جست‌وجوی استاد و پژوهشگر

Nancy J. Philpمشاهده پروفایل

استاد

• Retinal Metabolism
• Monocarboxylate Transporters
• Retinal Pigment Epithelium
• +۵ مورد دیگر

Nancy J. Philp, PhD, serves as Professor in the Department of Pathology & Genomic Medicine at Thomas Jefferson University and Associate Dean for PhD & MD/PhD Programs within the Jefferson College of Life Sciences. She earned her PhD from the University of Michigan in 1995. Dr. Philp's research investigates metabolic homeostasis in the retina, specializing in monocarboxylate transporters (MCTs) and CD147 within the retinal pigment epithelium (RPE). Her laboratory employs genetic, biochemical, and imaging techniques to study how MCTs facilitate lactate transport between Müller glial cells and photoreceptors, with discoveries including MCT3's basolateral expression in RPE. Current projects examine tissue-specific trafficking of transporter proteins, MCT12's role in cataract formation, SLC16A8 regulation in aging, and tissue factor's dual functions in oxidative stress and epiretinal membrane development. As Associate Dean, she oversees graduate education programs while leading a research laboratory focused on retinal metabolism and transporter biology.

• Ophthalmology
• Biomedical Engineering
• Stem Cell Biology
• +۵ مورد دیگر

Mark S. Humayun is a University Professor at the University of Southern California (USC), holding joint appointments in the Keck School of Medicine and the Viterbi School of Engineering. He serves as Director of the USC Ginsburg Institute for Biomedical Therapeutics and Co-Director of the USC Roski Eye Institute. His expertise lies at the intersection of ophthalmology, biomedical engineering, and stem cell biology. Humayun earned his MD from Duke University and PhD from the University of North Carolina, Chapel Hill. He pioneered the Argus II retinal implant, the first FDA-approved bionic eye for restoring vision in the blind, for which he received the National Medal of Technology and Innovation (2016). His research focuses on retinal prosthetics, stem cell therapies, and non-invasive neurostimulation techniques. Key contributions include advancements in ultrasound-based vision restoration and bioengineered retinal implants. Humayun has over 300 publications and 140 patents, with awards such as the IEEE Medal for Innovations in Healthcare Technology (2020) and ARVO Fellow (2022). His work bridges clinical practice and engineering, addressing retinal degeneration and macular diseases through innovative technologies. Notable achievements include leading the development of the Argus II, which has restored partial vision to patients with retinitis pigmentosa. Current research explores next-generation implants, stem cell-derived RPE therapies, and ultrasonic stimulation for broader vision restoration. His interdisciplinary teams collaborate across engineering, computer science, and medicine to tackle complex ophthalmic challenges.

• Neurobiology
• Ophthalmology
• Physiology
• +۴ مورد دیگر

Jimmy Zhou is a Professor at Yale University School of Medicine, with joint appointments in the Departments of Cellular and Molecular Physiology and Neuroscience. His research focuses on retinal neurobiology, investigating synaptic circuits, neurotransmitter systems, and developmental mechanisms in visual processing. PhD, University of Houston (1989) MSc, University of Houston (1984) BS, Fudan University (1982) Dr. Zhou's work spans retinal physiology, direction selectivity in starburst amacrine cells, contrast processing, and the role of vGluT3 amacrine cells in retinal circuits. He explores how spontaneous retinal activity shapes visual map development and contributes to retinal degeneration models. His recent publications (2015-2023) highlight vGluT3 amacrine cell circuits, retinal wave dynamics, optogenetic techniques, and cone-rich retinal organoids. Key themes include neurotransmitter co-release, synaptic integration, and retinal disease modeling. Dr. Zhou leads research supported by NIH grants (e.g., Vision Core Grant renewal in 2022) and mentors through Yale's academic programs. His lab investigates retinal networks at the intersection of neuroscience and biomedical data science.

Jeremiah Limمشاهده پروفایل

مدرس ارشد

• Biomarkers
• Ocular imaging
• Electroretinography
• +۷ مورد دیگر

Jeremiah Lim is a Senior Lecturer at the School of Allied Health within the Department of Optometry and Vision Science at The University of Western Australia. He holds a PhD in Neuroscience from the University of Melbourne, specializing in Alzheimer’s disease ocular phenotypes, and has additional qualifications in optometry and education. His research focuses on neurodegenerative diseases (Alzheimer’s/Parkinson’s), retinal imaging , and biomarkers , with particular emphasis on translating ocular findings to broader neurological insights. Key projects include retinal hyperspectral imaging in disease models and improving eye health literacy in disadvantaged communities. Recent work emphasizes mouse models for studying neurodegeneration, electrophysiology , and gene therapy applications. Lim has authored over 25 peer-reviewed articles, with notable contributions to retinal biomarker development and clinical optometry practices. Awards: Alexander-Guelma Clinical Fellow in Neuroscience (2019), Eberhard Dodt Memorial Award (2016) Grants: Perth Eye Foundation (2024–2027), Diabetes Research Foundation of WA (2024–2025) His interdisciplinary approach bridges optometry, neuroscience, and clinical practice, aiming to advance early disease detection and patient care strategies.

Dennis O. Cleggمشاهده پروفایل

استاد

• Stem Cell Research
• Ocular Disease Therapy
• Neural Development
• +۳ مورد دیگر

Dennis O. Clegg is a Professor in the Department of Molecular, Cellular and Developmental Biology at the University of California, Santa Barbara (UCSB). He holds leadership roles, including former Chair of the Department of Molecular, Cellular and Developmental Biology (2004–2009) and Co-Director of the UCSB Center for Stem Cell Biology and Engineering. His research focuses on stem cell therapies for ocular diseases, particularly age-related macular degeneration (AMD), and neural development. Clegg earned his B.S. in Biochemistry from UC Davis and his Ph.D. in Biochemistry from UC Berkeley. He is an internationally recognized expert in regenerative medicine, with contributions to RPE differentiation and bioengineered therapies. Research interests include stem cell-derived retinal pigment epithelium (RPE) for AMD treatment, soft tissue regeneration using adipose stem cells, and the molecular basis of epigenetic memory in stem cells. His work integrates interdisciplinary collaborations with engineers, clinicians, and industry partners, such as the California Project to Cure Blindness. Key achievements include the development of RPE-based implants and synthetic scaffolds for cell transplantation. Awards include the National Eye Institute Audacious Goals Award, UCSB Distinguished Teaching Award, and Pacific Coast Business Times Champions in Health Care Award. He serves on advisory boards for the California Institute for Regenerative Medicine and NIH Center for Regenerative Medicine. Recent studies highlight HLA-mismatched RPE implant survival in AMD patients and advancements in cryopreservation for RPE cells. Education: Ph.D. Biochemistry, UC Berkeley B.S. Biochemistry, UC Davis Affiliations: UCSB Center for Stem Cell Biology and Engineering Center for BioEngineering Center for Nanomedicine Grants & Collaborations: Funded by CIRM and NIH Partnerships with USC, Caltech, and Geron, Inc.

• hearing loss
• vestibular dysfunction
• brain disorders
• +۷ مورد دیگر

Dr. Saima Riazuddin is a Professor at the University of Maryland School of Medicine, with joint appointments in Otorhinolaryngology-Head & Neck Surgery and Biochemistry & Molecular Biology. Her research focuses on the molecular genetics of inherited disorders, particularly hearing loss, vestibular dysfunction, intellectual disability, and Usher syndrome, utilizing human genetics, mouse models, and zebrafish models to identify disease-causing genes and elucidate their functional mechanisms. PhD in Molecular Genetics (University of Punjab, Pakistan) MPH in Leadership Management & Policy (University of Cincinnati) MBA in Business Administration (University of Cincinnati) Her lab investigates the genetic factors determining hearing sensitivity, pathogenic mutations affecting ear/eye structure, and molecular mechanisms of auditory/vision functions. Publications in Nature Genetics , Cell , and Molecular Psychiatry highlight discoveries in genes like TRIOBP , CIB2 , and ELMOD3 linked to deafness syndromes. Scientific accolades include the Medal of Honor from Pakistan's President. Research spans linkage analysis, functional gene characterization, and therapeutic design for genetic hearing/visual impairments.

Scott E. Countsمشاهده پروفایل

دانشیار

• Alzheimer's Disease
• Neurodegenerative Disorders
• Vascular Dementia
• +۳ مورد دیگر

Scott E. Counts is an Associate Professor of Translational Neuroscience at Michigan State University's College of Human Medicine, based at the Grand Rapids Research Center. He holds a secondary appointment in Family Medicine. His research focuses on molecular mechanisms underlying neuronal vulnerability in Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), and vascular contributions to dementia progression. His lab employs advanced techniques like laser capture microdissection, RNA sequencing, and in vivo gene transfer to study neurodegenerative pathways. Education: B.A. in History and English, Davidson College (1986) Ph.D. in Neuroscience, Emory University School of Medicine (2000) Research Interests: Dr. Counts investigates noradrenergic locus coeruleus degeneration's impact on cerebrovascular function in AD models, biomarker development, and vascular-neuronal interactions in dementia. His work bridges molecular pathology with clinical outcomes to identify disease-modifying therapies. Labs/Teams: Leads the Counts Lab, collaborating on projects involving rodent models, human tissue analysis, and neurovascular dysfunction studies. Collaborators include experts in neuroimaging (Dorrance, Lipton) and dementia biomarkers.

• Ophthalmology
• Diabetic Macular Edema
• Retinal Diseases
• +۳ مورد دیگر

Kara Gibson serves as an Assistant Clinical Professor in the Department of Anesthesia at McMaster University. Despite her primary academic appointment in anesthesia, her scholarly activity is overwhelmingly concentrated in ophthalmology, with 20+ publications (2023-2025) focused on diabetic macular edema (DME) therapeutics and retinal imaging analysis. Her research centers on evaluating faricimab—a dual Ang-2/VEGF-A inhibitor—in phase 3 clinical trials (YOSEMITE, RHINE, ALTIMETER) and real-world studies. Key interests include quantitative analysis of retinal fluid dynamics, hyperreflective foci, and hard exudates using optical coherence tomography (OCT), with emphasis on comparative efficacy against aflibercept and potential for extended dosing intervals. A secondary focus involves obstetric anesthesia, evidenced by her 2023 publication on COVID-19 ethical challenges in parturient care. Analysis of her 15 most recent publications reveals consistent themes: faricimab demonstrates superior anatomical control (reduced intraretinal fluid, hyperreflective foci, and macular leakage) and durability compared to aflibercept, enabling extended dosing (Q16-20W). Her work bridges clinical trial data with real-world applicability, predominantly published in high-impact ophthalmology journals including Investigative Ophthalmology and Visual Science and Clinical and Experimental Ophthalmology . Dr. Gibson maintains active collaborations with retinal research teams, evidenced by her contributions to multi-center trials. Her scholarly impact is reflected in Mendeley readership (27-53 readers per recent publication) and media coverage, though no formal awards or student mentorship details are documented.

Jenny Mortonمشاهده پروفایل

استاد

• Neurobiology
• Huntington's Disease Research
• Sleep Disorders
• +۳ مورد دیگر

Professor Jenny Morton is a leading neurobiologist at the University of Cambridge , Department of Physiology, Development and Neuroscience. Her research focuses on Huntington's disease using sheep and mouse models , investigating neurodegeneration , circadian rhythm disruption , and cognitive impairments . She serves as Director of Studies in Medicine and Veterinary Medicine at Newnham College. Professor of Neurobiology (Cambridge, 2018) Director of Studies, Newnham College Her lab develops translational animal models to study disease progression through neurophysiological recordings , EEG analysis , and magnetic resonance imaging . Recent work includes executive function assessment in sheep and pharmacological interventions for neurodegenerative symptoms. Key publications reveal trends in sleep disorder research , neural oscillation abnormalities , and environmental enrichment effects on Huntington's disease progression. The lab maintains a Cambridge MRI database for animal models and explores biomarker development through metabolic profiling.

• Ophthalmology
• Ocular Immunology
• Retinal Degeneration
• +۵ مورد دیگر

Andrew Dick is the Duke Elder Chair & Director of the Institute of Ophthalmology at University College London (UCL), and concurrently serves as Professor of Ophthalmology at the University of Bristol. He also co-directs the NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL-Institute of Ophthalmology. His medical training includes an MBBS and BSc (Hons) in Biochemistry from the University of London, followed by an MD from the University of Aberdeen. Research Focus Professor Dick's research centers on ocular immunology and inflammatory diseases, with seminal work on TNF-alpha's role in retinal inflammation and degeneration. His lab investigates macrophage plasticity, immune regulation (CD200R, C5aR, IRAK-M pathways), and develops biologic therapies for blinding diseases. His bench-to-bedside approach has revolutionized anti-TNF treatments for uveitis. Publication Trends Recent publications (2024-2025) demonstrate strong emphasis on: 1) Multimodal imaging guidelines for uveitis syndromes, 2) Genetic and machine learning approaches to retinal phenotyping, 3) Novel therapeutics including gene therapies and JAK inhibitors, and 4) Mechanisms of retinal degeneration involving Bruch's membrane and autophagy pathways. Awards and Honors Fellow of Academy of Medical Sciences (2007) Alcon Research Institute Award (2011) Doyne Medal & Lecture Duke-Elder Lecture Constable Annual Public Lecture Certificate of Excellence (EVER) Golding Medal & Llewellyn Scholarship Professional Leadership Professor Dick has authored foundational textbooks (e.g., The Eye: Basic Science in Practice ), chaired WHO uveitis classification committees, served as ARVO Vice-President and EVER President, and held editorial roles for major ophthalmology journals including Progress in Retinal and Eye Research .

• Ion Transport Physiology
• Molecular Cell Biology
• Biophysics
• +۳ مورد دیگر

Thomas J. Jentsch is a leading Professor at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin, with secondary affiliation to the Max Delbrück Center (MDC) . He holds dual doctorates in Medicine and Physics from Freie Universität Berlin and has pioneered research in ion transport physiology since co-founding the Center for Molecular Neurobiology Hamburg in 1988. Head of Jentsch Group at FMP since 2006 World leader in chloride channel research His research bridges molecular physiology and human genetics , focusing on: CLC family chloride channels/transporters VRAC/LRRC8 volume-regulated channels ASOR/TMEM206 acid-activated channels Pathologies: neurodegeneration, deafness, osteopetrosis, hypertension Recent work includes breakthroughs in VRAC channel structure (2023) and CLCN7 channelopathies (2024). His lab employs genetically modified mouse models and human mutation analysis to uncover disease mechanisms.

• Neuroimmunology
• Stem Cell Biology
• Multiple Sclerosis
• +۳ مورد دیگر

Lou Brundin is a Professor/Senior Physician at Karolinska Institutet , leading the Stemcells and inflammation research group within the Department of Clinical Neuroscience. He holds academic appointments including Head of the Neurology Section since 2011 and has been a Professor since 2008. Education: MD (Karolinska Institutet, 1987), PhD in Sensory Physiology (1991), and postdoctoral training at the University of Sussex (1991–1992). His career includes roles as Vice President of R&D at Karolinska Hospital (2001–2003) and Director of Studies in Neurology since 2004. Research Focus: Neural stem cell biology, neuroinflammation, and multiple sclerosis (MS). His group investigates mechanisms of neural repair through stem cells and inflammatory pathways, aiming to enhance CNS regeneration. Key areas include oligodendrocyte remyelination, nitric oxide effects on neurogenesis, and mesenchymal stem cell therapies. Publications: Over 50 peer-reviewed articles, with recent work on T cell autoantigens in MS, mesenchymal stem cell trials, and neuroinflammatory mechanisms. His research bridges clinical neurology and experimental neuroscience. Awards: 2009 Swedish Society of Neurology's Golden Hammer Teaching Prize for educational excellence. Advising & Leadership: Supervised 5 PhD students and co-supervised 3. Currently mentors 2 PhD students and 3 postdocs. Active in academic governance, including national neurology curriculum boards. Labs/Teams: Leads a 10-member interdisciplinary team combining neurology, neurosurgery, and neurobiology. Collaborates on translational projects like the MESEMS clinical trial for MS therapies.

Siddharth Bankaمشاهده پروفایل

استاد بالینی

• Rare genetic disorders
• Genomics
• Chromatinopathies
• +۳ مورد دیگر

Siddharth Banka is a Clinical Professor in the Division of Evolution, Infection and Genomics at the University of Manchester and a Consultant Clinical Geneticist at the Manchester Centre for Genomic Medicine (Manchester University NHS Trust). His research focuses on improving diagnosis, management, and treatment of rare genetic disorders through genomic and functional studies. He leads initiatives such as the Manchester Rare Conditions Centre, aiming to enhance clinical care, research, education, and advocacy for individuals with rare diseases. His work spans chromatinopathies, inborn errors of metabolism, and advanced diagnostics using DNA methylation arrays. Education: MBBS from Lokmanya Tilak Medical College (University of Mumbai, 2002), PhD from University of Manchester (2012), CCST in Clinical Genetics (UK). Research interests include identifying novel genetic disorders, understanding disease mechanisms through model systems (e.g., iPSCs, zebrafish), and developing clinical guidelines. Key contributions include discoveries in disorders like Kabuki syndrome and TET3-related Beck-Fahrner syndrome. He collaborates internationally and leads projects funded by MRC, NIHR, and others. Scientific awards include the Distinguished Achievement Medal (2012), ESHG Poster Award (2011), and multiple travel fellowships. He supervises numerous PhD students and mentors in clinical and genomic medicine.

• Biomedical Engineering
• Medical Statistics
• Ophthalmology
• +۳ مورد دیگر

Prof. Konstantin Kotliar is a Professor at Aachen University of Applied Sciences, specializing in Biomedical Engineering and Medical Statistics. He teaches courses in Mathematics, Advanced Medical Statistics, and Space Physiology. His research focuses on retinal vessel analysis to study microvascular dysfunction in diseases such as Fabry disease, diabetes, and Alzheimer’s. Kotliar’s work bridges ophthalmology, neuroscience, and cardiovascular science, with a particular interest in developing non-invasive diagnostic tools for early disease detection. His studies often involve collaborations with global health initiatives and clinical trials, such as the EndoAfrica-NWU Study. He has contributed to understanding neurovascular coupling mechanisms and their implications for neurological disorders. Research interests include retinal vessel dynamics, cardiovascular risk stratification, and the application of statistical methods in medical diagnostics. Kotliar’s methodologies span from biomechanical modeling to machine learning-driven image analysis, emphasizing translational research with clinical relevance. His work has implications for improving therapies and preventive measures in chronic diseases.

Gemma Marfany Nadalمشاهده پروفایل

استاد

• Molecular Genetics
• Hereditary Retinal Dystrophies
• CRISPR/Cas9 Gene Editing
• +۳ مورد دیگر

Gemma Marfany Nadal is a University Professor at the Faculty of Biology, University of Barcelona, with affiliations to the Department of Genetics, Microbiology and Statistics and the Human Molecular Genetics Research Group. She serves as Academic Secretary of the Bioethics Commission of the University of Barcelona (CBUB), Member of the Institute of Biomedicine of the University of Barcelona (IBUB), and former Member of the Biology Degree Study Council. Her research focuses on hereditary retinal dystrophies, gene discovery (notably CERKL ), CRISPR/Cas9 genomic editing, proteostasis in retinal neurodegeneration, and bioethics. She has led projects funded by the European Union (PROTEOSTASIS), TV3's Marathon Foundation, the Ministry of Economy and Competitiveness, CIBER, and the Ministry of Science, Innovation and Universities. Notable scientific contributions include studies on CERKL 's role in retinal health, sphingolipid metabolism, and deubiquitinating enzyme expression. She has published extensively in journals like Investigative Ophthalmology & Visual Science and PLoS One , emphasizing retinal disease mechanisms and therapeutic strategies. Scientific awards include the VI Distinction from the Faculty of Doctors of the University of Barcelona for outstanding dissemination activities. She has created the genetic diagnostic spin-off DBGen Ocular Genomics and contributes to public science communication through a weekly column in El Nacional and quarterly columns in Mètode magazine under the section 'Gens i Gent'.