جست‌وجوی استاد و پژوهشگر

Oleg Sysoevمشاهده پروفایل

عضو هیئت علمی

• Monotonic Regression
• Data Mining
• Machine Learning
• +۴ مورد دیگر

Oleg Sysoev is a Senior Associate Professor in the Department of Computer and Information Science (IDA) at Linköping University, Sweden. He specializes in Statistics and Machine Learning, contributing to the Master's program 'Statistics and Machine Learning'. His academic background includes a Master's in Applied Mathematics from Russia and a doctoral thesis in Statistics at Linköping University (2010), focusing on monotonic regression for large datasets. Research Interests: Monotonic regression and interpolation Machine learning methods (decision trees, kernel smoothing, neural networks) Data mining in public health Bootstrap methods and computational statistics Optimization techniques Grants & Collaborations: Lead researcher in a SEK 13 million project (Swedish Research Council) applying AI to forensic analysis for solving murders. Member of the Wallenberg AI, Autonomous Systems and Software Program (WASP), a major Swedish research initiative. Associated with the Division of Statistics and Machine Learning (STIMA), focusing on data-driven methodologies. Teaching & Academic Leadership: Responsible for teaching at undergraduate and graduate levels in statistics and machine learning. Supports curriculum development for the Master's program in Statistics and Data Mining.

Bart Eggenمشاهده پروفایل

استاد

• Neurosciences
• Cell Biology
• Neuroinflammation
• +۵ مورد دیگر

Prof. Bart Eggen is a Professor in the Department of Biomedical Sciences of Cells & Systems at the University of Groningen's Faculty of Medical Sciences. His research focuses on neuroinflammation, neurodegenerative diseases (e.g., Alzheimer's, multiple sclerosis), and microglial biology. He leads the Molecular Neurobiology section and holds roles on the Scientific Advisory Boards of Alzheimer Nederland and the Dutch Society for MS Research. Key research interests include gene expression regulation, epigenetics, and cellular mechanisms underlying neurodegeneration. Recent work explores microglia's role in synaptic pruning, remyelination, and aging-related inflammation. Eggen has published over 150 peer-reviewed articles and collaborates internationally on projects like the Netherlands Neurogenetics Database (NND). Education: Not explicitly stated in provided texts. Research Highlights: Focuses on microglia dynamics, neuroinflammation, and translational research linking basic biology to neurological disorders. His laboratory investigates cellular senescence in brain aging, epigenetic reprogramming in microglia, and omics approaches to study glial biology. Collaborative projects include brain organoid models for neurodegeneration and glioblastoma research. Eggen's work has implications for developing therapies targeting microglial dysfunction in diseases like Alzheimer's and multiple sclerosis. Awards/Grants: Not explicitly listed in provided texts, though his prolific publication record suggests sustained research funding. He chairs/advises multiple national research initiatives.

• Hypertension
• Cardiovascular Disease
• Immunology
• +۵ مورد دیگر

Antony Vinh is an Associate Professor in the Department of Microbiology, Anatomy, Physiology and Pharmacology at La Trobe University, Australia. He leads the Hypertension and Diabetes Division within the Centre for Cardiovascular Biology and Disease Research (CCBDR). His research focuses on immune system roles in cardiovascular and renal diseases, including hypertension, vascular inflammation, and fibrosis. He holds editorial roles at Frontiers in Physiology and Scientific Reports , and previously co-chaired the Cardiovascular Special Interest Group. Education: PhD in Physiology (Monash University, 2008) Postdoctoral training at Emory University's Division of Cardiology Bachelor of Biomedical Science (Monash University, 2002) Research Interests: Immune cell contributions to hypertension, inflammasome pathways, gut microbiome interactions, and therapeutic development for cardiovascular diseases. His work emphasizes translational studies using animal models and single-cell technologies. Grants: NHMRC Ideas Grant (2023–2027): Targeting IL-18-mediated inflammation in kidney disease NHMRC Project Grants (2018–2021): B cell roles in hypertension and IL-18 signaling in kidney disease Labs/Teams: Co-leads the Hypertension and Diabetes Division at CCBDR, focusing on multidisciplinary approaches to vascular and renal pathophysiology.

Wen Zhongمشاهده پروفایل

استادیار

• Precision Medicine
• Multi-Omics Integration
• Systems Biology
• +۳ مورد دیگر

Wen Zhong is an Assistant Professor and Docent at Linköping University, affiliated with the Department of Biomedical and Clinical Sciences (BKV) within the Division of Cell and Neurobiology. Her research focuses on multi-omics integration, genetics-phenotype interplay, and data-driven strategies for precision medicine. She leads a research group supported by the SciLifeLab-Wallenberg DDLS Program, aiming to develop AI-based tools for molecular diagnostics and patient stratification. Her work includes collaborative projects like the Human Protein Atlas, contributing to brain disorder research and therapeutic strategies. Key affiliations include SciLifeLab Linköping and the Wallenberg Centre for Molecular Medicine. Over 20 publications span topics such as Alzheimer's disease, preterm infant proteomics, and neuropeptide profiling in the prefrontal cortex. Her research bridges bioinformatics, systems biology, and clinical applications, with a focus on translating molecular data into precision medicine solutions. Recent articles emphasize multi-omics integration for tissue mapping, neurodegenerative mechanisms, and pediatric health. Her lab utilizes advanced platforms like the Berzelius supercomputer for data-driven analyses. Future work aims to expand molecular health networks and AI-driven decision support systems in precision medicine.

Anne Fletcherمشاهده پروفایل

دانشیار

• Immunology
• Fibroblasts
• Stromal Cells
• +۵ مورد دیگر

Associate Professor Anne Fletcher is an immunology researcher at Monash University's Biomedicine Discovery Institute, leading the Stromal Immunology Laboratory. She holds positions as Associate Professor (Research) in Biochemistry & Molecular Biology and is a Graduate Research Coordinator overseeing 150+ postgraduate students. Her work focuses on stromal cells' roles in immune regulation, particularly in lymphoid organs and tumors, aiming to develop therapeutic strategies targeting these cells in cancer and autoimmune diseases. Education: PhD in Immunology from Monash University (2008), with postdoctoral training at Harvard Medical School and Dana-Farber Cancer Institute. Notable roles include Chair of the Monash Functional Genomics Platform and leadership in diversity initiatives. Awards include the NHMRC CJ Martin Fellowship and recognition as a Key Opinion Leader in Immunoncology. Research Interests: Fibroblast-like stromal cells' functions in immune health/disease, tumor microenvironment modulation, and stromal cell-based therapies. Techniques used include RNA-Seq, mouse models, and live cell imaging. Recent publications emphasize stromal cell suppression mechanisms, tumor immunity, and fibroblast heterogeneity. Her work bridges basic science and clinical translation, with projects funded by grants addressing colorectal cancer and immunotherapy advancements.

• Histiocytic Disorders
• Pediatric Oncology
• Immunology
• +۴ مورد دیگر

Jan-Inge Henter is a Senior Professor at Karolinska Institutet's Department of Women's and Children's Health, specializing in Pediatric Oncology and Hematologic Disorders. He leads the Translational Research group in Childhood Cancer and Histiocytic Diseases, focusing on improving survival outcomes for patients with histiocytic disorders like Hemophagocytic Lymphohistiocytosis (HLH) and Langerhans Cell Histiocytosis (LCH). His research bridges clinical and molecular studies, addressing treatment resistance and cytokine storm syndromes. Education: MD from Uppsala University (1980), PhD in Pediatrics from Karolinska Institutet (1990). Awards: Received multiple honors including the 2023 Grand Silver Medal for his contributions to pediatric oncology and KI leadership. Leadership: Former Director of Research & Education at Karolinska University Hospital (2012–2017), President of the Histiocyte Society (2004–2007). Research Focus: HLH diagnostics, LCH pathogenesis, and translational therapies like SAMHD1 inhibition in AML. His group also explores immune-related complications of CAR-T cell therapies. Grants: Secured funding from the Swedish Childhood Cancer Foundation for projects addressing pediatric oncology and rare diseases. Labs/Teams: Leads a multidisciplinary team including postdocs, PhD students, and clinical researchers, collaborating globally on HLH and LCH initiatives.

Carrie Miceliمشاهده پروفایل

استاد

• Muscular Dystrophy
• Immunology
• Gene Therapy
• +۴ مورد دیگر

Dr. M Carrie Miceli is a Professor in the Department of Molecular, Immunology, and Microbiology (MIMG) at the University of California, Los Angeles (UCLA). She holds a PhD in Immunology from Duke University Medical Center (1988), a postdoctoral fellowship in Immunology at Stanford University Medical Center (1993), and a BA in Biochemistry and Cell Biology from UCSD (1983). Her research focuses on Muscle Cell Biology, Pathophysiology, and Therapeutics, particularly in Duchenne Muscular Dystrophy (DMD). She has led multiple NIH-funded projects, including grants as Principal Investigator for studies on Galectin-1 regulation and Coreceptor Modification of TCR signals. Her research emphasizes translational approaches to address DMD, including gene therapy strategies (e.g., CRISPR-Cas9, exon skipping), biomarker discovery through transcriptomics, and therapeutic development. Key contributions include identifying dantrolene as an enhancer of exon skipping and developing patient-specific muscle models using micromolded hydrogels. Dr. Miceli’s work bridges immunology and muscle biology, exploring how immune modulation impacts dystrophic pathology. Notable achievements include demonstrating osteopontin’s role in fibrosis and macrophage polarization in DMD. Her lab also investigates T cell signaling mechanisms, particularly the role of scaffold proteins like DLG1 in immune cell function. Awards and honors are not explicitly listed in the provided text, though her extensive NIH funding and publication record reflect her academic impact. She collaborates widely, including with Stanley Nelson on genomic approaches to DMD. Her work is published in high-impact journals like Cell Stem Cell, Nature Immunology, and Molecular Therapy.

Tianyuan Luمشاهده پروفایل

استادیار

• Genetic epidemiology
• Statistical genetics methodology
• Predictive modeling
• +۶ مورد دیگر

Tianyuan Lu is an Assistant Professor in the Department of Biostatistics and Medical Informatics at the University of Wisconsin–Madison, affiliated with the School of Medicine and Public Health. His research focuses on developing statistical genetics methodologies for genetic epidemiology, predictive modeling, and biomarker discovery, with applications in complex diseases including cardiovascular conditions, diabetes, mental health disorders, and infectious diseases like severe COVID-19. He leads the Lulab, which integrates multi-omics data with advanced statistical techniques to uncover disease mechanisms. His work emphasizes Mendelian randomization, proteogenomic analysis, and polygenic risk prediction, addressing critical questions about gene-environment interactions and causal pathways. Notable contributions include methods for nonlinear Mendelian randomization, ancestry-aware proteomic studies, and scalable machine learning models for single-cell data. He has developed open-source tools such as COSIME and SharePro to advance collaborative genomic research. Research highlights include identifying COL6A3-derived endotrophin as an obesity-coronary artery disease mediator, discovering vitamin D’s role in Alzheimer’s via two-sample MR, and creating plasma protein-based hip fracture risk scores. His projects often involve large-scale datasets like the UK Biobank, leveraging multi-omics integration to bridge basic science and clinical translation.

• Human Genetics
• Psychiatric Disorders
• Neurobehavioral Traits
• +۳ مورد دیگر

Roel A. Ophoff is a Professor-in-residence in both the Department of Psychiatry and Biobehavioral Sciences and the Department of Human Genetics at the University of California, Los Angeles (UCLA). His research focuses on human genetic and genomic studies of psychiatric disorders and neurobehavioral traits, with a particular emphasis on bipolar disorder, schizophrenia, and eating disorders. He holds a PhD in Human Genetics from Leiden University (1997). Education: PhD in Human Genetics, Leiden University, 1997 Affiliations: UCLA Department of Psychiatry and Biobehavioral Sciences UCLA Department of Human Genetics Member of the Psychiatric Genomics Consortium His work bridges clinical psychiatry and genetics, leveraging large-scale genomic analyses to uncover biological mechanisms underlying mental health conditions. Ophoff has contributed to landmark studies on genetic risk variants, epigenetic aging, and polygenic risk scores for bipolar disorder, schizophrenia, and depression. He collaborates with international consortia such as ENIGMA and PUMAS to address health disparities in underrepresented populations. Recent research highlights include: Circulating metabolite mapping in cerebrospinal fluid for Alzheimer’s disease progression Wastewater sequencing for public health surveillance Cell-type-specific gene expression analysis in neuropsychiatric disorders His studies frequently integrate multi-omics data (genomics, epigenomics, transcriptomics) to dissect complex trait biology. Ophoff also explores translational applications of genetic findings, such as improving diagnostic accuracy and personalized medicine strategies.

• Gene Therapy
• Stem Cell Biology
• Skin Disorders
• +۵ مورد دیگر

**Michele DE LUCA** is a **Full Professor** at the **University of Modena and Reggio Emilia**, affiliated with the **Department of Life Sciences (former Biomedical Sciences)**. His research focuses on **gene therapy**, **epidermal stem cell biology**, and **regenerative medicine**, particularly targeting genetic skin disorders like **epidermolysis bullosa (EB)** and **lamellar ichthyosis**. He leads clinical trials (e.g., Hologene 5) and pioneered **ex vivo gene-corrected epidermal stem cell transplantation**, enabling long-term skin regeneration in severe cases. His work integrates **CRISPR/Cas9 editing**, **transcriptomics**, and **epigenetic studies** to advance therapeutic strategies for **genodermatoses**. **Education & Research**: DE LUCA’s expertise spans **molecular biology**, **cellular models**, and **clinical translation** of stem cell therapies. His lab develops tools like **AlPaCas** (CRISPR allele-specific editing) and investigates mechanisms like **FOXM1/YAP signaling** in epidermal stem cell regulation. He collaborates internationally on **protein replacement therapies** and **cellular reprogramming**. **Publications**: Over 150 articles (2024–2009) highlight his contributions to **gene therapy efficacy**, **epithelial engineering**, and **clinical outcomes**. Notable works include *Regeneration of the entire human epidermis* (2018), *Allele-specific CRISPR editing* (2024), and *FOXM1-dependent histone regulation* (2024). **Awards & Grants**: Though no explicit awards listed, his work received EU funding for trials and **Holoclar** (first EU-approved stem cell therapy). He advocates for **regulatory compliance** in advanced therapies and critiques unproven stem cell interventions. **Labs & Teams**: Leads interdisciplinary teams at the **University of Modena**, collaborating with clinicians, engineers, and bioinformaticians. Focus areas include **next-generation sequencing for EB diagnosis** and **3D skin equivalents** for preclinical testing.

Yuji Nakadaمشاهده پروفایل

دانشیار

• Cardiac Regeneration
• Cardiovascular Biology
• Cell Cycle Regulation
• +۳ مورد دیگر

Yuji Nakada is an Associate Professor specializing in cardiovascular regeneration and cell cycle regulation. His work focuses on understanding mechanisms of cardiomyocyte proliferation and myocardial regeneration across species, including mice, pigs, and humans. He employs advanced techniques such as single-nucleus RNA sequencing and artificial intelligence for data analysis. Key research themes include hypoxia-induced regeneration, drug discovery for heart repair, and engineered cardiac tissue models. Nakada's studies explore metabolic pathways, gene expression modulation, and surgical interventions to enhance cardiac function post-injury. Recent projects involve identifying FDA-approved drugs that stimulate heart regeneration and developing three-dimensional cardiac spheroid cultures for better cell maturation. His laboratory also investigates the HIF-FOXM1 axis and YAP signaling pathways in promoting cardiomyocyte proliferation. Collaborative efforts integrate bioengineering approaches with biological insights to advance regenerative medicine strategies for cardiovascular diseases.

Samuel Leiboffمشاهده پروفایل

استادیار

• Plant Developmental Biology
• Genetics
• Genomics
• +۳ مورد دیگر

Samuel Leiboff is an Assistant Professor at Oregon State University's Department of Botany and Plant Pathology within the College of Agricultural Sciences. His lab focuses on quantitative approaches to understand plant development, particularly in maize and sorghum. Key areas include leaf and flower assembly, dynamic molecular changes during development, and the integration of computational biology with genetic analysis. Education: BSc in Environmental Sciences, UC Berkeley (Berkeley, CA) PhD in Integrative Plant Sciences (Plant Biology), Cornell University (Ithaca, NY) Research Interests: The lab employs comparative transcriptomics, quantitative genetics, and image processing to study plant development. Current projects involve analyzing hormone dynamics in cereal crops, stem cell regulation in Arabidopsis, and developing computational tools for morphometric analysis. Techniques include live imaging of protoplasts and high-resolution gene expression atlases. Teaching: Fall: BOT 599 - Special Topics in Plant Molecular Development Winter: BI 311 - Genetics Spring: BDS 411 - Case Studies in Biological Data Sciences Lab Activities: The Leiboff Lab actively collaborates on projects like the Plant Cell Atlas initiative and has developed tools for RNAseq analysis. Current lab members include students Diana Ruggiero and Nicholas Francis, along with postdoctoral researcher Maria Camila Medina Montes.

• Metabolic Disorders
• Diabetes Research
• Obesity Studies
• +۳ مورد دیگر

Silvia Corvera is a Professor of Molecular Medicine and holds the Endowed Chair in Diabetes Research at the University of Massachusetts Chan Medical School, within the T.H. Chan School of Medicine's Program in Molecular Medicine. She also serves as Director of the MD/PhD (MSTP) program and the Clinical Translational Research Pathway. Her academic journey includes an MD and MSc in Molecular Biology from the Universidad Nacional Autonoma de Mexico, followed by postdoctoral studies in the U.S. and faculty roles at the University of Pennsylvania and UMass Chan. Her research focuses on understanding cellular and molecular mechanisms underlying metabolic diseases such as type-2 diabetes, non-alcoholic fatty liver disease (NASH), and hypertension. Key areas include adipose tissue dynamics—specifically adipocyte expansion, brite/beige adipocyte function, and adipose organoid development. Collaborations with clinical partners in surgery and obstetrics-gynecology enhance translational research into metabolic disease associations with adipose distribution patterns. Dr. Corvera’s laboratory explores adipose tissue heterogeneity, including its role in energy homeostasis and therapeutic potential. Current projects involve analyzing adipose cell populations via single-cell RNAseq and investigating how genetic factors influence adipose patterning. Her work bridges basic science and clinical applications, addressing obesity-related pathologies and regenerative medicine opportunities. Notable contributions include defining adipose tissue angiogenesis in obesity, generating functional human adipose tissue in vivo, and elucidating mechanisms of adipocyte progenitor differentiation. Her lab actively engages trainees in rotation projects focused on adipocyte biology, cell signaling, and metabolic pathways. Lab activities emphasize interdisciplinary approaches, combining molecular biology, stem cell technology, and systems biology to advance treatments for metabolic disorders. Ongoing efforts investigate adipose-derived cell therapies, CRISPR-enhanced adipocyte browning, and the role of long noncoding RNAs in thermogenesis regulation.

Dannielle Engleمشاهده پروفایل

استادیار

• Pancreatic Cancer Research
• Organoid Models
• Glycobiology
• +۳ مورد دیگر

Roles & Affiliations: Dannielle Engle is an Assistant Professor at the Salk Institute for Biological Studies, leading the Engle Lab within the Regulatory Biology Laboratory. She focuses on pancreatic cancer research, combining organoid models and glycosylation studies to improve early detection and treatment. Education: B.A., Biological Sciences and Asian Studies, Northwestern University PhD, Biological Sciences, University of California, San Diego Research Interests: Engle’s work centers on pancreatic cancer’s early detection and treatment via organoid modeling and biomarker discovery. Key areas include: CA19-9 glycan’s role in pancreatitis and cancer Organoid-based precision medicine Tobacco-related pancreatic cancer mechanisms Her lab emphasizes interdisciplinary approaches to tackle pancreatic cancer’s high mortality rate. Publications & Trends: Recent articles highlight advancements in organoid pharmacology, glycobiology-driven therapies, and stromal-targeted treatments. These studies aim to bridge laboratory findings with clinical applications. Awards & Grants: Lustgarten Foundation-AACR Career Development Award (2021) Tobacco-Related Disease Research Program Award (2020) NIH NCI K99/R00 Pathway to Independence Award (2016-2018) Advising & Grants: Engle mentors graduate students and postdocs, focusing on pancreatic cancer biology and translational research. Active grants include projects on tobacco carcinogens and stromal HDAC inhibitors. Labs & Collaborations: The Engle Lab collaborates with institutions like UCSD and Cold Spring Harbor. Their work emphasizes organoid platforms and glycan signaling, with a lab philosophy combining scientific rigor and patient-focused ethics.

Anna Rosanas-Urgellمشاهده پروفایل

استاد

• Malaria Epidemiology
• Drug Resistance
• Plasmodium vivax
• +۲ مورد دیگر

Anna Rosanas-Urgell is Professor and Head of the Malariology Unit at the Institute of Tropical Medicine in Antwerp, Belgium. With a PhD in Genetics and MSc in Epidemiology, she leads research on molecular epidemiology of malaria, focusing on Plasmodium vivax biology, drug resistance mechanisms, and genomic surveillance tools for malaria elimination programs. Research encompasses: Plasmodium invasion mechanisms and host adaptation Emergence/spread of antimalarial drug resistance Host-parasite-environment interactions in transmission Development of molecular surveillance tools Leads international collaborations across Africa, South America, and Asia. Current projects include PvTRAg (structure-function of tryptophan-rich antigens) and be-IMPACT (malaria prevention in travelers).