معرفی
Karin Hochrainer is an Assistant Professor of Neuroscience at the Brain and Mind Research Institute, Weill Cornell Medical College (Cornell University), with a focus on neurovascular dysfunction and protein modifications in stroke and neurodegenerative disorders. Her career since 2012 has centered on molecular mechanisms underlying cerebral ischemia, tau pathology, and blood-brain barrier integrity.
- Ph.D. in Biochemistry, Medical University of Vienna (Austria), 2005
- M.S. in Molecular Biology, University of Vienna (Austria), 2000
Her research spans neurovascular biology, ubiquitination in stroke, and tauopathy mechanisms. Key themes include:
- Post-ischemic protein ubiquitination and kinase regulation
- Tau protein's role in neurovascular dysfunction
- Dietary salt-induced cognitive decline via tau phosphorylation
- Ubiquitin-ligase interactions (e.g., HERC3, NF-κB)
- Cerebral ischemia-reperfusion injury
Recent publications highlight trends in stroke proteomics, ubiquitin-SUMO crosstalk, and translational neuroprotection. Her work bridges molecular signaling (e.g., CaMKII, NF-κB) with clinical implications for Alzheimer's disease and stroke therapy.
Grants include:
- Cure Alzheimer’s Fund (2023–2026): Tau-induced postsynaptic dysfunction
- National Institute of Neurological Disorders & Stroke (2023–2027): Co-investigator role
