Paul Kingsley

Paul Kingsley, Ph.D. is a Research Assistant Professor (Part-Time) in the Department of Pediatrics, Hematology and Oncology at the University of Rochester School of Medicine and Dentistry. His academic credentials include a Ph.D. and M.S. in Developmental Biology from the University of Rochester (1992, 1987) and a B.A. in Biology from Reed College (1982), followed by a Cancer Center Fellowship in Hematopoiesis at the University of Rochester School of Medicine and Dentistry (1992-1994).

Dr. Kingsley's research focuses on:

• Embryonic Hematopoiesis
• Erythroid Differentiation
• Ontogeny of Hematopoietic Progenitors
• Erythroid Precursor Self Renewal

His laboratory employs diverse approaches including subtractive hybridization, degenerate PCR, genechip technology (Affymetrix), and in situ hybridization to investigate blood formation in mammalian embryos. His work examines how hematopoiesis initiates in the yolk sac, migrates to the fetal liver, and finally homes to the bone marrow at the end of gestation.

Dr. Kingsley's publication record demonstrates consistent focus on molecular mechanisms of blood cell development, with recent work emphasizing erythroid maturation, hematopoietic stem cell regulation, and chromatin dynamics during erythropoiesis. His research spans from fundamental developmental biology to potential clinical applications in blood disorders and radiation protection.

Key research contributions include:

• Mechanisms of erythroblast enucleation and maturation
• Regulation of hematopoietic stem cell specification and migration
• Chromatin remodeling during late-stage erythropoiesis
• Mitochondrial iron metabolism in heme synthesis
• Developmental origins of immune cell lineages
• Effects of radiation on hematopoietic recovery

Dr. Kingsley has maintained a productive research career with extensive collaboration, particularly with Dr. James Palis, resulting in numerous high-impact publications in journals such as Nature, Science, Blood, and The EMBO Journal.