جست‌وجوی استاد و پژوهشگر

• Organic Chemistry
• Medicinal Chemistry
• Synthetic Organic Chemistry
• +۳ مورد دیگر

Martin Di Grandi serves as Associate Professor of Chemistry at Fordham University with dual appointments at both the Lincoln Center (808C) and Rose Hill (JMH 538) campuses. His research program bridges synthetic organic chemistry with therapeutic applications, focusing on novel methodologies and biologically relevant molecular systems. Education Ph.D., March 1990, New York University B.Sc., May 1984, Fordham University His research demonstrates exceptional breadth across three interconnected domains: antiviral development targeting herpesviruses through thiourea-based portal protein inhibitors, natural product synthesis exemplified by tetrahydroisoquinoline methodologies for pancratistatin core construction, and fundamental reaction mechanisms including diastereoselective reductions of α-hydroxyketones. This work consistently emphasizes therapeutic relevance while advancing synthetic technique. Analysis of his 2009-2019 publications reveals a strategic evolution from target-specific inhibitor design (B-Raf, HIV RNase H) toward broader methodological contributions in cyclization chemistry and sustainable synthesis. The consistent thread is molecular innovation directed at biological challenges, particularly in oncology and virology, with increasing emphasis on mechanistic understanding and educational applications. No information regarding scientific awards is provided in the source material. His patent portfolio indicates significant translational impact, though specific advising relationships and grant funding details remain undocumented in the available text.

• Climate Modeling
• Urban Planning
• Water Resource Management
• +۳ مورد دیگر

Jeeno Soa George is a researcher at the Indian Institute of Technology Kharagpur , specializing in Climate-Land-Energy-Water Modelling . With a PhD in Architecture and Regional Planning, her career spans academia and industry collaboration in India. Education: PhD from IIT Kharagpur Current Role: Research Associate in climate modeling Industry Experience: IPE Global Pvt. Ltd., electric mobility startups, civic tech projects Research Interests include: Climate disaster resilience and data ecosystems Urban greenness and street-terrain network analysis GIS applications in water management and master planning Interdisciplinary approaches to energy-land-water interactions Publication Trends highlight her focus on integrating climate science with urban planning, particularly in developing GIS-driven models for drought analysis, infrastructure resilience, and terrain-sensitive city design. Her work spans diverse scales from local water systems in Marathwada to global urban network comparisons. Professional Contributions extend beyond academia, including: ADB-funded water sanitation projects Electric mobility startups with battery swap technology GIS-based master planning and metro daylight studies

Katherine Alexanderمشاهده پروفایل

استادیار

• Gene regulation
• Nuclear speckles
• Chromatin organization
• +۴ مورد دیگر

Katherine Alexander is an Assistant Professor at Cold Spring Harbor Laboratory (CSHL) and a member of the CSHL Cancer Center. She joined the institution in August 2024 after completing her Ph.D. at Cornell University in 2016 and her B.A. at Carleton College in 2010. Dr. Alexander leads the Alexander Laboratory, which focuses on understanding the fundamental mechanisms of gene regulation as mediated by nuclear speckles. Dr. Alexander's research centers on nuclear speckles, which are prominent gene-activating substructures within cell nuclei. Her work investigates two major levels of gene regulation by nuclear speckles: 1) regulation of what DNA is positioned next to speckles (mediated by DNA-binding transcription factors), and 2) regulation of speckle state, which varies in human cancer and correlates with survival and drug responsiveness. She seeks to build textbook models for nuclear-speckle-based gene regulation and apply these paradigms to improve disease outcomes and patient quality-of-life. Analysis of Dr. Alexander's recent publications reveals a strong focus on the relationship between nuclear speckles and cancer biology, particularly kidney cancer. Her work demonstrates how nuclear organization influences gene expression programs in both normal and pathogenic processes, with significant implications for understanding cancer progression and developing new therapeutic approaches. Her research bridges molecular biology, cell biology, and cancer research, creating a unique interdisciplinary approach to studying gene regulation. Dr. Alexander's work has received significant media attention, including features in CSHL's "At the Lab" series and "Cocktails & Chromosomes" segments, where she discusses the potential implications of nuclear speckle research for cancer care. Her research on nuclear speckles influencing kidney cancer patient outcomes was highlighted in January 2025 as "A speckle of hope for cancer patients."

Eric Barklisمشاهده پروفایل

استاد

• Virology
• HIV-1 Assembly
• Viral Matrix Proteins
• +۲ مورد دیگر

Eric Barklis is Professor at OHSU's Vollum Institute and directs the Electron Microscope Core Facility. His lab studies retroviral assembly mechanisms and host-pathogen interactions using structural and biochemical approaches. Research examines HIV-1 matrix protein functions, coronavirus entry inhibition, and lipid metabolism in viral replication. Recent work developed neutralizing nanobodies against SARS-CoV-2 variants. Publications characterize viral protein interactions with host membranes and nucleic acids. The lab collaborates extensively on antiviral development and lentiviral vector engineering.

Julian J.-L. Chenمشاهده پروفایل

استاد

• RNA Biochemistry
• Telomere Biology
• Ribonucleoprotein Complexes
• +۶ مورد دیگر

Julian J.-L. Chen is a Professor at Arizona State University's School of Molecular Sciences and a core faculty member at the Biodesign Center for Mechanisms of Evolution . His work bridges RNA biochemistry, telomere biology, and molecular evolution, with implications for cancer and aging. PhD in Molecular Biology/Biochemistry from Indiana University Postdoctoral training at Johns Hopkins University Faculty at ASU since 2004 Research focuses on telomerase ribonucleoprotein complexes , exploring their: Structural organization and functional domains Biogenesis pathways from protein-coding precursors Evolution across eukaryotes (insects, plants, fungi) Role in chromosome stability and disease Regulation in stem cells and tumors Molecular mechanisms of RNA-protein interactions Key publications cover telomerase RNA evolution (2025), structural studies (2023), and plant telomere biology (2022). Research is funded by NIH and NSF grants. Active projects include: Molecular Mechanism of Telomerase Action (NIH/NIGMS) Collaborative Research: Telomerase Structure in Photosynthetic Eukaryotes (NSF) Biogenesis of mRNA-Derived Telomerase lncRNA (NIH) He teaches Principles of Biochemistry (BCH 361) and mentors undergraduate/graduate research projects.

Viranga Tillekeratneمشاهده پروفایل

استاد

• Drug Design
• Natural Product Synthesis
• Anticancer Therapeutics
• +۴ مورد دیگر

Viranga Tillekeratne is a Professor at the University of Toledo's College of Pharmacy and Pharmaceutical Sciences, specializing in the Department of Medicinal and Biological Chemistry. His lab pioneers the development of small-molecule probes for drug design, focusing on natural product derivatives (e.g., epothilones and largazole) and redox-active electrocatalysts for electrochemical sensors. Research emphasizes anticancer agents, neurodegenerative therapeutics, and epigenetic modulators targeting histone deacetylases (HDACs). Education includes a D.Phil. from the University of Oxford (1975) and a B.S. from the University of Colombo, Sri Lanka (1969). Research Interests: Tillekeratne's work spans three core areas: Drug Design & Natural Products : Structural optimization of bioactive compounds (e.g., largazole analogues for HDAC inhibition, epothilones for microtubule targeting). Electrochemical Sensors : Development of quinone-capped electrocatalysts for thiol/neurotoxin detection. Mechanistic Therapeutics : Ferroptosis induction, neuroinflammation suppression, and isoform-selective enzyme inhibitors. Publication Trends (2018–2024): Recent articles highlight ferroptosis induction, HDAC inhibitor hybrids, microtubule-targeting agents, and neuroprotective strategies. Dominant themes include covalent probe design, structure-activity relationships, and translational applications in cancer/neurodegeneration. Labs & Collaborations: Leads an active research group at UToledo and collaborates with Dr. Jon R. Kirchhoff (Chemistry) on sensor development. Patents cover cofilin inhibitors for neuroinflammation and imidazole-based anticancer agents.

Nick Barlowمشاهده پروفایل

پژوهشگر ارشد

• Peptide Chemistry
• Small Molecule Drug Discovery
• Drug Targets (Peptidases, Proteases, GPCRs)
• +۴ مورد دیگر

Nick Barlow is a Research Fellow in Medicinal Chemistry at Monash University, leading a drug discovery group focused on peptide chemistry and small molecule drug development. His work bridges fundamental and translational research, targeting drug mechanisms involving peptidases, proteases, and GPCRs. He currently oversees diabetes research programs investigating melanocortin receptors' role in glucose control and has developed technologies enhancing membrane permeability of chemical tools and bioactive peptides. Barlow's team has advanced three peptide drug candidates to preclinical stages over the past five years, establishing startup companies for commercialization. His research contributes to UN Sustainable Development Goals addressing good health and well-being (SDG 3). Recent collaborations include projects on HIV-1 reverse transcriptase inhibition and cardiovascular disease mechanisms. Key projects include the 2021-2023 'Lead optimisation of novel inhibitors of IRAP' funded by Australian Research Council. His publications span peptide design, enzyme inhibition, and immunomodulatory mechanisms, reflecting expertise in drug delivery systems and fragment-based approaches.

Jeffrey DeStefanoمشاهده پروفایل

استاد

• Virology
• Molecular Biology
• Aptamer Technology
• +۳ مورد دیگر

Jeffrey DeStefano is a Professor in the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park. He holds a Ph.D. in Biochemistry from the University of Connecticut (1990). His research focuses on HIV and poliovirus replication mechanisms, aptamer development for antiviral applications, and nucleic acid-based diagnostics. He leads the DeStefano Lab, which explores viral enzyme inhibition, SARS-CoV-2 countermeasures, and XNA aptamer technologies. He teaches General Virology (BSCI437) and Graduate Virology (CBMG688K), and is affiliated with the Molecular & Cellular Biology (MOCB) graduate program. Research highlights include structural studies of HIV-1 Pol polyprotein, inhibition of SARS-CoV-2 using FANA aptamers, and development of high-fidelity aptamer-based detection assays. His work integrates virology, structural biology, and biotechnology to advance antiviral strategies and diagnostic tools. Recent projects involve optimizing Xeno-nucleic acid (XNA) aptamers for targeting viral proteins, such as the SARS-CoV-2 spike receptor-binding domain, and understanding magnesium effects on reverse transcriptase fidelity. Collaborations include studies on HIV integrase binding and viral polyprotein maturation mechanisms. No scientific awards are explicitly listed, though his contributions to antiviral research are notable. His lab’s work has implications for pandemic response and chronic viral infections like HIV/AIDS.

Serdal Kirmizialtinمشاهده پروفایل

دانشیار

• Physical Chemistry
• Computational Science
• Soft Matter
• +۵ مورد دیگر

Serdal Kirmizialtin is an Associate Professor of Chemistry at New York University Abu Dhabi (NYUAD), affiliated with the Faculty of Arts and Science. He holds a PhD in Physical Chemistry from the University of Texas at Austin (2007) and has held research positions at UT-Austin (postdoc/research associate), Los Alamos National Laboratories (2013–2015), and NYUAD since 2015. His research focuses on molecular machines, RNA folding, and computational methods integrating experiments like cryo-EM and SAXS with molecular dynamics simulations. Education: PhD in Physical Chemistry, University of Texas at Austin (2007) Postdoctoral Fellow and Research Associate at UT-Austin (2007–2013) Associate Research Scientist at Los Alamos National Laboratories (2013–2015) Research Interests: Computational modeling of biomolecular systems Mechanisms of molecular machines (e.g., HIV reverse transcriptase) RNA folding dynamics and ion interactions Development of novel computational tools (e.g., HB-CUFIX force field) Material science applications in environmental remediation Key Research Directions: Integrating experimental data (SAXS, cryo-EM) with simulations Understanding conformational transitions in enzymes Designing porous materials for pollutant capture Labs/Teams: Principal Investigator of the Kirmizialtin Lab at NYUAD, focusing on computational and theoretical approaches at the chemistry-biology-materials interface.

• Genetic Mutations
• Schizophrenia Research
• Somatic Mosaicism
• +۳ مورد دیگر

John Moran is a Professor in the Department of Human Genetics at the University of Michigan , focusing on genetic mutations , somatic mosaicism , and neurodevelopmental disorders . His work bridges molecular biology and neurogenetics , with key contributions to understanding schizophrenia origins in prenatal brain development. Key Collaborations : Icahn School of Medicine at Mount Sinai, Harvard Medical School, Boston Children's Hospital Research Themes : LINE-1 retrotransposons, Alu elements, somatic copy-number variants (sCNVs), and their role in disease etiology Research Focus : Dr. Moran’s research explores how non-inherited genetic mutations during embryonic development contribute to schizophrenia. He has pioneered methods like DeepMosaic for variant detection and analyzed single-cell genomic data to map mutation patterns in neurons. His work highlights NRXN1 and ABCB11 as disrupted genes in schizophrenia cases. Publication Trends : Recent articles emphasize somatic mosaicism in neuropsychiatric diseases , L1 retrotransposition in human cells, and genomic data resources for the Brain Somatic Mosaicism Network. Collaborations with institutions like Mass General Psychiatry and Physician's Weekly reflect interdisciplinary impact. Key Grants & Programs : Involved in the Allen Discovery Center and led projects like Comprehensive Genomic Datasets in BSMN . His team’s pandemic-era research on single-neuron genomes revealed non-random CNV patterns in neurotypical individuals. Labs & Teams : Leads a lab at the University of Michigan, collaborating with researchers such as Chris Walsh , Ryan Mills , and Edward Maury . His work intersects with the Brain Somatic Mosaicism Network , advancing tools for ultra-deep genome sequencing and mosaicism analysis .

Yanick Crowمشاهده پروفایل

پژوهشگر

• Neurogenetics
• Neuroinflammation
• Autoinflammatory Disorders
• +۳ مورد دیگر

Yanick Crow is the Head of the Neurogenetics and Neuroinflammation research team, focusing on understanding genetic and immunological mechanisms underlying neuroinflammatory disorders. His work has centered on Aicardi-Goutières syndrome (AGS) and type I interferonopathies, linking monogenic mutations to autoinflammatory pathways. The team investigates nucleic acid-driven inflammation, interferon signaling defects, and potential therapies targeting these mechanisms. Research interests include the interplay between genetic mutations, interferonopathies, and autoimmune diseases such as systemic lupus erythematosus. Collaborations with clinicians and immunologists allow translational studies connecting basic science to clinical applications, with a focus on developing novel treatments for rare and complex immune disorders. Key contributions involve identifying genetic drivers of autoimmunity and proposing JAK inhibitors as therapeutic candidates in interferonopathies. Team members include clinicians (PU-PH), postdoctoral researchers, and PhD students, reflecting multidisciplinary expertise. Publications highlight advancements in understanding cGAS-STING pathway dysregulation, COPA mutations, and mitochondrial nucleic acid roles in pathogenic inflammation. Ongoing work explores molecular mechanisms and clinical trials for interventions in neuroimmunological conditions.

Yida Anمشاهده پروفایل

مدرس

• Music Performance
• Violin
• Chamber Music
• +۳ مورد دیگر

Yida An is a Project Instructor at the Butler School of Music, University of Texas at Austin. He holds an Artist Diploma from Butler School of Music (studying with Brian Lewis), a Master of Music from Bard College Conservatory of Music (under Gil Shaham and Adele Anthony), and a Bachelor of Music from Central Conservatory of Music in Beijing (under Xie Haoming). His musical career includes roles as concertmaster of the Bard College Symphony Orchestra and solo performances with renowned conductors like Tan Dun and Leon Botstein. He has collaborated on major venues including Carnegie Hall and Lincoln Center, and organized solo recitals in New York. His performances span classical violin repertoire, chamber music, and orchestral collaborations, emphasizing both traditional and contemporary works. Education history includes Beijing Eastbank Academy of Music (2017-2018) and extensive touring with the Central Conservatory of Music Youth Symphony Orchestra. Notable collaborations include working with composer Joan Tower and participating in the Bard Music Festival. His musical contributions highlight technical mastery and artistic interpretation across diverse genres. While primarily focused on performance, his academic affiliations also involve interdisciplinary research in RNA biology and molecular mechanisms, as evidenced by publications in high-impact journals. These articles explore topics like group II intron mobility, exosome-mediated RNA sorting, and therapeutic applications of RNA sequencing technologies, showcasing a dual expertise in music and life sciences.

André Beaucheminمشاهده پروفایل

استاد

• Synthetic Organic Chemistry
• Catalysis
• Amination Methods
• +۳ مورد دیگر

André Beauchemin is a Full Professor in the Department of Chemistry and Biomolecular Sciences at the University of Ottawa and currently serves as the Vice-Provost, Graduate and Postdoctoral Studies. He holds a B.Sc. from Université Laval (1996) and a Ph.D. from Université de Montréal (2001), followed by postdoctoral research at Harvard University. His research focuses on the development of new synthetic methodologies, particularly in the areas of amination reactions, catalysis, and the synthesis of nitrogen-containing molecules with applications in medicinal chemistry. Key roles include leadership in academic administration, including former Vice-Dean for Graduate Studies and Entrepreneurship in the Faculty of Science. His awards include the Governor General’s Gold Medal (2002), Boehringer Ingelheim Research Excellence Award (2015), and multiple grants from NSERC and industry partnerships. Research interests emphasize efficient carbon-nitrogen bond formation, with applications in drug discovery. His lab has produced over 75 publications, including work on hydroamination reactions, masked isocyanate reagents, and heterocyclic chemistry. Collaborations span medicinal chemistry and virology, targeting antiviral agents and cancer therapies. He has mentored numerous graduate students and postdoctoral researchers, many of whom have pursued academic and industrial careers. His lab’s current projects include developing amide linchpin reagents and exploring redox-enabled hydroamination strategies.

• Virology
• HIV Drug Resistance
• Viral Evolution
• +۱ مورد دیگر

Daniele Armenia is an Associate Professor of Microbiology and Clinical Microbiology at Saint Camillus International University of Health Sciences in Rome. He holds a graduation in Pharmaceutical Biotechnology and a PhD in Medical Microbiology and Immunology from the University of Rome 'Tor Vergata'. His research focuses on virology, particularly HIV, HBV, and HCV, examining drug resistance mechanisms, viral fitness, evolution, and genotypic/phenotypic analyses. Armenia has contributed to numerous international publications and conferences. His research interests span virology, HIV drug resistance, viral evolution, and clinical microbiology. Recent work emphasizes optimizing antiretroviral therapies and understanding resistance pathways in diverse populations. Armenia's recent publications (2022-2025) predominantly explore HIV treatment optimization, drug resistance surveillance, and novel therapeutic strategies. Trends indicate a focus on pediatric/adolescent cohorts, next-generation sequencing applications, and real-world data from registries like PRESTIGIO.

• Virology
• Chikungunya Virus Research
• HIV-1 Research
• +۵ مورد دیگر

Katleen Vereecken is a virology researcher at the Institute of Tropical Medicine Antwerp (ITG) in Belgium with an extensive publication record spanning from 1995 to 2023. She has contributed to 33 research outputs with primary focus on viral pathogens including HIV-1, Chikungunya virus, and SARS-CoV-2. Her work is consistently published in reputable scientific journals with recent contributions appearing in Antibiotics-Basel , Viruses , Vaccines , and Frontiers in Microbiology . Dr. Vereecken's research spans multiple critical areas of virology, with particular expertise in viral pathogenesis and host-pathogen interactions. Her fingerprint analysis reveals strong concentrations in HIV-1 research (100%), Chikungunya virus studies (90%), Reverse Transcriptase Inhibitors (57%), and Dapivirine research (47%). She also investigates non-ribosomal peptide synthases, polyketide synthases, and SARS virus mechanisms, demonstrating a broad yet specialized approach to viral research. Her recent publications demonstrate a strategic focus on emerging viral threats, with significant contributions to understanding SARS-CoV-2 variants and vaccine efficacy against Omicron, alongside continued investigation of alphaviruses like Chikungunya. Her work integrates molecular virology, cell biology, and genomic approaches to address critical questions about viral replication, adaptation, and host cell entry mechanisms. Notably, her 2022 paper on Chikungunya virus adaptation mechanisms has received significant attention with 24 Mendeley readers. While no specific awards are mentioned in the available documentation, her research impact is evident through citation metrics and reader engagement across multiple platforms including X (formerly Twitter) and academic networks like Mendeley. Her work on the Omicron variant has garnered policy citations, indicating real-world impact on public health decision-making. Dr. Vereecken maintains active collaborations with key researchers at ITG, particularly with K.K. Ariën, L. Heyndrickx, and K. Bartholomeeusen, suggesting she is embedded within a productive research team focused on viral pathogenesis and antiviral strategies. Her laboratory work appears to focus on molecular mechanisms of viral entry and replication, with particular emphasis on Chikungunya virus and related alphaviruses.