معرفی
Prof. Dr. Gebhard Schertler leads the Structural Biology of Membrane Proteins group at the Paul Scherrer Institute (PSI) in Switzerland. His research focuses on the molecular mechanisms of G protein-coupled receptors (GPCRs), particularly light-activated rhodopsins, to bridge structural biology with cellular signaling pathways and pharmacological applications.
- Expertise in X-ray crystallography and cryo-EM for membrane protein structures
- Collaborations in spectroscopic analysis and optogenetic tool design
- Over 25 years of publications in top-tier journals (Nature, Science, PNAS, etc.)
Research Interests include: Understanding GPCR activation, ligand efficacy, and intracellular signaling dynamics through structural biology; developing optogenetic tools by analyzing retinal protein pockets; and linking receptor structure to physiological functions via interdisciplinary approaches.
Recent Publications highlight structural studies of GPCR-G protein complexes, bistable opsins, and advanced crystallography techniques. His group’s work spans retinal protein dynamics, ion pump mechanisms, and computational methods for time-resolved data analysis.
Students: Lea Jänisch, Flurin Stefan Hidber, Sarah Luise Schmidt, Deborah Walter. Group members include senior scientists (Xavier Deupi, Valérie Panneels) and project scientists working on GPCR signaling, membrane protein biochemistry, and structural informatics.
