معرفی
David T. Lodowski is an active Assistant Professor at Case Western Reserve University School of Medicine holding multiple appointments across the Department of Nutrition, Center for Proteomics and Bioinformatics, and Department of Pharmacology. He also serves as Director of the Biomedical Sciences Training Program. His laboratory focuses on elucidating the structural mechanisms of G protein-coupled receptors (GPCRs) and related signaling pathways using advanced structural biology techniques.
Dr. Lodowski completed his BS in cellular and molecular biology from Tulane University in 1998, followed by a PhD in Biochemistry from the University of Texas at Austin in 2005. He then completed a postdoctoral fellowship in the Palczewski Laboratory at Case Western Reserve University from 2005-2011, where he examined structural changes in bovine rhodopsin during photoactivation and GPCR activation.
His research primarily centers on GPCR signaling dynamics, utilizing X-ray crystallography, electron microscopy, and structural mass spectrometry to study macromolecular complexes. Additional research projects include developing biosensors for markers of hypoxia and fatigue, and investigating aquaporins as membrane gas channels. Dr. Lodowski teaches SYBB 501 Systems Biology & Bioinformatics Journal Club and CBIO 455 Molecular Biology I courses.
Analysis of his recent publications shows a strong focus on structural biology of membrane proteins, particularly GPCRs and ion channels, with increasing emphasis on protein footprinting techniques and biosensor development. His work bridges structural biology with physiological applications, demonstrating translational potential in understanding cellular signaling pathways.
Awards and Honors:
- Mt. Sinai Scholar (2012)
Current Funding: Biosis AFRL as associate project lead since July 15, 2020. Dr. Lodowski has mentored students through the Biomedical Sciences Training Program which he directs. His laboratory has determined numerous protein structures (including IDs 5HI9, 4X1H, 4YEU, and others) related to GPCR signaling pathways.
His research team employs a multidisciplinary approach combining structural biology, biophysics, and biochemistry to investigate the molecular mechanisms underlying GPCR activation and signaling, with implications for understanding numerous physiological processes and developing targeted therapeutics.
