Tracey A. Rouault

Dr. Tracey A. Rouault is a Physician Scientist leading the Section on Human Iron Metabolism at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH) in Bethesda, MD. Her research focuses on the molecular regulation of iron and iron-sulfur cluster metabolism in mammalian systems.

Research Interests: Dr. Rouault’s lab investigates the roles of iron regulatory proteins (IRPs) and iron-sulfur cluster biogenesis in health and disease. Her work spans neurodegenerative disorders such as Parkinson’s disease and Friedreich ataxia, hematologic conditions including anemias and polycythemia, and familial renal cancers. The lab employs mouse models, cell culture, and patient-derived lines to dissect the mechanisms of iron homeostasis and mitochondrial function.

Recent Research Trends: Analysis of her recent publications reveals a strong focus on the role of iron-sulfur clusters in metabolic reprogramming, immune cell function, and epigenetic regulation. Her work continues to uncover novel protein complexes and regulatory motifs involved in Fe-S cluster assembly and iron transport, with implications for understanding and treating rare genetic and metabolic diseases.

Scientific Awards:

• No specific awards mentioned in the provided text.

Advising and Grants: Dr. Rouault mentors post-doctoral and graduate fellows. Opportunities are available through the NIH Graduate Partnership Program with universities such as Johns Hopkins, University of Maryland, Oxford, and Cambridge. Her research is supported by the NIH intramural funding program, indicating ongoing grant support for her lab’s investigations into iron metabolism and related disorders.

Labs and Teams: She leads the Section on Human Iron Metabolism within NICHD, conducting interdisciplinary research that bridges biochemistry, genetics, and physiology to understand fundamental aspects of iron biology and their clinical implications.