Thomas J. Jentsch

Thomas J. Jentsch is a leading Professor at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin, with secondary affiliation to the Max Delbrück Center (MDC). He holds dual doctorates in Medicine and Physics from Freie Universität Berlin and has pioneered research in ion transport physiology since co-founding the Center for Molecular Neurobiology Hamburg in 1988.

• Head of Jentsch Group at FMP since 2006
• World leader in chloride channel research

His research bridges molecular physiology and human genetics, focusing on:

• CLC family chloride channels/transporters
• VRAC/LRRC8 volume-regulated channels
• ASOR/TMEM206 acid-activated channels
• Pathologies: neurodegeneration, deafness, osteopetrosis, hypertension

Recent work includes breakthroughs in VRAC channel structure (2023) and CLCN7 channelopathies (2024). His lab employs genetically modified mouse models and human mutation analysis to uncover disease mechanisms.