جست‌وجوی استاد و پژوهشگر

• Fungal Evolution
• Population Genetics
• Mitochondrial DNA Variation
• +۳ مورد دیگر

Jianping Xu is a Professor in the Department of Biology at McMaster University, specializing in the ecology and evolutionary genetics of fungi. His research explores evolutionary mechanisms in fungal populations from environmental, clinical, and host-associated contexts. Institution: McMaster University Department: Biology Research Overview: Integrates microbiology, molecular genetics, and quantitative approaches to study fungal evolution. Research Interests include: Population genetics of human and animal fungal pathogens Mitochondrial DNA variation and inheritance Development of biomarkers for fungal identification Microbiome impacts on host health Publication Trends show focus on fungal pathogenesis, environmental adaptation, and genomic analyses across species like Cryptococcus , Aspergillus , and agricultural fungi. Teaching & Outreach connects to McMaster's biology programs, with research stories highlighting fungal-based innovations (e.g., mushroom plastics) and clinical studies on drug-resistant pathogens.

Hugh Clarkeمشاهده پروفایل

استاد

• Reproductive Biology
• Infertility
• Oocyte Development
• +۳ مورد دیگر

Hugh Clarke, PhD is a Senior Scientist at the RI-MUHC, Glen site and a Professor in the Department of Obstetrics and Gynecology at McGill University 's Faculty of Medicine and Health Sciences. His research focuses on oocyte development within ovarian follicles. Research Interests: Oocyte growth and maternal molecule storage Germ cell-somatic cell communication Environmental toxin effects on oocyte quality Intercellular signaling mechanisms mRNA regulation during maturation Chromatin remodeling at fertilization Publications (2015-2024) reveal expertise in reproductive biology, with key projects examining: EGFR signaling in follicular decoupling mTOR pathway in follicle communication CNOT6-mediated mRNA deadenylation Transzonal projection architecture Epigenetic inheritance patterns Actin's role in meiotic processes Location: Lab F3-50, Royal Victoria Hospital, Montreal, QC H3A 1A1

• Medical Genetics
• Cytogenetics
• Oncology
• +۴ مورد دیگر

Susan B. Olson is a Professor in the Department of Medical Genetics at Oregon Health & Science University's School of Medicine. With over three decades of experience since earning her Ph.D. in Medical Genetics in 1987, she has established herself as a leading researcher in cytogenetics and molecular genetics, particularly focusing on Fanconi anemia and hematologic malignancies. Her work bridges basic science with clinical applications, contributing significantly to our understanding of genetic disorders and cancer mechanisms. Dr. Olson's research interests center on the molecular mechanisms of Fanconi anemia, acute myeloid leukemia, and other genetic disorders. Her laboratory investigates DNA repair pathways, particularly the Fanconi anemia pathway, and how defects in these processes lead to bone marrow failure and cancer predisposition. She has made significant contributions to understanding NUP98 rearrangements in leukemia, RUNX1 mutations, and the role of FANCD2 in DNA replication through fragile sites. Her work often combines cytogenetic analysis with molecular techniques to uncover novel mechanisms underlying genetic diseases. Analysis of Dr. Olson's recent publications (2016-2024) reveals a consistent focus on genetic mechanisms in cancer and inherited disorders. Her research spans from basic molecular studies of DNA repair mechanisms to clinical investigations of leukemia and lymphoma. A significant portion of her work centers on Fanconi anemia pathophysiology, with applications to understanding cancer development. She frequently employs advanced techniques including single-cell and spatial transcriptomics, cytogenetic analysis, and molecular diagnostics to address fundamental questions in medical genetics. Throughout her career, Dr. Olson has maintained productive collaborations with clinicians and researchers across multiple institutions, particularly with Stephen R. Moore at Oregon Health & Science University. Her work has been supported by various research grants focused on understanding the molecular basis of genetic disorders and developing potential therapeutic approaches, particularly for Fanconi anemia and acute myeloid leukemia.

• Mitochondrial Medicine
• Neuro-Ophthalmology
• Inherited Optic Neuropathies
• +۷ مورد دیگر

Professor Patrick Yu Wai Man is a leading academic clinician and researcher at Newcastle University, specializing in mitochondrial medicine and neuro-ophthalmology. His work bridges clinical ophthalmology with cutting-edge mitochondrial genetics, focusing on inherited optic neuropathies such as Leber Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (OPA1-related disorders), as well as Wolfram syndrome and other mitochondrial cytopathies. Education & Training: While specific degrees are not detailed, his extensive publication record from 2002 onwards and professorial rank indicate advanced clinical and research training in neurology, ophthalmology, and mitochondrial genetics. Research Interests: Mitochondrial genetics and disease mechanisms Inherited optic neuropathies (LHON, OPA1, Wolfram syndrome) Neuro-ophthalmology and retinal ganglion cell biology Translational therapies for mitochondrial eye diseases Zebrafish and cellular disease models Clinical genomics and next-generation sequencing diagnostics His research integrates clinical phenotyping with molecular genetics, utilizing advanced imaging, electrophysiology, and animal models to understand mitochondrial dysfunction in neurodegeneration. He has pioneered work on mitochondrial DNA maintenance, optic nerve pathology, and therapeutic strategies including idebenone and gene-based approaches. Scientific Contributions: Professor Yu Wai Man has published over 100 peer-reviewed articles since 2002, with significant contributions to understanding LHON pathophysiology, OPA1-related optic atrophy, and Wolfram syndrome. His work has defined genotype-phenotype correlations, identified novel disease genes (e.g., CISD2, CHCHD10), and advanced clinical trial readiness for mitochondrial optic neuropathies. Collaborations & Teams: He collaborates extensively with Professor Patrick Chinnery (mitochondrial genetics), Professor Rita Horvath (neurogenetics), and international consortia including the NINDS mitochondrial disease common data elements project. His research spans Newcastle University's mitochondrial research group and involves multidisciplinary teams in ophthalmology, neurology, and basic science.

• Stem Cell Research
• Ophthalmology
• Regenerative Medicine
• +۵ مورد دیگر

Professor Lyle Armstrong is a leading researcher at Newcastle University specializing in stem cell applications for ophthalmology and retinal disease modeling. His work focuses on developing induced pluripotent stem cell (iPSC)-derived retinal organoids to study inherited retinal disorders, evaluate therapeutic interventions, and understand disease mechanisms. He collaborates extensively with experts including Professor Majlinda Lako and Professor Evelyne Sernagor within Newcastle's research ecosystem. Armstrong's primary research interests include stem cell differentiation into retinal lineages, photoreceptor transplantation for vision restoration, and modeling genetic disorders such as Stargardt disease, retinitis pigmentosa, and age-related macular degeneration. His investigations frequently address mitochondrial dysfunction, splicing defects, and lysosomal storage pathologies in retinal cells. Recent work emphasizes single-cell transcriptomics to map retinal development and optimize disease modeling protocols. Analysis of his 2022-2025 publications reveals a strategic focus on translating stem cell models into clinical applications, particularly through drug screening, toxicity testing, and mechanistic studies of tissue-specific disease phenotypes. His editorial leadership in stem cell-ophthalmology methods underscores his influence in standardizing field protocols. No scientific awards were documented in the provided publication records. While student advising and grant details weren't explicitly listed, Armstrong's role as senior/corresponding author across 50+ publications indicates extensive mentorship of junior researchers. His work involves multidisciplinary teams spanning stem cell biology, genomics, and ophthalmology, though specific lab structures weren't detailed in the source material.

Alison Wardمشاهده پروفایل

دانشیار

• Nutritional Epigenetics
• Developmental Programming
• Livestock Production
• +۶ مورد دیگر

Alison Ward is an Associate Professor in the Department of Animal and Poultry Science at the University of Saskatchewan, Canada. Her research focuses on nutritional epigenetics, developmental programming, and molecular genetics in livestock, particularly examining how maternal nutrition affects fetal development and long-term health outcomes in beef cattle. She integrates multi-omics approaches, including transcriptomics and metabolomics, to study nutrient-gene interactions and improve precision agriculture practices. PhD (Animal Science), University of Saskatchewan MSc (Animal Science), University of Saskatchewan BSc (Animal Science), University of Saskatchewan Ward’s work bridges molecular biology, physiology, and genomics to address how maternal micronutrient and one-carbon metabolite supplementation during critical gestational periods alter fetal organ development, placental function, and epigenetic gene regulation. Her recent publications emphasize fetal liver programming, mitochondrial function, and transgenerational effects of maternal nutrition, with a strong focus on sustainable livestock production. Her research has been supported by grants from the USDA National Institute of Food and Agriculture, North Dakota Beef Commission, and other agricultural research bodies. She teaches ANSC 313 – Animal Breeding and Genetics, and has received teaching excellence awards from the University of Saskatchewan Students Union. 2024 Open Resources Initiative Award USSU Teaching Excellence Award

Sabine A. Fuchsمشاهده پروفایل

استاد

• Metabolic Diseases
• Genetic Diseases
• Pediatrics
• +۵ مورد دیگر

Sabine A. Fuchs is a Full Professor and pediatrician specializing in metabolic diseases at Utrecht University Medical Center (UMC-Utrecht), holding a Principal Investigator position at the Hubrecht Institute's Regenerative Medicine and Stem Cell Research group (RMCU). Her dual clinical-research role bridges patient care with translational science in pediatric genetic disorders. Her academic journey includes cum laude degrees in Pharmacy and Medicine from Utrecht University, supplemented by research in Edinburgh (Prof. Webb) and clinical training at Harvard Medical School. She completed pediatric specialization alongside a ZonMW AGIKO-funded PhD in metabolic diseases, later establishing her independent research line through a ZonMW Klinische Fellows grant. Dr. Fuchs' research centers on metabolic and genetic diseases in children, with emphasis on mitochondrial disorders and inborn errors of metabolism. She pioneers mRNA-based therapeutics, in vivo gene correction, and mitochondrial function restoration, developing innovative platforms like liver organoids for disease modeling. Her work integrates clinical insights with molecular diagnostics to address unmet therapeutic needs. Recent publications reveal strong trends in mRNA delivery systems for genetic diseases, aminoacyl-tRNA synthetase deficiency treatments, and advanced cellular screening for variant interpretation. Her group's work on mitochondrial phenotyping and amino acid metabolism demonstrates a multidisciplinary approach spanning nanomedicine, stem cell biology, and metabolic engineering. Her 2024 awards include: €200,000 Biotech Booster grant for HeLLO €150,000 ERC Proof of Concept grant for IMPACT €1.5 million ZonMW VICI grant for in vivo gene correction €15,000 Tjallingh Roorda Stichting grant for mitochondrial disease therapies Dr. Fuchs supervises PhD candidates through grants like the Tjallingh Roorda project and leads collaborative research funded by ZonMW, ERC, and Dutch foundations. Her grants portfolio exceeds €2 million in 2024, supporting translational pipelines from basic discovery to clinical application. She directs a research team within the RMCU at the Hubrecht Institute, collaborating with UMC-Utrecht clinicians and international partners to advance regenerative medicine approaches for childhood metabolic disorders through stem cell models and gene editing technologies.

Trevor J. McGillمشاهده پروفایل

استادیار

• Retinal Degenerative Diseases
• Gene Therapy
• Stem Cell Therapy
• +۳ مورد دیگر

Dr. Trevor J. McGill is a Research Assistant Professor at the Casey Eye Institute, Oregon Health & Science University (OHSU), School of Medicine. His research focuses on developing cell-based and gene therapies for retinal degenerative diseases using rodent and nonhuman primate models. His educational background includes: B.S. in 2002 from The University of Lethbridge MSc in 2004 from The University of Lethbridge Ph.D. in 2008 from The University of Lethbridge Dr. McGill's primary research interests include Retinitis Pigmentosa and Age-related Macular Degeneration. His lab employs both rodent and nonhuman primate models to translate cell-based and gene therapies into clinical trials for retinal degenerative diseases. His work spans gene therapy, stem cell therapy, and the development of preclinical models for diabetic retinopathy and other retinal conditions. Analysis of Dr. McGill's recent publications (2019-2025) reveals a strong focus on translational ophthalmology, particularly in stem cell and gene therapy for retinal degeneration. Key trends include the use of nonhuman primate models, development of gene augmentation therapies (e.g., for CNGB1-retinitis pigmentosa), and investigation of diabetic retinopathy mechanisms. His work also extends to immunology in transplantation and mitochondrial genetics. Dr. McGill leads a research laboratory at the Casey Eye Institute that utilizes advanced models of retinal degeneration. His team collaborates extensively with other researchers at OHSU and beyond, as evidenced by multi-institutional publications.

Walter Neupertمشاهده پروفایل

استاد

• Structure and function of membrane proteins
• Mitochondrial genomics and proteomics
• Mitochondrial diseases
• +۷ مورد دیگر

Walter Neupert was a renowned Professor and Chair of Physiological Chemistry at the University of Munich (1983–2010) and a Max Planck Fellow at the Max-Planck-Institute of Biochemistry (since 2008). His research focused on mitochondrial biology, membrane proteins, and organelle biogenesis. He passed away on June 22, 2019. **Positions Held**: Professor and Chair, Adolf-Butenandt-Institute, University of Munich (1983–2010) Professor, Institute of Biochemistry, University of Göttingen (1979–1983) Associate/Assistant Professor roles at Universities of Göttingen and Munich (1969–1979) **Research Interests**: Mitochondrial structure/function, protein trafficking, mitochondrial diseases, and molecular chaperones. His work advanced understanding of mitochondrial biogenesis and dynamics. **Awards & Memberships**: Recipient of the Gairdner-Foundation Prize (1998), Heinrich-Wieland-Prize (1993), and Otto Warburg-Medal (2000) Member of multiple academies: Academia Europaea, Bavarian Academy of Sciences, German Academy of Sciences Leopoldina **Leadership Roles**: Served as Chairman of the European Molecular Biology Council (1997–2000) and on councils for EMBO and the German Research Society (DFG).

• Bioinformatics
• Evolutionary Biology
• Comparative Genomics
• +۳ مورد دیگر

Berend Snel is a Professor of Bioinformatics at Utrecht University, Faculty of Science, Department of Biology. He leads the Evolutionary Genomics and Integrative Bioinformatics group and serves as chair of the executive board of the Utrecht Bioinformatics Center. His work contributes to Sustainable Development Goals related to life sciences and bioinformatics research. His research expertise spans across several domains: Evolutionary Biology Bioinformatics Comparative Genomics Eukaryote Evolution Big Data Analysis in Life Sciences Professor Snel's research focuses on the evolutionary genomics of eukaryotes, with particular interest in gene duplication, orthology, paralogy, and kinetochore evolution. His work integrates computational approaches with biological insights to understand fundamental evolutionary processes. His fingerprint analysis reveals strong contributions to research on Eukaryotes (100%), Genomics (84%), Gene Duplication (49%), Arabidopsis (47%), Kinetochore (46%), Orthology (46%), and Paralogy (44%). His recent publication trends show a continued focus on eukaryotic evolution, with particular emphasis on metabolic pathways, chromosome segregation mechanisms, spliceosome evolution, and the genomic consequences of endosymbiosis. His work increasingly integrates phylogenomics with structural and functional analyses to reconstruct evolutionary histories. Scientific recognition includes: NWO-Vici award (2015) Professor Snel has supervised numerous students and researchers, with 13 supervised works documented. His group participates in the Utrecht Exposome Hub and contributes to integrative bioinformatics approaches in life sciences. He serves on editorial boards for BMC Bioinformatics and Biology Direct, and Scientific Reports, and participates in PhD committees and national/international grant panels. His group is actively involved in several major conferences including NBCI, BioSB, and BBC.

• Evolutionary Ecology
• Telomere Dynamics
• Life-history Strategies
• +۲ مورد دیگر

Professor Pat Monaghan holds the Regius Chair of Zoology at the University of Glasgow's School of Biodiversity, One Health and Veterinary Medicine. Her research combines evolutionary ecology with physiological mechanisms, focusing on life-history strategies, effects of early-life conditions on development and aging, and conservation biology. Research Focus: Long-term consequences of early-life conditions, resource allocation trade-offs, telomere dynamics, oxidative stress, and mitochondrial function. Maintains long-term studies on red-billed chough conservation. Funding: Primarily supported by European Research Council Advanced Investigator Awards, BBSRC, NERC, Leverhulme Trust, AXA Foundation, and European Commission. Current Group Members: Dr. Winnie Bonner, Dr. Ed Ivimey-Cook, Dr. Sophie Dupont, Ms. Cara Cochrane, Dr. Claire Branston, Dr. Pablo Capilla Lasheras, Ms. Miranda Cichy, Ms. Sarah Fenn, Dr. Caroline Millet, Dr. Pablo Salmon

Steven Gorsichمشاهده پروفایل

دانشیار

• Stress Biology
• Cell Biology
• Genetics
• +۷ مورد دیگر

Steven Gorsich is an Associate Professor and Chairperson in the Department of Biology within the College of Science & Engineering. His research focuses on cellular stress mechanisms using the model organism Saccharomyces cerevisiae , integrating genetics, molecular biology, and microscopy. Education: B.S., Eastern Kentucky University, 1993 M.S., Eastern Kentucky University, 1996 Ph.D., University of Utah, 2002 His research interests include stress biology, mitochondrial dynamics, oxidative stress, and the impact of fermentation inhibitors on yeast. These studies aim to understand fundamental cellular processes and engineer more robust yeast strains for biotechnological applications. The publication record shows consistent work in yeast stress response, particularly to furfural and other fermentation inhibitors, with strong emphasis on genetic and metabolic pathways such as the pentose phosphate pathway. Research spans molecular mechanisms of cellular damage, mitochondrial morphology, and meiosis. Scientific Awards: No awards listed in the provided text. Dr. Gorsich advises graduate students, several of whom are co-authors on his publications. His lab investigates cellular stress and mitochondrial function, contributing to both basic science and applied biotechnology. He teaches a range of courses including Genetics, Cell Biology, Molecular Biology, Epigenetics, and Alternative Energy. Labs & Research Teams: His lab uses budding yeast to explore oxidative stress, mitochondrial morphology, and inhibitor tolerance in fermentation processes.

• Gene Therapy
• Fetal Medicine
• Medical Biotechnology
• +۵ مورد دیگر

Simon Waddington is a Professor of Gene Therapy at the University College London (UCL) within the Ega Institute for Women's Health and Faculty of Population Health Sciences . His work bridges gene therapy , maternal-fetal medicine , and genetic disorder research . Research interests focus on translational gene therapy for childhood inherited diseases , particularly neurodegenerative disorders , metabolic conditions , and lysosomal storage diseases . Key areas include viral vector engineering (AAV, lentivirus), placental-targeted therapies , and mitochondrial dysfunction interventions. His 150+ peer-reviewed publications grants exceeding £20M patent filings (x8) highlight achievements in journals like Nature , Science Translational Medicine , and Blood . Articles reveal trends in AAV-mediated gene delivery , preterm birth models , and multi-organ disease targeting . Collaborations span European Research Council , Medical Research Council , LifeArc , and institutions in Singapore, South Africa, and across Europe. He chairs UCL's Cell and Gene Therapy Therapeutic Innovation Network and co-founded Bloomsbury Genetic Therapies .

Jared Rutterمشاهده پروفایل

استاد

• Metabolism
• Mitochondrial Biology
• Cell Signaling
• +۶ مورد دیگر

Jared Rutter is Distinguished Professor of Biochemistry and an Adjunct Professor of Nutrition and Integrative Physiology at the University of Utah, where he is also an HHMI Investigator. His laboratory spans the Biological Chemistry and Molecular Biology PhD programs, using yeast, Drosophila, mammalian cells, and mice to dissect metabolism and mitochondrial biology. Education B.S., Brigham Young University Ph.D., University of Texas Southwestern Medical Center Research Focus The Rutter group is driven by a central question: how does metabolism control cell fate? They pursue three interlocking themes: MIDAS platform — high-throughput mass spectrometry coupled to equilibrium dialysis for systematic discovery of allosteric metabolite-protein interactions. Mitochondrial Biology — multidisciplinary genetics, imaging, and biochemical approaches to reveal evolutionarily conserved proteins governing mitochondrial function and human disease. Mitochondrial Pyruvate Carrier (MPC) — a complex they discovered in 2012 that dictates pyruvate fate, thereby steering energy production, stemness, and cancer cell proliferation. Publication Trends Across >50 high-impact papers from 2009-2025, Rutter’s work defines how metabolites serve as signaling molecules, how mitochondrial transporters gate metabolic flux, and how rewiring these pathways can treat cancer, heart failure, and inherited metabolic disorders. His most recent studies integrate metabolomics with structural biology to map allosteric networks and exploit them therapeutically. Scientific Awards While specific honors are not enumerated in the source text, Rutter’s designation as an HHMI Investigator and Distinguished Professor signals sustained national and international recognition. Training & Collaboration The Rutter laboratory welcomes rotation students and fosters cross-disciplinary collaborations across the University of Utah Health Sciences campus and beyond. Prospective trainees are encouraged to contact Dr. Rutter directly or follow the lab website and Twitter @RutterLab .

• Platelet Biology
• Coagulation Disorders
• Cancer Thrombosis
• +۳ مورد دیگر

Dr. Vivien Chen is an Associate Professor at the Concord Clinical School, University of Sydney, and leader of the Platelet and Thrombosis Research Laboratory at the ANZAC Research Institute. She holds clinical roles as a staff specialist haematologist at Concord Repatriation and General Hospital, leading the thrombosis clinic. Her research focuses on platelet biology, coagulation in cancer, and thrombotic mechanisms in cardiovascular diseases, with a translational emphasis on clinical applications. Education: MBBS (University of Sydney), BA, PhD (University of New South Wales), postdoctoral training at Harvard Medical School. Her expertise bridges basic science and clinical practice, particularly in cancer-associated thrombosis and myeloproliferative disorders. Research Interests: Dr. Chen investigates procoagulant platelet formation pathways, mitochondrial function in platelet activation, and thrombotic complications in conditions like coronary artery disease and sepsis. Her work also explores predictive biomarkers for thrombotic outcomes and novel antithrombotic strategies. Awards: Over 15 prestigious awards, including the Eberhard Mammen Young Investigator Award, NHMRC CJ Martin Fellowship, and University Medal for Medicine. Her recognition spans clinical, research, and educational contributions in thrombosis and haematology. Grants & Collaborations: Leads projects funded by NHMRC, National Heart Foundation, and international networks. Collaborates with institutions in Singapore and the UK on thrombosis mechanisms and clinical trials. Current studies include platelet-targeted therapies for coronary artery disease and biomarker discovery in myeloproliferative neoplasms. Labs & Teams: Directs the Platelet and Thrombosis Research Laboratory, integrating vascular biology and clinical haematology research. Engages in interdisciplinary projects with the Sydney Platelet Group and ANZAC Research Institute.