جستجوی استاد راهنمای دانشگاهی

Kathryn E. Dickerson, M.D., M.S.C.S., is an Assistant Professor in the Department of Pediatrics at UT Southwestern Medical Center, specializing in the Division of Hematology and Oncology. She holds dual appointments as a 2015 Translational Research Scholar in the UTSW Center for Translational Medicine and as an NIH KL2 scholar. Her clinical focus is pediatric hematology, emphasizing bone marrow failure disorders, cancer predisposition syndromes, and thalassemia/dyserythropoietic anemias. Her research investigates epigenetic regulation of myeloid malignancies, clonal hematopoiesis in childhood cancer survivors, and molecular mechanisms underlying acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and myeloproliferative disorders (MPD). Education: Bachelor's in Biochemistry (Indiana University), minor in Spanish Medical degree (Indiana University School of Medicine) Masters of Science in Clinical Sciences (UT Southwestern Center for Translational Medicine) Training: Pediatric residency with research pathway (Ohio State University/Nationwide Children’s Hospital) Pediatric hematology-oncology fellowship (UT Southwestern) Dr. Dickerson’s research bridges basic science and clinical practice, leveraging CRISPR-based epigenetic editing, genomic analysis, and translational studies to understand disease mechanisms. Key projects include interrogating enhancer dysregulation in leukemia, studying metabolic reprogramming in cancers, and evaluating clonal hematopoiesis in survivors of childhood cancers. Her work has advanced understanding of EZH2’s role in AML and identified therapeutic vulnerabilities in myeloid malignancies. Awards: 2015 Translational Research Scholar (UTSW Center for Translational Medicine) NIH KL2 Career Development Award Grants/Initiatives: NIH-funded investigator-initiated study on clonal hematopoiesis Industry/consortia-sponsored trials for bone marrow failure and rare blood disorders She collaborates with the Children’s Research Institute and North American Pediatric Aplastic Anemia Consortium, contributing to clinical trials and translational initiatives. Her lab focuses on developing biomarkers for disease severity (e.g., immature platelet fraction in pediatric COVID-19) and therapeutic strategies targeting epigenetic dependencies in leukemia.

• Pediatric Hematology
• Myeloid Malignancies
• Epigenetic Regulation
• +۴ مورد دیگر

Laura Rusche is a Professor in the Department of Biological Sciences at the University at Buffalo. Her research focuses on chromatin structure, gene expression regulation, and evolutionary mechanisms in yeast. She investigates how sirtuins and heterochromatin proteins like Sir3 contribute to epigenetic control and respond to metabolic stress. Her work spans multiple yeast species to understand evolutionary adaptations in protein functions and transcriptional circuits. Education: BS from Yale University (Molecular Biophysics & Biochemistry), PhD from Johns Hopkins University (Biochemistry), and postdoctoral training at UC Berkeley. Research Interests: Chromatin dynamics, sirtuin-mediated epigenetic regulation, gene duplication consequences, and fungal pathogen biology. Key projects include studying Sir2's role in NAD+ stress responses and the evolution of Sir3 from replication proteins. Lab: The Rusche Lab explores centromere stability, heterochromatin formation in Candida species, and evolutionary genomics. Recent work highlights unique centromere structures in Candida auris and the functional divergence of sirtuins across yeasts.

• Chromatin Biology
• Gene Expression Regulation
• Evolutionary Genomics
• +۳ مورد دیگر

Dr. Steven Jacobsen is a Professor in the Molecular, Cell, and Developmental Biology Department at the University of California, Los Angeles (UCLA), where he leads the Jacobsen Lab. His work focuses on epigenetic inheritance and gene regulation in Arabidopsis thaliana and mammalian stem cells, utilizing genetic screens, genomics, epigenomics, and biochemical approaches. The lab also pioneers CRISPR-mediated genome editing techniques. University: University of California, Los Angeles Department: Molecular, Cell, and Developmental Biology Research Interests: Jacobsen's research spans multiple interconnected domains in epigenetics, including DNA methylation patterning, histone modification interplay, and transposable element silencing. His team investigates how chromatin structure influences gene expression and epigenetic inheritance, with applications from plant development to human health. Key areas include: CRISPR-based epigenetic modifications RNA-directed DNA methylation (RdDM) mechanisms Chromatin compaction via MORC proteins Histone variant functions in methylation Transposon control in plant genomes Comparative epigenomics across species Advising Legacy: Over two decades, Dr. Jacobsen has mentored 21 former lab members who now hold academic and industry positions globally, including professors at Chinese Academy of Sciences, University of Georgia, and Southern University of Science & Technology. His lab's publications reveal a consistent focus on DNA methylation dynamics, chromatin remodeling, and small RNA pathways, with recent work emphasizing CRISPR innovations and structural insights into epigenetic regulators.

• Epigenetics
• Epigenomics
• Genetics
• +۴ مورد دیگر

Lauren Baker Banks is a Clinical Assistant Professor in the Department of Medicine at Memorial Sloan Kettering Cancer Center (MSK). She is affiliated with the Hematology-Oncology Fellows and Graduate Medical Education (GME) programs, and her research focuses on sarcoma biology and immune checkpoint blockade (ICB) therapies. Affiliations: Hematology-Oncology Fellows, Graduate Medical Education (GME), Department of Medicine, Solid Tumor Oncology Division, Division of Hematologic Malignancies Co-authors: Sandra D'Angelo, Ciara Kelly, Evan Rosenbaum, Jason Chan, Mark Dickson, Mary Keohan Her work spans clinical trials in leiomyosarcoma, dedifferentiated liposarcoma, and other sarcomas, with a focus on combination therapies involving PARP inhibitors, PD-1 inhibitors, and STING agonists. Recent studies analyze biomarkers like T cell phenotype and tumor microenvironment subtypes to predict ICB outcomes. Lauren's publications include contributions to Journal for ImmunoTherapy of Cancer , Annals of Oncology , and Journal of Clinical Oncology , with a strong emphasis on translational research linking immunology to sarcoma treatment. She has collaborated with key researchers in oncology and immunotherapy, including Evan Rosenbaum and Ciara Kelly. Her research activities align with histology-specific clinical trials and multidisciplinary approaches for extremity soft tissue sarcomas, highlighting the integration of targeted therapy, immunotherapy, and genomic profiling in advancing sarcoma care.

• Medical Oncology
• Cancer Immunotherapy
• Sarcoma Research
• +۳ مورد دیگر

Dr. Martin Taylor is an Associate Professor in Molecular Ecology at the University of East Anglia's School of Biological Sciences. He has held academic positions since 2013, including Senior Lecturer roles at Bangor University and postdoctoral research experience in Belgium. His primary research focuses on molecular ecology, evolution, and conservation of marine and freshwater fishes, with an emphasis on genetic methods like microsatellite markers and next-generation sequencing. Key interests include polyploidy in Corydoras catfishes, fisheries-induced evolution, and traceability of fish populations. Taylor leads projects on lobster ageing via DNA methylation and collaborates internationally on studies of biodiversity and conservation genetics. Education: BSc (Animal and Plant Biology) from the University of Leeds (1990–1993) and PhD from the University of Aberdeen/Southampton (1993–1996), studying speciation in African cichlids. Research projects include Woodland impacts on pollinator diversity Genetic basis of catfish venoms Development of novel ageing methods for European lobsters His work bridges fundamental and applied research, addressing challenges in fisheries management, conservation, and ecological sustainability. Taylor serves as an Associate Editor for Marine Biology and maintains an active lab group at UEA. Key contributions include advancing DNA-based methods for ecological and conservation applications, such as detecting jellyfish predation and tracking fish populations via genetic markers.

• Molecular Ecology
• Evolutionary Biology
• Conservation Genetics
• +۴ مورد دیگر

Guillaume Bourque is a Professor in the Department of Human Genetics at McGill University's Faculty of Medicine. He serves as an Investigator at the Victor Phillip Dahdaleh Institute of Genomic Medicine and as the Scientific Director of the Canadian Centre for Computational Genomics (C3G). His laboratory is based at 740 Dr Penfield Ave, Room 6103, Montréal, Québec, Canada, H3A 1A4, where he leads research in computational genomics and bioinformatics. Professor Bourque's research focuses on understanding mammalian genomes using comparative genomic and epigenomic analyses. His lab investigates the evolution of regulatory sequences , the role of transposable elements in gene regulation , and the impact of genome rearrangements in evolution and cancer . His team develops computational methods and resources for the functional annotation of genomes with special emphasis on sequencing-based assays including ChIP-seq, RNA-Seq, exome- and whole-genome sequencing, and single-cell analysis. The lab's work involves examining billions of DNA base pairs to interpret how variation impacts basic biology and disease. Recent publications (2024-2025) demonstrate Bourque's leadership in pangenome graph construction , transposable element analysis , epigenomic profiling , and cancer genomics . His work spans multiple disciplines from basic genome evolution to clinical applications in cancer and infectious disease. Notable projects include the development of tools like DeepPolisher for genome assembly polishing and contributions to understanding the genomic basis of long COVID. Bourque's laboratory is actively recruiting postdocs and graduate students with backgrounds in programming or statistics. The lab emphasizes quantitative approaches to biology, requiring applicants to have experience in quantitative biology as a plus. His collaborative work extends across multiple institutions and international consortia, reflecting the interdisciplinary nature of modern genomic research.

• Bioinformatics
• Computational Genomics
• Comparative Genomics
• +۵ مورد دیگر

Jill A Kreiling is an Associate Professor (Research) in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University School of Medicine. She also serves as the Associate Director of the Brown Center on the Biology of Aging since July 2018. Her research focuses on the molecular mechanisms of aging, particularly examining the role of transposable elements, epigenetic changes, and cellular senescence in the aging process. Dr. Kreiling's research interests span several key areas in aging biology and molecular mechanisms of age-related changes. Her work has significantly contributed to understanding how retrotransposable elements become active during aging, how heterochromatin formation changes with age, and how these molecular changes impact tissue function and age-related diseases. She has developed innovative approaches to study aging processes using various model systems including mouse models, zebrafish, and cell culture systems. Her research program has been consistently supported by NIH funding, including her current role as Principal Investigator on an R01 grant focused on identifying biomarkers in salivary vesicles for preclinical Alzheimer's disease. She has published extensively in high-impact journals including Nature, Cell, and Aging Cell, with her work being cited widely in the aging research community. Dr. Kreiling has received several prestigious awards including the Mentored Research Scientist Development Award (K01) from the National Institute on Aging (2011-2017). Her collaborative network includes prominent researchers in the aging field such as John Sedivy and Nicola Neretti at Brown University. As an educator, Dr. Kreiling has taught Introductory Microbiology and has mentored numerous students and postdoctoral fellows in her laboratory. Her research program provides valuable training opportunities for students interested in aging research, molecular biology, and translational approaches to age-related diseases.

• Aging Biology
• Molecular Biology
• Cell Biology
• +۴ مورد دیگر

Timo Hytönen is a Professor in the Department of Agricultural Sciences at the University of Helsinki's Faculty of Agriculture and Forestry. He holds a Docentship in the same department and is an integral member of the Viikki Plant Science Centre (ViPS). His academic leadership extends to supervising doctoral students across three major programs: Sustainable Use of Renewable Natural Resources, Integrative Life Science, and Plant Sciences. Additionally, he maintains an external position as Principal Research Scientist at NIAB EMR in Genetic Genomics & Breeding since November 2018. Professor Hytönen's research interests span plant genetics, molecular biology, and crop production sciences with a specialized focus on berry crops, particularly strawberries. His work investigates fundamental plant processes including flowering time regulation, environmental adaptation mechanisms, fruit development, and disease resistance. His research integrates genomic, transcriptomic, and epigenetic approaches to understand how plants respond and adapt to environmental challenges. His extensive publication record (88 publications) reveals a strong focus on woodland strawberry (Fragaria vesca) as a model system for studying economically important traits in berry crops. Recent work demonstrates expertise in QTL mapping, genome-wide association studies, circadian rhythm adaptation, and the genetic basis of climate adaptation. His research shows consistent emphasis on translating basic science into practical applications for crop improvement. Professor Hytönen leads significant research projects including 'Mansikan vihreä vallankumous' (Strawberry Green Revolution) funded by the Academy of Finland and 'ASTROS: How meristems guide plant reproductive development' supported by the Jane and Aatos Erkko Foundation. He is also a Principal Investigator in the Viikki Plant Science Centre (ViPS), a major collaborative research infrastructure. His academic service includes extensive peer review activities (37 manuscript reviews), hosting academic visitors (32 instances), and participation in numerous conferences and seminars. He has provided guidance to graduate students and supervised doctoral candidates, contributing significantly to the training of next-generation plant scientists.

• Plant Genetics
• Berry Crop Breeding
• Molecular Biology
• +۵ مورد دیگر

Andreas Kautt is Assistant Professor of Biology at Washington University in St. Louis, investigating evolutionary mechanisms driving biological diversity through integrative approaches combining genomics, behavioral experiments, and fieldwork. Research focuses on two primary systems: North American deer mice and Missouri crayfish. Research themes include: Genomic basis of behavioral divergence and sensory evolution Molecular mechanisms of speciation in cichlid fish radiations Genetic assimilation in morphological evolution Development of novel genomic tools for speciation research Recent work explores olfaction genetics in deer mice, parallel evolution in pigmentation, and hybrid speciation mechanisms. Publications demonstrate expertise in evolutionary genomics, behavioral ecology, and molecular evolution across diverse vertebrate systems.

• Evolutionary Genetics
• Behavioral Ecology
• Adaptive Radiation
• +۲ مورد دیگر

Professor Anne Ferguson-Smith is a leading mammalian developmental geneticist and epigeneticist at the University of Cambridge, holding the Arthur Balfour Professorship of Genetics. As Pro-Vice-Chancellor for Research, she oversees the university's research strategy while maintaining her laboratory's focus on genomic imprinting and epigenetic inheritance . Her work bridges experimental and computational approaches through affiliations with the Cambridge Stem Cell Institute, Cambridge Neuroscience, and the Centre for Trophoblast Research. Research in her lab investigates epigenetic mechanisms in developmental processes , particularly through the lens of Dlk1-Dio3 imprinted domain studies. Current themes include: Stem cell epigenetic programming Environmental modulation of epigenetic states Role of repetitive elements in genomic regulation Her group integrates mouse and zebrafish models with high-throughput genomics and mathematical modeling . Key collaborations include: Wellcome Trust UKRI Medical Research Council BBSRC NIH Scientific honors include: Elected EMBO Member (2006) Academy of Medical Sciences (2012) Fellow of the Royal Society (2017) Commander of the Order of the British Empire (CBE) The lab maintains family-friendly research practices and actively participates in interdisciplinary collaborations across Cambridge and internationally.

• Genomic Imprinting
• Epigenetics
• Developmental Genetics
• +۳ مورد دیگر

Ritwick Sawarkar is a Principal Investigator at the MRC Toxicology Unit and affiliated with the Department of Genetics under the School of Biological Sciences at the University of Cambridge. He leads the Sawarkar Group, focusing on molecular mechanisms linking chromatin biology, environmental stress response, and transcriptional regulation. Education: PhD in Genetics (Indian Institute of Science, 2010) Previous roles: Postdoctoral Fellow at ETH-Zürich (2010-2014), Independent Group Leader at Max Planck Institute (2014-2019) Research Interests : The Sawarkar Group investigates how chromatin interprets environmental stress signals to modulate transcriptional responses. Key questions include: (i) Cellular pathways sensing stress/toxins, (ii) Chromatin's role in stress adaptation, and (iii) Transcriptional mechanisms for cellular survival. Their work integrates genomics, single-cell transcriptomics, proteomics, and mouse models to explore stress response pathways. Article Trends : Recent publications highlight his expertise in chromatin-mediated stress responses, non-coding RNA interactions, and proteostasis networks. Collaborations with pharmaceutical companies emphasize translational applications for drug toxicology and RNA therapeutics. Scientific Awards : ERC Consolidator Grant (2018) Alfred Tissières Young Investigator Award (2019) Group Members : His team includes PhD students (Dimitris Aspri, Roberto Campalastri), Research Associates (Simone Baldan, Christo Christov), and MPhil students (Anfas Muhammed, Keely Xia), among others.

• Chromatin Biology
• Environmental Stress Response
• Transcriptional Regulation
• +۳ مورد دیگر

Anne Pringle is a Professor in the Department of Bacteriology at the University of Wisconsin–Madison, where she leads the Pringle Laboratory. Her research focuses on the evolution and ecology of fungi, particularly natural populations of invasive species like Amanita phalloides (death cap), lichen demographics, and fungal responses to global change. She is actively involved in field research, genomic analysis, and public science communication. Her research interests span fungal ecology, evolutionary biology, invasion dynamics, mycorrhizal symbiosis, and conservation. Using fungi as model organisms, her lab investigates broad ecological and evolutionary principles, including spore dispersal, gene birth, nitrogen deposition effects, and the evolutionary origins of toxicity. She emphasizes both field and molecular approaches. The recent publications reflect a strong focus on invasive fungal species, particularly Amanita phalloides in California. Themes include biogeography, genetic origins, mycorrhizal relationships, reproductive strategies, and ecological impacts. There is also significant work on lichen demography, wood-decay fungi, and citizen science initiatives like the Golden Oyster Project. MSA Fellow NAMA Fellowship Forest Mycology Research Award Multiple student travel awards Pringle mentors several students, including PhD candidates and researchers involved in fieldwork, genomics, and public outreach. Her lab has received recognition for research on snake disease, nitrogen deposition, and gene evolution. She collaborates widely and promotes fungal science through media appearances, iBiology talks, and KQED features. The Pringle Lab conducts field forays, retreats, and engages in community science, maintaining strong ties with mycological societies and bioinformatics resources at UW-Madison.

• Fungal Ecology
• Evolutionary Biology
• Invasion Biology
• +۷ مورد دیگر

Stephen L Helfand is the George D. Eggleston Endowed Professor of Biochemistry at Brown University, where he serves as Professor in the Department of Molecular Biology, Cell Biology and Biochemistry and Vice-Chair of Research in the Department of Neurology. His work focuses on the molecular genetics of aging , using Drosophila melanogaster to investigate how chromatin changes, transposable elements, and metabolic pathways like the INDY gene influence longevity and age-related diseases. Education: BS (1975) and MD (1979) from Stanford University and Albert Einstein College of Medicine Key Research Areas: Mechanisms of aging Chromatin remodeling Transposable elements in aging Metabolic regulation of lifespan Neurodegenerative disease models His 15 most recent articles (2019-2011) highlight interdisciplinary work bridging genetics, epigenetics, and metabolism. Common themes include chromatin dynamics , mitochondrial function , and transposable element activation in aging, with applications to human diseases like Alzheimer's. Scientific Awards Glenn Awards (2007-2009, 2014-2016) MERIT Award (2004-2016) Fellow of AAAS (2017) and Gerontological Society of America (2017) NIH grants (R01AG067306, R01AG024353, P01AG051449) He contributes to translational neuroscience and aging research through affiliations with Brown University's Center for Computational Molecular Biology , Carney Institute for Brain Science , and Center for Translational Neuroscience . His lab has developed rapid assays for lifespan-extending interventions and demonstrated connections between sirtuins, caloric restriction, and p53 regulation.

• Molecular Genetics of Aging
• Longevity
• Neurodegeneration
• +۷ مورد دیگر

Louis Lambrechts is a Researcher and Head of the Insect Infection & Immunity Group at the Institut Pasteur in Paris, France, within the Department of Virology. His research focuses on the ecology, evolution, and genetics of mosquito-virus interactions, particularly involving Aedes aegypti and arboviruses such as dengue and Zika. He leads a dynamic research team and multiple national and international projects funded by agencies including ANR and EU consortia. His research interests include arbovirus transmission dynamics, vectorial capacity, mosquito genetics, evolutionary ecology, host-pathogen interactions, and the role of microbiota in vector competence. He employs genomics, quantitative genetics, and experimental evolution to understand the mechanisms underlying variation in mosquito susceptibility to viral infection. His work has important implications for predicting and controlling arboviral disease outbreaks. Lambrecht’s recent publications reveal key insights into the genetic and environmental factors influencing arbovirus transmission, including the role of mosquito population variation in Zika transmission in Africa, the impact of endogenous viral elements, and the discovery of antiviral roles for cytochrome P450 enzymes. His research integrates molecular biology, field studies, and computational modelling, contributing to a comprehensive understanding of vector-borne disease systems. He has mentored numerous PhD students, postdoctoral researchers, and visiting scientists, fostering a collaborative and interdisciplinary research environment. His lab collaborates widely with institutions across Europe, Africa, and the Americas. Lambrecht’s work is supported by multiple ongoing projects such as CAZIKANO, INTRANZIGEANT, ANR PILGRIM, and LIPOARBO-IVI, focusing on Zika virus transmission, genetic drivers of vectorial capacity, and mosquito-virus specificity. His lab is also involved in broader initiatives like the LabEx IBEID and the Emerging Infectious Diseases program at Institut Pasteur.

• Arbovirus transmission
• Insect-virus interactions
• Mosquito genetics
• +۱۲ مورد دیگر

Jef D. Boeke is the Sol and Judith Bergstein Director of the Institute of Systems Genetics and a Professor in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine. He holds a PhD from Rockefeller University and has pioneered research in synthetic biology, retrotransposition mechanisms, and yeast genetics. His work includes leading the international Sc2.0 project to synthesize the first eukaryotic genome and the 'Dark Matter Project' exploring non-coding DNA functions. Research interests focus on genome engineering, synthetic genomics, epigenetics, and applications to cancer biology. His lab develops CRISPR tools and synthetic regulatory systems, with notable contributions to understanding LINE-1 retrotransposons and chromatin structure. Over 489 publications highlight his work in Nature Communications, Molecular Cell, and Science. Awards: While specific prizes aren't listed, his leadership in groundbreaking projects like Sc2.0 and contributions to synthetic biology underscore his influential career. Grants and funding details are implied through active research programs. Advising: Supervises a multidisciplinary team of postdocs and graduate students working on projects ranging from antibiotic engineering to de-extinction approaches. Lab collaborations include international partnerships and industry-driven biotech applications. Labs/Teams: Directs the Boeke Lab, a hub for synthetic genome engineering and systems genetics. The lab’s interdisciplinary team bridges molecular biology, computational biology, and engineering to solve complex biological problems.

• synthetic biology
• genome engineering
• genomics
• +۵ مورد دیگر