معرفی
Alexander M. Mazo is a Professor in the Department of Biochemistry & Molecular Biology at Thomas Jefferson University's College of Life Sciences. His research focuses on epigenetic mechanisms, particularly how gene expression patterns are maintained during DNA replication and mitosis, and how alterations in these processes contribute to diseases such as cancer and fibrosis.
Dr. Mazo's research centers on epigenetics, specifically the role of chromatin structure and DNA modifications in maintaining gene expression patterns. His lab investigates how epigenetic bookmarks are maintained during DNA replication and mitosis, and how alterations lead to diseases including cancer and fibrosis. Key areas include the coordination of transcription and replication, nascent chromatin dynamics during cell differentiation, and the development of epigenetic-based therapies for cancer and fibrotic diseases.
His recent publications explore epigenetic mechanisms in disease contexts. Notable works include studies on the coordination of transcription and replication, RNA polymerase II activity during DNA replication, and the role of chromatin structure in fibrosis and leukemia. His research bridges molecular biology and clinical applications, with a focus on developing novel therapeutic strategies targeting epigenetic marks in cancer and fibrotic disorders.
Dr. Mazo leads an active research laboratory investigating epigenetic mechanisms. While specific grant details are not provided, his work has significant implications for understanding and treating cancer and fibrosis, suggesting ongoing research funding in these areas.
Dr. Mazo directs a research laboratory focused on epigenetic bookmarking and chromatin dynamics. His team employs advanced techniques to study the association of RNA and proteins with nascent DNA, aiming to uncover new models for epigenetic inheritance and develop therapeutic interventions for diseases like cancer and fibrosis.
