جست‌وجوی استاد و پژوهشگر

Gerta Hoxhajمشاهده پروفایل

استادیار

• Cancer Metabolism
• Cell Signaling
• Metabolomics
• +۵ مورد دیگر

Gerta Hoxhaj is an Assistant Professor at the Children's Medical Center Research Institute (CRI) at UT Southwestern Medical Center, with secondary appointments in the Departments of Biochemistry and Pediatrics. She leads an active research laboratory focused on understanding the molecular mechanisms of cancer metabolism. Dr. Hoxhaj received her academic training through the following institutions: Bachelor's degree in Molecular Biology, Genetics, and Chemistry from Bogazici University, Istanbul, Turkey Ph.D. in Biochemistry and Cell Signaling from the MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Scotland, UK Dr. Hoxhaj's research program centers on understanding how cancer cells rewire their metabolism to support growth and survival. Her laboratory investigates three fundamental questions: how cells integrate oncogenic signals to regulate metabolic activities; how metabolism is linked to tissue function; and how cells sense metabolite abundance to maintain homeostasis. Using approaches that combine classical biochemistry, metabolomics, cell biology, and mouse models, her team has made significant contributions to understanding the role of cellular reducing power (NADPH) in cancer metabolism, particularly through the regulation of NAD kinase (NADK). Her work has revealed novel connections between PI3K-Akt-mTORC1 signaling and metabolic pathways including nucleotide synthesis and redox balance. Analysis of Dr. Hoxhaj's recent publications shows a strong focus on mitochondrial metabolism, particularly the role of NADPH in powering essential processes like fatty acid synthesis and protein lipoylation. Her research bridges structural biology (with cryo-EM studies of NADK), cellular metabolism, and cancer biology, revealing how metabolic reprogramming supports tumor growth. A consistent theme across her work is the identification of how oncogenic signaling pathways directly regulate specific metabolic enzymes and processes. Dr. Hoxhaj has received numerous prestigious awards and recognitions for her research: Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research V Foundation Scholar American Cancer Society Scholar Pew-Stewart Scholar for Biomedical Science 2025 TAMEST Mary Beth Maddox Award and Lectureship 2024 Vilcek Prize for Creative Promise in Biomedical Science Dr. Hoxhaj mentors a dynamic research team including postdoctoral fellows, Ph.D. students, and research associates. Her laboratory has secured significant funding from multiple sources including the National Institutes of Health, Welch Foundation, CPRIT, and USDA National Institute of Food and Agriculture. Her research on cancer metabolism has important implications for developing new therapeutic strategies targeting metabolic vulnerabilities in cancer cells. The Hoxhaj Laboratory is part of the Genetic and Metabolic Disease Program at CRI, collaborating closely with other researchers at UT Southwestern including those in the Harold C. Simmons Comprehensive Cancer Center. Her team's recent work on mitochondrial NADPH has opened new avenues for understanding how metabolic pathways are rewired in cancer, with potential applications for multiple cancer types.

Julie Championمشاهده پروفایل

استاد

• Protein Engineering
• Nanomaterials
• Immunology
• +۵ مورد دیگر

Julie Champion is the William R. McLain Endowed Term Professor in the School of Chemical and Biomolecular Engineering at Georgia Institute of Technology. She holds a Ph.D. in Chemical Engineering from the University of California Santa Barbara and completed NIH postdoctoral training at Caltech. As Faculty and Associate Chair for Graduate Studies, her work spans protein engineering , nanostructured biomaterials , and biocatalysis applications . Education: B.S.E. (University of Michigan), Ph.D. (UC Santa Barbara), NIH Postdoc (Caltech) Her research focuses on creating self-assembled protein nanomaterials for immunotherapy , cancer treatment , and industrial biocatalysis . Key projects include: Thermoresponsive protein nanosheets pH-sensitive vesicles for drug delivery Enzyme-immobilizing protein-inorganic hybrids Hexameric antibody delivery nanocarriers AvrA-based anti-inflammatory therapies Universal subunit vaccines via nanoparticle platforms Scientific recognition includes: Fellow, American Institute for Medical and Biological Engineering (2021) ACS Women Chemists Rising Star Award (2021) Georgia Tech BioEngineering Outstanding Advisor Award (2014) NSF BRIGE Award NIH Postdoctoral Fellowship NSF Graduate Fellowship Her lab at the Engineered Biosystems Building hosts ongoing outreach initiatives like the TEC Camp for middle school girls and Project ENGAGES for high school research mentorship.

• Computer Architecture
• Hardware Design
• Signal Processing
• +۷ مورد دیگر

Prof. Dr.-Ing. Holger Blume serves as Vice President for Research and Transfer at Leibniz University Hannover while maintaining his academic position as Professor in the Architectures and Systems Section within the Faculty of Electrical Engineering and Computer Science. He holds multiple leadership positions including Chairperson of the Research Commission and Central Ethics Committee, Executive Board member of eNIFE (Leibniz Research Initiative for Neurosciences), and membership in both the Laboratory of Nano and Quantum Engineering and L3S Research Centre. His research interests span computer architecture, hardware design, signal processing, AI accelerators, hearing aid technology, and biomedical engineering. His work bridges theoretical computer science with practical applications in automotive systems, medical devices, and quantum engineering. Professor Blume's research demonstrates strong interdisciplinary connections between electrical engineering, computer science, and biomedical applications, with particular emphasis on hardware-oriented solutions for real-world problems. Analysis of his recent publications (2023-2025) reveals a strong focus on hardware acceleration for AI and signal processing applications, particularly in automotive radar/LiDAR systems and hearing aid technology. His work shows consistent innovation in RISC-V processor design, specialized hardware for mathematical functions, and biomedical applications of engineering principles. The research demonstrates a clear trajectory toward energy-efficient, specialized computing architectures for specific application domains. As Vice President for Research and Transfer, Professor Blume oversees significant research initiatives at Leibniz University Hannover, which hosts multiple Clusters of Excellence including PhoenixD (Photonics, Optics, and Engineering), QuantumFrontiers, and Hearing4all. The university participates in numerous collaborative research centers and junior research groups funded by DFG, BMBF, and EU programs. Professor Blume is actively involved in multiple research facilities including the Laboratory of Nano and Quantum Engineering and the L3S Research Centre. His work connects with Leibniz University's research focuses on optical technologies, quantum optics and gravitational physics, and biomedical research and technology. His leadership positions indicate strong involvement in shaping the research strategy and ethical framework of the university's scientific endeavors.

Erik Henning Thiedeمشاهده پروفایل

استادیار

• Theoretical Chemistry
• Computational Chemistry
• Machine Learning in Chemistry
• +۱۱ مورد دیگر

Erik Henning Thiede is an Assistant Professor of Chemistry at Cornell University, affiliated with the Department of Chemistry and Chemical Biology. He joined the faculty in Summer 2023 and leads the Thiede Lab, which focuses on understanding protein motion and function through computational tools that integrate machine learning, molecular simulation, and chemical physics. PhD in Chemistry from the University of Chicago (advised by Profs. Aaron Dinner and Jonathan Weare) Postdoctoral Research at Flatiron Institute CCM (collaborating with Prof. Risi Kondor, Dr. Pilar Cossio, and Dr. Sonya Hanson) The lab's research spans several key areas: Developing algorithms to extract free energies from cryo-EM data Creating permutation-equivariant machine learning models for chemical systems Improving error estimation in molecular simulation frameworks like MBAR Applying Wasserstein flows and probabilistic methods to cryo-EM analysis Expanding cryo-EM capabilities for disordered protein regions Integration of experimental data with computational simulations His lab's publications highlight trends in computational chemistry, including the application of graph neural networks, Bayesian inference, and advanced statistical methods to molecular dynamics. These works bridge chemical physics, machine learning, and structural biology. As an academic advisor, Thiede mentors a diverse group of graduate students and postdoctoral researchers. His lab actively collaborates with interdisciplinary teams across Cornell and other institutions, with current projects involving chemical engineering, applied mathematics, and biophysics. The Thiede Lab at Cornell is committed to open and inclusive science. Values include curiosity, openness to new ideas, mutual support in research, and active inclusion of diverse backgrounds. The lab occupies space at 214 Baker Lab and maintains a research website at thiedelab.github.io .

Philip Romeroمشاهده پروفایل

دانشیار

• Protein Engineering
• Computational Biology
• Machine Learning
• +۳ مورد دیگر

Philip Romero, Ph.D., is an Associate Professor in the Department of Biomedical Engineering at Duke University. He earned his doctorate from the California Institute of Technology in 2012 and leads the Romero Lab, which relocated to Duke in 2023. His research focuses on developing computational and experimental methods for protein engineering, with applications spanning therapeutics, biocatalysis, and synthetic biology. Research Interests: Romero's work integrates machine learning, microfluidics, and high-throughput experimentation to study protein fitness landscapes. Key areas include: Self-driving laboratories for autonomous protein optimization Neural network models for predicting protein functions Therapeutic enzyme engineering (ACE2, caspases, lysins) Microfluidic platforms for deep mutational scanning His recent publications demonstrate a strong emphasis on machine learning-guided protein design, with 80% of post-2022 publications involving AI/ML methods. Therapeutic applications against infectious diseases (particularly SARS-CoV-2) and microbiome engineering represent emerging directions. Lab & Advising: The Romero Lab develops novel technologies for protein engineering, including custom gene library assembly platforms and droplet microfluidics systems. Romero mentors graduate students (e.g., Nishit, who recently defended a thesis on transcription factor engineering) and has collaborated with researchers across computational biology, metabolic engineering, and virology.

Ville Paavilainenمشاهده پروفایل

پژوهشگر

• Biochemistry
• Cell Biology
• Molecular Biology
• +۹ مورد دیگر

Ville Paavilainen is a Research Director at the Institute of Biotechnology, University of Helsinki, and supervisor for doctoral programs in Biomedicine and Integrative Life Science. With a postdoctoral background at the University of California, San Francisco (2008–2014), he focuses on Biochemistry , Cell Biology , and Molecular Biology , particularly mechanisms of protein translocation, membrane biology, and structural modeling. His research includes groundbreaking work on Sec61 translocon inhibition for cancer therapy and mitochondrial gene expression noise . Recent publications address lipid scrambling pathways, glioma stem cell targeting, and actin regulation. Active projects span EU-funded drug discovery and NIH collaborations. Key scientific contributions include Elucidating Sec61-client interactions Developing computational models for signal peptide prediction Uncovering mitochondrial-ER communication mechanisms He has supervised PhD theses (e.g., Paul Carlson) and contributed to over 39 research outputs. His work bridges structural biology, computational modeling, and translational pharmacology, with applications in tumor biology and neurodegenerative disease research.

Michael Landsbergمشاهده پروفایل

دانشیار

• Structural Biology
• Cryo-Electron Microscopy
• Microbial Pathogenesis
• +۶ مورد دیگر

Dr. Michael Landsberg is an Affiliate Associate Professor at the Institute for Molecular Bioscience and Associate Professor at the School of Chemistry and Molecular Biosciences , University of Queensland . He specializes in single-particle cryo-electron microscopy (cryo-EM) and structural biology , focusing on molecular machines involved in microbial pathogenesis and innate immunity . His research spans from studying bacterial pore-forming toxins to viral infection mechanisms and protein trafficking . Education: BSc (Chemistry), Central Queensland University PhD (Biochemistry), University of Queensland (2003) Research interests include revolutionizing structural biology through cryo-EM to study membrane proteins and multi-component complexes without crystallization. His work on ABC toxins has implications for biopesticides and targeted protein delivery . He also investigates immune signaling pathways (e.g., TIR domains ) and neurodegenerative mechanisms (e.g., SARM1 ). Scientific grants include >$13.5M in competitive funding from Australian Research Council (ARC) and National Health and Medical Research Council (NHMRC) . He supervises PhD students in projects spanning toxin specificity , immune signaling , and virus structures . Key article trends reveal expertise in macromolecular complexes , infectious disease mechanisms , and innovative biotechnological tools . His work bridges structural biology with practical applications in health and agriculture .

Nidhi Bansalمشاهده پروفایل

استاد

• Alternative Dairy Processing
• Non-Bovine Milk Systems
• Milk Protein Structure and Functionality
• +۴ مورد دیگر

Professor Nidhi Bansal is a leading expert in dairy and food bioprocessing at the University of Queensland (UQ) , serving as the Director of Teaching & Learning in the School of Agriculture and Food Sciences. With over 150 publications and an h-index of 38 (Google Scholar), her work bridges agricultural sciences , food chemistry , and clinical nutrition . PhD in Dairy Chemistry (University College Cork, 2007) B.Tech in Dairy Technology (SMC College of Dairy Science, 2003) Research Focus: • Non-Thermal Processing: Leading UQ's 'non-thermal processing research program' since 2011, developing pulsed electric field (PEF) and high-pressure processing (HPP) to preserve milk biomolecules while ensuring microbial safety. • Non-Bovine Milk Systems: Pioneering research on camel milk and human milk , exploring their composition, enzymology, and bioactive properties. • Milk Protein Structure: Investigating protein interactions, denaturation, and functional properties like foaming, gelling, and emulsification. Recent Article Trends highlight contributions to Precision Fermentation , Milk Foam Science , and Camel Milk Applications . Her work has been cited in 103 countries across 25 disciplines, including Medicine and Chemical Engineering . Scientific Leadership: Program Lead for the $165M Food and Beverage Accelerator (FaBA) Trailblazer Grant CI on grants exceeding $183M from NHMRC, ARC, and industry partners Director of UQ’s Education and Training Program in the Strategic University Reform Fund ($6.9M) Mentoring Excellence: Supervised 27 HDR students (12 as principal advisor) and >60 coursework students. Authored multiple Food Chemistry and Journal of Dairy Science publications with significant impact on infant nutrition and food safety .

Paul Kingsleyمشاهده پروفایل

عضو هیئت علمی

• Embryonic Hematopoiesis
• Erythroid Differentiation
• Ontogeny of Hematopoietic Progenitors
• +۳ مورد دیگر

Paul Kingsley, Ph.D. is a Research Assistant Professor (Part-Time) in the Department of Pediatrics, Hematology and Oncology at the University of Rochester School of Medicine and Dentistry. His academic credentials include a Ph.D. and M.S. in Developmental Biology from the University of Rochester (1992, 1987) and a B.A. in Biology from Reed College (1982), followed by a Cancer Center Fellowship in Hematopoiesis at the University of Rochester School of Medicine and Dentistry (1992-1994). Dr. Kingsley's research focuses on: Embryonic Hematopoiesis Erythroid Differentiation Ontogeny of Hematopoietic Progenitors Erythroid Precursor Self Renewal His laboratory employs diverse approaches including subtractive hybridization, degenerate PCR, genechip technology (Affymetrix), and in situ hybridization to investigate blood formation in mammalian embryos. His work examines how hematopoiesis initiates in the yolk sac, migrates to the fetal liver, and finally homes to the bone marrow at the end of gestation. Dr. Kingsley's publication record demonstrates consistent focus on molecular mechanisms of blood cell development, with recent work emphasizing erythroid maturation, hematopoietic stem cell regulation, and chromatin dynamics during erythropoiesis. His research spans from fundamental developmental biology to potential clinical applications in blood disorders and radiation protection. Key research contributions include: Mechanisms of erythroblast enucleation and maturation Regulation of hematopoietic stem cell specification and migration Chromatin remodeling during late-stage erythropoiesis Mitochondrial iron metabolism in heme synthesis Developmental origins of immune cell lineages Effects of radiation on hematopoietic recovery Dr. Kingsley has maintained a productive research career with extensive collaboration, particularly with Dr. James Palis, resulting in numerous high-impact publications in journals such as Nature, Science, Blood, and The EMBO Journal.

Hualu Zhouمشاهده پروفایل

استادیار

• Food Science
• Food Nanotechnology
• Emulsion Technologies
• +۷ مورد دیگر

Dr. Hualu Zhou is an Assistant Professor in the Department of Food Science & Technology at the University of Georgia's College of Agricultural & Environmental Sciences. She leads the Laboratory of Future Foods and Biomaterials at the UGA Griffin campus, where her research focuses on developing innovative plant-based food systems and sustainable biomaterials through advanced scientific principles. Dr. Zhou earned her undergraduate degree from Nanchang University (2010-2014), completed her Master's at Xiamen University (2014-2017), and obtained her Ph.D. from the University of Massachusetts Amherst (2017-2021), followed by postdoctoral research there (2021-2023) before joining UGA faculty in 2023. Her research program integrates experimental food science techniques including nanotechnologies, emulsion technologies, and INFOGEST in vitro digestion models with computational approaches such as molecular modeling and data analysis. Current projects focus on: (1) developing plant-based food alternatives using low-energy methods; (2) creating standardized assessment methods for plant-based foods; and (3) exploring food nanotechnology applications for enhanced bioactive compound delivery. Her work emphasizes sustainability, health benefits, and practical food system applications. Analysis of Dr. Zhou's recent publications reveals a strong emphasis on pH-driven processing technologies, plant protein functionality, and innovative delivery systems for bioactive compounds. Her research bridges fundamental food chemistry with practical applications, particularly in developing plant-based meat and dairy alternatives. She maintains extensive collaborations, especially with Dr. D.J. McClements, demonstrating an interdisciplinary approach to solving complex food science challenges. Dr. Zhou has served as a reviewer for numerous scientific journals and has contributed to over 50 reviewed papers in prestigious publications including Food Chemistry, Food Hydrocolloids, and Trends in Food Science & Technology. She also serves on the Early Career Advisory Board for the Journal of Agricultural and Food Chemistry and as an Editorial Board member for Grain & Oil Science and Technology. As an advisor, Dr. Zhou currently mentors Master's student Anthony Suryamiharja, Ph.D. student Minghe Wang, and collaborates with postdoctoral associate Xiping Gong. She has served on graduate committees and trained numerous undergraduate researchers. Her extension work through FoodPIC connects her research with industry partners developing plant-based products like pecan milk and polyphenol-enriched peanut butter. The recently renovated Laboratory of Future Foods and Biomaterials maintains state-of-the-art equipment for food chemistry analysis, including instrumentation for microscopy, HPLC, laser diffraction, and rheometry.

• Biophysical Chemistry
• Medical Diagnostics
• Analytical Biochemistry
• +۳ مورد دیگر

Mr. Axel Jeibmann is a Researcher at the University of Bielefeld , affiliated with both the Faculty of Chemistry and the School of Medicine . He works within the Biophysical Chemistry and Diagnostics group, focusing on interdisciplinary research at the interface of chemistry, biology, and clinical diagnostics. Contact Information: Phone: +49 521 106-2028 Office: UHG F1-114 Research Interests: Biophysical methods development Diagnostics for biomedical applications Interdisciplinary chemical biology Protein structure-function analysis Medical device innovation Translational chemistry

• Progranulin research
• Neuroprotection
• Tissue repair
• +۴ مورد دیگر

Andrew Bateman, PhD is a Senior Scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) at the Glen site, where he leads research in the Metabolic Disorders and Complications Program within the Centre for Translational Biology. He holds a professorship in the Department of Medicine, Faculty of Medicine and Health Sciences at McGill University, with specific affiliation to the Division of Endocrinology at the McGill University Health Centre. Dr. Bateman's research primarily focuses on progranulin, a protein that plays crucial roles in cell communication, neuroprotection, tissue repair, and cancer progression. His work has demonstrated that progranulin instructs nearby cells to divide and move, inhibits cell death caused by challenges such as starvation or chemotherapeutic drugs, and is essential for keeping nerve cells alive. Notably, his research has shown that losing half of the brain's progranulin levels through mutation causes frontotemporal dementia, a devastating degenerative brain disease. His laboratory also investigates how progranulin is overexpressed in many cancers, rendering cancer cells more aggressive, and how blocking progranulin may serve as a route to cancer therapy. Additionally, his work explores progranulin's role in reducing inflammation and promoting wound repair, including angiogenesis, which has potential applications for people suffering from chronic wounds. Analysis of Dr. Bateman's publication record reveals a consistent focus on progranulin across multiple disciplines including neuroscience, molecular biology, oncology, and vascular biology. His research spans from fundamental protein structure and evolution to clinical applications in neurodegenerative diseases and cancer. A notable trend in his work is the exploration of progranulin's dual role in both neuroprotection and cancer progression, highlighting the complex nature of this regulatory protein. His research has evolved from early work on corticostatic peptides and the immune-hypothalamic-pituitary-adrenal axis to his current specialized focus on progranulin's multifaceted biological functions. Dr. Bateman has made significant contributions to understanding the role of progranulin in various physiological and pathological processes. His work has implications for developing therapeutic approaches for neurodegenerative diseases, cancer treatment, and wound healing. He has established himself as a leading researcher in the field of progranulin biology, with numerous publications in high-impact journals spanning several decades of research.

Juli Feigonمشاهده پروفایل

استاد

• Nucleic Acid Structure
• Telomerase Biology
• RNA-Protein Complexes
• +۴ مورد دیگر

Dr. Juli Feigon is a Distinguished Professor in the Department of Chemistry and Biochemistry at UCLA's College of Letters and Science, where she has been a faculty member since 1985. Her research focuses on the structure and function of nucleic acids using multidimensional NMR spectroscopy, X-ray crystallography, and cryo-EM to study telomerase, riboswitches, and RNA-protein complexes. As a member of the National Academy of Sciences and recipient of numerous prestigious awards, she has established herself as a leader in structural biology of nucleic acids. Dr. Feigon received her B.A. from Occidental College and her M.S. and Ph.D. from the University of California, San Diego where she studied with Dr. David Kearns. Her postdoctoral work was completed at the Massachusetts Institute of Technology as a Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellow with Dr. Alex Rich. Dr. Feigon's laboratory studies nucleic acid structure and function with emphasis on telomerase structure and mechanism, H/ACA RNPs biogenesis, and riboswitch dynamics. Her group uses NMR spectroscopy as a primary tool, complemented by X-ray crystallography, cryo-EM, and biochemical methods to understand how RNA and RNA-protein complexes function in the cell and how mutations can lead to disease. Current research focuses on structure, function, dynamics, assembly, and folding of human telomerase, Tetrahymena telomerase, riboswitches, H/ACA RNPs, and other noncoding RNAs. Analysis of Dr. Feigon's recent publications reveals a progression from fundamental RNA structure studies to increasingly complex biological systems. Her work has evolved from isolated RNA domains to full complexes and holoenzymes, with growing integration of multiple structural biology techniques. While maintaining her core focus on telomerase structure, her research has expanded to include connections to human diseases like cancer and neurodegenerative conditions, demonstrating the broad applicability of her structural insights. Member, National Academy of Sciences (2009) Glenn T. Seaborg Medal (2024) Herbert Newby McCoy Award (2022) Dorothy Crowfoot Hodgkin Award from Protein Society (2017) Founders Award from the Biophysical Society (2019) Presidential Young Investigator, National Science Foundation (1989-1994) Camille and Henry Dreyfus Teacher/Scholar Award (1990) Dr. Feigon has mentored numerous postdoctoral fellows and graduate students who have gone on to independent positions at institutions worldwide. Her laboratory has been exceptionally successful in securing postdoctoral fellowships for its members, including American Heart Association, NIH Ruth L. Kirschstein, and Life Sciences Research Foundation awards. She established the 'Juli Feigon Helping Hands Award' to support postdoctoral fellows, research staff, and graduate students who are primary caregivers for dependent children or other family members, with matching funds from the Department of Chemistry and Biochemistry. The Feigon Laboratory maintains state-of-the-art NMR facilities including an 800MHz Bruker Avance with TCI cryoprobe, 600MHz with TXI cryoprobe, and two 500MHz spectrometers. The lab collaborates extensively with UCLA's DOE shared facilities for crystallization, protein expression, and X-ray/EM structure determination, as well as the EICN EM facility featuring Titan Krios and other advanced electron microscopy equipment. Her research group continues to investigate the structure, function, dynamics, assembly, and folding of telomerase and other non-coding RNA complexes.

Tamara Bidoneمشاهده پروفایل

استادیار

• Biophysics
• Molecular Dynamics Simulations
• Coarse-graining
• +۴ مورد دیگر

Tamara Bidone serves as an Assistant Professor of Biomedical Engineering and Adjunct Assistant Professor of Biochemistry and Molecular Pharmaceutics at the University of Utah, conducting interdisciplinary research through the Bioscience Programs with emphasis on computational approaches to biological macromolecules and cellular mechanics. Her academic foundation includes: B.S. from Polytechnic University of Turin, Italy M.S. from Polytechnic University of Turin, Italy Ph.D. from Polytechnic University of Turin, Italy Dr. Bidone's research program centers on elucidating structure-function relationships in biological macromolecules, particularly adhesion proteins and their role in cellular dysfunction and disease. She develops and applies advanced computational methodologies including molecular dynamics simulations, coarse-graining techniques, Brownian dynamics, and agent-based mesoscale modeling to investigate molecular and macromolecular dynamics. Her work spans biophysics, computational biology, and cellular mechanics with specific focus on integrin-mediated adhesion, cytoskeletal dynamics (actin and microtubules), and mechanical regulation of cellular processes. Analysis of her 15 most recent publications (2023-2025) reveals a dominant trend in computational modeling of cellular adhesion mechanisms and cytoskeletal dynamics. Key thematic areas include integrin activation pathways (particularly αIIbβ3), microtubule tip mechanics, actin bundle formation, and data-driven approaches integrating machine learning with biophysical simulation. Her methodological innovations feature generative modeling, manifold learning, and equation-free dynamics applied to complex protein systems, providing critical insights into force-regulated conformational changes and disease mechanisms. While no specific laboratory name is provided in available materials, her research contributes significantly to computational biosciences at the University of Utah, advancing fundamental understanding of cellular mechanics through sophisticated simulation frameworks that bridge molecular and cellular scales.

David T. Lodowskiمشاهده پروفایل

استادیار

• Structural Biology
• G Protein-Coupled Receptors (GPCRs)
• X-ray Crystallography
• +۵ مورد دیگر

David T. Lodowski is an active Assistant Professor at Case Western Reserve University School of Medicine holding multiple appointments across the Department of Nutrition, Center for Proteomics and Bioinformatics, and Department of Pharmacology. He also serves as Director of the Biomedical Sciences Training Program. His laboratory focuses on elucidating the structural mechanisms of G protein-coupled receptors (GPCRs) and related signaling pathways using advanced structural biology techniques. Dr. Lodowski completed his BS in cellular and molecular biology from Tulane University in 1998, followed by a PhD in Biochemistry from the University of Texas at Austin in 2005. He then completed a postdoctoral fellowship in the Palczewski Laboratory at Case Western Reserve University from 2005-2011, where he examined structural changes in bovine rhodopsin during photoactivation and GPCR activation. His research primarily centers on GPCR signaling dynamics, utilizing X-ray crystallography, electron microscopy, and structural mass spectrometry to study macromolecular complexes. Additional research projects include developing biosensors for markers of hypoxia and fatigue, and investigating aquaporins as membrane gas channels. Dr. Lodowski teaches SYBB 501 Systems Biology & Bioinformatics Journal Club and CBIO 455 Molecular Biology I courses. Analysis of his recent publications shows a strong focus on structural biology of membrane proteins, particularly GPCRs and ion channels, with increasing emphasis on protein footprinting techniques and biosensor development. His work bridges structural biology with physiological applications, demonstrating translational potential in understanding cellular signaling pathways. Awards and Honors: Mt. Sinai Scholar (2012) Current Funding: Biosis AFRL as associate project lead since July 15, 2020. Dr. Lodowski has mentored students through the Biomedical Sciences Training Program which he directs. His laboratory has determined numerous protein structures (including IDs 5HI9, 4X1H, 4YEU, and others) related to GPCR signaling pathways. His research team employs a multidisciplinary approach combining structural biology, biophysics, and biochemistry to investigate the molecular mechanisms underlying GPCR activation and signaling, with implications for understanding numerous physiological processes and developing targeted therapeutics.