جست‌وجوی استاد و پژوهشگر

• Cancer
• Liver Pathology
• Tumor Suppression
• +۶ مورد دیگر

Professor Alain de Bruin (born 1968) is a distinguished academic at Utrecht University, serving as Professor in the Department of Biomolecular Health Sciences within the Faculty of Veterinary Medicine. Since January 1, 2020, he has been Head of the Department of Biomolecular Health Sciences. His academic journey began with veterinary medicine studies at the University of Hannover in Germany, followed by a PhD from the University of Bern in Switzerland in 1999. After specializing in veterinary pathology and completing a postdoctoral position at Ohio State University, he was appointed professor of pathobiology at Utrecht University in 2005. In 2010, he founded the Netherlands Molecular Pathology Center (UU/UMCG) and became an honorary professor of molecular pathology at the University of Groningen in 2014. Professor de Bruin's research primarily focuses on cancer biology, liver pathology, tumor suppression mechanisms, and aging processes. His expertise includes in vivo modeling, cell cycle analysis, generating transgenic mouse models, pathological analysis of animal disease models, and single-cell transcriptomics. His work centers on proteins that regulate cell proliferation, particularly E2F transcription factors, which he has discovered play critical roles in inhibiting cancer cell growth. His research themes span Life Sciences, Regenerative Medicine, and the Utrecht Platform for Organoid Technology. Analysis of his recent publications reveals a consistent research trajectory centered on cell cycle regulation, particularly the atypical E2F transcription factors (E2F7 and E2F8), and their roles in cancer development, polyploidization, and liver disease. His work demonstrates how these factors influence tumor suppression, angiogenesis, and cellular responses to DNA damage. The publications span multiple disciplines including cancer biology, molecular oncology, hepatology, and regenerative medicine, with applications in both human and veterinary medicine. Professor de Bruin has held significant leadership positions, including chairing the research council (2017-2019) and coordinating the 'Regenerative Medicine, Stem Cells, and Cancer' research program (2013-2019). He serves on the editorial board of 'Frontiers in Cell and Developmental Biology' and participates in review committees for NWO-Rubicon/Veni, the research alliance UTwente/UU/UMCU, and the Comprehensive Cancer Center at Ohio State University. His laboratory work has made significant contributions to understanding how E2F transcription factors regulate cell proliferation, with implications for developing novel cancer therapy strategies. His research on polyploidization mechanisms has provided insights into liver regeneration and tumor development, while his work on senescence has implications for aging-related diseases.

Jaap Keijerمشاهده پروفایل

استاد

• Energy metabolism
• Mitochondrial function
• Metabolic pathways
• +۷ مورد دیگر

Jaap Keijer is a Full Professor and Chairholder in the Department of Human and Animal Physiology at Wageningen University & Research. His research focuses on metabolic physiology, particularly energy metabolism, mitochondrial function, and the interplay between diet, aging, and chronic metabolic diseases. He leads projects investigating nicotinamide nucleotide transhydrogenase (NNT) in energy metabolism, galactose's effects on metabolic programming, and the role of environmental factors like hypoxia in muscle physiology. He serves on the editorial board of Molecular Nutrition and Food Research and advises the German Institute of Human Nutrition. His work integrates molecular, cellular, and whole-organism approaches to understand health and disease mechanisms. Key research themes include metabolic adaptations in obesity, mitochondrial dysfunction in aging, and translational biomarker development for physical activity and metabolic health. Dr. Keijer teaches courses on molecular nutritional physiology, model organisms for lifespan research, and dissection-free human/animal physiology. His projects address clinical challenges such as sarcopenia, atrial fibrillation, and nutrient interventions for metabolic disorders. Recent studies explore dietary galactose's programming effects on intestinal metabolism and the impact of NNT deficiency on cardiac health. His lab employs advanced techniques like single-cell transcriptomics and Seahorse extracellular flux analysis to study metabolic pathways in humans and animal models. Publications emphasize mitochondrial dysfunction, metabolic biomarkers, and translational models for aging and disease. His work bridges basic research and clinical applications, aiming to improve metabolic health through dietary and lifestyle interventions. Current initiatives include developing a human gut-on-a-chip model and validating integrative biomarkers for physical activity in adolescents.

Shibiao Wanمشاهده پروفایل

استادیار

• Machine Learning
• Bioinformatics
• Computational Biology
• +۱۴ مورد دیگر

Dr. Shibiao Wan serves as Assistant Professor in the Department of Genetics, Cell Biology and Anatomy at University of Nebraska Medical Center (UNMC), with a courtesy appointment in Biostatistics. He is Co-Director for the Bioinformatics and Systems Biology (BISB) PhD Program and Assistant Director for the Bioinformatics and Systems Biology Core. With over 14 years of experience in machine learning and bioinformatics, Dr. Wan leads an active research program developing computational methods for biomedical data analysis. Dr. Wan's research spans computational biology and biomedical informatics with focus on single-cell analysis, multi-omics integration, spatial transcriptomics, and cancer research. His laboratory develops AI and machine learning approaches to analyze genomics, transcriptomics, epigenetics, proteomics, metabolomics, and medical imaging data. Key contributions include methods for protein subcellular localization prediction, cancer subtyping, and multi-omics integration for precision medicine applications. His recent publications show a strong trend toward multi-modal data integration for disease diagnosis and subtyping, particularly in cancer (medulloblastoma, leukemia, lung cancer) and neurodegenerative disorders (Alzheimer's disease). His laboratory has developed numerous bioinformatics tools including SHARP for single-cell RNA-seq analysis, RaMBat for medulloblastoma classification, RanBALL for leukemia subtyping, and WIMOAD for Alzheimer's diagnosis. Dr. Wan has received significant recognition including the Springer Nature Editor of Distinction Award (2025), UNMC New Investigator Award (2024), FIRST Award from Nebraska EPSCoR (2023), and the Outstanding Young Alumni Award from HK PolyU (2022). He was named among the top 1% reviewers globally by Clarivate in both 'Cross-Field' and 'Biology and Biochemistry' categories (2019). As Co-Director of the BISB PhD Program, Dr. Wan actively mentors graduate students in bioinformatics and computational biology. His laboratory comprises a multidisciplinary team working at the intersection of computer science, statistics, and biomedical research. Dr. Wan serves as Editor-in-Chief for Current Proteomics and holds editorial positions with numerous high-impact journals including Briefings in Functional Genomics, BMC Bioinformatics, and Frontiers journals. The Wan Lab at UNMC focuses on machine learning and bioinformatics (MLAB), developing computational methods to unravel molecular biological systems using heterogeneous biomedical data. The lab collaborates extensively with scientists in cancer biology, metabolism, immunology, pathology, and developmental biology to translate computational findings into biological insights and potential clinical applications.

• Immunology
• Transplant Immunology
• T Cell Immunology
• +۷ مورد دیگر

Nicolle Litjens is an Assistant Professor at Erasmus MC, Faculty of Medicine, in the Department of Internal Medicine. Her research is centered on immunological mechanisms in organ transplantation, particularly focusing on T-cell responses, immune monitoring, and immunosuppression in kidney and liver transplant recipients. Her research interests include T cell immunology , alloreactive T cell dynamics , antibody-mediated rejection , and the impact of bariatric surgery on immune function . She employs advanced techniques such as single-cell RNA sequencing and flow cytometry to investigate immune cell phenotypes and functions in clinical contexts. The recent publications highlight a strong trend toward translational immunology , with emphasis on donor-specific hyporesponsiveness , polyfunctional T cells , and intracellular pharmacokinetics of immunosuppressive drugs . Her work bridges molecular immunology with clinical outcomes in transplantation. She has contributed to over 75 research outputs, including original articles and reviews, and has supervised several junior researchers. Her collaborative network spans national and international institutions in the field of transplant immunology.

Renee Hoekzemaمشاهده پروفایل

استادیار

• Algebraic Topology
• Manifold Theory
• Mathematical Biology
• +۶ مورد دیگر

Renee Hoekzema is an Assistant Professor in the Department of Mathematics within the Faculty of Science at Vrije Universiteit Amsterdam (VU Amsterdam). Her research spans multiple disciplines including mathematics, biology, and cognitive science, with a particular focus on topological structures and their applications across scientific domains. Dr. Hoekzema's research interests encompass a diverse range of mathematical and interdisciplinary topics: Algebraic Topology and Manifold Theory Geometric Analysis and Spectral Methods K-Theory and Cobordism Invariants Mathematical Biology and Developmental Patterns Mathematical Cognition and Spatial Reasoning Feature Selection and Unsupervised Learning Methods Her recent publications demonstrate a strong interdisciplinary approach, bridging pure mathematics with applications in biology, medical imaging, and cognitive science. Dr. Hoekzema frequently applies topological and geometric methods to problems in developmental biology and mathematical cognition, showing how abstract mathematical structures can illuminate concrete scientific questions. Her work on manifolds with odd Euler characteristic represents significant contributions to geometric topology, while her research on visuo-spatial thinking explores the cognitive foundations of mathematical expertise across multiple dimensions of analysis. Dr. Hoekzema serves as Principal Investigator for the research project "Shapes inside shapes in mathematics, physics, and biology" (2022-2025), which has generated substantial academic and public engagement across multiple platforms including news outlets, social media, and Wikipedia. She also teaches "Elements of Geometry" and maintains an active research profile with publications spanning mathematical topology, biological applications, and cognitive aspects of mathematical thinking, demonstrating her commitment to both theoretical advancement and practical scientific applications.

Natalia Goriounovaمشاهده پروفایل

دانشیار

• Neuroscience
• Neurophysiology
• Synaptic Transmission
• +۴ مورد دیگر

Dr. Natalia Goriounova is an Associate Professor at the Vrije Universiteit Amsterdam’s Faculty of Science, affiliated with the Integrative Neurophysiology department and Amsterdam Neuroscience (Cellular & Molecular Mechanisms, Systems & Network Neuroscience). Her research focuses on human cortical neuron diversity, synaptic mechanisms, and their roles in cognition and neurological disorders. She leads a multiscale project on IQ-excitability relationships in the human cortex and teaches advanced neuroscience courses. Her work bridges electrophysiology, transcriptomics, and morphological analysis to uncover human-specific neuronal adaptations. Key areas include interneuron diversity, voltage-gated ion channel properties, and synaptic plasticity in human neocortical circuits. Over 37 publications highlight contributions to understanding human brain evolution and cognitive correlates of neuronal properties. Notable recent findings include morpho-electric diversity in hippocampal neurons, human-specific fast-spiking neuron specializations, and genetic links to cognitive ability. She actively contributes to open science through datasets on neuronal properties and cortical evolution, with widespread academic impact.

• Immunology
• Respiratory Medicine
• Autoimmunity
• +۳ مورد دیگر

Prof. Rudi Hendriks is a Full Professor at Erasmus University Medical Center (Erasmus MC) in the department of Pulmonary Medicine. His research focuses on immunological mechanisms underlying respiratory and autoimmune diseases, including asthma, cystic fibrosis, and spondyloarthritis. He has published 251 peer-reviewed articles and supervised 34 students. Key research interests include B cell biology, T cell immunology, mast cell function, and inflammatory pathways in chronic respiratory diseases. His recent work investigates aberrant B cell signaling in spondyloarthritis, epigenetic regulation of mast cell activity, and transcriptomic profiling in cystic fibrosis.

• Developmental Biology
• Stem Cell Research
• Organoid Technology
• +۳ مورد دیگر

Professor Alexander van Oudenaarden is a distinguished academic at Utrecht University, where he serves as Professor in the Faculty of Science, specifically within the Developmental Biology department. His research program focuses on cutting-edge approaches in developmental biology, stem cell research, and organoid technology. Dr. van Oudenaarden's research interests span multiple areas of developmental and cellular biology. He is particularly known for his work on stem cell systems, organoid development, and spatial transcriptomics. His laboratory has made significant contributions to understanding embryonic development through stem cell models, cancer therapy applications using organoids, and sex-specific gene expression patterns. His approach often combines quantitative methods with biological systems to uncover fundamental principles of development and disease. His publication record demonstrates significant impact, with multiple high-profile papers in journals such as Nature, Cell, and Nature Genetics. His 2018 paper on blastocyst-like structures generated from stem cells has been particularly influential, garnering over 386 citations and receiving attention from 35 news outlets. The research has implications for understanding early embryonic development and potential regenerative medicine applications. LifeTime and improving European healthcare through cell-based interceptive medicine (2020) - Highly cited review with over 121 citations Blastocyst-like structures generated solely from stem cells (2018) - Landmark paper with 386 citations Oral mucosal organoids as a potential platform for personalized cancer therapy (2019) - Significant contribution to cancer research with 294 citations Professor van Oudenaarden leads a research group focused on developmental dynamics and biocomplexity. His team employs advanced techniques including single-cell analysis, spatial transcriptomics, and organoid culture systems to address fundamental questions in developmental biology and their applications to human health. The group has established collaborations across Europe and maintains strong ties with clinical researchers to translate basic findings into potential therapeutic approaches.

Anna de Bruyn-Rybczynskaمشاهده پروفایل

مدرس

• Oncology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Dr. Anna de Bruyn-Rybczynska is a Lecturer in Biomedical Sciences at the University of Groningen, jointly affiliated with the Faculty of Science and Engineering and Faculty of Medical Sciences. She coordinates the BSc Biology: Biomedical Sciences program and serves as major coordinator for the Numerus Fixus application process. Her research focuses on: Oncology diagnostics using transcriptome analysis Molecular biomarkers in lung cancer Non-invasive liquid biopsy techniques RNA aberrations in cancer progression Her recent publications demonstrate a strong focus on developing transcriptome-based diagnostic tools for non-small cell lung cancer, with emerging work in molecular imaging of cellular processes. Publications consistently explore oncology biomarkers and personalized medicine approaches. Dr. de Bruyn-Rybczynska advises multiple PhD students and coordinates laboratory components of the Biomedical Sciences curriculum. She leads the Education & Lab Team Biology at the Zernike Campus.

• Embryogenesis
• Plant Development Biology
• Molecular Genetics
• +۳ مورد دیگر

Kim Boutilier is an EPS Senior Researcher at BIOS Plant Development Systems, part of Wageningen University & Research. Their research focuses on plant embryogenesis, particularly in Arabidopsis and Brassica species, with emphasis on microspore embryogenesis, cell fate regulation, and auxin signaling. They lead projects exploring haploid induction mechanisms and somatic embryogenesis. Key projects include investigating novel genes for parthenogenesis in soybean (2025–2028), maternal haploid induction (2025–2026), and single-cell analyses of microspore embryogenesis (2024–present). Co-promoting PhD candidates M. Vos and C. Darmawan in plant development studies. Publishes extensively on embryogenesis mechanisms, with recent works in Plant Journal , Proceedings of the National Academy of Sciences , and Plant Physiology . Datasets include genomic sequencing of haploid Arabidopsis and transcriptomic analyses of microspore embryogenesis.

Jeroen de Ridderمشاهده پروفایل

استاد

• Bioinformatics
• Cancer Genomics
• Molecular Medicine
• +۳ مورد دیگر

Jeroen de Ridder is a Full Professor at Utrecht University's Faculty of Medicine, leading the Bioinformatics in molecular medicine research group at University Medical Center Utrecht (UMCU) within the strategic cancer program. His work bridges computational innovation with clinical molecular medicine. His research focuses on developing data science methodologies for disease biology, specializing in cancer genomics through nanopore sequencing applications. Key interests include non-invasive diagnostics via liquid biopsies, tumor heterogeneity analysis, and pathogen detection in immunocompromised patients. His lab pioneers tools for oxidative DNA damage quantification and multimodal tumor profiling, translating computational insights into clinical oncology and infectious disease management. Recent publications reveal a cohesive trajectory in nanopore sequencing applications: 2025 studies emphasize cancer biomarker detection (8-oxo-dG), pediatric fungal diagnostics, and tumor cell-free DNA profiling, while 2024 work extends to neurological contexts including stroke genetics and glioblastoma diagnostics. This demonstrates consistent innovation in adapting sequencing technologies for diverse clinical challenges across oncology, neurology, and infectious diseases. Complementing his academic role, de Ridder serves as Chief Science Officer at Cyclomics BV, overseeing R&D translation from academic research to biotechnology applications in molecular diagnostics.

Nomdo Jansoniusمشاهده پروفایل

استاد

• Glaucoma
• Perimetry
• Optical coherence tomography
• +۴ مورد دیگر

Prof. Dr. Nomdo Jansonius is Professor of Ophthalmology at the University of Groningen's Faculty of Medical Sciences and heads the Department of Ophthalmology at the University Medical Center Groningen (UMCG). His academic career spans both physics and medicine, with a specialization in glaucoma research and clinical ophthalmology. Jansonius coordinates the EU-funded doctoral network EGRET AAA (2023-2027) and previously led the EGRET and EGRET+ research training programs (2016-2020). He serves as co-editor of Acta Ophthalmologica and sits on the editorial board of Investigative Ophthalmology & Visual Science. Dr. Jansonius's research primarily focuses on glaucoma, perimetry, optical coherence tomography, physiological optics, retinal physiology, and ophthalmic epidemiology . His work bridges fundamental biophysics with clinical applications, particularly in developing diagnostic methods for glaucoma. He leads the Groningen Glaucoma Group and has made significant contributions to understanding visual field defects, vision-related quality of life in glaucoma patients, and the relationship between systemic conditions and ocular diseases. His recent publications demonstrate a strong emphasis on vision-related quality of life assessment tools, genetic factors in glaucoma, and comparative studies between glaucoma and other neurodegenerative conditions like Parkinson's disease. Jansonius frequently collaborates with international research consortia including the European Eye Epidemiology Consortium and the Global Biobank Meta-analysis Initiative. Board of directors member and co-editor, Acta Ophthalmologica Editorial board member, Investigative Ophthalmology & Visual Science Member, Imaging and Perimetry Society (IPS) Member, European Association for Vision and Eye Research (EVER) Member, Association for Research in Vision and Ophthalmology (ARVO) Professor Jansonius has supervised numerous research projects and PhD candidates. His current EU-funded EGRET AAA doctoral network trains early-stage researchers in glaucoma research. His laboratory work combines advanced imaging techniques with visual function assessment to develop better diagnostic and monitoring tools for glaucoma patients. The Groningen Glaucoma Group maintains active collaborations with research institutions worldwide, particularly in genetic studies of glaucoma and comparative analyses of visual field testing methodologies.

Diana Spieringsمشاهده پروفایل

پژوهشگر

• Single cell sequencing
• Genome instability
• Structural variations
• +۴ مورد دیگر

Diana Spierings is a Researcher at the Faculty of Medical Sciences, University Medical Center Groningen , affiliated with the Molecular Oncology (MO) department. Her work focuses on single-cell sequencing , genome instability , and cancer biology , contributing to the UN Sustainable Development Goals (SDG 3: Good Health and Well-being; SDG 17: Partnerships for the Goals) . Research interests include structural variations , ageing , stem cells , and immunology . She received the UMCG Innovation Prize for Research in 2019. Active in academic presentation, including a talk at the Dutch Hematology Congress (2018). Her research explores chromosomal instability , aneuploidy , and mitotic processes in cancer contexts, with datasets shared on platforms like ZENODO and figshare . Articles highlight her expertise in cancer diagnostics , genomic medicine , and chemotherapy response mechanisms .

Stefan Semrauمشاهده پروفایل

دانشیار

• Cell-fate Decision-making
• Single-cell Transcriptomics
• Stem Cell Biology
• +۶ مورد دیگر

Dr. Stefan Semrau is an Associate Professor at the Leiden Institute of Physics (LION) within the Faculty of Science at Leiden University . His research focuses on quantitative single-cell biology, particularly studying cell-fate decision-making using embryonic stem cells as a model system. Develops single-cell RNA-seq and single-molecule FISH methods Applies machine learning and mathematical modeling to decode stem cell differentiation Investigates interplay of epigenetics, cell cycle, and signaling molecules His work addresses both fundamental biological dynamics and applications in regenerative medicine and cancer stem cell eradication . Recent publications emphasize single-cell transcriptomics and gene fusion quantification . The Semrau Lab maintains collaborations across disciplines and develops tools like fuseFISH for cancer research. Scientific Awards FOM-Projectruimte Grant (2016) for stem cell dynamics research Advising & Collaborations Current advisees include PhD students studying retinoic acid-induced differentiation and lineage priming. The lab integrates computational and experimental approaches through partnerships with biotech and physics teams.

• Mucosal Immunity
• Microbiota
• Metabolism
• +۷ مورد دیگر

Dr. Olaf Perdijk is an Assistant Professor in the Department of Pharmacology at the Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University. His research focuses on understanding the intricate mechanisms by which host-microbe interactions in the gut modulate systemic and local immune responses and disease susceptibility. He aims to harness the therapeutic potential of microbes and metabolites through innovative approaches. Dr. Perdijk earned his PhD from Wageningen University in 2018, where he investigated novel early-life ingredients derived from raw cow's milk and their potential to modulate immune responses in neonates. Following his doctoral studies, he joined the Mucosal Immunology Research Group at Monash University, Australia, focusing on gut microbe-immune system communication in allergic diseases such as atopic dermatitis and allergic asthma. His research spans two primary arms: Preventing childhood asthma through early-life microbiome interventions and understanding the metabolic requirements of developing airway epithelium Exploring gut-brain axis interactions , particularly how ketogenic diets modulate neuronal excitability and epilepsy susceptibility, and how postbiotics regulate systemic metabolic and immune health Dr. Perdijk employs advanced methodologies including single-cell transcriptomics, immunofluorescence, molecular biology, primary cell culture, metabolomics, and bioinformatics to investigate these complex mechanisms. His recent publications reveal a strong focus on microbial metabolites and their regulatory roles in immunity. Key themes include how short-chain fatty acids influence skin barrier integrity, microbial metabolism of tyrosine in protecting against airway inflammation, and how antibiotic-induced dysbiosis disrupts metabolite production leading to exacerbated allergic responses. His 2024 review in Physiological Reviews establishes the microbiome as an integral player in respiratory immunity, while his work on neuroimmunology bridges immunology and neuroscience in understanding lung function. As an educator, Dr. Perdijk teaches courses including Pharma and Nutrition (CPS-333), Immunopharmacology (FA-MA215), Advanced Pharmacology (DI-411-13), and tutorials on chronic inflammatory conditions (FA-BA303). His teaching directly reflects his research expertise in mucosal immunology, host-microbiome interactions, and immunopharmacology. Dr. Perdijk's work has garnered significant attention in the scientific community, with multiple publications featured in high-impact journals and picked up by numerous news outlets. His research on the microbiome's role in respiratory immunity and the gut-brain axis represents cutting-edge interdisciplinary science with potential therapeutic applications.