Hidekazu Tsukamoto

Hidekazu Tsukamoto, PhD, is a Professor of Pathology at the Keck School of Medicine, University of Southern California, with over 30 years of leadership in alcoholic liver disease (ALD) and liver cancer research. His work spans molecular mechanisms of hepatic stellate cell activation, TLR4/TGF-β signaling, and mitochondrial-epigenetic crosstalk in hepatocarcinogenesis.

• Institution: University of Southern California
• Department: Pathology

Research Interests: Dr. Tsukamoto’s studies focus on:

• Epigenetic regulation in liver fibrosis and cancer
• NOTCH/Wnt signaling in tumor-initiating cells
• Microbiome-liver axis in ALD
• Inflammatory pathways in steatohepatitis
• Metabolic reprogramming of hepatic cells
• miRNA-based diagnostics and therapies

Article Trends: His recent publications emphasize mitochondrial signaling (e.g., ABCB10, NOTCH-TBC1D15 interactions), immune modulation (IL-17, TLR4), and precision animal models (CRISPR-HCC, ethanol infusion systems). Retracted works highlight challenges in reproducibility.