جست‌وجوی استاد و پژوهشگر

Hussein Al-Mossawiمشاهده پروفایل

عضو هیئت علمی

• Rheumatology
• Translational Immunology
• Autoimmune Inflammatory Diseases
• +۶ مورد دیگر

Dr Hussein Al-Mossawi is an NIHR Academic Clinical Lecturer in Rheumatology at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, and concurrently a Fellow by Special Election in Medical Sciences and lecturer in pathology & immunology at St Edmund Hall, University of Oxford. He also lectures at Exeter College. Education 2006 – BMBCh (Medicine), Trinity College, University of Oxford 2016 – DPhil (Translational Immunology), University of Oxford 2016 – MA, University of Oxford MRCP (Rheumatology), Royal College of Physicians Research Focus Dr Al-Mossawi’s research centres on dissecting immune responses in autoimmune inflammatory diseases, with a particular emphasis on psoriatic arthritis and spondyloarthritis. Using cutting-edge single-cell multi-omics, flow cytometry and patient-derived clinical trials, his group investigates: GM-CSF biology and its role in axial & peripheral spondyloarthritis IL-7R polymorphisms and inflammatory signalling Immunological mechanisms underpinning psoriatic arthritis Biomarker discovery for stratified therapy Scientific Awards Wellcome Trust Clinical Fellowship (2012–2016) Research Leadership & Funding Dr Al-Mossawi currently leads translational projects funded by the NIHR and Wellcome Trust, including the phase 2 NAMASTE trial targeting GM-CSF in axial spondyloarthritis and the Oxford Psoriatic Arthritis Centre (Ox-PACE) programme. He mentors early-career clinician-scientists and contributes to undergraduate teaching in pathology and immunology across multiple Oxford colleges. Laboratory & Teams He works within the Oxford Psoriatic Arthritis Centre (Ox-PACE) and collaborates closely with the Powrie and Bowness groups at the Kennedy Institute of Rheumatology and the Translational Gastroenterology Unit, fostering interdisciplinary projects that span rheumatology, hepatology and mucosal immunology.

Timothy E Reddyمشاهده پروفایل

دانشیار

• Gene Regulation
• Statistical Genetics
• Functional Genomics
• +۴ مورد دیگر

Timothy E Reddy serves as an Adjunct Professor in the Department of Biostatistics & Bioinformatics and Associate Professor in Molecular Genetics and Microbiology at Duke University. He is a core faculty member of the Duke Center for Statistical Genetics and Genomics and the Center for Combinatorial Gene Regulation, with appointments spanning biostatistics, molecular genetics, and biomedical engineering. His research integrates computational and experimental approaches to dissect gene regulatory mechanisms underlying complex diseases. Education: Ph.D. in Genetics, Boston University (2007) Dr. Reddy's research centers on noncoding genetic variation, epigenome editing, and statistical genomics. He pioneers CRISPR-based high-throughput functional assays to annotate regulatory elements and elucidate disease mechanisms in conditions like multiple sclerosis, schizophrenia, and polycystic ovary syndrome. His work bridges genome-wide association studies with mechanistic validation through epigenome editing and multi-omics integration, emphasizing combinatorial effects of regulatory variants. His recent publications demonstrate a cohesive trajectory in developing and applying functional genomics tools, particularly CRISPR-based epigenome editing screens and statistical frameworks for variant interpretation. Key themes include cell-type-specific regulatory networks, noncoding variant pathogenesis, and translational applications for complex disease therapeutics across neurological, metabolic, and immune disorders. Dr. Reddy leads multiple NIH-funded initiatives including the Duke FUNCTION Center (NHGRI), with current grants spanning CRISPR-based GWAS refinement (Open Philanthropy), noncoding variation in multiple sclerosis (NIAID), and schizophrenia genomics (NIMH). His collaborative projects involve institutions including Northwestern University and Mount Sinai, focusing on metabolic and reproductive disorders through integrated omics approaches. As co-director of the Duke Center for Statistical Genetics and Genomics, he drives interdisciplinary efforts to map combinatorial noncoding causes of disease. His lab develops cutting-edge epigenome editing technologies like HyperCas12a for multiplexed regulatory screens while maintaining active collaborations with clinical researchers for translational applications.

• Genetics
• Metabolism
• Cardiovascular Diseases
• +۴ مورد دیگر

Aldons Lusis is a Professor at the David Geffen School of Medicine, UCLA, with joint appointments in the Department of Human Genetics, Microbiology, Immunology & Molecular Genetics. He serves as Vice Chair of Human Genetics and is affiliated with multiple research institutes, including the Brain Research Institute, CTSI Center for Duchenne Muscular Dystrophy, and JCCC Cancer and Stem Cell Biology Program. His laboratory is located at the Molecular Biology Research Building (MRL) on the UCLA campus. Dr. Lusis leads a multidisciplinary research program focused on systems genetics, cardiometabolic diseases, and microbiome interactions. His work integrates genomics, metabolomics, and computational biology to dissect mechanisms underlying atherosclerosis, heart failure, non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome. Key research themes include mitochondrial dysfunction, sex-specific metabolic regulation, and gut microbiome-host crosstalk. His recent publications demonstrate a strong emphasis on tissue-organ communication (e.g., liver-heart axis), genetic determinants of mitochondrial function, and therapeutic targeting of metabolic pathways. Research leverages mouse diversity panels, human cohorts (METSIM), and multi-omics approaches to identify novel disease mechanisms. Dr. Lusis directs a collaborative research environment with extensive NIH funding, including grants supporting investigations into cardiac hypertrophy, diabetes genetics, and environmental impacts on metabolic health. His lab utilizes advanced genomic editing, single-cell technologies, and systems biology pipelines to resolve complex traits.

Sabina Berrettaمشاهده پروفایل

دانشیار

• Molecular Psychiatry
• Neurobiology of Psychiatric Disorders
• Amygdala Circuitry
• +۷ مورد دیگر

Sabina Berretta, MD , is an Associate Professor of Psychiatry at Harvard Medical School and an investigator at McLean Hospital, where she directs a laboratory focused on the molecular and cellular pathology of psychiatric disorders. Academic Affiliations: Harvard Medical School – Department of Psychiatry McLean Hospital – Belmont, Massachusetts Research Focus: The Berretta laboratory investigates how molecular and cellular abnormalities disrupt brain circuits underlying emotion regulation. A central theme is the role of the amygdala in schizophrenia and bipolar disorder , with particular emphasis on circadian control of gene expression and the involvement of extracellular matrix (ECM) components such as perineuronal nets (PNNs) and chondroitin sulfate proteoglycans . Recent work demonstrates that circadian patterns of somatostatin expression in the human amygdala are disturbed in bipolar disorder, while ECM abnormalities in the thalamic reticular nucleus may contribute to thalamo-cortical disconnectivity in schizophrenia. Methodological Approaches: The group integrates single-cell RNA-sequencing , spatial multi-omics , quantitative mass spectrometry , and natural language processing of clinical records to dissect disease mechanisms across brain regions, cell types, and peripheral tissues. Publication Landscape (2019–2025): Over this period, Dr. Berretta has co-authored more than 40 high-impact papers. These publications reveal a trajectory from foundational neuropathological descriptions of ECM alterations to cutting-edge systems-biology analyses of PTSD, major depressive disorder, Alzheimer’s disease, Huntington’s disease, and suicide. Notable studies include multi-cohort single-nucleus transcriptomic atlases of Parkinson’s disease, identification of somatic DNA-repeat expansions driving neurodegeneration, and integrative glycomic-proteomic dissections of myelinated versus non-myelinated brain regions in psychiatric disease. Scientific Awards & Recognition: While specific awards are not detailed in the provided text, Dr. Berretta’s sustained publication record in Nature , Cell , Science , and JAMA Psychiatry underscores international recognition for her contributions to the molecular understanding of serious mental illness. Collaborations & Funding: She collaborates extensively with the Psychiatric Genomics Consortium PTSD Working Group, the Harvard Brain Tissue Resource Center, and multiple NIH-funded initiatives. Her work bridges basic neuroscience and clinical psychiatry, positioning her laboratory at the forefront of precision psychiatry research. Laboratory Website: Berretta Laboratory at McLean Hospital

Vilde Olsson Lalunمشاهده پروفایل

پژوهشگر ارشد

• Plant Molecular Biology
• Genetics
• Evolutionary Biology
• +۷ مورد دیگر

Vilde Olsson Lalun is a postdoctoral fellow at the Centre for Ecological and Evolutionary Synthesis (CEES), University of Oslo. She obtained her BSc and MSc in Molecular Biology at UiO in 2013 and 2015, respectively, and completed her PhD in Genetics in 2020 under the supervision of Prof. Melinka Alonso Butenko. Her current research integrates experimental biology and bioinformatics within the interdisciplinary REPEAT project, focusing on how short tandem repeat (STR) variation influences adaptation and gene expression in Arabidopsis thaliana and Atlantic cod. Education 2013 – BSc in Molecular Biology, University of Oslo 2015 – MSc in Molecular Biology (Plant Genetics), University of Oslo 2020 – PhD in Genetics, Department of Biosciences, University of Oslo Thesis: "Molecular investigation of receptor kinase signaling specificity in Arabidopsis thaliana" Research Interests Dr Lalun’s work sits at the intersection of molecular plant biology , evolutionary genomics , and functional genetics . During her PhD she dissected peptide ligand–receptor kinase specificity using the IDA–HAE/HSL2 signalling module as a model. Presently, she investigates how STR length polymorphisms modulate gene expression and organismal fitness under environmental stress, leveraging both Arabidopsis and Atlantic cod as complementary model systems. Core methodological strengths include generation of transgenic lines, advanced live-cell imaging, quantitative microscopy, and integrative bioinformatic analyses. She actively contributes to the REPEAT consortium, an interdisciplinary team that addresses fundamental questions of genome plasticity and climate adaptation. By coupling large-scale comparative genomics with targeted experiments, the project aims to clarify how repetitive DNA elements shape regulatory networks controlling development and immunity. Publication Profile Across 11 peer-reviewed papers (2017-2025) in high-impact journals such as Nature Communications , PNAS , eLife , and Plant Cell , her research spans three major themes: Functional dissection of peptide signalling pathways in plant development and immunity. Comparative genomics of short tandem repeats and their impact on gene regulation. Mechanistic studies of receptor kinase activation and signalling specificity. The 2024-2025 outputs include a lead-author review on plant peptide ligands and multi-omics studies that link STR variation to gene body architecture in eukaryotes. Teaching & Outreach Dr Lalun is a committed educator and science communicator. She instructs two undergraduate courses: BIOS1120 – Physiology BIOS3610 – Molecular Plant Science Beyond the classroom she co-hosts the Norwegian-language podcast BioPodden , produces popular-science YouTube lectures, and gives interviews that demystify plant genetics for the public. Collaborations & Networks She is an active member of the Butenko Group at UiO and collaborates extensively within the CEES and the national REPEAT project network. The lab provides cutting-edge facilities for molecular biology, microscopy and bioinformatics, ensuring a vibrant environment for integrative research.

• Mitochondrial fatty-acid β-oxidation
• Post-translational redox modifications
• Nitric-oxide signalling
• +۶ مورد دیگر

Paschalis-Thomas Doulias is Associate Professor of Organic Chemistry and Biochemistry in the Department of Chemistry at the University of Ioannina, Greece. His laboratory, located in Ioannina Campus building X3-106D, investigates the molecular mechanisms governing mitochondrial fatty-acid β-oxidation and their translational exploitation for rare inherited disorders of long-chain fatty-acid oxidation. Research Interests His research spans two tightly integrated themes: Basic Research: Elucidating post-translational redox modifications—particularly S-nitrosylation, acetylation and succinylation—that regulate key enzymes of mitochondrial fatty-acid oxidation. Work uses genetically modified mouse models (Sirt-3 -/- , Sirt-5 -/- , eNOS -/- and VLCAD Cys238Ala knock-in) complemented by cellular mutagenesis to dissect how energetic demand is coupled to enzymatic flux. Translational Research: Developing nitric-oxide-based therapies for long-chain fatty-acid oxidation disorders (LC-FAODs). The group pioneered the concept that augmenting NO signalling restores catalytic efficiency of mutant VLCAD, and is currently validating FDA-approved NO donors and proprietary hybrid NO-plus-substrate molecules in patient-derived cells and a humanised VLCAD-deficient mouse. Publication Landscape (2020-2025) Over the past five years, Doulias and collaborators have generated 15 high-impact articles that collectively map redox-proteomic landscapes in cardiovascular, neurodegenerative and metabolic disease contexts. Recurring keywords include S-nitrosylation, TCA-cycle compromise, mitochondrial energetics, HFpEF, ALS and Alzheimer’s disease, underscoring a unifying theme of redox-metabolic crosstalk. Scientific Awards & Recognition While specific honours are not enumerated, the consistent citation of his work (H-index 30, 3571 citations) attests to significant peer recognition. Funding & Collaborations Active translational projects include medicinal-chemistry optimisation of NO-donating compounds and in vivo efficacy testing in humanised mouse models of VLCAD deficiency, implying sustained competitive funding and multi-disciplinary partnerships. Laboratory & Team The group operates within the Department of Chemistry core facilities, leveraging state-of-the-art proteomics, metabolomics and transgenic animal resources to advance both basic and pre-clinical goals.

• Molecular Biology
• Transcriptomics
• HPV-Related Cancers
• +۳ مورد دیگر

Dr. Hiroko Matsunaga is a Senior Researcher (Research Associate Professor) at Waseda University's Research Organization for Nano & Life Innovation since 2025. She previously held positions at Waseda University (1993-2018), Central Research Laboratory at Hitachi, Ltd. (1993-2018), and was a Visiting Scholar at Iowa State University (2001-2003) and Aika State University (1994-1995). She earned her Doctor of Science from Osaka Prefecture University in 1993. Education: PhD (Science) from Osaka Prefecture University (1989-1993) Her research focuses on molecular biology, particularly in single-cell and microtissue transcriptomics, HPV18-related cervical cancers, and spatial gene expression analysis in diseases like Alzheimer's and Marfan syndrome. She has pioneered methods for spatial transcriptomics using FFPE tissues and developed tools for precision medicine in rare cancers. Recent publications highlight her work in spatial transcriptomics, HPV18 infection mechanisms, and applications of organoid models. Her methodologies integrate advanced biotechnology with bioinformatics to address tumor heterogeneity, viral carcinogenesis, and cardiovascular pathologies. She contributes to grants like the JSPS-funded project on personalized lung cancer medicine. She has co-authored patents in nucleic acid analysis, cell collection systems, and gene detection methods. Collaborations span institutions like Osaka University, Iowa State University, and Aika State University.

Alexander Pintoمشاهده پروفایل

دانشیار

• Cardiovascular Research
• Heart Failure
• Diabetes and Cardiovascular Disease
• +۴ مورد دیگر

Associate Professor Alexander Pinto leads the Cardiac Cellular Systems laboratory at the Baker Heart and Diabetes Institute and holds a co-appointment with La Trobe University. His research investigates how cellular networks in the heart contribute to heart failure and how extra-cardiac tissues and blood factors regulate this network, with emphasis on hypertension, obesity, and diabetes-induced cardiac alterations. His educational background includes: BBiomedSc(Hons) from Monash University PhD from Monash University Pinto employs cutting-edge computational biology, single-cell omics, 3D imaging, and mouse genetics to explore reversible cardiac changes in metabolic diseases. His work bridges cardiovascular physiology, metabolic disorders, and cellular mechanisms, with significant focus on sex-dependent differences in cardiac cellularity and fibrosis pathways. The integration of multi-omics approaches defines his methodological innovation. Publications from 2012-2021 reveal consistent investigation into cardiac cellular composition through single-cell transcriptomics, highlighting diabetes-related diastolic dysfunction and sex-specific hormonal regulation. Key trends include mapping fibrosis mediators, stress-induced hypertrophy drivers, and macrophage roles in cardiac immunity. His awards include: Baker Institute Fellowship (2021) No student advising or grant information was specified in available materials. His laboratory maintains active collaborations with research groups across Australia and the United States. Pinto directs the Cardiac Cellular Systems laboratory while co-leading the Heart Failure Program, utilizing advanced imaging and genetic models to dissect cardiac network dynamics in disease contexts.

• Computational Biology
• Immunology
• Genetics
• +۳ مورد دیگر

Ghaith ABDESSALEM is a postdoctoral fellow in computational biology at the IMAGINE Institute, University of Paris, working in the 'Inflammatory Responses and Transcriptomic Networks in Diseases' Laboratory since May 2018. His research focuses on rare inflammatory disorders using single-cell multi-omics technologies including scRNAseq, scCITEseq, and scATACseq with 10X Genomics platforms. Education: Master's degree in Fundamental and Applied Immunology Doctoral research at the Laboratory of Biomedical Genomics and Oncogenetics, Pasteur Institute in Tunis His expertise bridges genetic, immunological, and computational domains to investigate rare inherited inflammatory diseases. Specializing in Next Generation Sequencing data analysis (exome, genome, microarray), he developed human exome/genome sequencing pipelines accredited through the H3Africa network. Current work examines rare hereditary skin disorders in North African populations and molecular signatures of SARS-CoV-2-related inflammatory syndromes using cutting-edge single-cell multi-omics approaches. His 2020-2021 publications reveal consistent focus on transcriptional networks in immune cells and bone biology, demonstrating advanced applications of multi-omic integration to dissect disease mechanisms in inflammatory disorders and skeletal development. Research spans from fundamental osteoblast regulation to clinical manifestations of viral-triggered hyperinflammation. He operates within the 'Inflammatory Responses and Transcriptomic Networks in Diseases' Laboratory, which employs high-throughput single-cell technologies to decode molecular pathways in rare inflammatory conditions through computational biology frameworks.

Joanna Jankowskyمشاهده پروفایل

استاد

• Alzheimer's Disease
• Neuroscience
• Neurodegenerative Diseases
• +۴ مورد دیگر

Joanna Jankowsky serves as Professor of Neuroscience and Theodore and Bertha Bryan Professor of Environmental Medicine at Washington University School of Medicine, leading research on Alzheimer's disease pathogenesis through genetically engineered mouse models. Her work investigates genetic, environmental, and aging factors influencing dementia risk and progression. Her educational background includes: PhD in Cellular and Molecular Neuroscience, California Institute of Technology (1993-1999) BA in Biology, Amherst College (1987-1991) Dr. Jankowsky's research centers on Alzheimer's disease mechanisms , with emphasis on TMEM106B genetics , disease heterogeneity , and amyloid-targeting interventions . Her lab develops transgenic models to dissect neural circuit vulnerability and protein aggregation dynamics, exploring how genetic variants influence resilience to tauopathy and amyloid pathology. Recent publications (2021-2024) reveal consistent focus on Alzheimer's mechanisms using transgenic models, with key themes including TMEM106B's protective role in tauopathy, activity-dependent neurodegeneration in memory circuits, and innovative Aβ-targeting gene therapies. These works bridge neuroscience, molecular genetics, and therapeutic development. Her scientific recognition includes: Vivian L. Smith Endowed Chair in Neuroscience (Baylor College of Medicine, 2020-2025) Alzheimer’s Association Zenith Fellows Award (2019-2022) NIH Director’s New Innovator Award (DP2, 2007-2012) NIH Mentored Research Scientist Award (K01, 2004-2009) NARSAD Young Investigator Award (2004-2006) Dr. Jankowsky mentors trainees through the Jankowsky Lab while securing major grants including NIH New Innovator and Zenith Fellow awards. Her collaborative work spans neuroscience departments and leverages viral vector technologies for therapeutic development. The Jankowsky Lab maintains three core research thrusts: TMEM106B isoform effects on dementia risk using multi-omics approaches, structural determinants of protein aggregate toxicity, and amyloid-targeting gene therapies delivered via neuroscience-derived viral tools. The lab actively distributes its mouse models to accelerate global Alzheimer's research.

• Medical Biotechnology
• Biochemistry
• Cell Biology
• +۶ مورد دیگر

Pirkko Mattila serves as Research Director and Senior Researcher at the Institute for Molecular Medicine Finland (FIMM), University of Helsinki, holding a joint appointment with the Finnish Red Cross Blood Service since 2014. She supervises the Doctoral Programme in Biomedicine and has maintained continuous research activity for over 35 years through roles at Haartman Institute and industry. Her academic credentials include: Docent (2011) PhD (1993) Master of Science in Biochemistry (1989) Dr. Mattila's research integrates medical biotechnology with molecular pathology, focusing on cellular stress responses in genetic disorders, oxidative stress mechanisms in age-related macular degeneration, and neutrophil inflammasome dynamics during viral infections. She pioneers single-cell analytics to dissect disease heterogeneity, with recent work establishing quality frameworks for multi-omics in personalized medicine through European infrastructure projects. Her publication trajectory shows increasing translational focus since 2015, with 2024-2025 outputs spanning high-impact journals in omics methodology (Nature Biotechnology), ophthalmology (IOVS), and immunology (PLoS Pathogens). This reflects strategic alignment with EU initiatives like EATRIS-Plus for clinical implementation. Dr. Mattila actively mentors doctoral candidates through structured supervision in the Biomedicine Programme. Her current research is sustained by two major grants: EU-OPENSCREEN ERIC Suomi FIRI (Academy of Finland, 2025-2027) as Project Manager Airway disease pathogenesis project (since 2011) as core participant She directs the FIMM Single-Cell Analytics facility, a national infrastructure providing cutting-edge omics services to academic and clinical partners across the Nordic region. The lab emphasizes quality-controlled workflows and cross-validation with histopathology, supporting her vision of precision medicine grounded in molecular evidence.

Emma Sofie Timm Allerمشاهده پروفایل

پژوهشگر ارشد

• Plant Stress Response
• Epigenetics
• Bioinformatics
• +۲ مورد دیگر

Emma Sofie Timm Aller is a Postdoc at the Department of Plant and Environmental Sciences, Section for Molecular Plant Biology, within the Faculty of Science at the University of Copenhagen. She is affiliated with the DynaMo Center for dynamic molecular interactions, where she investigates plant-environment interactions through molecular and epigenetic lenses. Her academic credentials include: MSc in Biology-Biotechnology from the University of Copenhagen (2013-2015) BSc in Biology-Biotechnology from the University of Copenhagen (2009-2013) Dr. Aller's research examines how plants develop phenotypic variation to cope with environmental stress through non-genetic mechanisms, with particular focus on stress signal communication across plant generations. She employs advanced bioinformatic techniques to analyze sequencing data and map molecular networks affected by stressors. Her work bridges computational biology with experimental plant science to address climate resilience challenges. Publication analysis reveals consistent emphasis on epigenetic regulation of plant plasticity, with recent work expanding from foundational trait stability studies (2018) to comprehensive transgenerational inheritance frameworks (2022). The research trajectory demonstrates increasing integration of multi-omics approaches to dissect stress response pathways. As an active member of the DynaMo Center, she collaborates within interdisciplinary teams studying dynamic molecular interactions in plant systems. Her current work continues to explore epigenetic memory mechanisms while investigating stress signal transmission between neighboring plants.

• Twin Genetics
• Nature versus Nurture
• Genetics of complex disease
• +۲ مورد دیگر

Erik Ehli serves as Medical Associate Professor in Biomedical & Translational Sciences and Assistant Professor in Psychiatry at the University of South Dakota's Sanford School of Medicine. His research bridges clinical psychiatry with genetic epidemiology, specializing in twin studies to dissect nature-nurture interactions in complex diseases. Education: Ph D, Basic Biomedical Sciences, University of South Dakota, 2013 BS, Nursing, South Dakota State University, 2005 MS, Basic Biomedical Sciences, University of South Dakota, 2004 BS, Biology, Northern State University, 1998 Dr. Ehli's research program centers on twin genetics to quantify hereditary versus environmental contributions across multiple domains. His work spans cancer genetics (investigating familial aggregation), pharmacogenetics (drug response variability), and complex disease genetics (integrating multi-omics approaches). The Nature versus Nurture framework underpins all investigations, utilizing twin cohorts to isolate genetic effects from environmental confounders in psychiatric and metabolic conditions. Recent publications demonstrate methodological diversity: genomic sequencing of medicinal leech models (2020), neurobehavioral phenotyping in alcohol-affected populations (2018), and translational phytochemical trials (2012). This portfolio reveals consistent focus on gene-environment interplay across species and experimental paradigms, with increasing emphasis on molecular mechanisms underlying psychiatric and metabolic disorders.

• Neuroimmunology
• Neurodegenerative Diseases
• Single-cell Omics
• +۴ مورد دیگر

Marc Beyer serves as Group Leader at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, holding the academic rank of Associate Professor. His research investigates bidirectional immune-brain interactions during aging and neurodegeneration, with emphasis on T cell and microglial mechanisms in Alzheimer's, Parkinson's, and post-COVID neurological complications. Dr. Beyer's group pioneers single-cell multi-omic approaches including snRNA-seq, scATAC-seq, and spatial transcriptomics to decode cellular heterogeneity in neurodegenerative contexts. Key projects involve creating human brain cell atlases (DFG-NGS collaboration), characterizing dopaminergic neuron transcriptional changes in Parkinson's, and exploring 'innate immune memory' in microglia. The NeuroCOV initiative identifies peripheral blood immune signatures linked to long-term cognitive decline after SARS-CoV-2 infection. Scientific Awards: No awards specified in source materials. Dr. Beyer directs multiple high-impact projects including a large DZNE cohort study on peripheral immunity in early dementia and the European NeuroCOV consortium. These initiatives employ high-throughput single-cell analysis of PBMCs to develop biomarkers for early therapeutic intervention, though specific grant details and student mentorship records remain unlisted. The research team operates from DZNE's Venusberg Campus facility, utilizing CRISPR-Cas9 lineage tracing (LINC mouse model), high-dimensional flow cytometry, and multimodal omics platforms to dissect neuroimmune crosstalk in physiological and pathological CNS states.

Luke Evansمشاهده پروفایل

استادیار

• Statistical Genetics
• Quantitative Genetics
• Genetic Architecture
• +۶ مورد دیگر

Luke Evans serves as an Assistant Professor at the University of Colorado Boulder, holding dual appointments in the Department of Ecology and Evolutionary Biology and the Institute for Behavioral Genetics. His research integrates quantitative and statistical genetics to investigate the genetic architecture of complex traits, with particular emphasis on aging, psychiatric disorders, and substance use behaviors. Dr. Evans completed his Ph.D. at Northern Arizona University in 2012. His research program focuses on developing and applying methods for estimating heritability and investigating the genomic architecture of complex traits. He has made significant contributions to understanding the genetic basis of psychiatric disorders, particularly through examining gene-gene interactions and tissue-specific contributions to heritability. Analysis of Dr. Evans' recent publications reveals a strong focus on psychiatric genetics, particularly the genetic architecture of internalizing disorders and their relationship with substance use. His work frequently employs advanced genomic structural equation modeling and gene-gene interaction analyses to dissect complex trait architecture. A notable trend in his recent work involves applying these methods to understand aging-related traits and neurological conditions like Alzheimer's disease. Dr. Evans serves as Principal Investigator on the Hevolution/AFAR New Investigator Award grant titled 'Gene-gene interaction associations with frailty to identify core genes of aging and their biological context' and as Co-Investigator on multiple NIH-funded projects including studies on addiction genetics, psychiatric disorders, and cognitive aging. He is actively recruiting graduate students for fall 2026 and postdoctoral researchers for his lab. The Evans Lab employs quantitative and statistical genetics approaches to investigate the genetic architecture of complex traits, with particular emphasis on aging, psychiatric disorders, and substance use behaviors. The lab collaborates extensively with researchers across multiple institutions and disciplines, contributing to large-scale genomic studies and developing novel analytical methods for understanding complex trait architecture.