جست‌وجوی استاد و پژوهشگر

Maheswari Senthilمشاهده پروفایل

استاد

• Surgical Oncology
• Peritoneal Carcinomatosis
• Gastrointestinal Cancer
• +۴ مورد دیگر

Maheswari Senthil is a Professor in the Division of Surgical Oncology at the UCI School of Medicine. She holds leadership roles including Chief of the Division of Surgical Oncology, Vice Chair of Surgical Research, and Medical Director of the UCI Center for Clinical Research. Her work focuses on peritoneal malignancies, colorectal cancer, and innovative therapies like cytoreductive surgery combined with HIPEC. She leads the Peritoneal Malignancy Program at the Chao Family Comprehensive Cancer Center. Research Interests: Her research emphasizes peritoneal carcinomatosis, gastrointestinal malignancies, and translational studies in surgical oncology. She explores biomarkers (e.g., exosomes) for early detection and treatment response prediction. Her work also addresses disparities in cancer care and palliative treatment utilization. Clinical Contributions: Dr. Senthil is a leader in advancing surgical techniques and multidisciplinary approaches for advanced cancers. She contributes to global initiatives to improve cancer surgery outcomes in resource-limited settings.

Todd C Holmesمشاهده پروفایل

استاد

• Neural Circuit Mapping
• Synaptic Connectivity
• Visual Cortex
• +۳ مورد دیگر

Todd C. Holmes, PhD, is a Professor in the Department of Physiology & Biophysics at the University of California, Irvine (UCI) School of Medicine. His research focuses on the structural and functional organization of neural circuits, particularly in the visual cortex and hippocampus. Dr. Holmes employs advanced techniques like laser scanning photostimulation and viral tracing to map synaptic connectivity, emphasizing the balance between excitatory and inhibitory inputs in cortical microcircuits. His work has revealed layer-specific synaptic wiring diagrams and redefined understanding of how inhibitory connections mirror excitatory pathways in the mouse visual cortex (V1). Dr. Holmes is affiliated with the UCI Center for Neural Circuit Mapping, contributing to interdisciplinary studies on Alzheimer’s disease models, optogenetic tools, and neurovascular interactions. He has secured funding from NIH grants (e.g., MH105427, R01NS095355) and collaborates on projects involving genetic engineering and high-resolution brain imaging techniques. His research extends to circadian rhythms, Drosophila neurobiology, and neuropsychiatric disorder models, leveraging transgenic approaches and behavioral analyses. Recent studies explore microglia’s role in synaptic connectivity and the application of novel viral vectors for circuit tracing.

Johan Leveauمشاهده پروفایل

استاد

• Phyllosphere microbiology
• Bacterial mycophagy
• Microbial metagenomics
• +۴ مورد دیگر

Johan Leveau is a Professor of Plant Pathology at the University of California, Davis. His research focuses on the microbiology of plant surfaces (phyllosphere), microbial interactions in plant ecosystems, and the application of molecular tools to study microbial communities. He leads studies on bacterial mycophagy, microbial metagenomics, and bioreporter technology for environmental monitoring. His work bridges fundamental microbiology with agricultural applications, addressing challenges in plant health and sustainable agriculture. Research Highlights: Discovered novel species of Collimonas bacteria from forest soils Developed models explaining microbial colonization patterns on leaf surfaces Explored antifungal secondary metabolites for biocontrol applications Investigated the role of plant hormones (e.g., IAA) in shaping microbial communities Advanced understanding of phyllosphere microbiota's impact on plant disease dynamics Key Projects: Leader of the UC Davis Phyllosphere Microbiology Lab Co-founded the International Citrus Microbiome Consortium Developed the PHYLLOSIM agent-based model for microbial dispersion Recipient of grants for phytobiome research and microbial biotechnology His recent work emphasizes predictive ecology of phyllosphere communities and the integration of microbiome data into agricultural management strategies.

Shyam Prabhakarمشاهده پروفایل

استاد پژوهشی

• Genomics
• Transcriptional Regulation
• Bioinformatics
• +۷ مورد دیگر

Shyam Prabhakar is a Senior Group Leader and Associate Director at the A*STAR Genome Institute of Singapore (GIS). His research focuses on gene-regulatory mechanisms in human diseases using high-throughput omics technologies and computational methods. Key roles include leading the Laboratory of Systems Biology and Data Analytics, and contributing to initiatives like the Human Cell Atlas (HCA) and Asian Immune Diversity Atlas (AIDA). Research Interests: Transcriptional regulation in cancer, autism, and immune disorders Single-cell and spatial omics data analysis Development of algorithms for genomic data interpretation Major Achievements: First single-cell transcriptomic analysis of colorectal tumors (Nature Genetics 2017) Landmark studies on histone acetylation in autism (Cell 2016) and tuberculosis immunity (Nature Microbiology 2022) Key contributions to spatial omics tools like BANKSY (Nature Genetics 2024) Labs/Teams: Prabhakar Lab, Spatial and Single Cell Systems Platform, Human Cell Atlas initiatives.

Yenan Brycesonمشاهده پروفایل

استاد

• Immunology
• Hematology
• Cell Biology
• +۳ مورد دیگر

Yenan Bryceson is a Professor in the Department of Medicine at Karolinska Institutet, specializing in immunology and hematology. He leads the Yenan Bryceson Group at the Center for Hematology and Regenerative Medicine (HERM), focusing on molecular mechanisms of hyperinflammatory disorders and cytotoxic lymphocyte function in health and disease. His research combines clinical insights with genetic and immunological studies to develop personalized treatments, particularly in cancer immunotherapy. Education: PhD in Medicine from Karolinska Institutet (2008). Research Interests: Molecular basis of immunodeficiencies, cytotoxic lymphocyte biology (NK cells and T cells), hyperinflammatory syndromes, and translational immunotherapy. His work explores how genetic defects in cytotoxic pathways lead to severe immune disorders and cancer susceptibility. Collaborations: Partnerships with institutions globally, including Moffit Cancer Center, CeMM Research Center (Vienna), and NIH, to advance understanding of immune system dysfunction and therapeutic applications. Grants: Funded by the Swedish Research Council, Wallenberg Foundation, Swedish Cancer Foundation, and Center for Innovative Medicine. Labs/Teams: The Yenan Bryceson Group includes postdocs, PhD students, and researchers investigating cytotoxic lymphocyte differentiation, immune surveillance, and genetic immunodeficiencies. Key projects involve developing NK cell therapies and understanding cytokine storm syndromes.

Johan Hartmanمشاهده پروفایل

استاد

• Precision Pathology
• Breast Cancer Therapy
• Digital Image Analysis
• +۴ مورد دیگر

Professor Johan Hartman is a leading academic and clinician at Karolinska Institutet, serving as a Professor and Senior Consultant in the Department of Oncology-Pathology. His primary role combines research leadership in precision pathology with clinical expertise in breast pathology at Karolinska University Hospital. Hartman leads a research group focused on personalized breast cancer therapy through advanced technologies like AI-driven histopathology analysis, molecular genomics, and patient-derived tumor models. Education & Qualifications: Doctoral Degree (2008), Karolinska Institutet Medical Degree (2008), Karolinska Institutet Docent (2015), Karolinska Institutet Research Focus: Hartman’s lab pioneers innovations in precision medicine, particularly in predicting treatment responses using digital pathology, AI, and genomic profiling. Key areas include tumor heterogeneity, AI tools for diagnostic accuracy, and translational research linking molecular profiles to clinical outcomes. His group has developed clinical-grade AI systems for breast cancer risk stratification and tumor characterization. Publications & Impact: With over 100 peer-reviewed articles in high-impact journals (e.g., Science, Nature Communications), Hartman’s work emphasizes breast cancer therapy prediction, immune profiling, and molecular diagnostics. Recent studies include AI-driven TIL analysis, spatial transcriptomics, and genomic heterogeneity in tumors. Awards & Recognition: 2023 Karolinska Institutet Innovation Award 2022 Athena Prize (Vetenskapsrådet) 2016 Clinical Investigator Award (Swedish Cancer Society) Grants & Collaborations: Leading projects funded by Radiumhemmets Forskningsfonder, Vinnova, and industry partnerships Co-founder of Stratipath, a KI spin-off advancing precision pathology tools Labs & Teams: Hartman’s group includes postdocs, PhD students, and clinical researchers. Key members focus on AI in pathology, tumor modeling, and translational oncology. The team collaborates internationally on initiatives like the International Immuno-Oncology Biomarker Working Group.

Jellert Gaublommeمشاهده پروفایل

استادیار

• Microbial Ecology
• Human Microbiome
• Bacteriophages
• +۳ مورد دیگر

Jellert Gaublomme is Assistant Professor of Biological Sciences at Columbia University. His research develops and applies multi-omic technologies to study biomolecular interactions during development, physiology, and disease, with particular focus on the human microbiome in immunological, neurological, and cancer contexts. Gaublomme combines cutting-edge wet-lab techniques with computational approaches to investigate microbial communities and host-microbe interactions. Current projects include developing CRISPR-based tools for multimodal phenotyping of cells and tissues, single-cell analysis of the gut microbiome, and investigating bacteriophage roles in human health. His lab creates computational pipelines for integrative analysis of genomic, transcriptomic, and proteomic datasets. Gaublomme has developed innovative methods including nuclei multiplexing with barcoded antibodies for single-nucleus genomics and bioorthogonal labeling to track microbial activity. His work reveals how microbial community dynamics influence health outcomes in chronic diseases including cystic fibrosis and cancer.

Wenyi Wangمشاهده پروفایل

استاد

• Cancer Genomics
• Bioinformatics
• Machine Learning in Healthcare
• +۵ مورد دیگر

Dr. Wenyi Wang is a Professor in the Department of Bioinformatics and Computational Biology at The University of Texas MD Anderson Cancer Center. She leads the Statistical Bioinformatics Lab, focusing on advancing computational methods for cancer genomics, transcriptomics, and risk modeling. Her work integrates statistical rigor and AI to address challenges in understanding tumor heterogeneity, cancer evolution, and clinical translation. She holds adjunct professorships at Rice University and Texas A&M University. Research Interests: Multi-omic deconvolution, tumor microenvironment dynamics, cancer risk prediction using Bayesian and machine learning models, and development of tools for mutation calling (e.g., MuSE, DeMixT). Her lab’s current directions include DNA–RNA dynamics in cancer and spatial transcriptomics to map tumor architectures. Publications: Dr. Wang’s recent work includes high-impact studies on deconvolution methods (e.g., DeMixSC), TP53 mutation annotation, and clinical risk prediction models. Her lab’s tools like CliPP and DeMixNB advance precision medicine by enabling accurate analysis of tumor evolution and heterogeneity. Awards: While personal awards are not explicitly listed, her research has garnered institutional recognition, including inclusion on MD Anderson’s Wall of Science for contributions to cancer discovery. Grants and Collaborations: Collaborates with clinicians and experimental biologists to translate computational insights into clinical practice. Her lab trains students across interdisciplinary programs, emphasizing training in quantitative sciences and translational research. Labs/Teams: The Statistical Bioinformatics Lab fosters a community dedicated to bridging bioinformatics and clinical oncology, with ongoing projects supported by grants and collaborations across institutions.

Paul W. Sternbergمشاهده پروفایل

استاد

• Systems Biology
• Cellular and Developmental Biology
• Evolutionary Biology
• +۶ مورد دیگر

Paul W. Sternberg is the Bren Professor of Biology and William K. Bowes Jr. Leadership Chair at the California Institute of Technology's Division of Biology and Biological Engineering. He holds a B.A. from Hampshire College (1978) and a Ph.D. from MIT (1984). His research focuses on systems biology of C. elegans development, neural circuits underlying sex and sleep, and functional genomics of nematodes. Sternberg pioneered tools like Textpresso for text mining in biological literature and co-leads WormBase, a central database for nematode research. His work includes sequencing genomes of parasitic nematodes and studying behavior, such as CO 2 response and host-finding mechanisms. Awards include HHMI Investigator (1992–2017) and the Thomas Hunt Morgan Medal (2023). Research interests span systems biology, evolutionary biology, and microbiology. Key projects involve understanding developmental decisions (e.g., dauer larva formation), neural circuitry, and applying genomics to combat parasitic nematodes. Collaborations include the Alliance of Genome Resources and Gene Ontology Consortium. Sternberg’s lab also studies cell migration and signaling pathways in development, leveraging CRISPR and optogenetics. Education: B.A., Hampshire College; Ph.D., MIT Awards: HHMI Investigator (1992–2017), Thomas Hunt Morgan Medal (2023) Labs/Teams: Sternberg Lab, WormBase, Alliance of Genome Resources

Stephen Quakeمشاهده پروفایل

استاد

• Biophysics
• Genomics
• Microfluidics
• +۳ مورد دیگر

Stephen Quake is the Lee Otterson Professor of Bioengineering and Professor of Applied Physics at Stanford University, and co-President of the Chan Zuckerberg Biohub. He holds a B.S. in Physics and M.S. in Mathematics from Stanford University (1991) and a Ph.D. in Theoretical Physics from the University of Oxford (1994). His research focuses on biophysics, genomics, and medical technology, particularly in developing non-invasive diagnostic tools like the first non-invasive prenatal test for Down syndrome. His innovations have revolutionized genetics and medicine through microfluidic automation and cell-free nucleic acid analysis. Research Interests include biophysics, single-cell analysis, microfluidics, and prenatal diagnostics. His work bridges physics, engineering, and biology, with applications in healthcare, such as replacing invasive procedures with blood-based tests. Key contributions include advancements in DNA sequencing, liquid biopsies, and understanding cellular mechanisms in diseases like diabetes and neurodegeneration. Awards & Recognition: Not explicitly listed, but his work has received widespread acclaim for its transformative impact on medicine. Advising & Grants: Leads the Quake Lab and collaborates on projects funded by institutions like the Chan Zuckerberg Initiative. Labs & Teams: Directs the Quake Lab, focusing on biomedical innovation and cell biology.

• Neuroanatomy
• Connectomics
• Neural circuits
• +۵ مورد دیگر

Professor Hong Wei Dong is a faculty member in the Department of Neurobiology at the David Geffen School of Medicine, University of California Los Angeles (UCLA). His research focuses on creating comprehensive connectome maps of the C57Bl/6 mouse brain to understand functional network organization and behavioral output mechanisms. He integrates Connectomics Genetics 3D high-resolution imaging Artificial intelligence to explore the fundamental architecture of the central nervous system. Key research directions include: Classification of mouse brain/spinal cord cell types through anatomic, molecular, and physiological properties Development of microscopy/histological technologies for human brain mapping at axonal resolution Application to neurodegenerative disease models (Alzheimer’s, Huntington’s) Recent publications highlight his work on: Visceromotor cortex networks High-resolution brain atlases Thalamic subnetworks Neuronal diversity analysis Advanced image processing tools Transsynaptic tracing methodologies Awardeeship highlights: Suzanne Eaton Memorial Prize Taylor M. Brown Memorial Award His lab develops scalable technologies like Gossamer for petabyte-scale image processing and Morphohub for multi-morphometry generation, while maintaining affiliations with UCLA Brain Research & Artificial Intelligence Nexus (B.R.A.I.N.) and NIH T32 training grants.

Xuan Vinh Toمشاهده پروفایل

پژوهشگر ارشد

• Neuroimaging
• Traumatic Brain Injury (TBI)
• Neuroinflammation
• +۵ مورد دیگر

Dr. Xuan Vinh To is a Postdoctoral Research Fellow at the Queensland Brain Institute, The University of Queensland. His research focuses on neuroimaging techniques and their application to traumatic brain injury (TBI), neuroinflammation, and neurodegenerative diseases such as Alzheimer's. He holds a PhD in Neuroscience from The University of Queensland (2021). Education: PhD in Neuroscience, The University of Queensland, 2021 Research Interests: Development of advanced MRI techniques for TBI assessment Neuroinflammation biomarker discovery Functional connectivity analysis in aging and disease Preclinical imaging in rodent models Machine learning applications in neuroimaging Publications Trends: His work shows strong focus on translational neuroimaging, particularly in TBI pathophysiology and recovery mechanisms. Recent studies explore MRI biomarkers linking inflammation, structural changes, and cognitive outcomes in both clinical and preclinical settings. Data Resources: He has contributed multiple datasets on TBI neuroimaging through platforms like The University of Queensland's data repository, enabling reproducible research in rodent models and clinical TBI cohorts.

Melissa J. Spencerمشاهده پروفایل

استاد

• Muscular Dystrophy
• Gene Therapy
• CRISPR
• +۴ مورد دیگر

Melissa J. Spencer is a Professor in the Department of Neurology at the University of California Los Angeles (UCLA) School of Medicine. Her research focuses on muscular dystrophies , particularly Duchenne muscular dystrophy (DMD) and limb girdle muscular dystrophies (LGMDs) , with an emphasis on gene therapy , CRISPR applications , and immune modulation in therapeutic contexts. Principal Investigator on multiple NIH grants including R01NS117912 (2020-2025) for AAV vector optimization Co-Principal Investigator on NIH RC1AR058333 (2009-2011) for exon skipping research Research Trends in her recent publications span: Gene Delivery Systems (AAV, nanoparticles, CRISPR strategies) Immune Response Analysis in gene therapy recipients Muscle Fibrosis mechanisms and macrophage polarization Therapeutic Development for LGMD and DMD Her work integrates molecular biology , genomics , and clinical applications to address degenerative muscle conditions.

Atom Sarkarمشاهده پروفایل

استاد

• Neurosurgery
• Neuro-oncology
• Molecular Neuroscience
• +۶ مورد دیگر

Atom Sarkar is a Professor of Neurosurgery at Drexel University College of Medicine and director of Stereotactic, Functional, and Epilepsy Surgery at the Global Neurosciences Institute. A board-certified neurosurgeon, he also directs the Philadelphia Voice Tremor Center. His academic career spans multiple institutions including The Ohio State University, where he previously led neurological nanomedicine and epilepsy programs. Dr. Sarkar holds dual MD/PhD degrees from the University of Miami School of Medicine and a BS in Biology from Brown University. Education: BS in Biology - Brown University MD - University of Miami Leonard M. Miller School of Medicine (1998) PhD in Biophysics - University of Miami (with honors) Research Focus: Dr. Sarkar specializes in neuro-oncology, molecular neuroscience, and translational nanomedicine. His work integrates advanced technologies such as single-molecule mechanics and gene therapy with clinical neurosurgery. Key areas include brain tumor evolution mechanisms, HIV neuropathology, and interdisciplinary approaches to movement disorders like Parkinson's disease. He has pioneered novel treatments for epilepsy and functional neurological disorders through stereotactic and minimally invasive surgical techniques. Awards & Recognition: Lawrence Mervis Teacher of the Year Award Young Investigator Travel Scholarship (Academy of Molecular Imaging) NIH/NIDA Grant Co-Investigator (2023-2025) Grants & Collaborations: Current research includes NIH-funded studies on adult human brain tissue cultures for NeuroHIV research and multi-scale glioma analysis through the Philadelphia Coalition for a Cure. Past work includes a landmark AAV2-GAD gene therapy trial for Parkinson's disease. Labs & Teams: Leads multidisciplinary teams at Drexel and Global Neurosciences Institute focusing on nanotechnology applications in neurosurgery, neuro-oncological imaging, and functional neurosurgical innovations.

Davide Mazzaمشاهده پروفایل

دانشیار

• Biophysics
• Cell Biology
• Cancer Research
• +۴ مورد دیگر

Davide Mazza is an Associate Professor in Physics at Vita-Salute San Raffaele University, Milan, Italy, and heads the Imaging of Gene Regulation Unit at the Experimental Imaging Center of San Raffaele Scientific Institute. His career spans institutions including the National Institutes of Health (USA) and European Marie Curie Fellowships. PhD in Physics (2008) and Master in Physics (2004) from University of Genoa, Italy Research Interests focus on biophysics , chromatin organization , transcription factor dynamics , and onco-suppressor mechanisms , with a specialization in advanced microscopy techniques (e.g., single-molecule tracking, fluorescence correlation spectroscopy). His work bridges quantitative biology and cancer epigenetics . Scientific Contributions include 15+ recent publications on topics like chromatin accessibility , transcriptional regulation , and 3D microenvironmental effects on gene expression . Articles highlight interdisciplinary approaches combining physics , cell biology , and clinical oncology . 2019-2023 : AIRC Investigator Grant for chromatin reorganization in p53 signaling 2018 : Worldwide Cancer Research Grant for chromatin organization in oncogene-induced senescence 2015-2018 : Fondazione Cariplo Grant for single-molecule p53 dynamics 2010 : Marie Curie Individual Fellowship for postdoctoral research 2005 : GIC Italian Cytometry Society prize for M.Sc. thesis Teaching & Mentorship includes 2016-2022 adjunct professorship in Physics at UNISR and leadership in Ph.D. programs (e.g., co-organizer of microscopy schools, member of doctoral committees). He has supervised Zeno Lavagnino (Marie Curie project, 2018) and hosted EMBO Short-term Fellows. Laboratory & Collaborations include the Experimental Imaging Center (since 2020) and the Cancer Imaging Unit (2014-2019). His work intersects nanomedicine (e.g., CEN European Center for Nanomedicine) and quantitative imaging in oncology.