Julia Jeannine Mack

Julia Jeannine Mack is an Assistant Adjunct Professor in the Department of Medicine at UCLA. Her research program focuses on vascular biology, endothelial mechanotransduction, and lipid metabolism. She investigates molecular pathways linking hemodynamic forces, cholesterol transport, and inflammatory responses in cardiovascular diseases.

Her primary research interests include:

• Mechanisms of endothelial cell response to shear stress and mechanical stimuli
• Cholesterol metabolism and its impact on vascular inflammation
• Lipid-mediated signaling in atherosclerosis development
• Metabolic regulation of immune-vascular interactions
• Novel therapeutic targets for vascular protection

Analysis of her recent publications reveals a strong emphasis on vascular mechanobiology, lipid metabolism, and inflammation. Her work consistently integrates molecular biology techniques with physiological models to explore endothelial adaptations to hemodynamic forces, cholesterol trafficking pathways, and their roles in atherosclerosis. The research demonstrates advanced methodologies including in vivo imaging, lipidomics, and genetic manipulation across multiple model systems.