Hong Wei Dong

Professor Hong Wei Dong is a faculty member in the Department of Neurobiology at the David Geffen School of Medicine, University of California Los Angeles (UCLA). His research focuses on creating comprehensive connectome maps of the C57Bl/6 mouse brain to understand functional network organization and behavioral output mechanisms.

He integrates

• Connectomics
• Genetics
• 3D high-resolution imaging
• Artificial intelligence

to explore the fundamental architecture of the central nervous system.

Key research directions include:

• Classification of mouse brain/spinal cord cell types through anatomic, molecular, and physiological properties
• Development of microscopy/histological technologies for human brain mapping at axonal resolution
• Application to neurodegenerative disease models (Alzheimer’s, Huntington’s)

Recent publications highlight his work on:

• Visceromotor cortex networks
• High-resolution brain atlases
• Thalamic subnetworks
• Neuronal diversity analysis
• Advanced image processing tools
• Transsynaptic tracing methodologies

Awardeeship highlights:

• Suzanne Eaton Memorial Prize
• Taylor M. Brown Memorial Award

His lab develops scalable technologies like Gossamer for petabyte-scale image processing and Morphohub for multi-morphometry generation, while maintaining affiliations with UCLA Brain Research & Artificial Intelligence Nexus (B.R.A.I.N.) and NIH T32 training grants.