جست‌وجوی استاد و پژوهشگر

Lydia Sorokinمشاهده پروفایل

استاد

• cell-matrix interactions
• leukocyte extravasation
• blood vessels
• +۴ مورد دیگر

Lydia Sorokin is a Professor at the Institute of Physiological Chemistry and Pathobiochemistry within the University of Münster , Germany. She serves as Spokesperson for the Cells in Motion Interfaculty Centre and actively contributes to the Imaging Network and CiM-IMPRS graduate program . Research Focus: Cell-matrix interactions, leukocyte extravasation, blood vessel biology, secondary lymphoid organs, and neuroinflammatory processes. Key Contributions: Elucidating laminin functions in vascular integrity, neuroinflammatory disease mechanisms, and extracellular matrix regulation of immune cell migration. Publication Trends: Recent studies (2022-2024) explore CNS macrophage heterogeneity , endothelial-laminin interactions , and neurovascular unit dysfunction in diseases like multiple sclerosis and cerebral small vessel disease. Earlier work (2012-2020) established roles for laminins and matrix metalloproteinases in blood-brain barrier regulation, immune cell trafficking, and tissue-specific matrix responses. Collaborations & Networks: Active in Cells in Motion , Imaging Network , and CiM-IMPRS graduate program. Collaborates with institutions across Europe on neurovascular and immunology research. Contact: sorokin@uni-muenster.de

Michael Autieriمشاهده پروفایل

استاد

• Vascular Inflammation
• Anti-inflammatory Cytokines
• Vascular Occlusive Diseases
• +۵ مورد دیگر

Michael Autieri is a Professor and Director at the Lemole Center for Integrated Lymphatics and Vascular Research , Associate Director of the Cardiovascular Research Center , and holds affiliations with the Center for Metabolic Disease Research and Sol Sherry Thrombosis Research Center at Lewis Katz School of Medicine, Temple University . He earned his PhD from Hahnemann University in Philadelphia, PA. Research Focus: Regulation of vascular inflammation via endogenous anti-inflammatory cytokines (e.g., IL-19), mechanisms of atherosclerosis, restenosis, allograft vasculopathy, and therapeutic angiogenesis for peripheral vascular disease. Key Contributions: IL-19's role in macrophage polarization, cholesterol homeostasis, endothelial/smooth muscle proliferation, and mRNA stability. Recent work includes FXR1 regulation of vascular contractility, mitochondrial fission in hypertension, and neuro-lymphatic communication via CXCL12/CXCR4. Article Trends: Over 15 most recent publications, Autieri's work spans RNA biology (e.g., FXR1, ILF3), lymphatic-vascular crosstalk (e.g., IL-19, Prox1), metabolic-inflammatory syndromes (e.g., LDLRAP1, adipose dysfunction), and novel therapeutic targets (e.g., stress granules, chemokine signaling). His research integrates vascular biology , immunometabolism , and RNA regulatory networks to combat cardiovascular diseases.

• Vascular Biology
• Inflammation
• Atherosclerosis
• +۳ مورد دیگر

Hai Feng Zhang is an Associate Research Scientist in the Department of Pathology at Yale University School of Medicine. His research focuses on vascular biology and inflammation-driven diseases, particularly exploring mechanisms of endothelial dysfunction in conditions like atherosclerosis and cerebral cavernous malformations (CCM). He holds a PhD from the National University of Singapore and degrees from China Agricultural University. Education: PhD, National University of Singapore MS, China Agricultural University, Endocrinology BS, China Agricultural University, Biochemistry and Physiology Research Interests: His work investigates how inflammatory signals (e.g., TNF) and reactive oxygen species disrupt endothelial homeostasis. Key areas include: - Molecular mechanisms of vascular inflammation - Role of SUMOylation in vascular remodeling - Mitochondrial dysfunction in endothelial pathologies - CCM pathogenesis and therapeutic targets Key Contributions: Recent studies have uncovered roles for SRF SUMOylation in smooth muscle differentiation and identified mitochondrial pathways (TRX2, ATPIF1) critical for vascular health. Collaborations with teams like the Jenny Zhou Lab advance understanding of brain endothelial progenitor signaling and CCM development. Labs/Teams: Active member of the Jenny Zhou Lab, collaborating on translational vascular research projects.

Mariappan Muthuchamyمشاهده پروفایل

استاد

• Cardiac Muscle Physiology
• Lymphatic System Biology
• Mechanotransduction
• +۴ مورد دیگر

Mariappan Muthuchamy is a Professor of Medical Physiology and Director of the Cardiovascular Research Institute at Texas A&M University. His research focuses on cardiac and lymphatic muscle contraction mechanisms, mechanotransduction signaling, and the interplay between mechanical forces and cellular functions. He holds the Lyndon Baines Johnson Research Award. Education: B.S. Chemistry, Madurai Kamaraj University, India (1980) M.S. Biochemistry, Madurai Kamaraj University, India (1983) Ph.D. Biochemistry/Molecular Biology, Madurai Kamaraj University, India (1991) Research Interests: Dr. Muthuchamy’s work explores molecular mechanisms underlying cardiac muscle dynamics in health and disease, including thin filament activation, crossbridge kinetics, and mechanotransduction. His lab employs molecular, cellular, and structural techniques to study myofilament regulation. He pioneered methods to exchange myofibrillar proteins via transgenic manipulation. Additionally, he investigates lymphatic muscle contraction, its role in fluid transport, and its unique smooth-striated hybrid contractile properties. Recent work includes studying lymphatic dysfunction in metabolic disorders and inflammatory conditions using advanced tools like Atomic Force Microscopy (AFM) and microphysiological systems (e.g., Lymphangion-Chip). Key Findings: Established AFM-fluorescence microscopy fusion for mechanotransduction studies. Discovered lymphatic muscle’s role in systemic fluid dynamics and disease pathogenesis (e.g., lymphedema, metabolic syndrome). Linked inflammatory mediators (e.g., IL-1β, TNF-α) to lymphatic pump impairment. Awards: Lyndon Baines Johnson Research Award (Lyndon Baines Johnson Foundation) Lab & Collaborations: His lab includes Research Assistant Akshaya Narayanan (akshaya.narayanan@tamu.edu). Collaborations focus on translational research in cardiovascular and lymphatic physiology, leveraging engineered tissues and animal models. Ongoing projects target lymphatic dysfunction in amyotrophic lateral sclerosis, Duchenne muscular dystrophy, and metabolic diseases. Labs/Teams: Cardiovascular Research Institute (CRI) at Texas A&M, with interdisciplinary teams studying mechanobiology, integrin signaling, and lymphatic-inflammatory interactions.

Karen Peeblesمشاهده پروفایل

مدرس ارشد

• Physiotherapy
• Cardiorespiratory Interactions
• Cerebral Blood Flow Regulation
• +۳ مورد دیگر

Karen Peebles is a Senior Lecturer (Teaching and Leadership) in the Department of Health Sciences at Macquarie University, Australia. With over 20 years of combined clinical and academic experience, she specializes in cardiopulmonary physiotherapy and in vivo physiological research focusing on respiratory-cardiovascular interactions in health and disease. Her work has been published in high-impact international physiology journals. Biography highlights 15+ years of research outputs Active in teaching award initiatives Research interests include: Dynamic cerebral autoregulation and stroke risk mechanisms Orthostatic intolerance in hypermobility disorders Baroreflex function and vascular stiffness Cardiorespiratory interactions in human models Muscle reflex control post-spinal injury Lymphedema assessment techniques Recent publications focus on interarm blood pressure variability , postural orthostatic tachycardia syndrome , and hypermobility disorder epidemiology . Teaching awards include: 2023 Excellence in Education - Rising Star 2023 Learning & Teaching Award (Inclusive Teaching) 2018 Macquarie University Vice-Chancellor’s Citation Active in organizing Macquarie University Research Symposia for Medical Doctorate and Physiotherapy programs since 2022.

Sotiris Mastoridisمشاهده پروفایل

عضو هیئت علمی

• Transplant Immunology
• Extracellular Vesicle Biology
• Surgical Outcomes
• +۳ مورد دیگر

Sotiris Mastoridis is a Clinical Lecturer in General Surgery at the University of Oxford, affiliated with Jesus College. He holds academic appointments in both the Medical Sciences Division and the Department of Surgery. His academic background includes a medical degree from Imperial College London, an NIHR-funded Academic Clinical Fellowship in General Surgery, and a PhD in transplant immunology and extracellular vesicle biology from King’s College London. Research interests focus on immunological mechanisms governing tolerance and activation post-transplantation, alongside extracellular vesicle biology. He actively contributes to surgical outcomes research, particularly in pancreatic, hepatic, and oncologic surgeries. Mastoridis has published extensively on surgical innovation (e.g., robotic HPB surgery), pandemic-related surgical adaptations, and biomarker discovery in transplantation. His work integrates clinical practice with translational research, addressing challenges in surgical technique optimization, postoperative complication mitigation, and immunological tolerance in organ transplantation. Notable projects include predictive models for pancreatic surgery outcomes and investigations into IL-2’s role in regulatory T-cell function. Mastoridis teaches clinical medicine to undergraduate students at Jesus College, emphasizing surgical education and evidence-based practice. His research has been supported by international collaborations, as evidenced by his participation in multi-center studies like the COVDISurg initiative. He maintains a strong focus on advancing surgical preparedness globally and improving outcomes for complex surgical cases.

Paul Rileyمشاهده پروفایل

استاد

• Cardiovascular Development
• Regenerative Medicine
• Stem Cell Biology
• +۵ مورد دیگر

Professor Paul Riley is a leading academic in cardiovascular development and regenerative medicine. He holds roles as Professorial Fellow in Medicine at Jesus College, British Heart Foundation Professor of Regenerative Medicine, and Chair of Development and Cell Biology at the University of Oxford's Department of Physiology, Anatomy and Genetics. He also directs the Institute of Developmental & Regenerative Medicine. His research focuses on cardiac regeneration, lymphatic vasculature, and macrophage biology, with a particular interest in translating developmental mechanisms to adult heart repair. Paul has received prestigious awards, including the European Society of Cardiology's Outstanding Achievement Award (2008) and Fellowship of the Academy of Medical Sciences (2014). Education: BSc Zoology (Leeds, 1987-1990); PhD Zoology (UCL, 1992-1995) Positions: Postdoctoral training at Mount Sinai Hospital (Toronto) and Oxford, followed by roles at UCL-Institute of Child Health before moving to Oxford in 2011. His research interests include transcriptional control of heart development, congenital heart disease modeling, and stem cell-derived cardiac repair. He teaches undergraduate and postgraduate courses at Oxford and UCL, covering topics like cardiovascular development and stem cell biology. His lab investigates epicardial progenitor cells, cardiac lymphatics, and macrophage interactions in regeneration. Scientific achievements include discovering epicardial cell potential for heart regeneration and elucidating lymphatic roles in post-injury repair. His work bridges basic science and clinical applications, aiming to develop novel regenerative therapies for heart disease.

Elias Hobeikaمشاهده پروفایل

پژوهشگر

• B Cell Biology
• Signal Transduction
• Lymphocyte Development
• +۳ مورد دیگر

Dr. Elias Hobeika is a Group Leader specializing in B cell biology, focusing on survival mechanisms and signaling pathways in mature B cells. His research investigates how deletion of components of the B cell antigen receptor (BCR) and its signaling machinery affects cellular homeostasis, utilizing Tamoxifen-inducible B cell-specific Cre strains to manipulate "floxed" alleles like immunoglobulin heavy chain, Iga, Igb, and Syk. His work aims to translate findings to human B cells in lymphatic disorders and murine models of malignant B cell development. Key research areas: B cell antigen receptor (BCR) signaling BAFF-R mediated survival pathways Role of Syk, PI3K, and ATM-p53 in B cell homeostasis Mouse models for B cell lymphomas Translational studies in human lymphatic disorders Recent publications (2010–2016) reveal consistent focus on: Signal transduction in B cell development Kinase/phosphatase equilibrium in malignant transformation Chemotaxis mechanisms via CXCR4 and ZAP-70 Regulation of terminal differentiation by oncogenic factors

Stephen E. Braunمشاهده پروفایل

استادیار

• Gene Therapy
• HIV/AIDS Research
• Virology
• +۵ مورد دیگر

Stephen E. Braun is an Assistant Professor of Pharmacology at Tulane University. His research focuses on gene therapy strategies targeting lympho-hematopoietic cells, with a strong emphasis on HIV/AIDS research. He has over 25 years of experience in translational research, including studies in non-human primates (NHP) and clinical trial advancements. His work involves developing CAR T-cell therapies, lentiviral vector engineering, and mesenchymal stem cell-based antiviral approaches. Education: BS in Genetics and Cell Biology, Biochemistry, University of Minnesota (1987) PhD in Genetics, University of Minnesota (1993) Postdoctoral Fellowship at Walther Oncology Center, Indiana University School of Medicine (1993–1997) Research Interests: Dr. Braun’s lab develops novel gene therapy approaches to combat HIV/AIDS, including CAR T-cell redirection, HIV-resistant T-cell engineering, and MSC-mediated viral inhibition. His work bridges in vitro studies with large-animal models and clinical application. Key Awards: NIH Post-Doctoral Training Award (1993–1995) Leukemia Society of America Fellow Award (1995–1998) Center for AIDS Research Scholar Award (2003–2006) Early Investigator Award (30th Annual NHP AIDS Symposium, 2012) Grants & Collaborations: His research has been supported by NIH and private foundations. Collaborations span institutions such as the National Primate Research Centers and the American Society of Gene & Cell Therapy. Labs/Teams: Active in Tulane’s Division of Veterinary Medicine and collaborates with the Comparative Pathology and Immunology research groups.

Joseph Muddمشاهده پروفایل

استادیار

• HIV/AIDS Research
• Immunology
• Virology
• +۳ مورد دیگر

Joseph C. Mudd is an Assistant Professor in the Department of Microbiology and Immunology at Tulane University, leading the Mudd Laboratory within the Division of Immunology. His research focuses on understanding mechanisms of HIV-1 persistence and reservoir maintenance, particularly exploring interactions with co-infecting viruses like CMV and the impact of nutritional interventions on SIV pathogenesis. He holds a PhD from Case Western Reserve University. Research Interests: Latent HIV reservoir dynamics CMV-driven immune activation and reservoir persistence Nutritional regulation of viral pathogenesis Immunometabolic pathways in chronic infections Funding: ORIP/NIH: $400,000 (Mechanisms of CD4 down-regulation in African green monkeys) NIAID/NIH: $5.1M (Role of RhCMV in SIV reservoir persistence) Laboratory Team: Ph.D. students Naveen Suresh Babu and Maggie Hallmet, Post-Doc Chrysostomos Perdios, and Research Technician Celeste D. Collaborators include prominent researchers like Clovis Palmer and Joshua Schiffer. Lab Location: 18703 Three Rivers Road, Covington, LA 70433

Matt Rutarمشاهده پروفایل

دانشیار

• Retinal Degenerative Diseases
• Immunology
• Ophthalmology
• +۳ مورد دیگر

Matt Rutar is an Associate Professor in the Department of Biomedical Science, Molecular & Biochemical Therapeutics at the University of Canberra, within the Faculty of Science and Technology. His research focuses on understanding molecular and cellular drivers of vision-threatening retinal diseases, particularly age-related macular degeneration (AMD). He holds an Honorary Senior Fellow position at the University of Melbourne's Anatomy and Neuroscience department. Education: PhD in Biomedical Science from Australian National University (2008-2011). Postdoctoral research at John Curtin School of Medical Research (JCSMR) and the University of Melbourne, where he established an independent laboratory funded by NHMRC grants. Research interests include immunological mechanisms in retinopathies, environmental/lifestyle influences on eye disease, and developing therapeutic targets for AMD. He leads projects funded by organizations like the Ophthalmic Research Institute of Australia and NHMRC, including studies on neutrophils in choroidal neovascularization and Wnt signaling in multiple sclerosis. Advising: Open to supervising PhD/Masters/Honours students in his research themes. His work bridges basic science and clinical applications, aiming to translate immune regulation discoveries into novel therapies for retinal disorders. Current laboratory facilities at University of Canberra support advanced molecular and cellular investigations into retinal pathologies.

• Biomedical Engineering
• Mathematical Biology
• Biophysics
• +۳ مورد دیگر

Associate Professor Charles Macaskill is affiliated with the Faculty of Science at the University of Sydney. His research focuses on mathematical and computational modeling in biomedical systems, particularly lymphatic muscle physiology, fluid dynamics in embryonic tissues, and cardiovascular-related phenomena. He collaborates internationally, as evidenced by grants from the NIH and ARC. Key research interests include lymphatic pacemaking mechanisms, atherosclerotic plaque dynamics, and the biophysical underpinnings of cellular signaling pathways. His work bridges theoretical models with experimental data, addressing clinical conditions like lymphedema and cardiovascular disorders. Recent publications emphasize lymphatic valve formation, ion channel effects on muscle cell behavior, and fluid dynamics in developmental systems. He has secured significant grants for projects such as 'Lymphatic pacemaking and pumping in lymphedema' and 'Dynamics of atherosclerotic plaque formation'.

Per Kristian Eideمشاهده پروفایل

استاد مدعو

• Neurosurgery
• Cerebrospinal Fluid Dynamics
• Glymphatic System
• +۳ مورد دیگر

Per Kristian Eide is an Adjunct Professor in the Department of Neurosurgery at the University of Oslo's Faculty of Medicine, affiliated with the Institute of Clinical Medicine. His work focuses on neurosurgical research, particularly cerebrospinal fluid (CSF) dynamics, glymphatic system function, hydrocephalus, and neurological disorders such as Chiari malformation and idiopathic intracranial hypertension. His research integrates clinical neurosurgery with advanced imaging techniques like MRI to study CSF flow and molecular clearance mechanisms. He has contributed to studies on CSF tracer dynamics, glymphatic MRI, and the role of sleep deprivation in brain fluid dynamics. His research groups include the K.G. Jebsen Centre for Brain Fluid Research and Neurovascular & Cerebrospinal Fluid Research Group. Notable collaborations involve investigating genetic risk factors for normal pressure hydrocephalus and developing imaging biomarkers for CSF disorders. His clinical expertise includes surgical and non-invasive management of CSF-related conditions, with particular attention to pediatric neurosurgery and outcomes in craniosynostosis cases. Publications emphasize translational research linking basic CSF biology to clinical applications, including diagnostic markers for hydrocephalus and therapeutic strategies for glymphatic dysfunction. His work also addresses neurovascular interfaces, lymphatic pathways, and the pathophysiology of brain sagging dementia.

Geoffrey P. Lukeمشاهده پروفایل

دانشیار

• Ultrasound Imaging
• Photoacoustic Tomography
• Nanoparticle Theranostics
• +۲ مورد دیگر

Geoffrey P. Luke is Associate Professor of Engineering at Dartmouth's Thayer School of Engineering, directing the Functional and Molecular Imaging Lab. His research develops nanoparticle-enhanced ultrasound and photoacoustic imaging for cancer diagnostics and therapy. Current projects include multiplex imaging of tumor biomarkers using phase-change nanodroplets and NIH-funded oral cancer detection systems. Publications focus on advanced contrast agents (gold nanorods, perfluorocarbon nanodroplets) and wavelength-optimized spectroscopic imaging for applications in sentinel lymph node mapping and image-guided photothermal therapy. Recent work emphasizes clinical translation of hybrid imaging modalities.

Jonathan I. Leckenbyمشاهده پروفایل

استادیار

• Peripheral Nerve Regeneration
• Facial Paralysis Reanimation
• Vascularized Composite Allotransplantation
• +۳ مورد دیگر

Jonathan I. Leckenby is an Assistant Professor in the Departments of Surgery (Plastic Surgery) and Neuroscience at the University of Rochester School of Medicine and Dentistry. He holds joint credentials and is affiliated with the UR Medicine Faculty Group and Accountable Health Partners. His research focuses on peripheral nerve regeneration, facial paralysis reanimation, and vascularized composite allotransplantation. He has been involved in groundbreaking work, including pioneering techniques like free functional platysma transfer for eye closure restoration and using 3D electron microscopy to study nerve regeneration. Dr. Leckenby’s academic journey includes degrees from King's College London and St. George's Hospital Medical School, followed by training in plastic surgery and postdoctoral research at Harvard under Jeff Lichtman. Education: Bachelor's in Basic Medical Science and Advanced Human Anatomy, King's College London M.B.B.S., St. George's Hospital Medical School Ph.D. in Neuroscience (postdoctoral, Harvard University) Research Interests: Dr. Leckenby’s lab investigates mechanisms to enhance peripheral nerve regeneration, reduce chemotherapy-induced neuropathy, and improve outcomes in facial paralysis surgery. His work integrates advanced imaging (e.g., diffusion MRI for facial nerve pathways) and 3D microscopy to visualize axonal behavior. Key projects include developing standardized outcome measures for facial reanimation and optimizing immunosuppression in transplant patients. Publications: His 2024 paper on rodent nerve regeneration models highlights advancements in repair techniques. Recent work includes systematic reviews on VCA complications and novel surgical techniques for facial paralysis. His research often bridges clinical practice and laboratory science, aiming to translate findings into patient care. Awards: Recipient of the CMSR Discovery Award (2021), W.G. Stuber Fellowship (2020), and the Wissenschaftpreis (2016). His contributions span international collaborations, including work in Switzerland and the U.S. Grants & Advising: Secured a Department of Defense grant for lymphatic system research in transplantation. Advised over a dozen students/postdocs, including Miranda Chacon and Scott Echternacht. His lab collaborates widely, focusing on translational medicine. Labs/Teams: Lead of the Leckenby Lab, which combines clinical innovation with basic science. Projects include developing an automated facial symmetry index (AFSI) and studying murine models for neuropathy prevention.