorylation , ANKRD1 mutations , and tubulin detyrosination as therapeutic targets. She co-authored guidelines for autophagy assays and ESC consensus documents. Scientific Awards : No explicit awards mentioned in the text.

• Breast Cancer Metastasis
• Cytoskeletal Dynamics
• Tumor Suppressor Genes
• +۳ مورد دیگر

Michele Vitolo is an Assistant Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. Her research focuses on understanding the molecular mechanisms of breast cancer metastasis, particularly the role of PTEN loss and microtentacle formation in tumor progression. She has developed innovative models and assays to study cytoskeletal dynamics and signaling pathways in cancer cells. University of Maryland Baltimore (PhD, 2004) Franklin and Marshall College (BS, 1995) Dr. Vitolo's research investigates how tumor suppressor gene inactivation affects cancer cell behavior. Key areas include: PTEN loss-induced microtentacle formation Interplay between PI3K and Ras/MAPK pathways Calcium signaling in metastatic processes Epigenetic regulation of cytoskeletal networks Development of novel cell tracking methodologies Identification of therapeutic targets for metastatic disease Her work has been recognized through the NCI Mentored Scientist Research Award. Dr. Vitolo has authored numerous publications examining: Cytoskeletal alterations in detached cancer cells Role of tubulin modifications in metastasis Signaling mechanisms promoting tumor cell reattachment Therapeutic approaches targeting microtentacle formation

Gaia Piginoمشاهده پروفایل

پژوهشگر

• Structural Biology
• Cell Biology
• Molecular Biology
• +۴ مورد دیگر

Dr. Gaia Pigino is a biologist and Associate Head of the Structural Biology Research Centre at Human Technopole , Milan, Italy, following 9 years as a Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) , Dresden, Germany. She collaborates with Alessandro Vannini to advance structural biology research at Human Technopole. Education: Ph.D. in Evolutionary Biology, University of Siena (2007), supervised by Prof. F. Bernini and Prof. C. Leonzio Diploma in Natural Science (Summa cum laude), University of Siena (2002), supervised by Prof. C. Leonzio and Prof. F. Bernini Her laboratory investigates the molecular mechanisms of ciliary self-organization , focusing on intraflagellar transport (IFT), tubulin post-translational modifications, and axonemal architecture. Key research areas include: Tubulin Code regulation IFT train dynamics Primary and motile cilia in health/disease Microtubule doublet function Cryo-electron tomography Protein sorting and signaling Recent publications highlight advancements in understanding the high-resolution structure of the ciliary glycocalyx , IFT cycle mechanics, and tubulin tyrosination/detyrosination roles in ciliary transport. Her work bridges structural biology and human disease, particularly diabetes and ciliopathies. Scientific Awards: EMBO Member (2022) ERC Consolidator Grant (2018) Keith R. Porter Fellow Award (2018) DFG Grant (2019) Multiple EMBO, HFSP, and Marie Curie Fellowships to advisees Dr. Pigino advises a team of researchers, including Helen Foster , Nikolai Klena , and Adrian Nievergelt , and contributes to structural biology through grants and collaborations. Her lab employs cutting-edge techniques like CRISPR/Cas and MicroSplit to explore ciliary mechanics and cellular ultrastructure.

• Pharmacology
• Toxicology
• Cardiovascular Research
• +۳ مورد دیگر

Niels Pietsch is a researcher at the Institute of Experimental Pharmacology and Toxicology within the Medical Faculty of University Medical Center Hamburg-Eppendorf (UKE). His work focuses on molecular mechanisms in cardiovascular and neurological contexts. Research Interests: Investigating tubulin post-translational modifications in cardiac and neuronal function Modeling genetic cardiomyopathies using human iPSC-derived cardiomyocytes Studying proteopathy mechanisms in cardiac diseases Translational pharmacology of inotropic compounds Publication Trends: His recent work emphasizes cytoskeletal dynamics, protein aggregation diseases, and drug development for heart conditions, with methodologies spanning stem cell research and molecular pathology. Laboratory Affiliation: Works in the Experimental Pharmacology and Toxicology division at UKE, a hub for interdisciplinary biomedical research.

Benjamin Prosserمشاهده پروفایل

دانشیار

• Cardiac Mechanobiology
• Cellular Biophysics
• Super-Resolution Imaging
• +۴ مورد دیگر

Dr. Benjamin Prosser is an Associate Professor at the Department of Physiology, Perelman School of Medicine, University of Pennsylvania. He leads a multidisciplinary lab combining cellular biophysics, cardiology, and RNA biology to develop therapies for heart and brain diseases. Prosser is also a mentor in Penn's SUIP and PREP programs, hosts workshops for underrepresented STEM undergraduates, and serves on the admissions committee for the Cell Biology, Physiology and Metabolism graduate group. His research focuses on cardiac mechanobiology , particularly how microtubules regulate heart cell mechanics and signaling. Recent work has expanded into neurodevelopmental disorders following his daughter's diagnosis with STXBP1 encephalopathy, leading to antisense oligonucleotide therapy development. The lab also investigates heart failure mechanisms using human iPSC models and advanced imaging techniques. Analysis of his recent publications reveals trends in tubulin post-translational modifications , sarcomere mechanics , and neurogenetic disorders . Key collaborations include the Leducq Cytoskeletal Network , the STXBP1 Foundation , and Ionis Pharmaceuticals . Awards highlight his contributions to early career cardiology and translational research . Scientific Awards 2011 Outstanding Postdoctoral Scholar Award 2017 Linda Pechenik Montague Investigator Award 2017 AHA Early Career Investigator 2018 UM SOM Outstanding Alumnus 2021 Leducq Transatlantic Network Coordinator Prosser's lab is affiliated with the Pennsylvania Muscle Institute , Cardiovascular Institute , and professional societies including the Biophysical Society and American Heart Association . His work bridges basic science and clinical applications , emphasizing diversity initiatives in STEM training.

Tracey A. Rouaultمشاهده پروفایل

پزشک-پژوهشگر

• Iron Metabolism
• Iron-Sulfur Cluster Biogenesis
• Neurodegenerative Diseases
• +۷ مورد دیگر

Dr. Tracey A. Rouault is a Physician Scientist leading the Section on Human Iron Metabolism at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH) in Bethesda, MD. Her research focuses on the molecular regulation of iron and iron-sulfur cluster metabolism in mammalian systems. Research Interests: Dr. Rouault’s lab investigates the roles of iron regulatory proteins (IRPs) and iron-sulfur cluster biogenesis in health and disease. Her work spans neurodegenerative disorders such as Parkinson’s disease and Friedreich ataxia, hematologic conditions including anemias and polycythemia, and familial renal cancers. The lab employs mouse models, cell culture, and patient-derived lines to dissect the mechanisms of iron homeostasis and mitochondrial function. Recent Research Trends: Analysis of her recent publications reveals a strong focus on the role of iron-sulfur clusters in metabolic reprogramming, immune cell function, and epigenetic regulation. Her work continues to uncover novel protein complexes and regulatory motifs involved in Fe-S cluster assembly and iron transport, with implications for understanding and treating rare genetic and metabolic diseases. Scientific Awards: No specific awards mentioned in the provided text. Advising and Grants: Dr. Rouault mentors post-doctoral and graduate fellows. Opportunities are available through the NIH Graduate Partnership Program with universities such as Johns Hopkins, University of Maryland, Oxford, and Cambridge. Her research is supported by the NIH intramural funding program, indicating ongoing grant support for her lab’s investigations into iron metabolism and related disorders. Labs and Teams: She leads the Section on Human Iron Metabolism within NICHD, conducting interdisciplinary research that bridges biochemistry, genetics, and physiology to understand fundamental aspects of iron biology and their clinical implications.

Susan L. Baneمشاهده پروفایل

استاد

• Chemical Biology
• Microtubules
• Tubulin
• +۴ مورد دیگر

Susan L. Bane is a Professor in the Department of Chemistry at the State University of New York at Binghamton. She holds a BS in Chemistry from Davidson College (1980) and a PhD in Biochemistry from Vanderbilt University (1983), followed by postdoctoral research at the University of Virginia (1984-85). Education: BS (Davidson College), PhD (Vanderbilt University) Her research in Chemical Biology focuses on microtubules and their interactions with chemotherapeutic agents like Taxol and colchicine. She investigates molecular mechanisms of drug binding, site-specific fluorescent labeling of proteins, and the structural dynamics of microtubules using organic synthesis and spectroscopic techniques (absorption, emission, NMR). Her work aims to improve anticancer drug design and develop tools for live-cell imaging. Analysis of her articles reveals a sustained emphasis on microtubule-targeted therapeutics, fluorescent probe development, and conformational studies of tubulin-drug complexes. Recent publications highlight bioorthogonal chemistry, boron-nitrogen heterocycles, and oxidative stress detection in cellular systems. Current lab projects include designing simplified Taxol analogs, elucidating colchicine-site interactions, and creating novel fluorescent sensors for biomolecular carbonylation. Techniques span organic synthesis, protein purification, and advanced spectroscopy. Contact: sbane@binghamton.edu | Personal Site

• Cardiomyopathy
• Gene Therapy
• Autophagy
• +۳ مورد دیگر

Prof. Lucie Carrier is a faculty member at the Institute of Experimental Pharmacology and Toxicology , University Medical Center Hamburg-Eppendorf. She leads a research group focused on hypertrophic cardiomyopathy (HCM), sarcomere mutations, and autophagy-lysosomal pathways. Her work bridges molecular mechanisms with translational therapies, including gene editing and pharmacological interventions. Research Interests: Cardiomyopathy pathogenesis, tubulin dynamics, iPSC disease modeling, proteotoxic stress, CRISPR/Cas9 applications, ESC consensus guidelines. Recent Publications (2024-2023): Her 2024 studies explore tubulin tyrosination in heart function and RNA editing therapies. 2023 articles investigate EGFR/IGF1R signaling and tubulin cycles, while 2022 work includes consensus documents on cardiovascular models and ACTN2 proteopathy. Scientific Awards: Recipient of European Society of Cardiology (ESC) Research Grants. Collaborations: Active in ESC Working Groups on Myocardial Function and Cellular Biology of the Heart. Her team uses iPSC-derived cardiomyocytes, mouse models, and proteomic analysis to identify therapeutic targets.

Martin Tannerمشاهده پروفایل

استاد

• Enzymology
• Biochemistry
• Organic Chemistry
• +۳ مورد دیگر

Professor Martin Tanner is a faculty member in the Department of Chemistry at the University of British Columbia (UBC), within the Faculty of Science. He serves as the Interim Graduate Advisor and leads the Tanner Research Group, focusing on mechanistic enzymology. His research explores enzyme-catalyzed reactions, particularly stereochemical control in biosynthetic processes, with a focus on enzymes like ADP-heptose 6-epimerase and sialic acid synthases. Techniques employed include isotopic labeling, synthetic organic chemistry, and molecular biology. Education: B.Sc. (University of Alberta, 1985), Ph.D. (UCLA, 1990 under Donald J. Cram), and postdoctoral training at Harvard University (1990-1992 under Jeremy R. Knowles). Awards include the Bernard Belleau Award (2010) and the Merck Frosst Lecture Award (2004). He contributes to editorial roles, such as on the Bioorganic Chemistry journal. His research group investigates enzymes critical to bacterial lipopolysaccharide biosynthesis, sialic acid metabolism, and tubulin polyglutamylation. Recent work includes inhibitor design targeting enzymes involved in bacterial resistance and cell wall synthesis. The lab’s projects highlight interdisciplinary approaches to understanding enzyme mechanisms and developing potential therapeutic agents. Awards and honors span recognition for research contributions, including the UBC Faculty of Science Achievement Award (2003) and early-career accolades like the Bio-Méga/Boehringer Ingelheim Young Investigator Award (1997). Current and past roles include leadership in professional organizations, such as the Executive Committee of the ACS Division of Biological Chemistry (2007-2009), and contributions to grant review panels, including NSERC and CIHR.