معرفی
Nathaniel W. Snyder, PhD, MPH, is an Associate Professor in the Department of Cardiovascular Sciences at the Lewis Katz School of Medicine, Temple University. He also holds academic positions in the Center for Metabolic Disease Research (Assistant Professor) and Cancer and Cellular Biology (Assistant Professor). His research focuses on metabolic pathways, epigenetic regulation, and their roles in cardiovascular health, cancer, and developmental biology. Snyder’s lab employs advanced analytical chemistry and mass spectrometry to study compartmentalized metabolism and its implications in disease mechanisms.
Education: Snyder earned his MPH from the University of Pennsylvania (Philadelphia, PA), followed by a PhD and postdoctoral fellowship in Pharmacology at the University of Pennsylvania Perelman School of Medicine.
Research Interests: The Snyder Lab explores metabolic reprogramming in cancer, epigenetic modifications driven by metabolites (e.g., histone acetylation, lactylation), and the interplay between metabolism and cellular compartmentalization. Key projects include studying propionate metabolism across tissues, the role of acetate in tumor quiescence, and metabolic vulnerabilities in low-p16 cancers.
Publications: Over 150 peer-reviewed articles, including high-impact studies in Nature Metabolism, Cancer Discovery, and Cell Reports, reflect his contributions to metabolism, epigenetics, and oncology. Recent work highlights novel metabolic pathways in glioblastoma and ovarian cancer, as well as mechanisms linking diet to cardiovascular transcriptional regulation.
Lab & Collaborations: The Snyder Lab collaborates with institutions globally, emphasizing translational research in metabolomics and systems biology. They maintain an active website with detailed research descriptions and open-access data (https://sites.google.com/temple.edu/nwsnyderlab).
