Todd C Holmes

Todd C. Holmes, PhD, is a Professor in the Department of Physiology & Biophysics at the University of California, Irvine (UCI) School of Medicine. His research focuses on the structural and functional organization of neural circuits, particularly in the visual cortex and hippocampus. Dr. Holmes employs advanced techniques like laser scanning photostimulation and viral tracing to map synaptic connectivity, emphasizing the balance between excitatory and inhibitory inputs in cortical microcircuits. His work has revealed layer-specific synaptic wiring diagrams and redefined understanding of how inhibitory connections mirror excitatory pathways in the mouse visual cortex (V1).

Dr. Holmes is affiliated with the UCI Center for Neural Circuit Mapping, contributing to interdisciplinary studies on Alzheimer’s disease models, optogenetic tools, and neurovascular interactions. He has secured funding from NIH grants (e.g., MH105427, R01NS095355) and collaborates on projects involving genetic engineering and high-resolution brain imaging techniques.

His research extends to circadian rhythms, Drosophila neurobiology, and neuropsychiatric disorder models, leveraging transgenic approaches and behavioral analyses. Recent studies explore microglia’s role in synaptic connectivity and the application of novel viral vectors for circuit tracing.