جست‌وجوی استاد و پژوهشگر

Robert Bruce Gilchristمشاهده پروفایل

استاد

• Oocyte Biology
• Reproductive Endocrinology
• In Vitro Maturation (IVM)
• +۳ مورد دیگر

Professor Robert Bruce Gilchrist is a Senior Researcher at UNSW Sydney's School of Women's and Children's Health , specializing in Oocyte Biology and Reproductive Endocrinology . He serves as Director of the Oocyte Biology Research Unit , pioneering advances in oocyte-somatic cell communication and in vitro maturation (IVM) technologies. B.Rur.Sc. (Hons), M.Sc.Agr, D.Sc.Agr. (University of Göttingen, Magna cum laude ), FSRB His research focuses on oocyte paracrine signaling through factors like GDF9 and BMP15, which regulate cumulus cell differentiation and folliculogenesis. He developed SPOM (Simulated Physiological Oocyte Maturation) and leads global efforts to implement hormone-free IVM systems in clinical and veterinary applications. Recent publications (2024-2025) highlight his work in metabolic imaging for oocyte quality assessment, NAD+ repletion for chemotherapy-induced infertility, and AI-driven radiomic signatures for reproductive aging analysis. His 274 total publications demonstrate impact across Reproductive Biology, Assisted Reproductive Technology, and Metabolic Reproductive Disorders. Scientific recognition includes: European Society for Human Reproduction and Embryology Established Scientist Award (2006) Society for Reproductive Biology Award for Excellence (2009) NHMRC Senior Research Fellowship (APP1023210, 2012-16) Current grants (2024-2025) involve IVM optimization (NHMRC Project Grants), GDF9/BMP15 signaling (NHMRC Development Grant), and non-invasive embryo diagnostics (NIH Grant). He has mentored 16 PhD/Masters students and 14 Honours students to completion.

Marilia Cascalhoمشاهده پروفایل

استاد

• Transplantation Immunobiology
• Genetic Susceptibility in Immunopathogenesis
• Novel Immunotherapies
• +۶ مورد دیگر

Marilia Cascalho is a Professor and Vice Chair for Research at the Department of Pathology, Case Western Reserve University School of Medicine. She also serves as a Member of the Immune Oncology Program at the Case Comprehensive Cancer Center. Her academic journey includes MD and PhD degrees from the University of Lisbon and UCSF, respectively, followed by postdoctoral training at the Hagedorn Research Institute and UCSF. Key Appointments : Vice Chair for Research (2024), Richard J. Fasenmyer Professor (2024) Prior Institutions : Mayo Clinic (1999-2008), University of Michigan (2008-2024) Research Interests focus on Immunobiology of organ transplantation Genetic susceptibility in immune-mediated diseases Development of mutable vaccines against viral evolution C3d-based immunotherapies for cancer TACI/TNFRSF13B polymorphisms in immunity Article Trends reveal contributions to transplantation science, B cell immunology, and cancer immunotherapy. Her work spans antibody-mediated immunity , adaptive immune responses , and somatic hypermutation mechanisms , with recent emphasis on piRNA biomarkers in transplant monitoring and metabolic reprogramming for graft survival . Scientific Awards include: Science Magazine Prize for Young Investigators (1999) NIH Grant Support (multiple awards) Gates Foundation Grant US-Israel Bi-National Science Foundation NIH Study Section Memberships Patents and Innovation highlight her inventions in Soluble C3d immunotherapies Mutable vaccine technology B cell repertoire analysis methods T cell diversity modulation Laboratory Focus integrates immunology, genetics, and bioengineering to develop therapies for transplant rejection, autoimmune diseases, and incurable cancers like multiple myeloma.

Xiao Dongمشاهده پروفایل

استادیار

• Aging
• Genetics
• Cell Biology
• +۴ مورد دیگر

Xiao Dong is an Assistant Professor at the University of Minnesota in the Genetics, Cell Biology and Development (TMED) department. Their research focuses on aging biology, somatic mutations, and cancer mechanisms, with significant contributions to understanding cellular senescence and its therapeutic implications. Research Interests: Aging and longevity mechanisms Genetic variants in age-related diseases Senolytic drug discovery Computational biology applications Recent Publications highlight advancements in: Machine learning for transcriptome analysis Somatic mutation profiling via single-cell sequencing Senomorphic microRNA identification TREM2 macrophage roles in metabolic liver disease Current collaborative projects include: Genetic variant-based drug discovery (NIH-funded) Cardiovascular regeneration with pioneer factors Exogenic organ development in gene-edited pigs

Florian Krammerمشاهده پروفایل

استاد

• Vaccinology
• Influenza research
• Viral immunology
• +۳ مورد دیگر

Prof. Florian Krammer is a Professor of Vaccinology at the Department of Microbiology, Icahn School of Medicine at Mount Sinai. He serves as Principal Investigator of the Sinai-Emory Multi-Institutional Collaborative Influenza Vaccine Innovation Center (SEM-CIVIC) and his laboratory is part of the NIH-funded Centers for Excellence in Influenza Research and Surveillance (CEIRS). His work focuses on developing broadly protective vaccines against influenza and other emerging RNA viruses. University of Natural Resources and Life Sciences, Vienna (Advanced training in biotechnology and applied virology) Prof. Krammer's research centers on understanding broadly-reactive immune responses against surface glycoproteins of RNA viruses, with a primary focus on influenza viruses but also including coronaviruses, hantaviruses, and filoviruses. His laboratory investigates cross-reactive antibody responses toward viral surface glycoproteins with the goal of translating basic research into novel vaccines and therapeutics. A major focus has been the development of a universal influenza virus vaccine that would protect against a range of influenza virus subtypes by boosting antibodies to the highly conserved HA stalk domain. His work has progressed from successful animal model testing to human clinical trials. Prof. Krammer's extensive publication record includes over 100 papers, with recent research focusing on neuraminidase-based vaccines, chimeric hemagglutinin approaches, mucosal vaccine delivery, and cross-reactive antibody responses to emerging variants. His laboratory has generated a large panel of research reagents for influenza and other RNA viruses, including recombinant proteins and monoclonal antibodies. Endowed Professor of Vaccinology, Icahn School of Medicine at Mount Sinai (2019) Member of the Vaccine and Edward Jenner Vaccine Society Young Investigator Program (2014-2017) ESWI Young Scientist Travel Award and 'Young Scientist Co-Chair' (2014) Options for the Control of Influenza VIII Promising Investigator Scholarship (2013) As Principal Investigator of SEM-CIVIC, Prof. Krammer leads a major initiative aimed at developing improved seasonal and universal influenza virus vaccines that induce long-lasting protection against drifted seasonal, zoonotic, and future pandemic influenza viruses. His laboratory team includes numerous postdoctoral fellows, research scientists, and administrative staff working on various aspects of viral immunology and vaccine development. The Krammer laboratory collaborates with multiple institutions including BioBus, Inc. and the Wild Bird Fund, and participates in the New York City Virus Hunters program to engage the community in scientific research.

Richard D. Pressمشاهده پروفایل

استاد بالینی

• Molecular Diagnostics
• Oncology
• Hematology
• +۳ مورد دیگر

Richard D. Press is a Clinical Professor and Medical Director of Molecular Pathology and the Molecular Diagnostics Center at the OHSU Knight Cancer Institute. He also serves as Program Director for the Molecular Genetic Pathology Fellowship. His research focuses on molecular diagnostic biomarkers in cancer and infectious diseases, as well as genetic alterations in common diseases. Dr. Press holds an M.D. and Ph.D. from Case Western Reserve University (1988), with residency training in Pathology and a fellowship in Molecular Pathology at the University of Pennsylvania. He is board-certified in Clinical Pathology and Molecular Genetic Pathology. Education: B.A., 1981, Northwestern University M.D./Ph.D., 1988, Case Western Reserve University Residency: Pathology, University of Pennsylvania Fellowship: Molecular Pathology, University of Pennsylvania Research Interests: Molecular diagnostics in oncology and infectious diseases Genetic biomarkers in acute myeloid leukemia (AML) and other hematologic malignancies Clonal evolution and measurable residual disease (MRD) in leukemia Publications Overview: His work spans molecular characterization of leukemia subtypes, validation of diagnostic assays, and clinical applications of next-generation sequencing (NGS). Recent studies investigate NUP98-rearranged AML, T-lineage childhood leukemia, and resistance mechanisms in chronic myeloid leukemia. Labs/Teams: Director of the Molecular Diagnostics Center at OHSU, leading cutting-edge diagnostic research and training programs for pathologists.

Konstantin Khrapkoمشاهده پروفایل

استاد

• Mitochondrial Biology
• Aging Biology
• Human Evolution
• +۳ مورد دیگر

Konstantin Khrapko is a Professor at Northeastern University with joint appointments in the College of Science and Bouvé College of Health Sciences. His primary affiliation is the Biology department, focusing on mitochondrial genetics, aging, and human evolution. His research explores somatic mtDNA mutations’ roles in aging and disease, mitochondrial population dynamics, and the use of mtDNA pseudogenes to study human ancestry. Expertise includes mitochondrial biology, including mutation mechanisms, epigenetic regulation (e.g., mtDNA methylation), and the interplay between mitochondrial dysfunction and aging. His lab develops advanced molecular tools like high-efficiency single-molecule PCR and next-generation sequencing for analyzing individual mtDNA molecules. Key research themes include mitochondrial population genetics, the origins of somatic mutations, and evolutionary studies using nuclear mtDNA pseudogenes (NUMTs). Recent work addresses mitochondrial heterogeneity in embryos, the impact of maternal age on mitochondrial inheritance, and mechanisms preserving mitochondrial integrity across generations. Publications span over two decades, emphasizing mitochondrial mutation spectra in aging, cancer, and neurodegenerative diseases. His work bridges basic science and translational research, with implications for understanding aging-related diseases and evolutionary biology.

• Cancer Research
• Bioinformatics
• Proteomics
• +۳ مورد دیگر

Dr. Rebecca Poulos is an NHMRC Early Career Fellow and Conjoint Lecturer at the Children’s Medical Research Institute, University of Sydney. Her research focuses on cancer genomics, proteomics, and data science, particularly integrating multiomic data to uncover cancer biomarkers and drug response mechanisms. She holds a BBus, BSc (Hons) with a University Medal, and a PhD from UNSW Sydney. Key research interests include cancer driver mutations, proteogenomics, and machine learning for multi-omics integration. Notable achievements include an NHMRC Early Career Fellowship and the Cancer Institute NSW Rising Star PhD Student Award. Her work spans pediatric cancer proteomics, drug response prediction, and reproducible large-scale proteomics. Recent studies highlight her contributions to cancer pathway modeling (DeePathNet), pediatric cancer molecular signatures, and proteomic stratification of prostate cancer. She leads projects funded by NHMRC and Sydney Cancer Partners, advancing precision medicine through proteomics. Her lab is embedded in the Cancer Data Science Group (ProCan), collaborating on pan-cancer proteomic maps and clinical applications.

Jennifer Anne Doudnaمشاهده پروفایل

استاد

• Genome Editing
• CRISPR Technology
• RNA Biology
• +۵ مورد دیگر

Jennifer Anne Doudna is a Nobel Laureate in Chemistry and the Li Ka Shing Chancellor's Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology at the University of California, Berkeley. She is also a faculty scientist at Lawrence Berkeley National Laboratory, a senior investigator at the Gladstone Institutes, and an adjunct professor at the University of California, San Francisco. Her academic journey began at Pomona College, continued with graduate studies at Harvard University, and included postdoctoral work at Massachusetts General Hospital, Harvard Medical School, and the University of Colorado Boulder with Thomas Cech. Dr. Doudna is best known for pioneering CRISPR-Cas9 genome editing technology, for which she received the Nobel Prize in Chemistry in 2020 alongside Emmanuelle Charpentier. Her research spans RNA biology, structural biology, and the development of genome editing tools. She directs the Innovative Genomics Institute (IGI), a Berkeley-UCSF collaboration focused on applying genome editing to human health, agriculture, and climate change challenges. Her current research focuses on discovering novel CRISPR-Cas systems, developing new genome editing tools, and creating delivery mechanisms for CRISPR therapeutics. Dr. Doudna's recent publications reveal an expanding application of CRISPR technology beyond basic research into practical solutions for global challenges. Her work now encompasses viral diagnostics (including rapid CRISPR-based COVID-19 tests), microbiome editing for climate applications, and therapeutic approaches for genetic diseases like sickle cell disease. This evolution from fundamental RNA structure research to real-world applications demonstrates the transformative potential of her discoveries. Nobel Prize in Chemistry (2020) Breakthrough Prize in Life Sciences (2015) Japan Prize (2017) Kavli Prize in Nanoscience (2018) Wolf Prize in Medicine (2020) National Medal of Technology and Innovation (2025) Dr. Doudna has mentored dozens of graduate students and postdocs who have established successful research programs and biotechnology companies. Her lab receives substantial funding for CRISPR delivery mechanisms, microbiome editing, and therapeutic applications. She actively participates in ethical discussions surrounding gene editing, supporting somatic editing while advocating caution regarding germline modifications. As founder and chair of the IGI governance board, she leads efforts to apply precision genome editing to microbial communities for climate and health applications, recently securing $70 million for this audacious initiative.

Jay Rasmussenمشاهده پروفایل

پژوهشگر

• Neurodegeneration
• Alzheimer's Disease
• Prion Diseases
• +۴ مورد دیگر

Dr. Jay Rasmussen is a Researcher at the Queensland Brain Institute, University of Queensland, Australia, specializing in molecular mechanisms of neurodegenerative disorders. His work bridges neuropathology and genomic research, focusing on Alzheimer's disease heterogeneity, prion pathologies, and the role of somatic genomic variation in brain aging, with recent emphasis on retrotransposon activity in neural development and degeneration. His academic foundation includes a BSc and MSc in Neurosciences from the University of Alberta, Canada, followed by a PhD at the University of Tübingen, Germany (2014) under Professor Mathias Jucker at the Hertie Institute and German Center for Neurodegenerative Diseases (DZNE). Since 2018, he has been a core member of Professor Geoffrey Faulkner's laboratory at the Queensland Brain Institute. Dr. Rasmussen's research explores neurodegenerative disease heterogeneity through multiple lenses: amyloid-beta polymorphism in Alzheimer's subtypes, prion-like propagation mechanisms , and somatic retrotransposition in neural tissues. His seminal work revealed distinct conformational strains of amyloid plaques that define Alzheimer's etiological variants, while current research demonstrates how LINE-1 retrotransposons influence interneuron development and contribute to age-related brain dysfunction. This integrative approach combines advanced neuropathological analysis with cutting-edge genomic techniques to unravel individual differences in disease susceptibility. Analysis of his 15 most recent publications (2014-2024) shows an evolution from classical protein aggregation studies toward genomic instability in aging brains. Early work characterized prion and amyloid seeding dynamics, while his current research pioneers retrotransposon biology in neural contexts, revealing conserved mechanisms from mouse to primate models. This trajectory highlights a strategic shift toward understanding how somatic genomic mosaicism contributes to neural diversity and vulnerability in neurodegeneration. No scientific awards or student mentorship activities were documented in available sources. His collaborative research operates within the Faulkner Laboratory at QBI, which employs multi-omics approaches and advanced imaging to investigate somatic mosaicism in age-related brain disorders through projects involving international consortia and cross-institutional partnerships.

• Lung Cancer Research
• Oncology
• Molecular Biology
• +۳ مورد دیگر

Heather Lazowski is a Researcher at the Yale School of Medicine, Yale University. Her research focuses on lung cancer mechanisms, molecular oncology, and cancer survivorship. She holds a BS in Medical Biology from the University of New England (2008). Key collaborators include Lynn Tanoue, Roy Herbst, and David Rimm. Her work spans genomic mutations (APOBEC, NFE2L2), RAS signaling pathways, and quality-of-life outcomes in lung cancer patients. Publications include studies in Lung Cancer and Clinical Cancer Research , addressing topics like APOBEC-driven carcinogenesis and therapeutic targets for RAS fusion proteins. Notable contributions include identifying prognostic biomarkers in early-stage lung adenocarcinomas and uncovering MEK inhibition sensitivity in oncogenic RAS-driven tumors.

• Genomics
• Transposable Elements
• Somatic Mutations
• +۳ مورد دیگر

Eunjung (Alice) Lee is an Associate Professor in Genetics and Genomics at Boston Children’s Hospital and Harvard Medical School. Her NIH-funded research investigates transposable elements and somatic mutations in cancer, aging, and neurodegeneration. Research Breakthroughs: Pioneered computational methods proving somatic retrotransposition in human cancers and neurons. Demonstrated how transposons shape cancer immunity and generate novel RNA isoforms through alternative splicing. Leadership: Leads transposon analysis for NIH's SMaHT Network and co-organizes the inaugural Keystone meeting on somatic mosaicism (2025). Received NIH New Innovator Award for high-impact genomic research.

• Fungal Genetics
• Evolutionary Biology
• Mycology
• +۳ مورد دیگر

Ben Auxier is an Assistant Professor in the Laboratory of Genetics at Wageningen University & Research. His research focuses on fungal genetics, evolutionary consequences of social and sexual interactions in fungi, and antifungal resistance in the human pathogen Aspergillus fumigatus . Originally from Canada, he holds a BSc and MSc from the University of British Columbia and a PhD from the Netherlands, where he worked with Dr. Duur Aanen. Research interests include nonself recognition genes ( het genes) in fungi and their role in viral evolution, as well as the genetic basis of agricultural antifungal resistance in A. fumigatus . He actively engages with the fungal research community through platforms like Bluesky, highlighting topics such as mycology, microbial ecology, and fungal genomics. His work integrates genomics, genetics, and evolutionary biology to address questions about fungal individuality, pathogen adaptation, and microbial interactions. Prospective students interested in fungal genetics are encouraged to contact him.

• Genomic Medicine
• Hereditary Breast and Ovarian Cancer
• BRCA1/BRCA2 Genetics
• +۳ مورد دیگر

Mads Thomassen is a Professor in Genomic Medicine at the Department of Clinical Research, University of Southern Denmark, and affiliated with the Research Unit of Clinical Genetics (Odense). His work spans molecular pathology, hereditary cancer genetics, and precision oncology. Institution: University of Southern Denmark Key Affiliations: KI, OUH, Research Unit of Clinical Genetics Academic Rank: Professor Contact: mads.thomassen@rsyd.dk Research Interests: BRCA1/BRCA2 genetic variants and breast cancer predisposition Multi-omics analysis of hematological malignancies Long-read sequencing for splicing variant characterization Liquid biopsy applications in lymphoma mutation detection Germline BRCA testing implementation and epidemiology JAK2 mutation analysis in cardiovascular and hematological comorbidities Recent Publications demonstrate expertise in integrating genomic data with clinical outcomes, particularly in hereditary cancer diagnostics and hematological disease monitoring. He leads the Molecular Tumor Profiling and MESTAR projects. Network includes collaborations with institutions like SDU, OUH, and international researchers in genomic medicine and oncology.

John Rudgeمشاهده پروفایل

استاد

• Mantle Dynamics
• Magma Ascent
• Theoretical Geophysics
• +۴ مورد دیگر

John Rudge is a Professor in the Department of Earth Sciences at the University of Cambridge. His research focuses on theoretical geophysics and geochemistry, with a strong emphasis on mantle convection, magma dynamics, and rock rheology. He employs mathematical modeling, numerical solutions of partial differential equations, and statistical techniques to study Earth and planetary interiors, collaborating closely with geophysicists, geochemists, and material scientists. Research Interests: Mantle convection and dynamic topography Magma ascent and extraction mechanisms Rheology of partially molten rocks Grain-scale modeling and upscaling to continuum laws Planetary interior dynamics and exoplanet habitability His recent publications span geodynamics, geochemistry, and interdisciplinary applications, including mantle rheology, melt transport, and hematologic oncology. Awards and grants are tied to his leadership in the Cambridge NERC Doctoral Landscape Awards (DLA) and collaborations in the C-CLEAR Doctoral Training Partnership.

Laura Moodyمشاهده پروفایل

دانشیار

• Molecular Plant Biology
• Developmental Biology
• Evolutionary Biology
• +۳ مورد دیگر

Dr. Laura Moody is an Associate Professor in Molecular Plant Biology and a Royal Society University Research Fellow at the University of Oxford. She is also a Tutorial Fellow at St John’s College. Her research focuses on understanding the genetic mechanisms underlying the 2D-to-3D growth transition in early land plants, particularly the moss Physcomitrium patens . This transition is critical for plant adaptation to terrestrial environments. Dr. Moody employs innovative approaches to elucidate the genetic networks enabling this pivotal developmental shift, addressing fundamental questions about plant evolution and terrestrialization. Her work leverages the unique growth phases of Physcomitrium patens , which allows experimental disruption of 3D growth without lethality. Key interests include the roles of proteins like N-Acetyltransferase-MAPK, prion-like proteins, and CURLY LEAF in regulating growth transitions. She investigates how these mechanisms evolved to enable land colonization, integrating molecular genetics, developmental biology, and evolutionary perspectives. Research Awards: Royal Society University Research Fellowship. Dr. Moody’s lab explores the interplay between genetics and plant morphology, aiming to uncover conserved and divergent pathways in land plant evolution. Her findings contribute to broader understanding of how genetic regulation shaped terrestrial life's establishment.