جست‌وجوی استاد و پژوهشگر

Tuba Nur Gideمشاهده پروفایل

عضو هیئت علمی

• Immunology
• Melanoma and skin cancer
• Therapeutics
• +۳ مورد دیگر

Dr. Tuba Nur Gide is an Adjunct Senior Lecturer at the Faculty of Medicine and Health, The University of Sydney, and a post-doctoral researcher at the Melanoma Institute Australia. She is also a member of the Charles Perkins Centre and actively contributes to the Cancer Research Network and Sydney Cancer Partners. Dr. Gide completed her PhD in 2019 with a focus on biomarkers of response and resistance to anti-PD-1 based immunotherapies in metastatic melanoma. Her educational background includes a Bachelor of Medical Science with Honors and she received the Australian Postgraduate Award during her doctoral studies. Dr. Gide's research centers on precision medicine approaches to cancer treatment, specifically developing predictive models to determine which patients will respond to immunotherapy versus those who would benefit from alternative treatments. Dr. Gide's work focuses on immunology, melanoma and skin cancer, and therapeutic development. She aims to move away from the 'one drug fits all' approach toward personalized immunotherapy that considers patients' clinical factors and tumor properties. Her research has been published in prestigious journals including Nature Medicine, Nature Communications, Clinical Cancer Research, and Cancer Cell, with a focus on the tumor immune microenvironment, biomarkers of response to immunotherapies, and mechanisms of resistance to cancer treatments. Dr. Gide leads the Personalised Immunotherapy Platform (PIP), a clinical tool developed to ensure advanced melanoma patients receive effective treatment based on their genetics and tumor biology. Her publications reveal a strong focus on spatial immune profiling, biomarker discovery, and understanding resistance mechanisms in immunotherapy. 2024 NHMRC Investigator Grant - EL1 2024 AAMRI Rising Star Finalist 2021 Cancer Institute NSW Early Career Fellowship 2017 Australia Day Awards, National Council of Women of NSW 2015 Australian Postgraduate Award Dr. Gide has secured significant grant funding including an NHMRC Investigator Grant in 2024 and Cancer Institute NSW grants in 2021. She works closely with renowned mentors including Professor Georgina Long, Professor Richard Scolyer, and Dr. James Wilmott. Dr. Gide is passionate about empowering women in cancer research and believes increased female representation in leadership positions is essential for encouraging young female researchers.

Jeffrey Rathmellمشاهده پروفایل

استاد

• Immunobiology
• Cancer Immunotherapy
• T Cell Metabolism
• +۵ مورد دیگر

Jeffrey Rathmell, Ph.D., is the Cornelius Vanderbilt Professor of Immunobiology and Director of the Vanderbilt Center for Immunobiology at Vanderbilt University School of Medicine. His work focuses on immunometabolism, cancer immunotherapy, and the metabolic regulation of immune cell function. He leads a research program investigating how metabolic pathways influence T cell behavior in cancer, sepsis, and autoimmune diseases. Key areas of interest include tumor microenvironment dynamics, immunotherapy resistance mechanisms, and the obesity-cancer connection. Education details are not explicitly listed in the provided text, but his role as a professor and researcher at Vanderbilt indicates advanced training in immunology and biochemistry. His lab has pioneered studies on how cellular metabolism shapes immune responses, particularly in CD4+ and CD8+ T cells. Research interests emphasize metabolic rewiring in T cells during critical illness, the role of metabolic checkpoints in cancer, and the development of therapies targeting immunometabolic pathways. Recent work highlights STING agonist delivery strategies, kynurenine-driven immunosuppression, and PD-1 regulation in tumor-associated macrophages. Publications span 2022–2025, with a focus on immunometabolic mechanisms in cancer, sepsis, and autoimmune conditions. Key themes include tumor escape mechanisms, metabolic dependencies of immune cells, and drug development targeting metabolic vulnerabilities. Labs/Teams: Vanderbilt Center for Immunobiology Grants/Support: Not explicitly listed but inferred through publication topics

Alexei Stuchebrukhovمشاهده پروفایل

استاد

• Computational Chemistry
• Biological Electron Transfer
• Proton Transport
• +۳ مورد دیگر

Dr. Alexei Stuchebrukhov is a Professor at University of California, Davis, leading a computational chemistry group focused on biological energy transduction. He earned his Ph.D. in Theoretical Chemical Physics from Moscow Physical and Technical Institute (1985), with postdoctoral work at Caltech. His research investigates proton-coupled electron transfer in respiratory complexes (I and IV), developing theories for proton pumping mechanisms in cytochrome systems and mitochondrial function. Pioneering contributions include the tunneling currents method for electron transfer analysis and theories of proton migration along membranes. Recent publications (2018-2021) examine respiratory complex dysfunction mechanisms, ROS production regulation, and computational methods for protein hydration. His work connects molecular-scale mechanisms to mitochondrial disorders and aging processes. Awards: BPH Advising Award (2022) Outstanding Mentor Award (2017) Beckman Young Investigator (1997) Sloan Fellowship (1996) He directs research on NADH dehydrogenase proton pumping in collaboration with structural biologists and maintains active development of computational tools for biological electron transfer.

• Liver Development
• Cell Signaling (Wnt/β-catenin pathway)
• Stem Cell Biology
• +۳ مورد دیگر

Zoe Burke is the Director of Teaching in the Department of Life Sciences at the University of Bath. Her research focuses on molecular mechanisms underlying liver development, stem cell biology, and cancer biology, particularly exploring the Wnt/β-catenin signaling pathway. She has contributed to understanding liver zonation, cellular reprogramming, and cancer cell behavior through peer-reviewed publications and editorial work in journals like Frontiers in Cell and Developmental Biology . Her research interests span liver development, cell signaling pathways, and their implications for regenerative medicine. Recent studies include investigations into breast cancer cell electrical excitability and the canonical Wnt pathway’s role in liver differentiation and homeostasis. Collaborations with institutions globally highlight her interdisciplinary approach to developmental and disease biology. Zoe has authored or co-authored 25 research outputs, including reviews and editorials, with a focus on translating molecular insights into therapeutic strategies. She actively contributes to advancing scientific communication through editorial roles and peer-review processes.

• Diabetes in Pregnancy
• Hyperglycemia Management in Critical Illness
• Diabetes Care Integration
• +۳ مورد دیگر

Professor Wah Cheung is a Clinical Professor at the Westmead Clinical School , University of Sydney , and serves as Director of the Department of Diabetes & Endocrinology at Westmead Hospital, as well as Director of the Centre for Diabetes & Endocrinology Research. His career spans significant leadership roles including past presidency of the Australian Diabetes Society and advisory positions with Diabetes Australia and the National Diabetes in Pregnancy Advisory Committee . Currently, he co-chairs the NSW Agency for Clinical Innovation In-Hospital Diabetes Management Committee and participates in the NSW Diabetes Taskforce . Research Interests : Diabetes in pregnancy, hyperglycemia management in critical illness, and diabetes care integration strategies. Clinical Trials : Led pivotal NHMRC-funded studies including the TOBOGM trial (2016-18) and TEXAIS trial (2017-19). Scientific Recognition : NHMRC grant recipient for diabetes detection in emergency settings and hyperglycemia stroke treatment research. Publications : Over 165 peer-reviewed articles focusing on gestational diabetes, acute hyperglycemia management, and postpartum diabetes risk. His work on diabetic retinopathy screening and mobile health interventions demonstrates commitment to translational research and implementation science. He maintains active collaborations across emergency medicine, cardiology, and obstetrics .

• Cardiac Regeneration
• Stem Cell Biology
• Developmental Biology
• +۵ مورد دیگر

Ching Ling Lien, PhD is Professor of Surgery, Cancer Biology, and Stem Cell Biology & Regenerative Medicine at the Keck School of Medicine, University of Southern California. She serves as Director of the Heart Regeneration Research Laboratory within the Department of Surgery at Children's Hospital Los Angeles (CHLA), where her research focuses on molecular mechanisms of cardiac regeneration. Her primary research interests center on comparative heart regeneration biology, specifically investigating why zebrafish exhibit remarkable cardiac regenerative capacity while mammals heal through scarring. Her laboratory employs genetic and genomic approaches to dissect zebrafish heart regeneration mechanisms, with particular focus on gene expression profiling during regeneration, conservation of regenerative pathways in mammals, and potential therapeutic applications for congenital and ischemic heart diseases. Key research areas include cardiac lymphatic vasculature development , coronary vessel revascularization , and metabolic regulation of cardiomyocyte proliferation . Dr. Lien's publication record demonstrates consistent leadership in cardiac regeneration research, with recent work emphasizing single-nuclei multiomic analyses , advanced imaging techniques for zebrafish hearts , and translational applications for human cardiac therapies. Her research bridges developmental biology, regenerative medicine, and cardiovascular disease modeling through innovative use of zebrafish and neonatal mouse models. Her laboratory maintains strong technical expertise in Zebrafish genetic models Cardiac injury and regeneration protocols Advanced cardiac imaging (ultrasound, microscopy) Single-cell genomics Cardiac lymphatic system analysis with research findings directly informing potential regenerative therapies for human heart disease.

• Alcoholic liver disease
• Hepatic stellate cell biology
• TLR4 and TGF-ß signaling in liver pathology
• +۵ مورد دیگر

Hidekazu Tsukamoto, PhD , is a Professor of Pathology at the Keck School of Medicine, University of Southern California, with over 30 years of leadership in alcoholic liver disease (ALD) and liver cancer research. His work spans molecular mechanisms of hepatic stellate cell activation, TLR4/TGF-β signaling, and mitochondrial-epigenetic crosstalk in hepatocarcinogenesis. Institution: University of Southern California Department: Pathology Research Interests : Dr. Tsukamoto’s studies focus on: Epigenetic regulation in liver fibrosis and cancer NOTCH/Wnt signaling in tumor-initiating cells Microbiome-liver axis in ALD Inflammatory pathways in steatohepatitis Metabolic reprogramming of hepatic cells miRNA-based diagnostics and therapies Article Trends : His recent publications emphasize mitochondrial signaling (e.g., ABCB10, NOTCH-TBC1D15 interactions), immune modulation (IL-17, TLR4), and precision animal models (CRISPR-HCC, ethanol infusion systems). Retracted works highlight challenges in reproducibility.

• Diabetic Cardiomyopathy
• Mitochondrial Metabolism
• Insulin Resistance
• +۳ مورد دیگر

E. Dale Abel is a Professor and Department Chair at the David Geffen School of Medicine, University of California Los Angeles (UCLA) . His work bridges cardiovascular research with metabolic disorders , focusing on diabetes-induced mitochondrial dysfunction and insulin signaling in cardiac health . Current research programs include modulating ROS via electromagnetic fields and mitochondrial dynamics in platelets . Education: MD and PhD in Molecular Medicine from University of Melbourne Training: Internship at Royal Melbourne Hospital; Fellowship at NIH His research interests center on diabetic cardiomyopathy , mitochondrial bioenergetics , and metabolic reprogramming in heart disease . Recent studies explore: 2024 Cell paper on evolving diabetes pandemic 2022 Circulation Research work on macrophage glucose suppression 2021 mitochondrial stress adaptation in Autophagy and eLife Scientific grants include: NIH R01HL157781 (2021-2025): Investigating MG53 in heart structure NIH R01DK125079 (2021-2026): Electromagnetic field therapy for diabetes NIH R01HL112413 (2015-2020): Cardiac insulin resistance mechanisms

Julia Jeannine Mackمشاهده پروفایل

استادیار مدعو

• Vascular Biology
• Endothelial Cell Biology
• Lipid Metabolism
• +۳ مورد دیگر

Julia Jeannine Mack is an Assistant Adjunct Professor in the Department of Medicine at UCLA. Her research program focuses on vascular biology, endothelial mechanotransduction, and lipid metabolism. She investigates molecular pathways linking hemodynamic forces, cholesterol transport, and inflammatory responses in cardiovascular diseases. Her primary research interests include: Mechanisms of endothelial cell response to shear stress and mechanical stimuli Cholesterol metabolism and its impact on vascular inflammation Lipid-mediated signaling in atherosclerosis development Metabolic regulation of immune-vascular interactions Novel therapeutic targets for vascular protection Analysis of her recent publications reveals a strong emphasis on vascular mechanobiology, lipid metabolism, and inflammation. Her work consistently integrates molecular biology techniques with physiological models to explore endothelial adaptations to hemodynamic forces, cholesterol trafficking pathways, and their roles in atherosclerosis. The research demonstrates advanced methodologies including in vivo imaging, lipidomics, and genetic manipulation across multiple model systems.

• Lipid Metabolism
• Immunology
• Cancer Biology
• +۷ مورد دیگر

Steven J. Bensinger is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics (MIMG) and the Department of Molecular and Medical Pharmacology at the University of California, Los Angeles (UCLA). He holds a VMD (Veterinary Medicine) from the University of Pennsylvania School of Veterinary Medicine and a PhD in Immunology from the University of Pennsylvania School of Medicine. His research focuses on understanding how lipid metabolism influences cell fate, with a particular emphasis on immune cells and cancer biology. Key areas include the role of lipids in inflammation, host defense, and cancer progression. Dr. Bensinger leads the Bensinger Lab, which employs cutting-edge techniques such as lipidomics and stable isotope labeling to study lipid metabolic pathways. His work has led to significant findings in areas like ferroptosis sensitivity in glioblastoma, cholesterol regulation in T cells, and the impact of lipid metabolism on tumor immunity. He has secured major grants from the NIH, including roles as Principal Investigator or Co-Investigator on projects related to lipid metabolism in diseases like atherosclerosis and cancer. Recent publications highlight his team's advancements in drug development (e.g., Tegavivint), metabolic reprogramming in immune cells, and the interplay between diet, lipid transport, and immune function. His interdisciplinary approach bridges basic science with translational research, aiming to translate metabolic insights into therapies for cancer, autoimmune disorders, and infectious diseases.

Annette Vincentمشاهده پروفایل

استاد آموزشی

• Molecular Biology
• Biochemistry
• Genomics
• +۳ مورد دیگر

Annette Vincent is a Teaching Professor and the Associate Dean for Diversity and Climate at Carnegie Mellon University in Qatar (CMU-Q). She serves as Program Director, Academic Advisor, and Outreach Coordinator for Biological Sciences at CMU-Q, with additional roles on the CMU-Q task force for Student Experience and Career Advisory Council. Education: Ph.D., Department of Biochemistry, The National University of Singapore, Singapore B.Sc. (Hons), Biochemistry, The National University of Singapore, Singapore Teaching in Higher Education Certificate, Learning Academy, Temasek Polytechnic, Singapore Problem-based Learning Facilitation Certificate, Learning Academy, Temasek Polytechnic, Singapore Dr. Vincent's research integrates molecular biology, biochemistry, and toxicology to investigate oxidative stress mechanisms in renal and neural systems. Her work examines sulfite-induced kidney damage, diclofenac nephrotoxicity, mitochondrial dysfunction in diabetes, and keloid pathogenesis through stem cell factor pathways. She also applies bacteriophage genomics for environmental biomonitoring and studies artificial sweetener impacts on kidney health. Her publication timeline (2004-2011) reveals evolving expertise from foundational studies on sulfite neurotoxicity and drug-induced kidney injury toward dermatological applications involving c-KIT signaling in keloids. The consistent thread is cellular stress response mechanisms across organ systems, with growing emphasis on translational therapeutic interventions. As Academic Advisor, Dr. Vincent mentors undergraduate students while spearheading outreach initiatives including the Biotechnology Explorer Program for Qatari secondary students and the Summer College Preview Program. Her leadership in curriculum development for laboratory courses demonstrates commitment to experiential learning. Dr. Vincent directs instructional laboratories for Molecular Biology, Biochemistry, Phage Genomics, and Stem Cell Engineering courses. Through the Biotechnology Explorer Program, she creates hands-on research experiences for pre-university students, strengthening CMU-Q's community engagement in Qatar's STEM education ecosystem.

• Adipocyte Biology
• Lipid Metabolism
• Metabolic Disease
• +۷ مورد دیگر

Claudio Javier Villanueva, PhD , is an Associate Professor in the Department of Integrative Biology and Physiology at the University of California, Los Angeles (UCLA), within the College of Letters and Science. His research program centers on adipocyte biology, lipid metabolism, and metabolic disease, with a focus on brown and beige fat thermogenesis, adipogenesis, and the transcriptional regulation of metabolic pathways. Education and Training: BA in Biology, California State University, San Bernardino (2001) PhD in Biomedical Sciences, University of California, San Francisco (2007) Postdoctoral training in Gene Regulation, University of California, Los Angeles (2012) Research Interests: Villanueva’s lab investigates the molecular mechanisms that govern adipocyte development and function, with an emphasis on how transcriptional networks control energy expenditure and lipid homeostasis. Key areas include: Adipocyte Plasticity: Understanding how white, brown, and beige adipocytes interconvert and respond to metabolic stress. Thermogenesis: Elucidating the molecular underpinnings of brown and beige fat activation and their roles in systemic metabolism. Transcriptional Regulation: Characterizing how transcription factors like PPARγ, TLE3, and PATZ1 regulate adipogenesis and metabolic reprogramming. Metabolic Disease: Exploring how obesity impairs adipose tissue function and contributes to systemic metabolic dysfunction. Research Funding: Villanueva has served as Principal Investigator or Co-Principal Investigator on multiple NIH-funded projects, including: IRACDA at UCLA (K12GM106996, 2016–2026) Role of TLE3 in beige adipocyte transcriptional regulation (R01DK103930, 2015–2021) Transcriptional regulation of beige adipocytes (R03DK103089, 2014–2016) Transcriptional role of TLE3 in brown adipose tissue (K01DK097285, 2013–2016) Fatty acid metabolism and DGAT1 deficiency (F31DK065312, 2004–2007)

Owen N. Witteمشاهده پروفایل

استاد

• Prostate Cancer
• Neuroendocrine Cancer
• T Cell Receptor Engineering
• +۶ مورد دیگر

Owen N. Witte is a Professor at the David Geffen School of Medicine , University of California Los Angeles (UCLA) , with dual appointments in Microbiology, Immunology & Molecular Genetics and Molecular and Medical Pharmacology . His research focuses on prostate cancer , neuroendocrine cancer , T cell receptor engineering , and molecular pharmacology . Research Highlights: Identified PGC-1α's role in neuroendocrine cancer progression Developed nanovial-based TCR screening for cancer immunopeptidomics Explored MYC-dependent RNA splicing in prostate cancer Mapped genomic/epigenomic landscapes of aggressive prostate cancer Scientific Awards: NIH U01CA233074 NIH R01CA222877 NIH R01CA220238 NIH U01CA164188 Collaborative Work includes immunotherapy development , cancer stem cell characterization , and precision medicine strategies for lethal neuroendocrine prostate cancer.

• Hematology
• Immunology
• Oncology
• +۳ مورد دیگر

Chiara Bonini is a Full Professor of Medical and Surgical Applied Sciences at the University of San Raffaele, Milan. She serves as Vice Director of the Division of Immunology, Transplants, and Infectious Diseases at the San Raffaele Scientific Institute (IRCCS) and heads the Experimental Hematology Unit. Trained at the University of Milan (Laurea in Medicine and Surgery, 1994) and the University of Pavia (Specialization in Hematology, 1998), she has held academic and clinical roles since 1998, including postdoctoral fellowships at Fred Hutchinson Cancer Research Center (Seattle) and the Memorial Sloan Kettering Cancer Center (New York). Her research focuses on immunotherapy and gene therapy for hematological malignancies, with a focus on CAR-T cells, regulatory T cells, and metabolic reprogramming. She has led clinical trials and contributed to over 450 publications. Recognitions include the Cancer Research Institute Fellowship (1999–2001). Bonini teaches Hematology across undergraduate and postgraduate programs and chairs editorial boards for journals like Human Gene Therapy and Frontiers in Immunology . She participates in international committees for the American Society of Gene and Cell Therapy and European Hematology Association.

Leonardo M. Ramos Ferreiraمشاهده پروفایل

استادیار

• Immunology
• Cancer Biology
• Regenerative Medicine
• +۴ مورد دیگر

Leonardo M. Ramos Ferreira is an Assistant Professor of Pharmacology & Immunology at the Medical University of South Carolina (MUSC) and the Hollings Cancer Center. He holds a courtesy appointment in Regenerative Medicine and Cell Biology. His research focuses on engineered immune receptors to control immune tolerance in autoimmunity and transplantation, while enhancing anti-cancer immunity. Ferreira earned his PhD at Harvard University, studying immune tolerance during pregnancy, and his postdoctoral work at UCSF involved developing CAR Treg therapies. He has expertise in CRISPR/Cas9 gene editing and CAR T cell engineering. Research Interests : Regulatory T cells, CAR T cell therapy, immune tolerance mechanisms, cancer immunotherapy, and metabolic reprogramming in tumors. His lab develops novel cellular therapies using engineered T cells to treat autoimmune diseases and solid tumors. Recent Work : His articles explore CAR Treg engineering for transplant tolerance, CRISPR-modified pluripotent stem cells, and progesterone's role in maternal-fetal tolerance. Notable contributions include redirecting T cells via chimeric antigen receptors and optimizing CAR T cell manufacturing processes. Labs/Teams : Leads the Ferreira Lab at MUSC, focusing on translational immunology and engineered cellular therapies. Collaborates with teams at UCSF and Harvard on CAR T cell translational research.