Alexey Khodjakov

Alexey Khodjakov is a senior researcher at the New York State Department of Health, Wadsworth Center, focusing on the Cellular and Molecular Basis of Diseases. His work investigates the molecular mechanisms of mitosis, particularly spindle assembly and chromosome segregation.

• PhD in Biology, Moscow State University, 1990
• Postdoctoral Training, University of Minnesota Medical School

His research employs laser microsurgery and advanced imaging to dissect spindle dynamics, revealing that cells can form functional spindles without centrosomes via kinetochore-mediated microtubule assembly. He also explores the implications of centrosome de novo assembly in cancer progression.

Recent publications highlight 3D kinetochore analysis, spindle forces, and chromosome congression mechanisms. His lab continues to investigate the balance between centrosomal and kinetochore-driven spindle formation in human cells.