جست‌وجوی استاد و پژوهشگر

Kevin D Sargeمشاهده پروفایل

استاد

• Protein Sumoylation
• Epigenetics
• Gene Bookmarking
• +۸ مورد دیگر

Kevin D. Sarge, PhD, is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, with a joint affiliation in the Toxicology Program. His research bridges molecular mechanisms of disease and epigenetic regulation, focusing on post-translational modifications and gene expression memory. Research Interests: Dr. Sarge's work centers on two major areas: (1) Protein sumoylation and its role in diseases such as cardiomyopathy and Alzheimer’s, where he discovered that sumoylation of lamin A and amyloid precursor protein (APP) regulates their function and localization; and (2) Gene bookmarking , an epigenetic process ensuring the inheritance of gene expression states through mitosis, involving HSF2 and TATA-binding protein (TBP). Publication Trends: His recent work (2005–2009) reveals a strong focus on sumoylation, stress response, and epigenetic mechanisms. Publications in journals like Nature Cell Biology and Science highlight his contributions to understanding how transcription factors and chromatin regulators maintain gene expression fidelity during cell division. Scientific Awards: No awards mentioned in the provided text. Advising and Grants: Dr. Sarge has mentored numerous researchers, including H. Xing, D.C. Wilkerson, and Y. Zhang, many of whom are co-authors on key publications. His lab has secured significant research funding, as evidenced by sustained productivity and high-impact publications, though specific grants are not listed. His work has implications for therapeutic development in neurodegenerative and cardiac diseases. Labs and Teams: His laboratory investigates molecular mechanisms using biochemical, genetic, and cell biological approaches, focusing on protein modifications and epigenetic memory. The team collaborates across disciplines, including toxicology and reproductive biology, reflecting the integrative nature of modern molecular biochemistry.

• Ubiquitin
• Enzyme
• Crystal Structure
• +۶ مورد دیگر

David Reverter Cendros is a Professor in the Department of Biochemistry and Molecular Biology at the Universitat Autònoma de Barcelona (UAB), where he leads the "Grup d'estructura i agregació de proteïnes" within the Institute of Biotechnology and Biomedicine "Vicent Villar Palasi" (IBB). His educational background includes: Ph.D. in Biological Sciences from Universitat Autònoma de Barcelona (1998) Master's in Biotechnology from Universitat Autònoma de Barcelona (1995) Degree in Biological Sciences from Universitat Autònoma de Barcelona (1993) Before joining UAB faculty, Dr. Reverter completed postdoctoral research at prestigious institutions including Memorial Sloan Kettering Cancer Center (2004-2007), Weil Medical College of Cornell University (2002-2003), and Max Planck Institute of Biochemistry (1999-2001). Dr. Reverter's research focuses on protein structure and function, particularly in the areas of ubiquitin and SUMO modification pathways. His work combines structural biology, biochemistry, and molecular biology approaches to understand: Ubiquitin E3 ligase activity SUMO conjugation and deconjugation mechanisms Protein-protein interactions in post-translational modification systems Structural basis of enzyme specificity Protein aggregation and amyloidogenesis His recent publications demonstrate a strong focus on the structural and functional characterization of the ubiquitin/SUMO pathway, with particular emphasis on enzyme specificity and regulation. The research spans from fundamental biochemical mechanisms to potential therapeutic applications in protein misfolding diseases. Dr. Reverter has secured significant research funding, currently leading multiple projects including: "Structural and Functional Characterization of the Ubiquitin E3 Ligase Activity of the Smc5/6 Complex" (2024-2026) "Structural and Functional Insights into the Ubiquitin/SUMO Conjugation and Deconjugation Pathway" (2022-2025) Previous projects on SUMO modification in DNA repair processes and ubiquitin-like post-translational modifications He has supervised 21 students and mentored numerous scholars throughout his career, contributing significantly to training the next generation of structural biologists and biochemists. Dr. Reverter is a member of the "Grup d'estructura i agregació de proteïnes" at the Institute of Biotechnology and Biomedicine, where his team employs cutting-edge structural biology techniques including X-ray crystallography to unravel complex protein modification systems.

Oliver Kerscherمشاهده پروفایل

استاد

• Molecular Biology
• Cell Biology
• Protein Degradation
• +۵ مورد دیگر

Oliver Kerscher is a Professor in the Department of Biology at the College of William and Mary, part of the Faculty of Arts & Sciences. His research focuses on the molecular mechanisms of protein modifiers, particularly SUMO and ubiquitin, in yeast and mammalian systems, with an emphasis on protein degradation and cellular stress response. Education: B.A. in Biology, The Johns Hopkins University M.A. in Biotechnology, The Johns Hopkins University Ph.D. in Biochemistry, Cellular and Molecular Biology (BCMB), The Johns Hopkins University School of Medicine His research interests lie in molecular and cellular biology, specifically post-translational modifications and protein homeostasis. His lab investigates how SUMO and ubiquitin pathways regulate cellular processes, contributing to fundamental understanding in cell signaling and disease mechanisms. There are no scientific awards listed in the provided information. Oliver Kerscher has been mentoring students through research in his lab and teaching courses such as Genetic Analysis and Genes, Genethics & Public Opinion. He joined William & Mary in 2006 after completing postdoctoral training at Yale University and the National Cancer Institute. He leads a research laboratory at William & Mary focused on protein modification pathways, utilizing model organisms to explore conserved cellular mechanisms.

Jo Morrisمشاهده پروفایل

استاد

• Cancer Genetics
• DNA Repair
• Post-translational Modifications
• +۵ مورد دیگر

Jo Morris is a Professor of Molecular Genetics at the University of Birmingham, UK. Her career spans roles including Reader in Cancer Genetics (2013–present), Senior Lecturer (2010–2013), and Fellowships at King’s College London (2007–2010, 2003–2006). She leads research at the intersection of cancer genetics, DNA repair, and post-translational modifications. Doctor of Philosophy, University of London (1999) Bachelor of Arts, University of York (1995) Research Focus: Morris's work explores how ubiquitin and SUMO pathways govern DNA damage responses, particularly in BRCA1-related breast and ovarian cancers. Her 2004 discovery of ubiquitin conjugation at double-strand breaks (108 citations) and subsequent studies on SUMO regulation of BRCA1 activity (Nature 2009) have shaped the field. Current projects include investigating SUMO activating enzymes and replication fork stability (grants from Cancer Research UK, Wellcome Trust, and Breast Cancer Campaign). Article Trends: Over 15 recent publications emphasize DNA repair mechanisms, synthetic lethality, and post-translational modifications. Key subfields include BRCA1/53BP1 interactions, SUMO/deubiquitinating enzymes (POH1, USP50), SENP7 chromatin regulation, and implications for cancer therapy. Scientific Awards: Breast Cancer Campaign Team of the Year 2009 Birmingham Founders Award 2017 SUMO in Double-Strand Break Repair Fellowship 2017 Grants & Collaborations: £1.4M Cancer Research UK grant (2015–2019) on ubiquitin in cancer £454.5K Breast Cancer Campaign Fellowship (2007–2011) Collaborations with Aga Gambus (MRC Fellow), CRUK Centre studentships, and international institutions (Queens University Belfast, University of Sydney).

Ben Haleمشاهده پروفایل

استاد

• Medical Virology
• Immunology
• Interferon Signaling
• +۳ مورد دیگر

Ben Hale is a Full Professor of Medical Virology at the Institute of Medical Virology , University of Zurich, Switzerland. Previously, he held academic positions at the University of Zurich (2015-2025) and the University of Glasgow (2011-2014). Education : PhD in Molecular Virology (2008, University of St Andrews); BSc (Hons) in Cell Biology & Pathology (2004, University of St Andrews). Research Focus : The Hale group investigates molecular mechanisms of the interferon system, interferon deficiencies in viral diseases, and host-virus interactions using multi-omics, molecular virology, and clinical cohort studies. His research spans Molecular Biology , Virology , and Immunology , with a particular emphasis on how viral proteins (e.g., influenza NS1, paramyxovirus V) manipulate interferon signaling and the role of autoantibodies in immunodeficiency. Recent work includes developing AIR cells for interferon detection and proximity proteomics of interferon signaling. Scientific Awards : 2013 - ERC Starting Grant 2012 - Wellcome Trust/Royal Society Sir Henry Dale Fellowship Hale's lab has trained doctoral students Florence Kwaschik and Chau Tran , and collaborates with clinicians and researchers globally. Funding comes from the Swiss National Science Foundation (SNF), Novartis Foundation, Hartmann Müller Foundation, and previous grants from the ERC and UK Medical Research Council (MRC).

• Cellular and Molecular Oncology
• Leukemia Research
• Anticancer Therapeutics
• +۶ مورد دیگر

Hugues de Thé holds the Chair of Cellular and Molecular Oncology at Collège de France, where he leads research on the cellular and molecular mechanisms underlying cancer treatment responses. His work bridges fundamental biology with clinical applications, focusing on how anticancer therapies work at the molecular level. Chair of Cellular and Molecular Oncology at Collège de France Researcher at Interdisciplinary Center for Research in Biology (CIRB) Principal investigator in leukemia and cancer therapeutics research Professor de Thé's research interests span several interconnected domains in cancer biology. His primary focus is on understanding the molecular mechanisms of anticancer treatments, particularly in a rare form of leukemia characterized by a simple genetic anomaly. He has pioneered research on how retinoic acid and arsenic oxide target and degrade the protein responsible for this leukemia. His work has expanded to investigate PML nuclear bodies, nuclear subdomains associated with stress response and cellular senescence that play crucial roles in therapeutic responses. More recently, his laboratory has explored how other anticancer agents like Actinomycin D and Doxorubicin function, discovering their unexpected modulation by PML proteins. His research integrates cell biology, molecular biology, and translational approaches to understand cancer treatment mechanisms. Professor de Thé has organized and participated in numerous significant conferences and symposia, including the François Jacob Day series and the THEMA Saint-Louis Institute symposium on leukemia. His teaching program consistently focuses on advancing understanding of cancer biology, with recent and upcoming courses examining oxidative stress and anti-tumor therapeutics, transcriptional regulation in cancer, and therapeutic response mechanisms. His academic contributions reflect a sustained commitment to advancing both the theoretical foundations and practical applications of cancer research. Throughout his career, Professor de Thé has maintained an active research program while contributing significantly to academic discourse through his teaching and conference organization. His work on PML nuclear bodies and SUMO conjugation has provided essential insights into post-translational modification pathways relevant to cancer treatment. His laboratory continues to investigate the cellular response to various anticancer agents, seeking to optimize therapeutic approaches through detailed molecular understanding.

Dirk Remusمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Genetics
• Genome Stability
• +۴ مورد دیگر

Dirk Remus, PhD , is a molecular biologist at the Molecular Biology Program of Memorial Sloan Kettering Cancer Center (MSKCC) and affiliated with the Gerstner Sloan Kettering Graduate School of Biomedical Sciences . His research focuses on the mechanistic basis of eukaryotic chromosome replication, particularly how replication stress and DNA modifications like SUMOylation impact genome stability and cancer progression. Education: PhD, University of California, Berkeley Key research areas include DNA replication , genomic instability , replication stress , and therapeutic target identification in cancer . Articles from 2022-2025 highlight structural and biochemical investigations into replication complexes, G-quadruplex interactions, and SUMO-mediated regulation of origin licensing. Scientific Awards: Louis V. Gerstner, Jr. Young Investigator Award (2011) EMBO Long-Term Fellowship (2006) Collaborations and grants include NIH funding (R01 GM074223, R35 GM141641) and industry partnerships with companies like AbCellera Biologics and Moderna. His work bridges fundamental replication biology with translational cancer research.

Karin Hochrainerمشاهده پروفایل

استادیار

• Neurovascular Biology
• Stroke Pathophysiology
• Protein Ubiquitination
• +۳ مورد دیگر

Karin Hochrainer is an Assistant Professor of Neuroscience at the Brain and Mind Research Institute, Weill Cornell Medical College (Cornell University), with a focus on neurovascular dysfunction and protein modifications in stroke and neurodegenerative disorders. Her career since 2012 has centered on molecular mechanisms underlying cerebral ischemia, tau pathology, and blood-brain barrier integrity. Ph.D. in Biochemistry, Medical University of Vienna (Austria), 2005 M.S. in Molecular Biology, University of Vienna (Austria), 2000 Her research spans neurovascular biology , ubiquitination in stroke , and tauopathy mechanisms . Key themes include: Post-ischemic protein ubiquitination and kinase regulation Tau protein's role in neurovascular dysfunction Dietary salt-induced cognitive decline via tau phosphorylation Ubiquitin-ligase interactions (e.g., HERC3, NF-κB) Cerebral ischemia-reperfusion injury Recent publications highlight trends in stroke proteomics , ubiquitin-SUMO crosstalk , and translational neuroprotection . Her work bridges molecular signaling (e.g., CaMKII, NF-κB) with clinical implications for Alzheimer's disease and stroke therapy. Grants include: Cure Alzheimer’s Fund (2023–2026): Tau-induced postsynaptic dysfunction National Institute of Neurological Disorders & Stroke (2023–2027): Co-investigator role

Jyoti R. Misraمشاهده پروفایل

استادیار

• Cancer Biology
• Developmental Biology
• Signal Transduction
• +۳ مورد دیگر

Jyoti R. Misra, Ph.D., serves as Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University. Her research centers on the Hippo signaling pathway's dual role in embryonic organ size regulation and cancer pathogenesis, utilizing Drosophila melanogaster as a primary model system for developmental studies while investigating YAP/TAZ dysregulation across multiple human malignancies. Her work examines how cell adhesion molecules Dachsous and Fat regulate Hippo-mediated growth control during development, and how oncogenic YAP/TAZ coactivators drive proliferation, metastasis, and therapy resistance in cancers including mesothelioma, uveal melanoma, and carcinomas of the lung, liver, breast, and thyroid. The Misra Lab employs integrated approaches spanning computational chemistry, chemical biology, and cell biology to develop targeted inhibitors against YAP activity, with recent emphasis on TEAD transcription factors and protein degradation strategies. Analysis of her publication record (2008-2024) reveals an evolving trajectory from foundational Drosophila genetics toward translational cancer therapeutics. Key themes include structural characterization of pathway components, assay development for inhibitor screening, and innovative strategies targeting TEAD palmitoylation and YAP-TEAD interactions. This progression demonstrates consistent focus on Hippo pathway mechanics with increasing clinical relevance in oncology. Scientific Awards: No awards were documented in the provided materials. Research is supported by National Institutes of Health funding. While specific advisees aren't listed, the Misra Lab maintains active investigations bridging developmental biology and cancer pharmacology, with particular emphasis on overcoming chemo- and immunotherapy resistance through YAP pathway modulation. The laboratory operates within Stony Brook's Department of Pharmacological Sciences, maintaining dual research tracks in Drosophila -based developmental genetics and mammalian cancer models, with current efforts concentrated on small-molecule degraders and allosteric modulators for clinical translation.

Al Coureyمشاهده پروفایل

استاد

• Developmental Biology
• Transcriptional Regulation
• Molecular Biology
• +۸ مورد دیگر

Al Courey is a Professor of Biochemistry at the University of California, Los Angeles (UCLA) and serves as the Associate Dean for Inclusive Excellence. His research focuses on the molecular basis of development using Drosophila as a model system, integrating biochemical and genetic approaches to study transcriptional regulation, Sumo-conjugation, and their implications for human health. Bachelor of Arts and Bachelor of Music from Oberlin College PhD in Biochemistry from Harvard University Courey's work explores how transcription factors like Dorsal establish embryonic polarity through gradient formation and signal transduction cascades. His lab investigates the roles of Groucho as a corepressor in chromatin remodeling and the function of SUMOylation in nuclear import, immune response, and stress adaptation. Recent publications highlight interdisciplinary applications of SUMO as a solubility tag and its interactions with histone deacetylases. His research spans developmental biology, molecular genetics, and protein biochemistry, with implications for understanding human diseases linked to transcriptional dysregulation. Scientific Awards : American Cancer Society Post-doctoral Fellowship, Searle Scholars Award, Basil O'Connor Starter Scholar Research Award Courey has mentored numerous graduate and undergraduate researchers, including current students Joseph Cao, Michael Chambers, and Pak Ning Kwong. His lab's collaborative environment has produced significant insights into gene regulatory networks and epigenetic mechanisms.

• Chromosome biology
• Cytogenetics
• Plant genetics
• +۵ مورد دیگر

Dr. Veit Schubert is a Senior Scientist at the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) in Gatersleben, Germany, with continuous employment since March 2002. Holding the academic qualification PD Dr. habil., he operates as a research-focused academic within Germany's premier plant genomics institute. His research spans chromosome biology , centromere dynamics , holocentric systems , and duckweed genomics , utilizing advanced cytogenetic techniques to study chromosome segregation, heterochromatin organization, and meiotic mechanisms. Recent work reveals evolutionary transitions between mono- and holocentric chromosomes through satellite DNA analysis. Analysis of his 15 most recent publications (2024-2025) shows dominant focus on centromere evolution (6 articles), duckweed genomics (5 articles), and meiotic mechanisms (4 articles), with methodologies emphasizing super-resolution microscopy, genome assembly, and epigenetic profiling. Scientific contributions include: Discovery of repeat-based holocentromeres in woodrush ( Luzula sylvatica ) Mechanistic insights into KNL2 regulation in centromere integrity Characterization of triploid hybridization in duckweed complexes Evolutionary models for holocentric chromosome emergence Dr. Schubert maintains active international collaborations across Europe and North America, with frequent co-authorships indicating strong grant support. His work bridges fundamental chromosome biology with practical applications in plant genome evolution and stability.

• Molecular Biology
• DNA Repair
• Protein Ubiquitination
• +۲ مورد دیگر

Leena Ackermann is a Guest Researcher at the Novo Nordisk Foundation Center for Protein Research within the Faculty of Health and Medical Sciences at the University of Copenhagen. She conducts research as part of the Mailand Group, focusing on molecular mechanisms of DNA damage response and repair. Her primary research interests include: Molecular mechanisms of DNA repair pathways Protein modification systems (ubiquitination and SUMOylation) Cellular stress responses and genome stability Cancer biology and therapeutic applications Dr. Ackermann's publication record from 2011-2024 reveals a consistent research trajectory examining how specialized protein modification systems regulate DNA repair processes. Her work has increasingly focused on the interplay between SUMOylation and ubiquitination in managing cellular stress and maintaining genome integrity, with significant implications for understanding cancer biology and developing novel therapeutic approaches. Her research within the Mailand Group has resulted in multiple high-impact publications in journals such as Nature Structural and Molecular Biology and EMBO Journal, demonstrating the significance of her contributions to the field of molecular biology and DNA repair mechanisms.

• DNA Repair
• Molecular Biology
• Biochemistry
• +۴ مورد دیگر

Stanley Mauldin serves as a Professor in the Department of Biology within the School of Arts & Sciences, specializing in molecular mechanisms of genomic integrity maintenance. His research program investigates DNA repair pathways with emphasis on interstrand crosslink resolution using Dictyostelium discoideum as a genetic model. Key focus areas include the roles of ubiquitin conjugation (via RAD18/RAD6 complexes), SUMOylation (through MMS21), and NEDD8 modification in DNA damage response systems. His laboratory has conducted molecular and biochemical characterization of DNA Polymerase Zeta, contributing to understanding translesion synthesis mechanisms in eukaryotic cells.