Yanick Crow

Yanick Crow is the Head of the Neurogenetics and Neuroinflammation research team, focusing on understanding genetic and immunological mechanisms underlying neuroinflammatory disorders. His work has centered on Aicardi-Goutières syndrome (AGS) and type I interferonopathies, linking monogenic mutations to autoinflammatory pathways. The team investigates nucleic acid-driven inflammation, interferon signaling defects, and potential therapies targeting these mechanisms.

Research interests include the interplay between genetic mutations, interferonopathies, and autoimmune diseases such as systemic lupus erythematosus. Collaborations with clinicians and immunologists allow translational studies connecting basic science to clinical applications, with a focus on developing novel treatments for rare and complex immune disorders.

• Key contributions involve identifying genetic drivers of autoimmunity and proposing JAK inhibitors as therapeutic candidates in interferonopathies.
• Team members include clinicians (PU-PH), postdoctoral researchers, and PhD students, reflecting multidisciplinary expertise.

Publications highlight advancements in understanding cGAS-STING pathway dysregulation, COPA mutations, and mitochondrial nucleic acid roles in pathogenic inflammation. Ongoing work explores molecular mechanisms and clinical trials for interventions in neuroimmunological conditions.