جست‌وجوی استاد و پژوهشگر

Peter Lyمشاهده پروفایل

استادیار

• Genomic Instability
• Chromothripsis
• Cancer Genetics
• +۶ مورد دیگر

Peter Ly is an Assistant Professor at the Children's Medical Center Research Institute (CRI) and holds secondary appointments in the Department of Cell Biology, Department of Pediatrics, and the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center. His research focuses on genomic instability and chromothripsis in cancer development. B.A. in Biology, Baylor University (2008) Ph.D. in Cancer Biology, UT Southwestern Medical Center (2012) Postdoctoral training, University of California San Diego & Ludwig Institute for Cancer Research (2019) Research Interests: The Ly Laboratory investigates the cellular and molecular mechanisms driving genomic instability in cancer, including chromothripsis, DNA damage response, mitotic errors, and centromere dysfunction. Their work bridges molecular cell biology and genetics using CRISPR/Cas9, high-resolution microscopy, cytogenetics, and genomics. Article Trends: Recent publications highlight the role of mitotic errors in generating chromothripsis, DNA repair pathways in genomic instability, and implications for oncogenesis and drug resistance. Key subfields include structural variation, ecDNA, and tumor evolution. Students & Lab Members: Elizabeth (Lizz) Maurais – Ruth L. Kirschstein NRSA Predoctoral Fellow Bing-Huan (Nemo) Wu – Ph.D. Student Justin Engel – Ph.D. Student (2021–2025) Alison Guyer – Research Technician (2020–2022) and Graduate Student Professional Affiliations: Dr. Ly has been a member of the American Society for Cell Biology since 2013.

• Genetics
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Masamitsu Sato is a Professor at the Department of Life Science and Medical Bioscience , Faculty of Science and Engineering , Waseda University . His research focuses on the molecular mechanisms of microtubule formation , gene expression during the cell cycle , and chromosome segregation in fission yeast (Schizosaccharomyces pombe) . He also investigates microtubule regulation in mammalian systems , such as tracheal cilia and renal tubules. Education: Ph.D. in Biophysics and Biochemistry, Graduate School of Science, University of Tokyo (2001) Master’s and Bachelor’s in Biophysics and Biochemistry, University of Tokyo His research interests span cell polarity , meiosis/mitosis differentiation , non-coding RNA , and cytoskeleton dynamics . Recent work includes microtubule catastrophe mechanisms , artificial chromosome segregation devices , and single-cell RNA-seq for dormancy breaking . His scientific awards include the Waseda Research Award (2018) , Yeast Consortium Fellow (2020, 2022) , and the Young Scientists' Prize (2012) . He has contributed to CRISPR/Cas9 optimization and fission yeast plasmid systems .

• Cystic Fibrosis
• Lung Cancer
• Cancer Therapeutics
• +۷ مورد دیگر

Judith Coppinger is a Senior Lecturer at RCSI's School of Pharmacy and Biomolecular Sciences, with dual affiliation as Principal Investigator at the National Children’s Research Centre since 2017. Her academic journey includes a PhD in Pharmacology from RCSI (2004), postdoctoral training at the Scripps Research Institute (2005-2011), and faculty roles at UC San Diego (2011-2013) and University College Dublin (2013-2017). Her research focuses on omics-based approaches to uncover dysregulated protein interactions in diseases like cystic fibrosis and cancer, with a particular emphasis on exosome-mediated signaling, kinase inhibitors for CFTR restoration, and BAG3 as a cancer therapeutic target. Key research areas include cystic fibrosis pathophysiology, lung cancer signaling pathways, and translational therapeutics. Her work spans basic science to clinical translation, such as investigating exosomes as biomarkers for disease progression and targeting the PI3K/Akt/mTOR pathway in cystic fibrosis. She has secured major grants including Science Foundation Ireland funding for exosome-based therapies and the Cystic Fibrosis Foundation for EV biomarker studies in CF. Judith has received awards including the Career Development Award (2014), Isenberg Fellowship (2011), and New Investigators Travel Award (2010). Her lab at RCSI collaborates with Trinity College Dublin and the National Children’s Research Centre to advance research in respiratory medicine and cancer biology. Teaching and supervision activities are integral to her role, contributing to training future biomedical researchers.

Andrea Musacchioمشاهده پروفایل

استاد

• Structural Biology
• Cell Division
• Kinetochore Assembly
• +۳ مورد دیگر

Prof. Andrea Musacchio is Director of the Mechanistic Cell Biology Department at the Max Planck Institute of Molecular Physiology. His research investigates molecular mechanisms of cell division, focusing on kinetochore assembly, spindle checkpoint signaling, and chromosome segregation using biochemical reconstitution, structural biology, and cellular analyses. Awarded the Leibniz Prize (2020), he has pioneered structural insights into mitotic regulation. Research explores kinetochore-microtubule interactions, checkpoint complex assembly, phase separation in cellular organization, and structural mechanisms of chromosome segregation. Recent work examines PLK1 kinase in centromere maintenance and conformational regulation of motor protein recruitment. Honors include the Vallee Visiting Professorship and Leibniz Prize for contributions to understanding cell division machinery. Publications consistently integrate structural biology with functional analyses of mitotic components.

Mathew Jonesمشاهده پروفایل

مدرس ارشد

• Cancer Genetics
• Cell Biology
• DNA Replication
• +۴ مورد دیگر

Dr Mathew Jones serves as Senior Lecturer in the School of Chemistry and Molecular Biosciences at the University of Queensland and holds a Senior Research Fellow position at the Frazer Institute. His molecular genetics research group operates at the intersection of cancer biology and DNA repair mechanisms, with active supervision of multiple PhD students across diverse projects. His primary research focuses on exploiting cancer-specific vulnerabilities in DNA replication, repair pathways, and cellular metabolism to develop targeted therapies. Key areas include replication stress responses, mitotic regulation, chromosomal instability, and the interplay between DNA damage response and immune activation. His work combines cutting-edge molecular biology, genomics, and computational approaches to translate basic discoveries into therapeutic strategies. Analysis of his 15 most recent publications reveals a strong emphasis on DNA replication stress mechanisms (40% of papers), mitophagy regulation in cancer metabolism (20%), and chromosomal instability pathways (25%). His 2025 publications particularly highlight innovative applications of nanopore sequencing for cancer diagnostics and novel PARP1 inhibition mechanisms. Principal Investigator for 2023-2025 Schrodinger Inc. grant: 'Define the mode of action for Cdc7 inhibition in TP53 wild type and mutant Acute Myeloid Leukemia (AML)' Lead on 2021-2023 ARC Discovery Project: 'Decoding the spatiotemporal control of DNA replication and repair' Current supervision of 4 PhD students including projects on cGAS/STING pathway regulation and iPSC-NK cell immunotherapy His research group maintains active collaborations with the Frazer Institute's clinical research facilities, bridging laboratory discoveries with patient-oriented applications through the Frazer Institute's translational research framework.

Mark Collinsمشاهده پروفایل

مدرس ارشد

• Proteomics
• Neurodegenerative Diseases
• Neuroscience
• +۳ مورد دیگر

Dr. Mark Collins is a Senior Lecturer in Biological Mass Spectrometry and Deputy Director of the Mass Spectrometry Centre at The University of Sheffield's School of Biosciences. His expertise lies in proteomics, focusing on post-translational modifications (PTMs) such as palmitoylation and their roles in neurodegenerative diseases like Alzheimer's and ALS. He holds a PhD in Neuroscience from the University of Edinburgh and has extensive postdoctoral experience at the Wellcome Trust Sanger Institute. Education: PhD in Neuroscience, University of Edinburgh (2001-2005) BSc in Biochemistry, University College Dublin (1996-2000) His research interests include neuroproteomics, palmitoylation regulation, and ALS pathogenesis. He employs advanced mass spectrometry techniques to study protein dynamics and signaling pathways. Key collaborations include work with Prof. Shaun Cowley (University of Leicester) and Prof. Pamela Shaw (University of Sheffield). Dr. Collins teaches modules in cell/molecular biosciences and directs the Mass Spectrometry-based Proteomics and Metabolomics course. He has secured grants from BBSRC, MRC, and other organizations. His articles highlight contributions to understanding bacterial pathogenesis, epigenetic regulation, and ALS biomarkers. He supervises multiple PhD students and co-leads the Mass Spectrometry Centre, supporting interdisciplinary research in proteomics.

Yumi Kimمشاهده پروفایل

دانشیار

• Chromosome Dynamics
• Meiosis
• Molecular Biology
• +۳ مورد دیگر

Yumi Kim is an Associate Professor in the Department of Biology at Johns Hopkins University, within the Krieger School of Arts & Sciences. Her research focuses on the molecular mechanisms governing chromosome dynamics during meiosis, particularly in C. elegans. She received her Ph.D. from UC San Diego and completed postdoctoral research at UC Berkeley. Education: Ph.D., University of California San Diego Postdoctoral Research, UC Berkeley Research Interests: Dr. Kim investigates how chromosomes organize and interact during meiosis. Her work centers on synaptonemal complex formation, kinase regulation (e.g., Polo-like kinase), and the molecular basis of crossover assurance. She employs genetic, biochemical, and live-cell imaging approaches to dissect these processes. Publications: Her recent work highlights discoveries in synaptonemal complex components, kinase-substrate interactions, and checkpoint regulation. Key themes include C. elegans meiotic progression and spatial-temporal control of meiotic events. Awards: No scientific awards explicitly listed in the provided text. Advising & Grants: No student names or grant details provided, though her lab likely focuses on training graduate students in meiosis research. Lab activities involve protein biochemistry, microscopy, and genetic analysis. Labs/Teams: Her lab is located in 385 UTL with contact details available. Research emphasizes C. elegans as a model organism for studying conserved meiotic mechanisms.

John J. Bellizziمشاهده پروفایل

دانشیار

• Biochemistry
• X-ray Crystallography
• Enzymology
• +۵ مورد دیگر

John J. Bellizzi is an Associate Professor in the Department of Chemistry & Biochemistry at the University of Toledo's College of Natural Sciences and Mathematics. He utilizes biochemistry and X-ray crystallography to investigate enzyme structure-function relationships. MIT (B.S., 1994) Cornell University (M.S., 1996; Ph.D., 2000) Harvard University (Postdoctoral Fellow) Research focuses on enzymes regulating circadian rhythms (casein kinase 1δ/ε, nocturnin) and natural product biosynthesis (flavin-dependent halogenases). Recent work includes kinetic studies of BorF/AbeF flavin reductases and structural analysis of tryptophan halogenases. Selected publications (2019-2021) reveal mechanistic insights into flavin-dependent halogenation, circadian rhythm regulation, and kinetochore protein assembly. Research outputs include structural characterizations of key enzymes and investigations into their catalytic mechanisms. Contact: john.bellizzi@utoledo.edu

• Cell Biology
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Laura Diaz-Martinez is an Associate Professor of Biology in the College of Arts and Sciences at Gonzaga University, where she has been teaching since 2019. Her academic journey began in Aguascalientes, Mexico, where she earned her B.Sc. in Biology and Chemistry from the Universidad Autónoma de Aguascalientes. She then pursued her Ph.D. in Molecular, Cellular, Developmental Biology and Genetics at the University of Minnesota, followed by postdoctoral research at UT-Southwestern Medical Center and a position as Research Assistant Professor at The University of Texas at El Paso. Dr. Diaz-Martinez is a dedicated cell biologist whose research focuses on understanding cellular mechanisms at the molecular level. She leads two primary research projects: (1) Discovery of gene function, particularly studying hundreds of genes with unknown functions that are required for cell survival, and (2) Investigating chalcones as potential anti-cancer drugs through collaboration with the Chemistry and Biochemistry Department. Her work combines microscopy with molecular biology techniques to unravel the complexity of cellular processes. Analysis of her recent publications reveals a consistent focus on cell division mechanisms, chromosome segregation, and the molecular regulation of the cell cycle. Her research has evolved to include significant contributions to understanding the ethical dimensions of undergraduate research education, reflecting her dual commitment to scientific discovery and pedagogical excellence. Her most recent work demonstrates increasing interdisciplinary collaboration, particularly in the areas of research ethics education and reproducibility in scientific methods. Dr. Diaz-Martinez teaches several courses including BIOL105 (Information Flow in Biological Systems), BIOL105L (Phage Discovery Lab), and BIOL399 (Advanced Topics: Molecular Mechanisms of Cell Division). She has been actively involved in integrating ethics and responsible conduct of research education into undergraduate research experiences, contributing to national discussions and assessments in this area. Her collaborative approach extends to working with students in her Advanced Cell Biology course to test novel chalcones for potential anti-cancer properties. Outside her research and teaching responsibilities, Dr. Diaz-Martinez enjoys hiking with her dogs, photography, and experimenting with new recipes. Her commitment to both scientific inquiry and student education creates a dynamic learning environment that bridges fundamental biological research with practical applications in medicine and education.

Alexey Khodjakovمشاهده پروفایل

پژوهشگر

• Cell Biology
• Molecular Biology
• Mitosis
• +۴ مورد دیگر

Alexey Khodjakov is a senior researcher at the New York State Department of Health, Wadsworth Center , focusing on the Cellular and Molecular Basis of Diseases . His work investigates the molecular mechanisms of mitosis, particularly spindle assembly and chromosome segregation. PhD in Biology, Moscow State University, 1990 Postdoctoral Training, University of Minnesota Medical School His research employs laser microsurgery and advanced imaging to dissect spindle dynamics, revealing that cells can form functional spindles without centrosomes via kinetochore-mediated microtubule assembly . He also explores the implications of centrosome de novo assembly in cancer progression. Recent publications highlight 3D kinetochore analysis , spindle forces , and chromosome congression mechanisms. His lab continues to investigate the balance between centrosomal and kinetochore-driven spindle formation in human cells.

Joshua Bembenekمشاهده پروفایل

دانشیار

• Cell Division Mechanisms
• Embryonic Development
• Separase Regulation
• +۵ مورد دیگر

Joshua Bembenek is an Associate Professor at Wayne State University School of Medicine, Department of Obstetrics and Gynecology, based at the C.S. Mott Center in Detroit. His research investigates cell division mechanisms in embryonic development, focusing on separase regulation, kinetochore functions, cytokinesis, and membrane dynamics using advanced microscopy and model organisms like C. elegans and zebrafish. Education: Ph.D. in Biomedical Sciences from UT Southwestern Medical Center B.S. in Molecular Biology from Texas A&M University Research Focus: Dr. Bembenek's lab explores how cell division orchestrates embryonic development, emphasizing: Separase's dual roles in chromosome segregation and exocytosis Securin-mediated regulation of separase dynamics Kinetochore proteins in cytoplasmic organization Specialized cytokinesis during morphogenesis The team employs lattice light-sheet microscopy for high-resolution imaging of live embryos. Publication Trends: Recent articles (2018–2025) predominantly address cell cycle regulation, vesicle transport, genetic mechanisms in development, and advanced imaging techniques, reflecting consistent focus on mitotic control and embryonic modeling. Laboratory: The lab emphasizes collaborative microscopy innovation, including work with pioneers like Eric Betzig, and maintains active scientific outreach via Twitter (@BembenekLab).

Chuna Ram Choudharyمشاهده پروفایل

استاد

• Protein Post-Translational Modifications
• Cell Signaling Networks
• Proteomics
• +۵ مورد دیگر

Dr. Chuna Ram Choudhary is a Professor and Group Leader at the Novo Nordisk Foundation Center for Protein Research (CPR) within the Faculty of Health and Medical Sciences at the University of Copenhagen , Denmark. His academic journey includes a PhD in Biochemistry (University of Münster, Germany, 2001–2006) and postdoctoral training at the Max Planck Institute for Biochemistry (2007–2009). He leads a research group focused on protein posttranslational modifications (PTMs) —particularly lysine acetylation and ubiquitylation —using quantitative mass spectrometry to map their roles in cell signaling networks and DNA repair . Research interests center on systems-wide analysis of PTMs, emphasizing their dynamic regulation of protein activity, stability, and localization in health and disease. His lab has pioneered methods for site-resolved acetylation stoichiometry and ubiquitylation dynamics , revealing connections between metabolism , transcription , and genome integrity . Collaborations span national and international institutions , including groups at CPR and beyond. Research output trends show a focus on ubiquitin and acetylation signaling , DNA repair mechanisms , and enhancer-promoter compatibility . His work has significant implications for cancer biology , cardiovascular diseases , and developmental processes . Scientific awards include: 2015: ERC Consolidator Grant 2014: Junior Researcher Prize (Danish Cancer Society) 2014: Hallas Møller Investigator Grant (NNF) 2013: EMBO Young Investigator 2012: Sapere Aude Grant (Danish Research Council) 2009: Artur Pappenheim Prize (German Society of Hematology and Oncology) Lab activities involve cutting-edge proteomics and mass spectrometry , with a strong emphasis on translational research and therapeutic target identification .

Tapas K. Mannaمشاهده پروفایل

دانشیار

• Cell Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Dr. Tapas K. Manna is an Associate Professor at the School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram . He holds a Ph.D. in Biochemistry (2004) from Jadavpur University and an M.Sc. in Chemistry (1997) from Calcutta University. His research focuses on kinetochore and centrosome biology , chromosome segregation , and mitotic spindle regulation in mammalian cells. Ph.D. in Biochemistry, 2004 (Jadavpur University, Bose Institute) M.Sc. in Chemistry, 1997 (Calcutta University) Manna's work explores the molecular mechanisms governing kinetochore-microtubule interactions , centrosome biogenesis , and mitotic checkpoint activation . His research combines biochemical , cell biological , biophysical , and imaging techniques to identify therapeutic targets for cancer and chromosomal disorders . Over the last decade, his publications have emphasized centriole duplication , ubiquitin signaling , microtubule dynamics , and spindle pole organization . Scientific Awards : S. Ramachandran National Bioscience Award (2019) Manna has received extramural funding from DST, CSIR, DAE, and DBT. His lab has mentored numerous students, including Ph.D. candidates and project fellows , many of whom have pursued postdoctoral work or Ph.D. programs internationally. His team investigates centrosome signaling pathways and mitotic regulation , with recent studies on CKAP5 and FBXW7 roles in chromosome stability .

Victor Bolanos-Garciaمشاهده پروفایل

مدرس ارشد

• Cell Division Regulation
• Structural Biology
• Cancer Research
• +۳ مورد دیگر

Dr. Victor Bolanos-Garcia is a Senior Lecturer in Clinical Biochemistry at Oxford Brookes University and Principal Investigator leading the Mechanisms of Regulation of Cell Division Group . With a PhD from the University of Cambridge and postdoctoral training at the MRC Laboratory of Molecular Biology, his research focuses on structural and biochemical mechanisms governing cell division regulation, particularly in cancer contexts. Research Interests include: Structural biology of mitotic checkpoint proteins (BUB1, BUBR1, Mps1) Molecular interactions in DNA damage repair systems Development of nanomaterials for cancer therapeutics Protein biochemistry for drug target validation Recent Publications address APC/C inhibitors for breast cancer, graphene-based delivery systems, and Mps1 kinase dynamics. His work has been instrumental in defining protein-protein interfaces for therapeutic intervention. Professional Memberships : Fellow of the Higher Education Academy (FHEA-UK) Member of Cancer Research UK Oxford Centre International Evaluator for Mexico's CONACyT Students Supervised : PhD: Natalie L. Curtis, Maria Kapanidou, Dave Gervais MSc: Multiple unnamed students Co-supervised: Samuel Connelly, Teresa Minguez Vinas, Brittany Almond External Co-supervision: University of Cambridge (Qian Wu, Takashi Ochi, Deepti Gupta, Ann Ling), University of Rennes (Lionel Chieze)

Patrick Meraldiمشاهده پروفایل

استاد

• Mitosis
• Centrosome
• Chromosome Segregation
• +۵ مورد دیگر

Patrick Meraldi is a Full Professor at the Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva. He serves as Head of Department since 2022 and previously led the Gender Equality Commission (2019-2022) and Translational Research Centre in Onco-Hematology (2016-2022). PhD in Molecular Biology (University of Geneva) Diploma in Biology (ETH Zurich) His research focuses on mitotic spindle dynamics , centrosome function , and chromosome segregation mechanisms in human cells. Key studies examine microtubule-kinetochore interactions , spindle symmetry regulation , and aneuploidy consequences in cancer and developmental disorders. Recent publications highlight asymmetric spindle organization and replication stress impacts on mitosis. He has secured multiple Swiss National Science Foundation grants for spindle regulation research and cryo-EM infrastructure. Ernst Th. Jucker Prize (2011) Walther Flemming Medal (2011) EMBO YIP Award (2009) Collaborations include MIT , Max Planck Institute , and ETH Zurich . His lab employs quantitative light microscopy , genetic perturbations , and biochemical analysis to unravel mitotic error mechanisms.