معرفی
Kevin D. Sarge, PhD, is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, with a joint affiliation in the Toxicology Program. His research bridges molecular mechanisms of disease and epigenetic regulation, focusing on post-translational modifications and gene expression memory.
Research Interests: Dr. Sarge's work centers on two major areas: (1) Protein sumoylation and its role in diseases such as cardiomyopathy and Alzheimer’s, where he discovered that sumoylation of lamin A and amyloid precursor protein (APP) regulates their function and localization; and (2) Gene bookmarking, an epigenetic process ensuring the inheritance of gene expression states through mitosis, involving HSF2 and TATA-binding protein (TBP).
Publication Trends: His recent work (2005–2009) reveals a strong focus on sumoylation, stress response, and epigenetic mechanisms. Publications in journals like Nature Cell Biology and Science highlight his contributions to understanding how transcription factors and chromatin regulators maintain gene expression fidelity during cell division.
- Scientific Awards: No awards mentioned in the provided text.
Advising and Grants: Dr. Sarge has mentored numerous researchers, including H. Xing, D.C. Wilkerson, and Y. Zhang, many of whom are co-authors on key publications. His lab has secured significant research funding, as evidenced by sustained productivity and high-impact publications, though specific grants are not listed. His work has implications for therapeutic development in neurodegenerative and cardiac diseases.
Labs and Teams: His laboratory investigates molecular mechanisms using biochemical, genetic, and cell biological approaches, focusing on protein modifications and epigenetic memory. The team collaborates across disciplines, including toxicology and reproductive biology, reflecting the integrative nature of modern molecular biochemistry.
