Alice Lepelley

Alice Lepelley is a researcher at Institut Pasteur in Paris working in Professor Yanick Crow's laboratory since 2018. Her work focuses on genetic causes of type I interferonopathies, investigating intracellular trafficking mechanisms and organelle functions in innate immune signaling pathways.

Her academic background includes:

• PhD in Virology (2011) from Université Pierre et Marie Curie, conducted at Institut Pasteur under Professor Olivier Schwartz, studying HIV-1 detection by plasmacytoid dendritic cells
• Postdoctoral research (2012-2018) at Columbia University's Department of Microbiology and Immunology with Professor Sankar Ghosh, examining mitochondrial homeostasis in macrophages and neurodegeneration in collaboration with the Alzheimer's Disease Research Center

Lepelley's research integrates immunology, genetics, and cell biology to unravel mechanisms of autoinflammatory diseases. Her work on STING-associated vasculopathies (SAVI), COPA syndrome, and nucleic acid sensing has revealed critical links between intracellular trafficking defects and pathological interferon signaling. She employs genetic, molecular, and cellular approaches to identify disease mechanisms with therapeutic implications for interferonopathies and related disorders.

Analysis of her publication record shows consistent focus on cGAS-STING pathway dysregulation, mitochondrial DNA-driven inflammation, and genetic variants in interferonopathies. Recent work (2024-2025) explores novel connections between PTPN1 haploinsufficiency and encephalopathy, and UNC93B1 variants in systemic lupus erythematosus, demonstrating translational impact from basic mechanisms to clinical phenotypes.

She actively contributes to Professor Crow's research team at Institut Pasteur, collaborating on investigations into the genetic architecture of innate immune disorders and participating in international studies of rare inflammatory conditions.