Dannielle Engle

Roles & Affiliations: Dannielle Engle is an Assistant Professor at the Salk Institute for Biological Studies, leading the Engle Lab within the Regulatory Biology Laboratory. She focuses on pancreatic cancer research, combining organoid models and glycosylation studies to improve early detection and treatment.

Education:

• B.A., Biological Sciences and Asian Studies, Northwestern University
• PhD, Biological Sciences, University of California, San Diego

Research Interests: Engle’s work centers on pancreatic cancer’s early detection and treatment via organoid modeling and biomarker discovery. Key areas include:

• CA19-9 glycan’s role in pancreatitis and cancer
• Organoid-based precision medicine
• Tobacco-related pancreatic cancer mechanisms

Her lab emphasizes interdisciplinary approaches to tackle pancreatic cancer’s high mortality rate.

Publications & Trends: Recent articles highlight advancements in organoid pharmacology, glycobiology-driven therapies, and stromal-targeted treatments. These studies aim to bridge laboratory findings with clinical applications.

Awards & Grants:

• Lustgarten Foundation-AACR Career Development Award (2021)
• Tobacco-Related Disease Research Program Award (2020)
• NIH NCI K99/R00 Pathway to Independence Award (2016-2018)

Advising & Grants: Engle mentors graduate students and postdocs, focusing on pancreatic cancer biology and translational research. Active grants include projects on tobacco carcinogens and stromal HDAC inhibitors.

Labs & Collaborations: The Engle Lab collaborates with institutions like UCSD and Cold Spring Harbor. Their work emphasizes organoid platforms and glycan signaling, with a lab philosophy combining scientific rigor and patient-focused ethics.