جست‌وجوی استاد و پژوهشگر

• Cancer Therapeutics
• Drug Resistance Mechanisms
• Immunotherapy
• +۳ مورد دیگر

Dr. Dong Yang is an Assistant Professor in the Department of Pharmaceutical Sciences within the College of Pharmacy and Health Sciences at St. John's University. His research focuses on overcoming drug resistance in cancer therapies, particularly targeting ABC transporters and leveraging natural products to enhance treatment efficacy. He explores immunotherapy strategies, such as CAR-T cell therapy, and investigates tumor microenvironment dynamics to improve patient outcomes. Affiliations: St. John's University, College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences Dr. Yang’s work spans multiple cancer types, including lymphoma, breast cancer, and gastrointestinal cancers. His contributions include developing novel therapeutic combinations to combat multidrug resistance and advancing understanding of molecular mechanisms underlying cancer progression. He has published extensively on topics like RNA methylation, ABC transporter inhibition, and the application of natural products in oncology. His research bridges basic science and translational medicine, aiming to translate findings into clinical applications. Key areas of interest include metabolic reprogramming in tumors, immune cell dysfunction in cancer, and the role of pharmacogenomics in personalized therapy. Dr. Yang collaborates on preclinical studies of drug candidates and contributes to drug discovery programs targeting specific cancer pathways. His work has implications for improving treatment strategies in hematologic malignancies and solid tumors.

• Cancer Biology
• Metabolic Mechanisms in Cancer
• Neuro-Oncology
• +۳ مورد دیگر

Samuel McBrayer is an Assistant Professor at the Children's Medical Center Research Institute (CRI) at UT Southwestern Medical Center. He specializes in cancer biology, focusing on metabolic mechanisms driving tumor formation, particularly in brain tumors. His research integrates genetic engineering, organoid models, and metabolomics to uncover vulnerabilities in IDH-mutant gliomas. Education: BA in Biochemistry (Baylor University), PhD in Cancer Biology (Northwestern University). Postdoctoral Training: Dana-Farber Cancer Institute/Harvard Medical School (Kaelin Lab). Research interests include metabolic reprogramming in glioma, synthetic lethality in cancer, and developing therapies targeting metabolic dependencies. Key projects involve IDH1 mutation-driven gliomagenesis and organoid-based precision oncology. Recent work highlights discoveries in pyrimidine biosynthesis vulnerabilities (Cancer Cell 2022) and immune activation via IDH inhibition (Science 2024). Awards include NCI grants and CPRIT funding ($2M+ in 2025). Lab Members: 18 current trainees including MD/PhD students, postdocs, and research associates. Key Collaborations: Dana-Farber, Harvard, and UT Southwestern departments. Future directions focus on translating metabolic insights into clinical therapies for glioma patients.

Sihan Wuمشاهده پروفایل

استادیار

• Cancer Biology
• Genomics
• Oncology
• +۴ مورد دیگر

Dr. Sihan Wu is an Assistant Professor at the Children’s Medical Center Research Institute (CRI) at UT Southwestern Medical Center and a CPRIT Scholar. He holds a secondary appointment in the Department of Pediatrics. His research focuses on understanding the molecular functions and evolutionary dynamics of extrachromosomal DNA (ecDNA) in cancer, particularly how ecDNA drives oncogene amplification, tumor heterogeneity, and therapeutic resistance. Education: Dr. Wu earned his BSc in Biotechnology from Sun-Yat-sen University’s Life Science School, followed by a Ph.D. in Biomedical Sciences from the Zhongshan School of Medicine at SYSU. His postdoctoral training at the Ludwig Institute for Cancer Research (UC San Diego) under Dr. Paul Mischel examined ecDNA’s structural and functional roles in cancer. Research Interests: The Wu Lab integrates genomic sequencing, high-resolution imaging, and computational biology to study ecDNA’s impact on cancer biology. Key projects include investigating ecDNA’s spatial organization, transcriptional regulation, and potential as therapeutic targets. Recent work has uncovered ecDNA’s role in cross-resistance mechanisms in small cell lung cancer and its contribution to Barrett’s esophagus transformation. Awards: He is a recipient of the CPRIT Scholar award, recognizing his innovative research on ecDNA in cancer progression. Lab & Collaborations: The lab collaborates with institutions globally, including the Verhaak Lab (Cold Spring Harbor) and the Mischel Lab (UCSD), to advance understanding of ecDNA biology. Current projects explore ecDNA’s interactions with the cancer genome and its role in immune evasion.

• Prostate Cancer
• Kidney Cancer
• Genitourinary Oncology
• +۳ مورد دیگر

Kevin Dale Courtney, M.D., Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center, specializing in Hematology and Oncology. His clinical and translational research focuses on genitourinary cancers, particularly prostate and kidney malignancies, with over 40 peer-reviewed publications. Duke University: Medical Degree & Doctorate in Molecular Cancer Biology University of California-San Francisco: Internal Medicine Residency Dana-Farber Cancer Institute/Beth Israel Deaconess Medical Center: Clinical & Postdoctoral Fellowships UT Southwestern: Master's in Clinical Sciences (2012) Clinical and translational research spans: prostate cancer hormone therapy optimization, kidney cancer metabolic vulnerabilities (especially hypoxia signaling), immune modulation in cancer, and combination therapies integrating radiotherapy and immunotherapy. Key contributions include HIF-2 inhibition strategies and investigations into tumor-immune interactions. Prominent publication trends include: Hypoxia signaling in renal cell carcinoma Immune checkpoint modulation Metabolic reprogramming in cancer Prostate cancer hormonal therapy Radiotherapy-immunotherapy synergy Targeted drug development Professional contributions include membership in the American Society of Clinical Oncology and advisory roles for the North Texas Prostate Cancer Coalition, supporting survivorship and family-centered care initiatives.

• Biosensors
• Bioengineering
• Nanobioengineering
• +۳ مورد دیگر

Chiara Ninfali is a Researcher leading the Biosensors for bioengineering group at the Institute for Bioengineering of Catalonia (IBEC) . Her work focuses on integrating bioengineering principles with advanced biosensing technologies to address challenges in healthcare and regenerative medicine. Her research interests include the development of innovative biosensors, nanobioengineering applications, and the molecular mechanisms underlying muscle regeneration and inflammatory processes. Her scientific contributions span interdisciplinary fields such as biomaterials, cellular engineering, and molecular oncology. She explores how transcription factors like ZEB1 regulate critical biological processes, including muscle atrophy, inflammation-driven carcinogenesis, and stem cell differentiation. Her studies utilize mouse models and human embryonic stem cells (hESCs) to uncover pathways with translational potential. Chiara’s collaborative projects aim to bridge fundamental research with clinical applications, emphasizing translational bioengineering solutions. Her work has been published in high-impact journals, with recent studies addressing ZEB1’s role in atherosclerosis, mitochondrial function in macrophages, and fasting-induced muscle atrophy mechanisms. Despite no explicit mention of awards in the text, her active research group and multiple publications reflect her contributions to bioengineering and molecular biology. Her lab’s focus on biosensors and regenerative therapies underscores her commitment to advancing healthcare technologies.

• Cellular metabolism
• Bone development
• Skeletal stem-cell biology
• +۴ مورد دیگر

Dr. Courtney Karner is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Nephrology within the Pak Center for Mineral Metabolism and Clinical Research . He began his faculty career at Duke University in 2015 and moved his laboratory to UT Southwestern in 2020, where he continues to lead an active research group. Education & Training: B.S. in Biology — East Central University, Ada, Oklahoma Ph.D. in Genetics & Developmental Biology — UT Southwestern Medical Center Post-doctoral Fellowship — Orthopedic Research & Cell Biology, Washington University School of Medicine in St. Louis Research Focus: The Karner laboratory deciphers how cellular metabolism controls cell-fate specification and differentiation during bone development and disease. By integrating genetics, metabolomics, and high-resolution imaging, the lab investigates how nutrient-sensing pathways, amino-acid transporters, and bioenergetic programs govern skeletal stem-cell activity, osteoblast/osteoclast differentiation, and cartilage biology. Key themes include glutaminolysis, oxidative stress regulation, and nutrient transport in both normal skeletal growth and pathological states such as scoliosis, chondrosarcoma, and obesity-related cartilage degeneration. Professional Service & Affiliations: Serves on the Propel Mentorship Program Mentoring Committee, UT Southwestern Member — Society for Developmental Biology Member — American Society for Bone and Mineral Research Member — Orthopaedic Research Society Member — Advances in Mineral Metabolism Laboratory & Team: The Karner Lab is located in the Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern. It comprises post-doctoral fellows, graduate students, and research staff who collectively explore metabolic regulation of skeletal biology using mouse genetics, advanced imaging, and biochemical assays. The lab is actively recruiting new trainees and collaborators interested in bone metabolism and developmental biology.

• Immunology
• Molecular Biology
• Cell Biology
• +۳ مورد دیگر

Stephanie Vargas Aguilar is an Assistant Instructor in the Department of Molecular Biology at the University of Texas Southwestern Medical Center's Medical School. Her research focuses on immune pathways in regeneration and macrophage biology, with particular emphasis on epigenetic regulation and metabolic diversity of immune cells. She contributes to projects such as ImmGen, leveraging systems biology approaches to analyze immune cell heterogeneity. Her work spans immunology, molecular biology, and cell biology, investigating topics like PD-1/PD-L1 pathway roles in neonatal heart regeneration, macrophage self-renewal mechanisms, and microglia development in brain homeostasis. She employs advanced network analysis and in vivo epigenetic studies to uncover cellular identity and plasticity. Recent articles highlight her focus on metabolic pathways in immune cells and the interplay between immune suppression and tissue repair. Though no awards or grants are listed here, her publications reflect a strong commitment to understanding fundamental mechanisms in immunology and regenerative medicine.

Sebastian Canovas Bernabeمشاهده پروفایل

دانشیار

• Reproductive Physiology
• Assisted Reproductive Technologies (ART)
• Epigenetics
• +۳ مورد دیگر

Sebastian Canovas Bernabe is an Associate Professor of Physiology at the Universidad de Murcia's Faculty of Nursing. He earned his PhD in 2007 from the same university with a thesis on 'Interacciones homólogas y heterólogas in vitro de gametos porcinos, bovinos y humanos y sus aplicaciones en el estudio de la fecundación.' His research focuses on reproductive physiology, epigenetic reprogramming during early embryo development, and the impact of assisted reproductive technologies (ART) on offspring health. Key research areas include the role of reproductive fluids in embryo culture, placental development, and molecular mechanisms regulating fertilization. His work spans cattle, pigs, and human models, with a strong emphasis on translational applications in livestock and human fertility. Notable contributions include studies on zona pellucida hardening, sperm functionality, and the effects of maternal supplementation on fetoplacental vascularity. He leads the 'Physiology of Reproduction' research group and has collaborated on European projects like European Joint Doctorates. His research integrates molecular biology, epigenetics, and animal science to address challenges in assisted reproduction and developmental biology.

Nathaniel W. Snyderمشاهده پروفایل

دانشیار

• Metabolic Biology
• Epigenetics
• Cancer Biology
• +۳ مورد دیگر

Nathaniel W. Snyder, PhD, MPH, is an Associate Professor in the Department of Cardiovascular Sciences at the Lewis Katz School of Medicine, Temple University. He also holds academic positions in the Center for Metabolic Disease Research (Assistant Professor) and Cancer and Cellular Biology (Assistant Professor). His research focuses on metabolic pathways, epigenetic regulation, and their roles in cardiovascular health, cancer, and developmental biology. Snyder’s lab employs advanced analytical chemistry and mass spectrometry to study compartmentalized metabolism and its implications in disease mechanisms. Education: Snyder earned his MPH from the University of Pennsylvania (Philadelphia, PA), followed by a PhD and postdoctoral fellowship in Pharmacology at the University of Pennsylvania Perelman School of Medicine. Research Interests: The Snyder Lab explores metabolic reprogramming in cancer, epigenetic modifications driven by metabolites (e.g., histone acetylation, lactylation), and the interplay between metabolism and cellular compartmentalization. Key projects include studying propionate metabolism across tissues, the role of acetate in tumor quiescence, and metabolic vulnerabilities in low-p16 cancers. Publications: Over 150 peer-reviewed articles, including high-impact studies in Nature Metabolism , Cancer Discovery , and Cell Reports , reflect his contributions to metabolism, epigenetics, and oncology. Recent work highlights novel metabolic pathways in glioblastoma and ovarian cancer, as well as mechanisms linking diet to cardiovascular transcriptional regulation. Lab & Collaborations: The Snyder Lab collaborates with institutions globally, emphasizing translational research in metabolomics and systems biology. They maintain an active website with detailed research descriptions and open-access data (https://sites.google.com/temple.edu/nwsnyderlab).

Sheng Wuمشاهده پروفایل

دانشیار

• Polycystic Ovary Syndrome (PCOS)
• Metabolic Syndrome
• Endocrinology
• +۱۵ مورد دیگر

Sheng Wu, PhD , is an Associate Professor at the Lewis Katz School of Medicine, Temple University , affiliated with the Center for Metabolic Disease Research and the Department of Medical Genetics and Molecular Biochemistry . Their research focuses on metabolic and reproductive dysfunction in polycystic ovary syndrome (PCOS), including insulin signaling, obesity, diabetes, and infertility in females. Education: PhD in Molecular Endocrinology, University of Victoria, Canada; Postdoctoral fellowship, Johns Hopkins University School of Medicine. Memberships: Society of Endocrinology, American Diabetes Association. Research Interests span PCOS, androgen receptor mechanisms, trained immunity, neuroendocrine regulation, and metabolic-inflammatory interactions in cardiovascular and neurodegenerative diseases. Key methodologies include mouse models, metabolomics, and epigenetic analysis. Publications (2025–2022) highlight roles of CD155/CD274 in aortic diseases, androgen receptor dynamics in metabolic health, TMAO's contribution to trained immunity, and epitranscriptomic regulators in atherosclerosis and tumors. Their work emphasizes cross-talk between metabolic syndrome and immune pathways. Scientific Awards: New Investigator Award (American Physiology Society), Early Investigator Award (Endocrinology Society).

Luke O’Neillمشاهده پروفایل

استاد

• Immunology
• Innate Immunity
• Immunometabolism
• +۳ مورد دیگر

Professor Luke O’Neill is the Chair of Biochemistry at Trinity College Dublin, leading the School of Biochemistry and Immunology. He holds a B.A. (Mod.) in Natural Sciences (Biochemistry) from Trinity College Dublin and a PhD in Pharmacology from the University of London. His research focuses on innate immunity, immunometabolism, and signal transduction in inflammation. He has pioneered studies on cytokines, inflammasomes, and the role of metabolic pathways in immune responses. Key roles include founding the Trinity Biomedical Sciences Institute (2011) and serving as Head of the School of Biochemistry and Immunology. He is a Fellow of Trinity College Dublin and the Royal Society (FRS). Notable awards include the Royal Irish Academy Gold Medal (2012), the Milstein Award (2018), and election to the European Molecular Biology Organization (2005). His research integrates immunology and metabolism, exploring how metabolic reprogramming influences immune cell function. Recent work highlights itaconate’s role in suppressing inflammation and its antiviral properties. He is also involved in commercial ventures, co-founding Inflazome and Sitryx, targeting immunometabolic therapies. Education: B.A. (1st Class), Trinity College Dublin (1985); PhD, University of London (1988) Affiliations: Trinity College Dublin, Royal Society Fellow, European Molecular Biology Organisation Member Key Contributions: Discovery of cytokine signaling pathways, NLRP3 inflammasome biology, metabolic regulation of immunity Publications span over 300 peer-reviewed articles, with a focus on innate immunity’s molecular mechanisms. His outreach includes radio appearances and best-selling science books like Humanology (2018) and Never Mind the B*ll*cks (2020).

• Cancer Therapy
• Pharmacology
• Nanoparticle Drug Delivery
• +۳ مورد دیگر

Xiaodong Ma is a Researcher at Åbo Akademi University, actively contributing to the MADNESS Centre of Excellence (2024–2028), a materials-driven initiative addressing antimicrobial resistance. His work aligns with UN Sustainable Development Goals related to health and innovation. Research Interests: Focused on advanced drug delivery systems, cancer therapeutics, and nanomedicine. Key areas include prodrug development, nanoparticle-based therapies, and biomaterials targeting cancers like gastric, ovarian, and pancreatic cancers. His innovations involve DNAzyme nanomachines, mitochondrial reprogramming, and metabolic therapy exploitation. Publications (2020–2024): Over 14 peer-reviewed articles, with recent works emphasizing carrier-free delivery systems, immunomodulatory therapies, and metabolic pathway targeting. Notable contributions include Nature Communications and Advanced Functional Materials publications. Project Leadership: Co-Investigator in the MADNESS project, collaborating with multidisciplinary teams across institutions. Research emphasizes translational applications in materials science and biomedicine. Technical Expertise: Prodrug design, DNA-based nanotechnology, mitochondrial therapies, and cancer metabolism modulation. His work bridges pharmaceutical science with engineering for clinical applications.

Islam Abd El-Daimمشاهده پروفایل

پژوهشگر ارشد

• Plant Science
• Microbiology
• Abiotic Stress Tolerance
• +۴ مورد دیگر

Islam Abd El-Daim is a Strategic Research Fellow at the Institute of Biological, Environmental & Rural Sciences (IBERS), Aberystwyth University. His research focuses on understanding microbial-mediated stress tolerance mechanisms in plants, particularly leveraging bacterial endophytes to enhance plant resilience under abiotic stresses. Key projects include investigating how halotolerant bacteria like Bacillus velezensis improve stress tolerance in Brachypodium and wheat with minimal transcriptional changes. Current projects include the UKRI-funded initiative 'Role of Perennial Biomass Crops microbiomes in reducing N2O emission' (2024-2025), where he leads efforts to explore plant-microbiome interactions for environmental sustainability. His work aligns with UN Sustainable Development Goals related to climate action and sustainable agriculture. Research outputs include peer-reviewed articles in Frontiers in Plant Science and collaborations on topics like holobiont dynamics and rhizobacterial stress mitigation. Media coverage includes a 2025 feature on his Brachypodium stress tolerance study.

Jeff Stuartمشاهده پروفایل

استاد

• Mitochondrial Biology
• Cell Physiology
• Cancer Metabolism
• +۷ مورد دیگر

Jeff Stuart is a Professor in the Department of Biological Sciences at Brock University . His research focuses on mitochondrial biology in health, aging, and disease contexts, with a particular emphasis on developing innovative tools for observing and manipulating mitochondrial networks in living cells. Key tools: MiNA (Mitochondrial Network Analysis), Hypoxio incubators, and O2/CO2 regulation systems Research platform: StuartLab GitHub for open-source scientific tools His work bridges cell physiology and applied biomedical engineering , with recent publications addressing: Cancer metabolism under physiological oxygen conditions Mitochondrial dynamics in disease states Physiological cell culture methodology Neurodegenerative disease mechanisms Thermogenic metabolism through nutritional supplements Jeff Stuart actively collaborates across disciplines, integrating bioinformatics , bioenergetics , and cellular imaging to advance experimental systems biology.

Rahul Kumarمشاهده پروفایل

استادیار

• Pulmonary Hypertension
• Hypoxia
• Vascular Remodeling
• +۳ مورد دیگر

Dr. Rahul Kumar is Assistant Professor of Medicine at UCSF, focusing on pulmonary vascular diseases. His research investigates immune mechanisms driving pulmonary hypertension (PH), particularly hypoxic PH and Schistosomiasis-associated PH. Using murine models and translational approaches, he examines myeloid cell contributions to vascular remodeling and inflammation. His research integrates immunology, vascular biology, and parasitology to understand macrophage and T-cell roles in PH pathogenesis. Current projects explore metabolic reprogramming in vascular cells, hypoxia signaling in immune cells, and novel therapeutic strategies targeting inflammation. Field studies examine genetic and inflammatory signatures in high-altitude PH.