جست‌وجوی استاد و پژوهشگر

Elizabeth Zuniga-Sanchezمشاهده پروفایل

استادیار

• Neuroscience
• Molecular Biology
• Developmental Biology
• +۳ مورد دیگر

Elizabeth Zuniga-Sanchez is an Assistant Professor in the Department of Ophthalmology at Baylor College of Medicine. Her research focuses on the molecular mechanisms governing synaptic specificity in the developing vertebrate nervous system, particularly using the mouse retina as a model system. She employs advanced techniques such as next-generation sequencing, CRISPR, and single-cell labeling to study neural circuit formation. Education : Bachelor of Science (BS) from University of California, Berkeley (2004) Doctor of Philosophy (PhD) from University of Southern California (2012) Postdoctoral Training at University of California, Los Angeles (2019–present) Research Interests : Dr. Zuniga-Sanchez investigates how neuronal subtypes form precise synaptic connections during development. Her work integrates molecular biology, genetics, and imaging to uncover principles of neural circuit assembly. Key themes include synaptic specificity, retinal development, and the role of proteins like ankyrins, neurofascin, and βII-spectrin in synaptic architecture. Publications : Her recent work highlights advancements in understanding retinal synapse formation, including studies on ankyrin proteins, βII-spectrin, and Wnt signaling. She also contributes to methodological innovations such as brainwide cell labeling techniques in mice. Awards & Funding : K99/R00 NIH Pathway to Independence Award (2021–2022) ARVO Genentech Career Development Award NIH-NEI Grant #EY028200 (2020–2023) Research to Prevent Blindness (RPB) Grant #R01EY033037 Advising & Grants : Dr. Zuniga-Sanchez leads a research group focused on ocular development and disease. Her grants support investigations into synaptic specificity mechanisms and retinal neuropil development. She collaborates on projects involving genetic tools like CRISPR and advanced imaging technologies. Labs & Teams : Her lab at Baylor College of Medicine studies neural circuit formation in the retina, bridging molecular genetics and systems neuroscience to address fundamental questions in developmental neurobiology.

Mary L Kraftمشاهده پروفایل

استاد

• Biomedical Engineering
• Chemical Engineering
• Cell Biology
• +۴ مورد دیگر

Mary L. Kraft is a Professor of Chemical and Biomolecular Engineering and Chemistry at the University of Illinois Urbana-Champaign, holding the Chien Family Professorial Scholar title. She also serves as Co-Chair of the Micro and Nanotechnology Lab and on the Institutional Biosafety Committee and Office of the Vice Chancellor for Research and Innovation. Her research focuses on combining engineering principles with advanced imaging technologies like NanoSIMS and Raman spectroscopy to study cell composition and biological function, particularly in biomedical applications. Key areas include stem cell differentiation for tissue engineering, drug delivery, and influenza virus replication mechanisms. Her work integrates computational statistics with chemical imaging for quantitative analysis at the single-cell level. Notable contributions include developing tools for non-invasive cell analysis and understanding lipid distributions in cellular membranes. She has received awards such as the AVS Prairie Chapter Early Career Research Award (2015) and the Walter A. Shaw Young Investigator Award (2014). Recent research trends emphasize lipid dynamics, membrane organization, and viral interactions with cellular membranes. Her publications span high-impact journals like ACS Nano and Biointerphases , with a focus on advancing analytical techniques for biomedical insights. Her lab, part of the College of Engineering, collaborates internationally and contributes to both applied and fundamental research in nanotechnology and cell biology.

• Quantitative Proteomics
• Cell Biology
• Mitochondrial Dynamics
• +۵ مورد دیگر

Macek is a Full Professor of Quantitative Proteomics and Director of the Proteome Center Tuebingen at the University of Tübingen, Germany. His research focuses on integrative proteomics, mitochondrial biology, bacterial physiology, and autophagy mechanisms. He holds a Doctorate in Biology from the University of Münster and a Diploma in Molecular Biology from the University of Zagreb. Key research interests include: Quantitative proteomics of cellular systems Mitochondrial dynamics and quality control Bacterial antibiotic production and resistance Host-pathogen interactions Cyanobacterial metabolism and circadian rhythms His work spans from fundamental biological processes to clinical applications such as precision medicine and cancer immunotherapy. Notable contributions include discoveries in Parkin-mediated mitophagy, antibiotic production regulation in Streptomyces, and AI-driven proteomic analysis. Macek has directed the Proteome Center Tuebingen since 2014, fostering collaborations across disciplines. His lab employs advanced proteomic techniques combined with computational biology to address complex biological questions.

Volkan Cevikمشاهده پروفایل

مدرس ارشد

• Plant Immunity
• Pathogen Evolution
• Molecular Biology
• +۳ مورد دیگر

Dr. Volkan Cevik is a Senior Lecturer in the Department of Life Sciences at the University of Bath, affiliated with the Milner Centre for Evolution. His research focuses on molecular mechanisms of plant immunity against pathogens, particularly the interaction between plants and Albugo candida . He investigates how immune receptors recognize pathogen effectors and how pathogens evolve to evade these defenses. His work also includes comparative genomics of pathogens to understand host specialization and virulence. Current research activities include: (1) studying White Rust Resistance (WRR) proteins and their signaling pathways, (2) engineering resistance proteins for broader specificity, (3) identifying susceptibility factors in host plants, and (4) evolutionary dynamics of Albugo candida races. His research contributes to UN Sustainable Development Goals related to food security and sustainable agriculture. Dr. Cevik has led or co-investigated multiple grants, including projects on high-resolution respirometry, confocal microscopy, and surveillance systems for white rust pathogens in India. His work spans plant-microbe interactions, pathogen genomics, and crop improvement through genetic engineering. Recent publications highlight advancements in genetic manipulation for disease resistance, immune receptor function, and pathogen effector biology. He collaborates internationally to advance understanding of plant immunity and pathogen evolution.

Tore Jahnsenمشاهده پروفایل

استاد

• cAMP-dependent protein kinases
• Protein kinases
• Sperm motility
• +۵ مورد دیگر

Tore Jahnsen is a Professor in the Department of Biochemistry at the University of Oslo. His research focuses on cAMP-dependent protein kinases (PKA), their regulation, structural biology, and roles in cellular processes such as sperm motility and signal transduction. He has collaborated widely, including with Professor Bjørn S. Skålhegg, and leads a research group of 9 members (technicians, students, and postdocs). He serves on the boards of Rheumatech AS and Spermatech AS. Education: Dr.med. (Ph.D.) in 1983 and Cand.med. (M.D.) in 1982 from the University of Oslo's Faculty of Medicine. His doctoral thesis examined adenylyl cyclases in rat testes. Research interests include PKA structure/function, phylogenetic analysis of catalytic subunits, heterogeneity in PKA genes (with implications for diagnostics/therapeutics), and human sperm metabolism/capacitation. His work spans biochemistry, molecular biology, and reproductive biology. Recent publications (2013–2007) highlight studies on PKA evolution, mutations in PKA genes, sperm glycolysis regulation, and roles of PKA in pre-mRNA splicing and T lymphocytes. His 1991 Anders Jahres Award recognized contributions to early-career science. Advising and grants: Supervises Ph.D. and master's students. Research group includes medical students and postdocs. Collaborates internationally on projects involving protein kinase signaling and reproductive biology. Research teams: Active in the 'cAMP and PKA' research group at the University of Oslo, exploring PKA's role across biological systems.

Kaijie Zhengمشاهده پروفایل

پژوهشگر ارشد

• Plant Proteomics
• Protein Processing
• Molecular Breeding
• +۳ مورد دیگر

Dr. Kaijie Zheng is a Postdoctoral Research Assistant at the Department of Biology, University of Oxford, affiliated with the van der Hoorn Group. His research focuses on plant proteomics, protein processing, and molecular breeding for agricultural applications. Research interests include: Secretory protein cleavage events in plants Proteome dynamics in Nicotiana benthamiana AI-driven approaches for soybean molecular design breeding Mechanisms of salt stress tolerance in Arabidopsis Trichome development regulation via MBW complexes Recent publications highlight his work on protein processing in plant expression systems, stress response signaling, and gene family evolution across species. Collaborations with Chinese soybean research teams underscore his interdisciplinary approach to modern agricultural challenges.

A. Gregory Materaمشاهده پروفایل

استاد

• Genetics
• Cell Biology
• RNA processing
• +۳ مورد دیگر

A. Gregory Matera is a Professor in both the Department of Genetics and the School of Medicine at the University of North Carolina at Chapel Hill. His research focuses on understanding the molecular mechanisms governing the assembly and subcellular localization of small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing. Key Research Areas: snRNP biogenesis, Spinal Muscular Atrophy (SMA), post-transcriptional histone modifications, and nuclear body dynamics. Model Systems: Utilizes fruitfly, mouse, and human models to study RNP assembly and transport. Recent publications highlight his work on histone modifications, Polycomb group function, innate immune signaling in SMA models, and structural analysis of RNA-processing complexes. His lab investigates how defects in snRNP assembly contribute to SMA pathogenesis and explores biomolecular condensate formation in nuclear bodies. Contact: matera@unc.edu

Qilong Yingمشاهده پروفایل

استاد

• Stem cell self-renewal
• Embryonic stem cell differentiation
• Cell fate determination
• +۲ مورد دیگر

Qilong Ying is Professor of Stem Cell Biology at USC's Keck School of Medicine. His lab investigates molecular mechanisms controlling embryonic stem cell self-renewal versus differentiation decisions. Pioneered rat embryonic stem cell derivation techniques enabling advanced genetic models for human disease research. Research focuses on signaling pathways (ERK, GSK3, AKT) regulating pluripotency, cardiac differentiation, and kidney development. Develops innovative organoid models for regenerative medicine applications and high-precision gene editing techniques. Honored with ISSCR's McEwen Innovation Award for stem cell technology advancements. Current collaborations with Shanghai Cell Therapy Group aim to improve hematopoietic stem cell expansion for clinical use. Recent publications explore: Paralog-specific ERK functions in fate determination Kcnh2-integrin complexes in embryonic development Nephron progenitor cell-based kidney organoids

• Genetics of Movement Disorders
• Neuroscience
• Molecular Biology
• +۳ مورد دیگر

Prof. Vincenzo Bonifati is a Full Professor in Clinical Genetics at Erasmus MC, part of Erasmus University Rotterdam. He holds an MD and neurology certification from the University of Rome La Sapienza (1988, 1992), and a PhD in genetics from Erasmus University (2003). His research focuses on molecular mechanisms of Parkinson’s disease and dystonia, with a strong emphasis on identifying genetic variants and their impact on disease pathways. He has published over 230 papers, achieving an H-index of 68 and over 20,000 citations. He served as co-Editor-in-Chief of Parkinsonism & Related Disorders (2018–2023). Research interests span genetic screening, neurodegenerative disease pathways, and translational studies in movement disorders. His work has identified genetic defects in hereditary parkinsonism, dystonia, and rare movement disorders. Recent studies include investigations into α-synuclein transmission in Lewy body diseases and genetic insights into hypermanganesaemia. He has supervised 9 academic works and collaborates globally on projects like the MJFF Global Genetic Parkinson's Disease Project. His contributions include developing diagnostic consensus guidelines for rare genetic disorders and advancing understanding of TFEB's role in Lewy body pathologies.

Jin Zhangمشاهده پروفایل

استاد

• Cell Signaling
• Molecular Biology
• Biochemistry
• +۳ مورد دیگر

Jin Zhang is a Professor holding joint appointments in the Departments of Pharmacology, Bioengineering, Chemistry and Biochemistry at the University of California San Diego (UCSD). He also affiliates with the Moores Cancer Center and the BioPAC (Bio-optical Probe Advancement Center). His research focuses on understanding the spatiotemporal regulation of cell signaling pathways, particularly protein kinases and phosphatases, using innovative approaches like genetically encoded fluorescent biosensors, superresolution imaging, and mathematical modeling. Key research areas include the cAMP/PKA, Ca²+/calcineurin, PI3K/Akt/mTOR, MAPK, and AMPK pathways, with applications in energy metabolism, axon development, insulin secretion, and tumorigenesis. The lab develops advanced tools such as activity biosensors, magnetic labeling strategies, and super-resolution imaging techniques to map biochemical activity architectures in living cells. BioPAC, a collaborative initiative co-founded by Zhang, aims to advance optical probe development and instrumentation to address biological and medical questions. His work bridges disciplines like biochemistry, biophysics, and engineering, emphasizing real-time visualization of signaling dynamics in native cellular contexts.

Ursula Jakobمشاهده پروفایل

استاد

• Oxidative Stress
• Aging Mechanisms
• Microbial Defense
• +۳ مورد دیگر

Ursula Jakob is the Patricia S. Yaeger Collegiate Professor in the Department of Molecular, Cellular, and Developmental Biology (MCDB) at the University of Michigan. She holds a B.S. (1991) and Ph.D. (1995) from Regensburg University, Germany. After postdoctoral research at the University of Michigan and roles as an Assistant Research Scientist, she joined the faculty in 2001. Her research focuses on oxidative stress, aging mechanisms, and microbial defense, with particular interest in how oxidants influence host defense and longevity. Her lab explores molecular chaperones like Hsp33 and investigates polyphosphate’s role in cellular processes. Jakob has been recognized with awards including the Burroughs Wellcome Fund Career Award and election to the Bavarian Academy of Sciences. Education and Career Path: B.S. and Ph.D. from Regensburg University (Germany), followed by postdoctoral training at UM and faculty appointment since 2001. She leads the Jakob Lab, which studies redox regulation, protein folding, and aging. Key contributions include discoveries about bleach’s antimicrobial effects and the role of early-life oxidants in lifespan determination. Research Interests: Molecular mechanisms of oxidative stress defense, redox regulation in aging, polyphosphate’s multifunctional roles, and protein chaperone dynamics. Her work bridges basic science and translational applications, such as developing therapies to combat microbial infections and age-related diseases. Awards and Honors: Biomedical Career Award (2000), UM Faculty Recognition Award, Bavarian Academy membership (2014), and UM Biological Scholar designation.

Oliver Crookمشاهده پروفایل

پژوهشگر ارشد

• Molecular Parasitology
• Protein-Protein Interactions
• Machine Learning in Biology
• +۴ مورد دیگر

Oliver Crook is a Research Fellow at the University of Oxford, holding the Todd-Bird Junior Research Fellowship at New College until 2027 and an MRC Career Development Award to lead his research group at the Kavli Institute. His work bridges molecular parasitology, computational biophysics, and artificial intelligence. He develops novel tools for biosecurity, protein design, and spatial proteomics, employing Bayesian models and machine learning. Dr. Crook earned an MMath from the University of Warwick and a PhD in Biochemistry from the University of Cambridge (Wellcome Trust Mathematical Genomics CDT), advised by Kathryn Lilley, Laurent Gatto, and Paul Kirk. He was previously a Research Associate in Oxford’s Department of Statistics with Charlotte Deane and a Florence Nightingale Fellow. He also contributed to a protein design group at the UK Government’s AI Safety Institute. Education: PhD in Biochemistry, University of Cambridge (2013-2017) MMath (Master of Mathematics), University of Warwick (2009-2013) His research focuses on: Uncovering malaria parasite-hijacked red blood cell proteins using multiscale experimental and computational methods Developing AI tools for protein design and interpreting genomic/protein language models Pioneering spatial proteomics and Bayesian statistical frameworks for proteomic analysis Publications highlight advancements in proteomic methodologies (e.g., msqrob2TMT, BANDLE), HDX-MS analysis, and biosecurity applications like lab-of-origin prediction. He has received the Peter Landshoff Prize and Fisher Memorial Award for impactful research. Current projects explore protein conformation design and malaria host-pathogen interactions. Grants & Awards: MRC Career Development Award, Todd-Bird Fellowship, Peter Landshoff Prize, Fisher Memorial Young Biometrician Award Advising: No listed advisees, but mentors emerging AI-bio researchers Labs: Kavli Institute research group, collaborations across Oxford’s Department of Statistics and UK Government initiatives

Mark Frickerمشاهده پروفایل

استاد

• Fungal Networks
• Biological Imaging
• Redox Signaling
• +۳ مورد دیگر

Professor Mark Fricker is Professor of Plant Sciences and Associate Head of Department at the University of Oxford, Department of Biology. His research combines quantitative imaging, network analysis, and redox biology to study cellular dynamics in plants and fungi. Key work includes: 1) Network analysis of fungal foraging strategies showing adaptive transport systems; 2) Collaborative Physarum polycephalum studies revealing efficient biological network design; 3) Development of redox imaging tools for glutathione and ROS dynamics; 4) Automated leaf venation network extraction using deep learning. Recent publications explore organelle quantification, synthetic compartmentalization, and urban growth modeling inspired by biological systems. Research integrates experimental biology with computational approaches.

John Stanley Mattickمشاهده پروفایل

استاد

• RNA Biology
• Noncoding RNA
• Genomics
• +۷ مورد دیگر

John Stanley Mattick is the SHARP Professor of RNA Biology in the School of Biotechnology and Biomolecular Sciences at UNSW Sydney. Previously, he served as Executive Director of Genomics England (2018-2019) and Director of the Garvan Institute of Medical Research (2012-2018). He holds leadership roles in genomic research, establishing key facilities like the HiSeq X10 sequencing platform. His career includes foundational roles at the University of Queensland, including founding the Institute for Molecular Bioscience and the Australian Genome Research Facility. Education: BSc (First Class Honours, Biochemistry) from the University of Sydney (1972) PhD in Biochemistry from Monash University (1978) DSc from the University of Queensland (2024) Research focuses on regulatory RNAs, noncoding DNA functions, and their roles in development, disease, and evolution. Key areas include RNA structure-function relationships, lncRNA roles in cognition, and the epigenetic trajectories of development. His work challenges traditional views of genomic 'junk' DNA, emphasizing the centrality of RNA in genetic regulation. Publications span over 300 peer-reviewed articles, cited over 100,000 times. Notable contributions include co-authoring RNA, the Epicenter of Genetic Information (2022), which won awards for Best Science Open Access Book. Awards and Honors: Officer in the Order of Australia (AO) Fellowships in the Australian Academies of Science, Health & Medical Sciences, and Technology & Engineering Recipient of the IUBMB Medal and HUGO Chen Medal Ranked #1 globally in noncoding RNA research (2023) Leadership and Service: Chaired major international genome conferences and advisory boards Contributed to ethical frameworks for genomic research and healthcare Member of the Queensland Studies Authority (2004-2007) Current research explores RNA modification dynamics, lncRNA functions in brain plasticity, and the genomic basis of complex traits.

Niles A. Pierceمشاهده پروفایل

استاد

• Biological Engineering
• Translational Research
• Chemical Engineering
• +۴ مورد دیگر

Niles A. Pierce is the John D. and Catherine T. MacArthur Professor of Applied and Computational Mathematics and Bioengineering at the California Institute of Technology (Caltech), serving as Executive Officer for Biology and Biological Engineering. He holds a B.S.E. from Princeton University (1993) and a D.Phil. from the University of Oxford (1997). His research focuses on engineering programmable nucleic acid systems for biomedical applications, including molecular diagnostics, synthetic biology, and bioimaging. Key innovations include the Hybridization Chain Reaction (HCR) and the NUPACK computational design framework. Research interests span dynamic nucleic acid nanotechnology, molecular programming, and translational medicine. His team develops tools for multiplexed imaging, CRISPR-based regulation, and instrument-free diagnostics. Notable honors include the Guggenheim Fellowship (2014–2015), Feynman Teaching Prize (2003), and Rhodes/Hertz Fellowships (1993). Education: B.S.E., Princeton University, 1993 D.Phil., University of Oxford, 1997 Administrative Roles: Executive Officer, Division of Biology and Biological Engineering (2007–2013, 2020–) MacArthur Professor (2024–) His labs specialize in four subgroups: programmable regulators, bioimaging technologies, diagnostics, and computational algorithms. Current projects address cell-selective CRISPR regulation, high-resolution protein imaging, and at-home pathogen detection. NUPACK software remains a cornerstone of nucleic acid design research. Awards: Rhodes Scholarship, Hertz Fellowship, 1993 Rozemberg Tulip Award, 2020 Guggenheim Fellowship, 2014–2015 Richard P. Feynman Teaching Prize, 2003 His work bridges computational mathematics and biological engineering, with applications in medicine and environmental microbiology. Future efforts emphasize molecular choreography for precise cellular control and scalable diagnostic platforms.