Xiao Dong

Xiao Dong is an Assistant Professor at the University of Minnesota in the Genetics, Cell Biology and Development (TMED) department. Their research focuses on aging biology, somatic mutations, and cancer mechanisms, with significant contributions to understanding cellular senescence and its therapeutic implications.

Research Interests:

• Aging and longevity mechanisms
• Genetic variants in age-related diseases
• Senolytic drug discovery
• Computational biology applications

Recent Publications highlight advancements in:

• Machine learning for transcriptome analysis
• Somatic mutation profiling via single-cell sequencing
• Senomorphic microRNA identification
• TREM2 macrophage roles in metabolic liver disease

Current collaborative projects include:

• Genetic variant-based drug discovery (NIH-funded)
• Cardiovascular regeneration with pioneer factors
• Exogenic organ development in gene-edited pigs